检索结果-南通市图书馆

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

供电服务风险防控市级实施策略

大众用电 2024年第8期 26-27页

作者：朱梓嘉黄宁喻舒婷国网衡阳供电公司湖南国网湖南供电服务中心(计量中心)

供电服务是指供电企业为客户提供与供电相关的服务,贯穿于电力生产和消费的整个过程,包括电力供应、销售、使用等多个环节,在提供电力服务过程中存在各类服务风险。为确保客户能够安全、可靠、经济地使用电能,同时满足客户日益增长的对... 详细信息

供电服务是指供电企业为客户提供与供电相关的服务,贯穿于电力生产和消费的整个过程,包括电力供应、销售、使用等多个环节,在提供电力服务过程中存在各类服务风险。为确保客户能够安全、可靠、经济地使用电能,同时满足客户日益增长的对电能质量和供电可靠性的需求,国网湖南省电力有限公司构建省市县所四级风险防控模式,本文将对供电服务风险防控在市级公司实施策略进行分析。

关键词：风险防控供电服务电力服务实施策略供电企业服务风险防控模式供电可靠性

Involvement of long non-coding RNAs in the progression of esophageal cancer

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2021年第5期41卷 371-388页

作者： Wenhua Xue Yuanyuan Zheng Zhibo Shen Lifeng Li Zhirui Fan Wenbin Wang zijia zhu Yunkai Zhai Jie Zhao Quancheng Kan Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052P.R.China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052P.R.China Internet Medical and System Applications of National Engineering Laboratory ZhengzhouHenan 450052P.R.China Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhouHenan 450052P.R.China

Esophageal cancer(EC)is one of the most common malignant tumors of the digestive system with high incidence and mortality rate ***,exploring the pathogenesis of ECand searching for new targeted therapies are the current research hotspot for EC *** non-coding RNAs(lncRNAs)are endogenous RNAs with more than 200 nucleotides,but without proteincoding *** recent years,lncRNAs have gradually become the focuses in the field of non-coding *** lncRNAs have been proved to be closely related to the pathogenesis of *** lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation,apoptosis,and metastasis by inhibiting or promoting target gene *** can also regulate the progression of EC through epithelial-mesenchymal transformation(EMT),which is closely related to the occurrence,development,and prognosis of *** this article,we review and discuss the involvement of lncRNAs in the progression of EC.

关键词： apoptosis biomarker diagnosis drug resistance esophageal cancer long non-coding RNA metastasis prognosis proliferation

Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2022年第2期2022卷 5-24页

作者： Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu zhuo Wang Yongyong Shi Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministryof Education)Shanghai jiao Tong University1954 Huashan RoadShanghai 200030China Biomedical Sciences Insttuteof Qingdao University(Qingdao Branch of SJTU Bio-X Institutes) Qingdao University Qingdao 266003China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Shanghai Key Laboratory of Sleep Disordered Breathing Shanghai liao Tong University Afliated Sixth People's Hospital.ShanghaiChina The First Afiliated Hospital of Zhengzhou Universily Zhengzhou 450052China Deparment of Psychiary First Teaching Hospital of Xinjiang Medical UniversitUrumqi 830046China

SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H *** acid mutations are enriched in the spike protein of SARS *** plays a crucial role in cell ***,the impact of these mutations on protein structure and function is *** the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein ***,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using *** clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta *** that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein *** analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 ***,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 *** findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants.

关键词： globally similarity finding

Scrutinizing the causal relationship between schizophrenia and vitamin supplementation:a Mendelian randomization study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bio-X Research 2022年第1期5卷 18-26页

作者： Aamir Fahira zijia zhu Zhiqiang Li Yongyong Shi Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Collaborative Innovation Center for Brain ScienceShanghai Jiao Tong UniversityShanghai Department of Pharmacy Henan Key Laboratory of Precision Clinical PharmacyThe First Afiliated Hospital of Zhengzhou UniversityZhengzhouHenan Province The Afiliated Hospital of Qingdao University The Biomedical Sciences Institute of Qingdao University(Qingdao Branch of SJTU Bio-X Institutes)Qingdao UniversityQingdaoShandong ProvinceChina

Objective: Observational studies have reported malnutrition and vitamin deficiency in patients with schizophrenia (SZ), which can lead to serious metabolic syndromes and decrease anti-psychiatric drug outcomes. Whereas, vitamin intake along with psychiatric medication can enhance the medication outcomes. However, it is still unknown if SZ induces vitamin deficiency. Herein, we conduct the Mendelian randomization analysis to explore the causal relationship between schizophrenia and vitamins ***: We retrieved the genome-wide summary statistical data for schizophrenia from recent SZ GWAS data (43,175 cases and 65,166 controls) and vitamins supplementation GWAS data from Neale’s GWAS datasets (more than 337,000 samples from the European population) and performed a two-sample Mendelian randomization analysis to determine the causal association of SZ with vitamin supplementation, in addition, we conduct the sensitivity analysis to obtain reliable results and remove confounding ***: SZ have causal relationships with vitamins A, B, C, D, and E (SZ/vitamin A: β = 0.002, se= 0.001, 95% confidence interval (CI): 0.001 to 0.004,P= 1.41E-05, heterogeneityP= 0.4486;SZ/vitamin B: β= 0.004, se= 0.001, 95% CI: 0.002-0.005,P= 7.0E-05, heterogeneityP= 0.2217;SZ/vitamin C: β= 0.004, se= 0.001, 95% CI: 0.002-0.007,P= 0.001, heterogeneityP= 0.1349;SZ/vitamin D: β= 0.003, se= 0.001, 95% CI: 0.002-0.005,P= 0.001, heterogeneityP= 0.433;SZ/vitamin E: β= 0.003, se= 0.001, 95% CI: 0.002-0.005,P= 5.0E-05, heterogeneityP= 0.1382).Conclusion: Our findings suggest that vitamin levels and supplementation should be carefully controlled in patients with SZ, which in turn may enhance the therapeutic effects of antipsychotic drug treatments.

关键词： dietary intake Mendelian randomization study psychiatric disorders unhealthy lifestyle vitamins supplementation

基于并行组合进化算法的光伏阵列最大功率点追踪

在线全文

学校读者我要写书评

暂无评论

电力系统保护与控制 2020年第4期48卷 1-10页

作者：朱梓嘉肖辉赵帅旗刘忠兵长沙理工大学电气与信息工程学院湖南长沙410114 湖南大学土木工程学院湖南长沙410082

针对光伏阵列在局部遮阴时功率的多峰输出,提出了一种新型并行组合进化算法(GA-DE-PSO),解决了传统采用的单一进化算法以及单一改进算法追踪最大功率时的不稳定性和精确性不足的缺点。该方法将所有的可行解个体随机分为两个子种群,并行... 详细信息

针对光伏阵列在局部遮阴时功率的多峰输出,提出了一种新型并行组合进化算法(GA-DE-PSO),解决了传统采用的单一进化算法以及单一改进算法追踪最大功率时的不稳定性和精确性不足的缺点。该方法将所有的可行解个体随机分为两个子种群,并行采用向量的差分进化模式和染色体的遗传模式,产生新型个体和备选个体。再通过粒子群算法进行混合选择,得到更为有效的可行域的指导信息,从而更快速地收敛到最优点,实现最大功率点追踪。仿真结果表明,组合算法保留了三种进化算法的优点,具有较高的寻优精度与稳定性。

关键词：局部遮阴最大功率点追踪粒子群算法差分进化算法遗传算法全局寻优

FOD缺口型损伤对TC4疲劳极限强度的影响

在线全文

学校读者我要写书评

暂无评论

航空动力学报 2018年第7期33卷 1584-1594页

作者：贾旭胡绪腾朱自佳嵇大伟宋迎东南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室南京210016 南京航空航天大学机械结构力学及控制国家重点实验室南京210016

针对TC4钛合金风扇/压气机叶片前缘常遭受的外物损伤(FOD)缺口型损伤,进行了不同冲击角度下高速弹道冲击试验研究、损伤特征与应力集中分析,开展了冲击后不处理和冲击后去残余应力退火试样的高循环疲劳试验和疲劳极限强度预测。结果表明... 详细信息

针对TC4钛合金风扇/压气机叶片前缘常遭受的外物损伤(FOD)缺口型损伤,进行了不同冲击角度下高速弹道冲击试验研究、损伤特征与应力集中分析,开展了冲击后不处理和冲击后去残余应力退火试样的高循环疲劳试验和疲劳极限强度预测。结果表明:随着冲击角度的增大入射侧损伤尺寸和应力集中系数基本保持不变,出射侧缺口损伤深度和损伤长度减小。损伤深度范围为0.6~1.5mm,应力集中系数范围为2.6~3.4。缺口型损伤试样的疲劳极限强度下降为光滑试样的27%~53%,与应力集中系数并不是呈反比关系。退火试样的高循环疲劳(HCF)性能或略微下降或基本不变,表明残余应力影响较小,残余应力对疲劳极限强度的影响程度不足光滑试样的10%。缺口型损伤试样的HCF性能与损伤底部半径的相关性不明显,随着最大损伤深度和损伤长度的增加而下降,表明制定维修手册时应着重考虑缺口型损伤的最大深度和损伤长度。Peterson经验公式对HCF性能的预测精度不理想,误差最大为45%,需要发展高精度的FOD缺口型损伤构件HCF性能预测方法。

关键词：外物损伤(FOD) 弹道冲击 TC4钛合金疲劳极限强度(FLS) 损伤特征疲劳预测

在线全文

学校读者我要写书评

暂无评论

凹坑型硬物损伤对TC4材料疲劳强度的影响

航空动力学报 2018年第4期33卷 969-979页

作者：胡绪腾贾旭朱自佳嵇大伟宋迎东南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室南京210016 南京航空航天大学机械结构力学及控制国家重点实验室南京210016

针对风扇/压气机叶片中叶盆/叶背遭受的硬物损伤(FOD)凹坑型损伤,进行了不同冲击角度下模拟FOD试验、损伤特征与应力集中分析,开展了冲击后不处理和冲击后去残余应力退火试样的高循环疲劳试验研究和疲劳强度的预测。结果表明:损伤深度... 详细信息

针对风扇/压气机叶片中叶盆/叶背遭受的硬物损伤(FOD)凹坑型损伤,进行了不同冲击角度下模拟FOD试验、损伤特征与应力集中分析,开展了冲击后不处理和冲击后去残余应力退火试样的高循环疲劳试验研究和疲劳强度的预测。结果表明:损伤深度和应力集中系数均随着冲击角度的增加而变大,损伤深度范围为0.1~0.5mm,应力集中系数范围为1.3~1.7。不同冲击角度条件下,凹坑型损伤试样疲劳强度相对光滑试样下降程度在50%~70%范围内,与应力集中系数并不是呈单调下降关系,最危险冲击角为60°。去残余应力退火后凹坑型损伤试样的高循环疲劳(HCF)性能有所提高,表明残余应力的影响程度不容忽略。去残余应力试样的HCF性能并不是随应力集中系数的增大而下降,验证了微结构损伤的影响,说明损伤深度作为制定可用极限或维修极限的唯一参量具有一定的局限性。对凹坑型损伤试样的疲劳强度的预测误差在±20%以内。

关键词：硬物损伤(FOD) 弹道冲击 TC4钛合金疲劳强度损伤特征疲劳预测

在线全文

学校读者我要写书评

暂无评论

基于BSO的局部阴影下光伏最大功率点追踪

电力系统及其自动化学报 2020年第6期32卷 74-79,100页

作者：赵帅旗肖辉刘忠兵朱梓嘉张万长沙理工大学电气与信息工程学院长沙410114 湖南大学土木工程学院长沙410082

为了减小局部遮阴情况PSC(partial shading condition)下光伏系统的功率失配损失,提高最大功率点追踪MPPT(maximum power point tracking)的追踪速度和准确性,提出了基于天牛群优化BSO(beetle swarm optimiza?tion)算法的MPPT控制方法.把由天牛须搜索BAS(beetle antennae search)借鉴粒子群的群体优化思想而得到的BSO方法应用到MPPT控制,利用天牛的个体进化和群体学习等优势来提高MPPT的追踪速度和精确度.设置了多种光照情况来作仿真验证,并用粒子群方法进行比较分析.结果表明,所提的方法追踪速度更快、精确度更高,且追踪过程更稳定、功率波动较小.

关键词：局部阴影天牛须搜索天牛群优化最大功率点追踪粒子群优化

基于CSA-IP&O的局部遮阴下光伏最大功率点追踪

在线全文

学校读者我要写书评

暂无评论

电力系统保护与控制 2020年第5期48卷 26-32页

作者：赵帅旗肖辉刘忠兵朱梓嘉长沙理工大学电气与信息工程学院湖南长沙410114 湖南大学土木工程学院湖南长沙410082

局部阴影遮挡(Partial Shading Condition,PSC)使得最大功率点追踪(Maximum Power Point Tracking,MPPT)的追踪速度和精度难以得到保证。对布谷鸟搜索算法(Cuckoo Search Algorithm,CSA)和自适应变步长的改进扰动观察法(Improved Perturbation and Observation,IP&O)进行了研究并应用到光伏的MPPT控制中。利用CSA出色的全局搜索能力快速收敛到全局最大功率点(Maximum Power Point,MPP)附近,然后利用IP&O出色的局部搜索能力快速、准确地收敛到MPP。最后设置了几种光照情况进行仿真,并用扰动观察法和粒子群(Particle Swarm Optimization,PSO)方法进行对比。通过仿真验证了所提出的方法具有更快的追踪速度和更高的精确度。

关键词：局部阴影遮挡布谷鸟搜索算法最大功率点追踪粒子群算法扰动观察法