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A novel PD-L1 targeting peptide self-assembled nanofibers for sensitive tumor imaging and photothermal immunotherapy in vivo

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Nano Research 2022年第8期15卷 7286-7294页

作者： Linping Fu Jianhu Zhang Chenchen Wu Weizhi wang Dong wang Zhiyuan Hu zihua wang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Key Laboratory of Standardization and Measurement for NanotechnologyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China School of Nanoscience and Technology Sino-Danish CollegeUniversity of Chinese Academy of SciencesBeijing 100049China Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhou 350122China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China

Programmed death 1(PD-1)and its ligand PD-L1 are two typical immune ***-based immune checkpoint blockade(ICB)strategy targeting PD-1/PD-L1 achieved a significant therapeutic effect on ***,due to the impenetrability of antibody drugs and the occurrence of immune-related adverse events,only a minority of patients benefit from this *** multimerization has been widely proved to be an effective method to improve receptor binding affinity through a multivalent synergistic *** this study,we report a novel peptide-aggregation-induced emission(AIE)hybrid supramolecular TAP,which can self-assemble into nanofibers through non-covalent interactions such as hydrogen bonds,with a specific nanomolar affinity to PD-L1 in vivo and in *** with near-infrared agents,it can be used for tumor imaging and photothermal therapy,which enables photothermal ablation of cancer cells for generating tumor-associated antigen(TAA)and triggering a series of immunological ***,our work suggests that synthetic self-assembled peptide nanofibers can be developed as attractive platforms for active photothermal immunotherapies against cancer.

关键词： programmed death 1(PD-1) targeting peptide self-assembly immune checkpoint blockade photothermal therapy

Person video alignment with human pose registration

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Frontiers of Computer Science 2023年第4期17卷 229-231页

作者： Yu ZHANG zihua wang Jingyang ZHOU Siya MI School of Computer Science and Engineering and the Key Lab of Computer Network and Information Integration(Ministry of Education)Southeast UniversityNanjing 211189China School of Cyber Science and Engineering Southeast UniversityNanjing 211189China Purple Mountain Laboratories Nanjing 211111China

1 Introduction and main *** alignment,especially human action alignment,is a challenging *** purpose is to develop an algorithm to match the same process so that videos can be *** the progress that has been made in image recognition,it is still a difficult problem for distinguishing from similar frames for alignment without context information.

关键词： alignment video frames

Enzymatic Conversion of Biobased Levulinic Acid into an Alternative Biofuel Candidate--Methyl Levulinate

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China Petroleum Processing & Petrochemical Technology 2020年第1期22卷 8-16页

作者： Xu Yanli Li Pan Chang Chun Xu Guizhuan Du Zeji wang zihua School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001 Henan Center for Outstanding Overseas Scientists Zhengzhou 450001 College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002

Methyl levulinate(ML)is a promising green candidate for bio-based diesel fuel and fuel *** efficient enzyme-catalyzed process to synthesize ML from levulinic acid(LA)in methanol was *** catalytic activity of a series of lipases including Novozyme 435(N435),NRTL IM,and 40086 was screened,and the N435 was identified as the optimal biocatalyst for the *** effects of lipase amount,methyl tert-butyl ether(MTBE)volume,methanol to LA molar ratio,reaction temperature,and magnetic stirrer speed on LA conversion and ML yield were *** response surface methodology was adopted to optimize the enzymatic conversion process,and the model validation experiments showed that the predicted values corresponded well with the experimental values.A LA conversion of 90.1%and a ML yield of 89.8%were achieved under reaction conditions covering:a temperature of 45°C,a reaction time of 4.6 h,a N435 dosage of 26 mg,a methanol to LA molar ratio of 3.6:1,a MTBE volume of 3.85 mL,and a stirrer speed of 150 r/*** N435 recycling experiment indicated that the lipase activity was quite high after 12 ***,upon using crude LA prepared from carbohydrates as the reactant,the conversion of LA and the ML yield decreased due to impurities existing in the crude LA.

关键词： enzyme methyl levulinate levulinic acid biomass

Mechanism of E' center induced by γ ray radiation in silica optical fiber material

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Nuclear Science and Techniques 2013年第4期24卷 28-31页

作者： LUO Wenyun XIAO Zhongyin WEN Jianxiang YIN Jianchong WU Wenkai CHEN Zhenyi wang zihua wang Tingyun School of Communication and Information Engineering Key Laboratory of Specialty Fiber Optics and Optical Access NetworksShanghai University School of Environmental and Chemical Engineering Shanghai Applied Radiation Institute Shanghai University

The characteristics of the best known defect centers E' in silica optical fiber material irradiated with ray were investigated by ESR at room temperature.A mechanism model of production of the E' center defect was *** production of E' center includes two processes creation and *** strained bonds(or oxygen replacement) in silica networks lead to the creation of new defects whose concentration increases linearly with the *** pre-existing defects produce the activation,which tends to *** to this model,the relation of E' center concentration changing with irradiation dose was obtained *** results are in good agreement with the experimental results.

关键词：光纤材料射线辐射机制石英缺陷中心二氧化硅机理模型缺陷产生

Glioblastoma cell-derived exosomes functionalized with peptides as efficient nanocarriers for synergistic chemotherapy of glioblastoma with improved biosafety

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Nano Research 2023年第12期16卷 13283-13293页

作者： Ying Zhou Long wang Lufei Chen Wei Wu Zhimin Yang Yuanzhuo wang Anqi wang Sujun Jiang Xuzhen Qin Zucheng Ye Zhiyuan Hu zihua wang Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative DiseasesSchool of Basic Medical SciencesFujian Medical UniversityFuzhou 350122China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China School of Nanoscience and Technology Sino-Danish CollegeUniversity of Chinese Academy of SciencesBeijing 100049China Department of Laboratory Medicine Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China

Glioblastoma(GBM)has been regarded as one of the most deadly and challenging cancers to treat with extremely poor *** limited efficacy of current chemotherapies might be attributed to the presence of glioma stem cells(GSCs)as well as the difficulties in passing through the blood–brain barrier(BBB)and targeting tumor ***-derived exosomes are emerging as novel and promising drug delivery ***,great concerns regarding the biosafety and BBB penetrability remain to be ***,we have developed a simple and feasible strategy to engineer GBM cell-derived exosomes with improved biosafety termed“Exo@TDPs”to deliver the cargos of chemotherapeutic agents temozolomide(TMZ)and doxorubicin(DOX)into GBM ***@TDPs decorated with angiopep-2(Ang-2)and CD133-targeted peptides improve the capacity to penetrate the BBB and target tumor *** in vitro and in vivo studies demonstrate that Exo@TDPs can cross the BBB,target GBM cells,penetrate into deep tumor parenchyma,and release the therapeutic cargos *** delivery of TMZ and DOX by Exo@TDPs exerts therapeutic effects to suppress the tumor growth and prolong the survival time of orthotopic syngeneic mouse GBM *** findings suggest that our developed Exo@TDPs loaded with chemotherapeutic drugs may bring new possibilities for the application of tumor cell-derived exosomes for brain tumor treatment.

关键词： glioblastoma tumor-derived exosome peptide temozolomide doxorubicin targeted chemotherapy

A novel peptide-based probe^(99m)Tc-PEG_(6)-RD-PDP2 for the molecular imaging of tumor PD-L2 expression

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Chinese Chemical Letters 2022年第7期33卷 3497-3501页

作者： Qi Luo Yunwei Zhang zihua wang Yining Sun Linqing Shi Yue Yu Jiyun Shi Zhiyuan Hu Fan wang Guangzhou Laboratory Guangzhou 510005China Medical Isotopes Research Center and Department of Radiation Medicine State Key Laboratory of Natural and Biomimetic DrugsSchool of Basic Medical SciencesPeking UniversityBeijing 100191China Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhou 350122China Key Laboratory of Protein and Peptide Pharmaceuticals CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China

Tumor-related PD-L2 expression is associated with the clinical efficacy of PD-1/PD-L1 blockade ***-L2-specific imaging can help selecting patients for appropriate *** this study,a PD-L2-targeting peptide(PDP2)was screened by the one-bead one-compound combinatorial library *** the retro-inverso D-peptide of PDP2(RD-PDP2)and PEGylation strategies,we developed a novel Tc-99m-labeled PD-L2-targeting peptide as a SPECT tracer(^(99m)Tc-PEG_(6)-RD-PDP2)for imaging of tumor PD-L2 *** radiolabeling yield of ^(99m)Tc-PEG_(6)-RD-PDP2 was greater than 95%by the standard HYNIC/tricine/TPPTS labeling procedure.^(99m)Tc-PEG_(6)-RD-PDP2 displayed high PD-L2-binding specificity both in vitro and in ***/CT imaging with^(99m)Tc-PEG_(6)-RD-PDP2 showed that the A549-PD-L2tumors were clearly visualized,whereas the signals in PD-L2-negative A549 tumors were much *** vivo blocking study suggested that the tumor uptake of^(99m)Tc-PEG_(6)-RD-PDP2 was PD-L2 specifically mediated.^(99m)Tc-PEG_(6)-RD-PDP2 is a promising SPECT probe for the non-invasive imaging of tumor PD-L2expression and has a great potential in guiding the anti-PD-1 or anti-PD-L1 immunotherapy of cancer.

关键词： PD-L2 Peptide probe SPECT imaging Immunotherapy

Guided Modes in a Four-Layer Slab Waveguide with Dispersive Left-Handed Material

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Journal of Electromagnetic Analysis and Applications 2010年第4期2卷 264-269页

作者： Lufa Shen zihua wang 不详

A four-layer slab waveguide including left-handed material is investigated numerically in this paper. Considering left-handed material dispersion, we find eight TE guided modes as frequency from 4 GHz to 6 GHz. The fundamental mode can exist, and its dispersion curves are insensitive to the waveguide thickness. Besides, the total power fluxes of TE guided modes are analyzed and corresponding new properties are found, such as: positive and negative total power fluxes coexist;at maximum value of frequency, we find zero total power flux, etc. Our results may be of benefit to the optical waveguide technology.

关键词： Slab Waveguide Left-Handed Material Dispersive Properties Total Power Fluxes

Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip

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Nano-Micro Letters 2018年第1期10卷 148-157页

作者： Ren Li Mingxing Zhou Jine Li zihua wang Weikai Zhang Chunyan Yue Yan Ma Hailin Peng Zewen Wei Zhiyuan Hu CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Academy for Advanced Interdisciplinary Studies Peking University University of Chinese Academy of Sciences Sino-Danish College University of Chinese Academy of Sciences Yangtze River Delta Academy of Nanotechnology and Industry Development Research

EGFR mutations companion diagnostics have been proved to be crucial for the efficacy of tyrosine kinase inhibitor targeted cancer therapies. To uncover multiple mutations occurred in minority of EGFR-mutated cells,which may be covered by the noises from majority of unmutated cells, is currently becoming an urgent clinical requirement. Here we present the validation of a microfluidic-chip-based method for detecting EGFR multimutations at single-cell level. By trapping and immunofluorescently imaging single cells in specifically designed silicon microwells, the EGFR-expressed cellswere easily identified. By in situ lysing single cells, the cell lysates of EGFR-expressed cells were retrieved without cross-contamination. Benefited from excluding the noise from cells without EGFR expression, the simple and cost-effective Sanger's sequencing, but not the expensive deep sequencing of the whole cell population, was used to discover multi-mutations. We verified the new method with precisely discovering three most important EGFR drugrelated mutations from a sample in which EGFR-mutated cells only account for a small percentage of whole cell population. The microfluidic chip is capable of discovering not only the existence of specific EGFR multi-mutations,but also other valuable single-cell-level information: on which specific cells the mutations occurred, or whether different mutations coexist on the same cells. This microfluidic chip constitutes a promising method to promote simple and cost-effective Sanger's sequencing to be a routine test before performing targeted cancer therapy.

关键词： EGFR mutation Single-cell analysis Microfluidic chip Tyrosine kinase inhibitor

Graphitic carbon nitride based single-atom photocatalysts

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Frontiers of physics 2020年第3期15卷 13-26,M0001页

作者： Junwei Fu Shuandi wang zihua wang Kang Liu Huangjingwei Li Hui Liu Junhua Hu Xiaowen Xu Hongmei Li Min Liu School of Physics and Electronics State Key Laboratory of Powder MetallurgyHunan Provincial Key Laboratory of Chemical Power SourcesCentral South UniversityChangsha410083China School of Metallurgy and Environment Central South UniversityChangsha410083China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China

Single-atom photocatalysts,due to their high catalysis activity,selectivity and stability,become a hotspot in the field of *** carbon nitride(g-C3N4)is known as both a good support for single atoms and a star *** g-C3N4-based single-atom photocatalysts exhibits great potential in improving the photocatalytic *** this review,we summarize the recent progress in g-C3N4-based single-atom photocatalysts,mainly including preparation strategies,characterizations,and their photocatalytic *** significant roles of single atoms and catalysis mechanism in g-C3N4-based single-atom photocatalysts are *** last,the challenges and perspectives for exploring high-efficient g-C3N4-based single-atom photocatalysts are presented.

关键词： graphitic carbon nitride single atoms atomically dispersed sites site-isolated catalysts photocatalysis