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天基信息网络弹性评估方法研究

空间电子技术 2023年第1期20卷 22-27页

作者：陶滢刘伟高梓贺陈特任术波周钠中国空间技术研究院通信与导航卫星总体部北京100094 国家航天局卫星通信系统创新中心北京100094

考虑到天基信息网络独具的网络拓扑周期性动态变化、星载网络设备难以按需替换、空间环境安全威胁复杂多样等特点,为了对网络故障、环境挑战或敌对行动时天基信息网络的弹性能力进行有效评估,提出了一种改进的天基信息网络弹性评估方法... 详细信息

考虑到天基信息网络独具的网络拓扑周期性动态变化、星载网络设备难以按需替换、空间环境安全威胁复杂多样等特点,为了对网络故障、环境挑战或敌对行动时天基信息网络的弹性能力进行有效评估,提出了一种改进的天基信息网络弹性评估方法。首先,简述了一种包含时间、概率、系统能力的三维弹性分析模型;考虑到各种不利事件以及各种能力适变方法及其具体措施对天基网络弹性能力的影响,分别提出了在采用单能力适变方法、多能力适变方法时的天基信息网络弹性计算方法,并进一步给出了确定场景下的天基信息网络弹性计算方法。实例分析表明,所提方法可以定量的方式对天基信息网络弹性能力进行有效评估,为天基信息网络各种能力适变方法及其具体措施的选择提供有益参考。

关键词：天基信息网络弹性评估方法

Subsurface damage pattern and formation mechanism of monocrystalline β-Ga_(2)O_(3) in grinding process

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Frontiers of Mechanical Engineering 2022年第2期17卷 117-127页

作者： Xin YANG Renke KANG Shang gao zihe WU Xianglong ZHU Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116024China

Monocrystalline beta-phase gallium oxide (β-Ga_(2)O_(3)) is a promising ultrawide bandgap semiconductor material. However, the deformation mechanism in ultraprecision machining has not yet been revealed. The aim of this study is to investigate the damage pattern and formation mechanism of monocrystalline β-Ga_(2)O_(3)in different grinding processes. Transmission electron microscopy was used to observe the subsurface damage in rough, fine, and ultrafine grinding processes. Nanocrystals and stacking faults existed in all three processes, dislocations and twins were observed in the rough and fine grinding processes, cracks were also observed in the rough grinding process, and amorphous phase were only present in the ultrafine grinding process. The subsurface damage thickness of the samples decreased with the reduction in the grit radius and the grit depth of cut. Subsurface damage models for grinding process were established on the basis of the grinding principle, revealing the mechanism of the mechanical effect of grits on the damage pattern. The formation of nanocrystals and amorphous phase was related to the grinding conditions and material characteristics. It is important to investigate the ultraprecision grinding process of monocrystalline β-Ga_(2)O_(3). The results in this work are supposed to provide guidance for the damage control of monocrystalline β-Ga_(2)O_(3)grinding process.

关键词： monocrystalline beta-phase gallium oxide grinding process subsurface damage nanocrystals amorphous phase

The Dynamic Inflammatory Tissue Microenvironment:Signality and Disease Therapy by Biomaterials

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Research 2021年第1期2021卷 164-194页

作者： Rani Mata Yuejun Yao Wangbei Cao Jie Ding Tong Zhou zihe Zhai Changyou gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China

Tissue regeneration is an active multiplex process involving the dynamic inflammatory *** a normal physiological framework,inflammation is necessary for the systematic immunity including tissue repair and regeneration as well as returning to *** cellular response and metabolic mechanisms play key roles in the well-orchestrated tissue *** this response is dysregulated,it becomes chronic,which in turn causes progressive fibrosis,improper repair,and autoimmune disorders,ultimately leading to organ failure and ***,understanding of the complex inflammatory multiple player responses and their cellular metabolisms facilitates the latest insights and brings novel therapeutic methods for early diseases and modern health *** review discusses the recent advances in molecular interactions of immune cells,controlled shift of pro-to anti-inflammation,reparative inflammatory metabolisms in tissue regeneration,controlling of an unfavorable microenvironment,dysregulated inflammatory diseases,and emerging therapeutic strategies including the use of biomaterials,which expand therapeutic views and briefly denote important gaps that are still prevailing.

关键词： metabolism inflammation immunity

Reactive oxygen species-scavenging nanoparticles coated with chondroitin sulfate protect cartilage against osteoarthritis in vivo

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Nano Research 2023年第2期16卷 2786-2797页

作者： Zhaoyi Wang Hao Xiong zihe Zhai Yuejun Yao Tong Zhou Haolan Zhang Cunyi Fan Changyou gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X PolymersDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Orthopedics Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Center for Healthcare Materials Shaoxing InstituteZhejiang UniversityShaoxing 312035China Department of Orthopedics The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration Building 3Langu Science and Technology ParkLane 70Haiji 6th RoadShanghai 201306China

Osteoarthritis(OA)is a prevalent chronic inflammatory disease in *** interventions confront systemic toxicity and insufficient *** unbalanced microenvironment of OA joints mainly fosters over-expressed reactive oxygen species(ROS),extracellular matrix disintegration,and apoptosis of *** this study,a kind of ROS-scavenging,biodegradable and drug-free nanoparticles(PP NPs)were constructed by the crosslinking of poly(propylene fumarate)(PPF)and ROS-scavenging poly(thioketal)(PTK).The high content of PTK and high crosslinking density of PPF and PTK innovatively endowed the NPs with slow degradation and prolonged ROS-elimination *** NPs were further surface-modified with chondroitin sulfate(CS),one of the dietary supplements for *** intrinsic properties of resultant PP-CS NPs were excavated in vitro and in *** PP-CS NPs could desirably consume 1,10-diphenyl-2-picrylhydrazyl(DPPH)radicals without toxicity to RAW264.7 cells in *** an average diameter of~300 nm,the PP-CS NPs could be intra-articular administrated in OA rats and showed prolonged joint retention time,allowing only one injection per ***,the PP-CS NPs possessed a prolonged ROS depletion and M2 macrophage induction effect,down-regulated inflammatory cytokines,and reduced glycosaminoglycans ***,the PP-CS NPs protected articular surface erosion,inhibited uneven cartilage matrix,and attenuated OA progression.

关键词： reactive oxygen species polythioketal osteoarthritis nanoparticles chondroitin sulfate

甲型流感病毒A/WSN/1933(H1N1)感染A549细胞的circRNA表达谱分析与鉴定

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畜牧与兽医 2024年第7期56卷 102-111页

作者：张晓婷郑一青曾亦然常丽凤陈纳卢渊录罗皓炜高紫荷平继辉南京农业大学动物医学院江苏南京210095

环状RNA(circRNA)已被证明在众多生物过程中起着重要的调控作用,而circRNA在甲型流感病毒(IAV)复制过程中的功能尚不清楚。本研究旨在利用高通量测序分析IAV感染A549细胞后的circRNA表达谱变化来挖掘能够影响病毒复制的circRNAs并对其... 详细信息

环状RNA(circRNA)已被证明在众多生物过程中起着重要的调控作用,而circRNA在甲型流感病毒(IAV)复制过程中的功能尚不清楚。本研究旨在利用高通量测序分析IAV感染A549细胞后的circRNA表达谱变化来挖掘能够影响病毒复制的circRNAs并对其进行初步功能鉴定。利用测序结果,对全部circRNAs进行特征分析、差异表达筛选;对差异circRNAs进行GO分析、KEGG分析;对候选circRNAs进行qPCR、RT-PCR验证及Sanger测序鉴定,并通过空斑试验确定影响病毒复制的circRNAs。结果:本试验共筛选到11 630条差异表达circRNAs,对其中6条circRNA进行了鉴定,最终确定novel_circ_007428具有抗病毒作用。本研究对甲型流感病毒感染A549细胞后的circRNA表达谱进行了分析与鉴定,为进一步研究circRNA在流感病毒感染中发挥的调控作用奠定了基础。

关键词：环状RNA 甲型流感病毒基因芯片测序 A549 表达谱 novel_circ_007428

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Dexamethasone-loaded ROS-responsive poly(thioketal)nanoparticles suppress inflammation and oxidative stress of acute lung injury

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Bioactive Materials 2022年第8期7卷 430-442页

作者： zihe Zhai Wei Ouyang Yuejun Yao Yuqi Zhang Haolan Zhang Feng Xu Changyou gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Department of Infectious Diseases The Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou310058China Department of Orthopedics The Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China

Acute lung injury(ALI)is associated with excessive inflammatory response,leading to acute respiratory distress syndrome(ARDS)without timely treatment.A fewer effective drugs are available currently to treat the ALI/***,a therapeutic nanoplatform with reactive oxygen species(ROS)-responsiveness was developed for the regulation of *** acetate(Dex)was encapsulated into poly(thioketal)polymers to form polymeric nanoparticles(NPs)(PTKNPs@Dex).The NPs were composed of poly(1,4-phenyleneacetonedimethylene thioketal)(PPADT)and polythioketal urethane(PTKU),in which the thioketal bonds could be cleaved by the high level of ROS at the ALI *** PTKNPs@Dex could accumulate in the pulmonary inflammatory sites and release the encapsulated payloads rapidly,leading to the decreased ROS level,less generation of pro-inflammatory cytokines,and reduced lung injury and mortality of *** sequencing(RNA-seq)analysis showed that the therapeutic efficacy of the NPs was associated with the modulation of many immune and inflammation-linked *** findings provide a newly developed nanoplatform for the efficient treatment of ALI/ARDS.

关键词： Acute lung injury Reactive oxygen species Inflammation Nanoparticles RNA-Seq

Gelatin-Based Metamaterial Hydrogel Films with High Conformality for Ultra-Soft Tissue Monitoring

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Nano-Micro Letters 2024年第2期16卷 347-364页

作者： Yuewei Chen Yanyan Zhou zihe Hu Weiying Lu Zhuang Li Ning gao Nian Liu Yuanrong Li Jing He Qing gao Zhijian Xie Jiachun Li Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China School of Mechanical Engineering Guizhou UniversityGuiyang 550025People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineClinical Research Center for Oral Diseases of Zhejiang ProvinceKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310006People’s Republic of China

Implantable hydrogel-based bioelectronics(IHB)can precisely monitor human health and diagnose ***,achieving biodegradability,biocompatibility,and high conformality with soft tissues poses significant challenges for *** is the most suitable candidate for IHB since it is a collagen hydrolysate and a substantial part of the extracellular matrix found naturally in most *** study used 3D printing ultrafine fiber networks with metamaterial design to embed into ultra-low elastic modulus hydrogel to create a novel gelatin-based conductive film(GCF)with mechanical *** regulation of GCF nearly covers soft tissue mechanics,an elastic modulus from 20 to 420 kPa,and a Poisson’s ratio from-0.25 to *** negative Poisson’s ratio promotes conformality with soft tissues to improve the efficiency of biological *** GCF can monitor heartbeat signals and respiratory rate by determining cardiac deformation due to its high ***,the gelatin characteristics of the biodegradable GCF enable the sensor to monitor and support tissue *** GCF metamaterial design offers a unique idea for bioelectronics to develop implantable sensors that integrate monitoring and tissue repair and a customized method for endowing implanted sensors to be highly conformal with soft tissues.

关键词： Implantable hydrogel-based bioelectronics Conformality 3D printing Metamaterial design

Structural basis for mechanochemical role of Arabidopsis thaliana dynamin-related protein in membrane fission

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Journal of Molecular Cell Biology 2011年第6期3卷 378-381页

作者： Liming Yan Yuanyuan Ma Yuna Sun Jian gao Xiaoyue Chen Jiewei Liu Congwan Wang zihe Rao Zhiyong Lou Laboratory of Structural Biology and MOE Laboratory of Protein Science School of MedicineTsinghua UniversityBeijing 100084China College of Life Sciences and Tianjin State Laboratory of Protein Science Nankai UniversityTianjin 300071China National Laboratory of Macromolecules Institute of BiophysicsChinese Academy of ScienceBeijing 100101China Beijing 107 Middle School BeijingChina

Dear Editor,Dynamins and dynamin-related proteins(DRPs)constitute a large superfamily of GTPases throughout animal,plant,and bacteria and play essential roles in core cellular processes(Praefcke and McMahon,2004).Plant specific dynamin-related subfamilies share essential functions with those in mammalian cell,***mediated endocytosis and fission of mitochondria.

关键词： chemical families constitute

Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB

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Protein & Cell 2023年第6期14卷 448-458页

作者： Shan Sun Yan gao Xiaolin Yang Xiuna Yang Tianyu Hu Jingxi Liang Zhiqi Xiong Yuting Ran Pengxuan Ren Fang Bai Luke WGuddat Haitao Yang zihe Rao Bing Zhang Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300353China Laboratory of Structural Biology Tsinghua UniversityBeijing 100084China National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Chemistry and Molecular Biosciences The University of QueenslandBrisbaneQueensland 4072Australia CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100101China Shanghai Clinical Research and Trial Center Shanghai 201210China

The adenosine 5'-triphosphate(ATP)-binding cassette(ABC)transporter,IrtAB,plays a vital role in the replication and viability of Mycobacterium tuberculosis(Mtb),where its function is to import iron-loaded ***,it adopts the canonical type IV exporter ***,we report the structure of unliganded Mtb IrtAB and its structure in complex with ATP,ADP,or ATP analogue(AMP-PNP)at resolutions ranging from 2.8 to 3.5Å.The structure of IrtAB bound ATP-Mg2+shows a“head-to-tail”dimer of nucleotide-binding domains(NBDs),a closed amphipathic cavity within the transmembrane domains(TMDs),and a metal ion liganded to three histidine residues of IrtA in the ***-electron microscopy(Cryo-EM)structures and ATP hydrolysis assays show that the NBD of IrtA has a higher affinity for nucleotides and increased ATPase activity compared with ***,the metal ion located in the TM region of IrtA is critical for the stabilization of the conformation of IrtAB during the transport *** study provides a structural basis to explain the ATP-driven conformational changes that occur in IrtAB.

关键词： ABC exporter-like importer iron-loaded siderophore IrtAB Mycobacterium tuberculosis ABC transporter