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Breaking or following the membrane-targeting mechanism:Exploring the antibacterial mechanism of host defense peptide mimicking poly(2-oxazoline)s

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Journal of Materials Science & Technology 2020年第24期59卷 220-226页

作者： Chengzhi Dai Min Zhou Weinan Jiang Ximian Xiao Jingcheng Zou Yuxin Qian zihao cong Zhemin Ji Longqiang Liu Jiayang Xie Zhongqian Qiao Runhui Liu State Key Laboratory of Bioreactor Engineering Frontiers Science Center for Materiobiology and Dynamic ChemistryKey Laboratory of Specially Functional Polymeric Materials and Related Technology(ECUST)Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China State Key Laboratory of Molecular Engineering of Polymers(Fudan University) Shanghai200438China

Peptides exert important biological functions but their application is hindered by their susceptibility to proteolysis and poor stability in ***,functional peptide mimics have drawn a great deal of attention to address this ***(2-oxazoline)s,a class of biocompatible and proteolysis-resistant polymer,can work as host defense peptide mimics without following the general membrane-targeting mechanism as shown in our previous *** observation encouraged us to figure out if poly(2-oxazoline)s are special and break the general membrane-targeting mechanism of host defense peptides and their *** this study,we aimed at the connection between structure and antibacterial mechanism of poly(2-oxazoline)s.A new γ-aminobutyric acid(GABA)-pendent poly(2-oxazoline)was synthesized and investigated to compare with glycine-pendent poly(2-oxazoline)in our previous study,with the former polymer has two extra CH2 groups in the sidechain to increase the hydrophobicity and *** depolarization assay suggested that incorporating two more CH2 groups into the sidechain of poly(2-oxazoline)resulted in a mechanism switch from DNA-targeting to membrane-targeting,which was supported by the slow time-kill kinetics and slightly distorted and sunken membrane ***,GABA-pendent poly(2-oxazoline)showed potent activity against methicillin-resistant *** and low hemolysis on human red blood ***,repeated use of the antimicrobial poly(2-oxazoline)did not stimulate bacteria to obtain resistance,which was an obvious advantage of membrane-targeting antimicrobial agents.

关键词： Poly(2-oxazoline) Host defense peptide Antibacterial mechanism Membrane-targeting Antimicrobial resistance

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Controllable Polymerization of N-Substituted β-Alanine N-Thiocarboxyanhydrides for Convenient Synthesis of Functional Poly(β-peptoid)s

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CCS Chemistry 2023年第4期5卷 994-1004页

作者： Ximian Xiao Min Zhou zihao cong Longqiang Liu Jingcheng Zou Zhemin Ji Ruxin Cui Yueming Wu Haodong Zhang Sheng Chen Maoquan Li Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237 Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 Department of Interventional and Vascular Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072

Poly(β-peptoid)is a class of polypeptide mimics that possesses excellent biocompatibility and resistance to ***,the synthesis of poly(β-peptoid)s with functionalities is a long-standing challenge that greatly hinders the functional study and application of poly(β-peptoid)*** report a controllable and easy synthesis of poly(β-peptoid)s bearing diverse functionalities via the ring-opening polymerization on N-substitutedβ-alanine N-thiocarboxyanhydrides(β-NNTAs).The polymerization can be carried out in openvesselsundermildconditions usingaminesas the initiators to provide poly(β-peptoid)s with targeted molecular weights,narrow dispersities,and diverse functionalities in the side chains and ***β-NNTAs polymerization is even compatible with initiators bearing unprotected hydroxyl *** amphiphilic/cationic poly(β-peptoid)s exhibit a broad spectrum and potent antibacterial activities against multidrug-resistant *** addition,the highly favored stability ofβ-NNTAmonomers for purification and storage highlights the advantages of thisβ-NNTA polymerization strategy for poly(β-peptoid)s synthesis,functional study,and application as a synthetic mimic of polypeptides.

关键词： ring-opening polymerization poly(β-peptoid) β-NNTA functionlization

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Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers

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Bioactive Materials 2021年第12期6卷 4531-4541页

作者： Ziyi Lu Yueming Wu zihao cong Yuxin Qian Xue Wu Ning Shao Zhongqian Qiao Haodong Zhang Yunrui She Kang Chen Hengxue Xiang Bin Sun Qian Yu Yuan Yuan Haodong Lin Meifang Zhu Runhui Liu State Key Laboratory of Bioreactor Engineering College of ChemistryChemical Engineering and Materials ScienceEast China University of Science and TechnologyShanghai200237China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China Jiangsu Key Laboratory of Advanced Functional Polymers Design and Application Soochow UniversitySuzhou215123China Department of Orthopedic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China

It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical *** defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant *** recent report on lithium hexamethyldisilazide-initiated superfast polymerization on amino acid N-carboxyanhydrides enables the quick synthesis of host defense peptide-mimicking peptide *** we reported a facile and cost-effective thermoplastic polyurethane(TPU)surface modification of peptide polymer(DLL:BLG=90:10)using plasma surface activation and substitution reaction between thiol and bromide *** peptide polymer-modified TPU surfaces exhibited board-spectrum antibacterial property as well as effective contact-killing ability in ***,the peptide polymer-modified TPU surfaces showed excellent biocompatibility,displaying no hemolysis and *** vivo study using methicillin-resistant Staphylococcus aureus(MRSA)for subcutaneous implantation infectious model showed that peptide polymer-modified TPU surfaces revealed obvious suppression of infection and great histocompatibility,compared to bare TPU *** further explored the antimicrobial mechanism of the peptide polymer-modified TPU surfaces,which revealed a surface contact-killing mechanism by disrupting the bacterial *** results demonstrated great potential of the peptide-modified TPU surfaces for practical application to combat bacterial infections that are associated with implantable materials and devices.

关键词： Peptide polymer Host defense peptide Antimicrobial surface MRSA Subcutaneous infection

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考虑供应商聚类的应急医疗物资协同配送仿真

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系统仿真学报 2022年第10期34卷 2303-2311页

作者：王喆邵鸿远丛子皓马雯雯武汉理工大学中国应急管理研究中心湖北武汉430070 武汉理工大学安全科学与应急管理学院湖北武汉430070 华中科技大学同济医学院附属同济医院湖北武汉430030

针对突发公共卫生事件应急处置中存在的地方政府医疗物资储备不足、配送效率低下等问题,设计了一种考虑供应商聚类的两阶段应急医疗物资公私协同选址分配模型。在备灾时利用模糊聚类算法实现供应商聚类,并与政府建立合作机制以实现应急... 详细信息

针对突发公共卫生事件应急处置中存在的地方政府医疗物资储备不足、配送效率低下等问题,设计了一种考虑供应商聚类的两阶段应急医疗物资公私协同选址分配模型。在备灾时利用模糊聚类算法实现供应商聚类,并与政府建立合作机制以实现应急医疗物资联合储备;在救援初期依托政府和各类供应商的物资储备及运输能力,构建以最小化物流总成本与需求未满足率加权和为目标的选址分配仿真模型。设计改进的非支配排序遗传算法对此两阶段模型进行求解。以新冠肺炎疫情中武汉市医疗物资调度设计仿真算例,并对比有无供应商聚类对模型的影响。仿真结果表明:该模型在协调政府和供应商的应急医疗物资储备、运输以及调度决策方面具有优势。

关键词：突发公共卫生事件应急医疗物资选址-分配问题模糊聚类公私协同非支配排序遗传算法

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基于成本共担契约的双供应商政企联合应急储备博弈模型

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中国安全生产科学技术 2023年第5期19卷 29-36页

作者：王喆梁梦宇丛子皓刘丹武汉理工大学中国应急管理研究中心湖北武汉430070 武汉理工大学安全科学与应急管理学院湖北武汉430070

为提高重大自然灾害应急物资保障能力,采用成本共担契约构建双供应商政企联合应急物资储备模型。通过分析政府和2个供应商之间的应急物资联合储备博弈过程,供应商决策以其利润最大化为目标,政府决策以成本控制为目标,构建政府处主导地... 详细信息

为提高重大自然灾害应急物资保障能力,采用成本共担契约构建双供应商政企联合应急物资储备模型。通过分析政府和2个供应商之间的应急物资联合储备博弈过程,供应商决策以其利润最大化为目标,政府决策以成本控制为目标,构建政府处主导地位、供应商处从属地位的stackelberg博弈模型,推导政府与供应商的最优决策策略以及政府与供应商多方共赢与供应链协调的条件,并进行算例验算。研究结果表明:基于成本共担契约的双供应商应急储备模型能够有效提高政府应对自然灾害的应急物资保障能力,实现供应链协调,改善政府成本和供应商利润。

关键词：应急物资储备成本共担契约 stackelberg博弈应急生产成本补贴供应链协调

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氨基酸聚合物用于提高冻干过程中蛋白稳定性的研究

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华东理工大学学报（自然科学版） 2020年第4期46卷 526-532页

作者：李冰丛自豪肖希勉武月铭刘润辉华东理工大学生物反应器工程国家重点实验室超细材料制备与应用教育部重点实验室教育部医用生物材料工程研究中心材料科学与工程学院上海200237

为提高蛋白在冻干过程中的稳定性,采用双(三甲基硅基)氨基锂(LiHMDS)引发的超快速氨基酸环内酸酐(NCA)开环聚合方法,制备了聚L-赖氨酸(PLL)均聚物和聚L-谷氨酸(PLG)均聚物。以β-半乳糖苷酶(β-Gal)为模型蛋白检测氨基酸均聚物在冻干过... 详细信息

为提高蛋白在冻干过程中的稳定性,采用双(三甲基硅基)氨基锂(LiHMDS)引发的超快速氨基酸环内酸酐(NCA)开环聚合方法,制备了聚L-赖氨酸(PLL)均聚物和聚L-谷氨酸(PLG)均聚物。以β-半乳糖苷酶(β-Gal)为模型蛋白检测氨基酸均聚物在冻干过程中对蛋白的保护效果,结果表明两种氨基酸均聚物的共混物对蛋白有保护效果,冻干后未添加氨基酸共混物保护剂的蛋白活性仅剩38%,添加氨基酸共混物保护剂的蛋白活性明显提升到77%,表明氨基酸共聚物能够在冻干过程中保护蛋白,显著提高蛋白稳定性。本文方法操作简单,可快速合成氨基酸聚合物并高效筛选蛋白稳定剂。

关键词：氨基酸聚合物 NCA聚合蛋白稳定性半乳糖苷酶冻干

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考虑维护水平的城镇防汛物资政企联合储备决策

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中国安全科学学报 2023年第4期33卷 202-209页

作者：王喆丛子皓梁梦宇刘丹马勇夏小棠武汉理工大学安全科学与应急管理学院湖北武汉430070 武汉理工大学中国应急管理研究中心湖北武汉430070 武汉理工大学航运学院湖北武汉430063 武汉科技大学城市建设学院湖北武汉430065

为科学制定城镇防汛物资代储方案,针对城镇洪涝灾害呈周期性随机发生的特点,通过构建微分博弈模型,研究政府与企业联合储备和持续维护的过程来保障应急处置需求,进而构建政府单一储备决策、政企联合储备决策和Stackelberg决策下的政企... 详细信息

为科学制定城镇防汛物资代储方案,针对城镇洪涝灾害呈周期性随机发生的特点,通过构建微分博弈模型,研究政府与企业联合储备和持续维护的过程来保障应急处置需求,进而构建政府单一储备决策、政企联合储备决策和Stackelberg决策下的政企维护水平模型,分析维护水平对物资损耗程度和系统利润的影响,并利用Mathematic软件,以2016年武汉城市内涝为背景进行仿真分析。结果表明:考虑政企维护水平可以有效减少物资损耗,政企联合储备决策优于Stackelberg决策和政府单一储备决策,在政企联合储备决策下政企双方维护水平、物资存量及系统的总利润可实现帕累托最优。

关键词：维护水平城镇防汛物资政企联合储备决策微分博弈 Stackelberg博弈

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Gas‐phase fluorination of conjugated microporous polymer microspheres for effective interfacial stabilization in lithium metal anodes

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Carbon Energy 2023年第10期5卷 77-90页

作者： zihao Li Lingchen Kong cong Peng Wei Feng School of Material Science and Engineering Tianjin UniversityTianjinChina Tianjin Key Laboratory of Composite and Functional Materials TianjinChina

Lithium(Li)metal anodes have attracted extensive attention due to their ultrahigh theoretical capacity and low ***,the uneven deposition of Li near the unstable electrode/electrolyte interfaces leads to the growth of Li dendrites and the degradation of active ***,we directly fluorinate alkyne-containing conjugated microporous polymers(ACMPs)microspheres with fluorine gas(F_(2))to introduce a novel fluorinated interlayer as an interfacial stabilizer in lithium metal *** density functional theory methods,it is found that as-prepared fluorinated ACMP(FACMP)has abundant partially ionic C–F *** C–F bonds with electrochemical lability yield remarkable lithiophilicity during *** in situ reactions between the active C–F bonds and Li ions enable transfer of lithium fluoride microcrystals to the solid electrolyte interphase(SEI)layers,guaranteeing effective ionic distribution and smooth Li ***,Li metal electrodes with the fluorinated interlayers demonstrate excellent cycling performances in both half-batteries and full cells with a lithium bis(trifluoromethanesulfonyl)imide electrolyte as well as a nonfluorinated lithium bis(oxalate)borate electrolyte *** strategy is highly significant in customizable SEI layers to stabilize electrode interfaces and ensure high utilization of Li metal anodes,especially in a nonfluorinated electrolyte.

关键词： conjugated microporous polymers fluorinated solid electrolyte interphase gas‐phase fluorination lithium metal anodes nonfluorinated electrolyte

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疫情防控常态化下社区交通网格化管理博弈模型分析

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物流技术 2021年第6期40卷 76-81页

作者：魏思源丛子皓谢梦婷王喆武汉理工大学湖北武汉430070

新冠疫情(COVID-19)爆发,部分社区出现车辆违章、社区秩序混乱等现象,增加了疫情防控工作的实施难度。为了帮助社区提高管理水平,采用演化博弈的理论和方法,通过社区网格管理构建社区和车辆决策模型,分析了双方策略选择的稳定性,并获得... 详细信息

新冠疫情(COVID-19)爆发,部分社区出现车辆违章、社区秩序混乱等现象,增加了疫情防控工作的实施难度。为了帮助社区提高管理水平,采用演化博弈的理论和方法,通过社区网格管理构建社区和车辆决策模型,分析了双方策略选择的稳定性,并获得各个因素对决策的影响。研究结果表明,社区与车辆之间主要趋向于三种进化稳定策略,分别是(检查,不违章),(检查,违章),(不检查,违章)。当疫情风险增加、社区检查管理成本减少,社区不检查时被行政处罚的力度增大时,社区倾向于选择检查策略;当车辆违章时的罚款增加,社区加强对车辆的安全教育时,车辆倾向于选择不违章策略。

关键词：重大疫情防控社区交通网格化管理演化博弈稳定性分析监管机制

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Remarkable mechanochromism and force-induced thermally activated delayed fluorescence enhancement from white-light-emitting organic luminogens with aggregation-induced emission

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Chinese Chemical Letters 2022年第10期33卷 4536-4540页

作者： Yitao Zheng Lingqi Zuo Letian Zhang zihao Huang Shufeng Li Zhan Yang Zhu Mao Suilian Luo cong Liu Fengqiang Sun Guang Shi Zhenguo Chi Bingjia Xu Key Laboratory of Theoretical Chemistry of Environment Ministry of Education/School of ChemistrySouth China Normal UniversityGuangzhou 510006China State Key Laboratory of Optoelectronic Materials and Technologies(Sun Yat-sen University) Guangzhou 510275China School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China Shenzhen Institute of Advanced Electronic Materials Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

The development of organic materials with white-light emission and thermally activated delayed fluorescence(TADF)properties in the solid state remain a ***,a series of white-light-emitting organic luminogens have been developed and are found to show aggregation-induced delayed fluorescence(AIDF)*** AIDF emitters present dual-emission consisted of prompt fluorescence and TADF in the crystalline *** white-light emissions can be easily tuned by altering the chemical structure and connecting position of the heterocyclic aromatic *** the stimuli of mechanical force and solvent vapor,the compounds exhibit remarkable and reversible mechanochromism,in which their emission colors are switchable between white and *** grinding,they also display linearly tunable luminescence colors,as well as force-induced TADF enhancement,which may be associated with the more compact molecular packing and the restriction of intramolecular *** results from time-resolved emission scanning and theoretical calculation suggest that the dual-emission of the AIDF luminogens likely results from the twisted intramolecular charge transfer transitions of the molecules,and the reversible mechanochromism properties probably stem from the interconversion of the quasi-axial and the quasi-equatorial conformations.

关键词： White-light emission Thermally activated delayed fluorescence Aggregation-induced delayed fluorescence mechanochromism Force-induced emission enhancement

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