Controllable Polymerization of N-Substituted β-Alanine N-Thiocarboxyanhydrides for Convenient Synthesis of Functional Poly(β-peptoid)s

作     者：Ximian Xiao Min Zhou Zihao Cong Longqiang Liu Jingcheng Zou Zhemin Ji Ruxin Cui Yueming Wu Haodong Zhang Sheng Chen Maoquan Li Runhui Liu Ximian Xiao;Min Zhou;Zihao Cong;Longqiang Liu;Jingcheng Zou;Zhemin Ji;Ruxin Cui;Yueming Wu;Haodong Zhang;Sheng Chen;Maoquan Li;Runhui Liu

作者机构：State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237 Key Laboratory for Ultrafine Materials of Ministry of EducationFrontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 Department of Interventional and Vascular SurgeryShanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2023年第5卷第4期

页      面：994-1004页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(nos.22075078 and 21861162010) the Free Exploring Basic Research Project at Shenzhen Research Institute of ECUST(no.2021Szvup042) the Program of Shanghai Academic/Technology Research Leader(no.20XD1421400) the National Natural Science Foundation of China for Innovative Research Groups(no.51621002) the China National Postdoctoral Program for Innovative Talents(no.BX2021102) the Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission,grant 2021 Sci&Tech 03-28) the Research Program of the State Key Laboratory of Bioreactor Engineering,the Fundamental Research Funds for the Central Universities(no.JKD01211520) 

主　　题：ring-opening polymerization poly(β-peptoid) β-NNTA functionlization 

摘      要：Poly(β-peptoid)is a class of polypeptide mimics that possesses excellent biocompatibility and resistance to ***,the synthesis of poly(β-peptoid)s with functionalities is a long-standing challenge that greatly hinders the functional study and application of poly(β-peptoid)*** report a controllable and easy synthesis of poly(β-peptoid)s bearing diverse functionalities via the ring-opening polymerization on N-substitutedβ-alanine N-thiocarboxyanhydrides(β-NNTAs).The polymerization can be carried out in openvesselsundermildconditions usingaminesas the initiators to provide poly(β-peptoid)s with targeted molecular weights,narrow dispersities,and diverse functionalities in the side chains and ***β-NNTAs polymerization is even compatible with initiators bearing unprotected hydroxyl *** amphiphilic/cationic poly(β-peptoid)s exhibit a broad spectrum and potent antibacterial activities against multidrug-resistant *** addition,the highly favored stability ofβ-NNTAmonomers for purification and storage highlights the advantages of thisβ-NNTA polymerization strategy for poly(β-peptoid)s synthesis,functional study,and application as a synthetic mimic of polypeptides.