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Cationic polymeric nanoformulation: Recent advances in material design for CRISPR/Cas9 gene therapy

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Progress in Natural Science:Materials International 2019年第6期29卷 617-627页

作者： Kaifeng Chen Shan Jiang Yun Hong zibiao li Yunlong Wu Caisheng Wu Fujian Provincial Key Laboratory of Innovative Drug Target Research State Key Laboratory of Cellular Stress Biology School of Pharmaceutical Sciences Xiamen University Institute of Materials Research and Engineering Agency for Science Technology and Research

CRISPR/Cas9(clustered regularly interspaced short palindromic repeat/clustered regularly interspaced short palindromic repeat associated proteins 9) gene editing platform is a promising therapeutic tool for genetic disorders, due to its ability to manipulate the pathogenic gene in genomic level and to easily target specific gene by manipulating single-guide RNA. However, its successful delivery remains a challenge. Up to now, great efforts have been made to explore an effective strategy for CRISPR/Cas9 delivery. But among those delivery methods,physical methods are mainly operated on cultured cells thus limited to laboratorial use; viral vectors are hindered by fetal immunogenic and carcinogenic effects thus dubious in clinical application. Therefore, cationic polymeric vectors, with the ability to interact with CRISPR/Cas9 system to form a nanoformulation as a nonviral approach, are attracting increasing attentions, due to advantages such as well protection of cargos, less limitation in payload size, low immunogenicity or carcinogenicity, potential modifications for further functions,and ease in mass production. In this review, the recent discoveries on polymeric vectors utilized in delivery of CRISPR/Cas9 system will be summarized. With emphasis on advanced features of those polymeric vectors or their nanoformulations to meet the demands of different CRISPR/Cas9 delivery forms(plasmid, m RNA or protein), the detailed illustrations on their disease treatment applications, such as cancer, diabetes or antibioticresistant infections, will also be reviewed.

关键词： CRISPR/Cas9 Polymeric vectors Gene therapy Gene delivery Cancer therapy

Advances in the design and development of SARS-CoV-2 vaccines

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Military Medical Research 2022年第4期9卷 484-513页

作者： Xue-liang Peng Ji-Si-Yu Cheng Hai-Lun Gong Meng-Di Yuan Xiao-Hong Zhao zibiao li Dai-Xu Wei Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi'an 710069China Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis WayInnovis#08-03Singapore 138634Singapore.

Since the end of 2019,coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread *** RNA genome of SARS-CoV-2,which is highly infectious and prone to rapid mutation,encodes both structural and non-structural *** is currently the only effective method to prevent COVID-19,and structural proteins are critical targets for vaccine ***,many vaccines are in clinical trials or are already on the *** review highlights ongoing advances in the design of prophylactic or therapeutic vaccines against COVID-19,including viral vector vaccines,DNA vaccines,RNA vaccines,live-attenuated vaccines,inactivated virus vaccines,recombinant protein vaccines and bionic nanoparticle *** addition to traditional inactivated virus vaccines,some novel vaccines based on viral vectors,nanoscience and synthetic biology also play important roles in combating ***,many challenges persist in ongoing clinical trials.

关键词： Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 Vaccine Synthetic biology Nanoscience

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Multifunctional Nanomaterials: Synthesis and their Efficient Performance

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Progress in Natural Science:Materials International 2019年第6期29卷 602-602页

作者： Enyi Ye zibiao li Institute of Materials Research and Engineering A*STAR

In the past few decades, the development of multifunctional nanomaterials has received contributions from interdisciplinary fields with the integration of chemistry, physics, material science, engineering and even biology. It has been demonstrated that the sizes, shapes, composition determine the properties and functionalities of nanomaterials. With

关键词： Multifunctional Nanomaterials Synthesis and their Efficient Performance

Flexible polymeric patch based nanotherapeutics against non-cancer therapy

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Bioactive Materials 2022年第12期7卷 471-491页

作者： Houjuan Zhu Justin Mah Jian Qiang Chen Gang Wang Chui Yu Chan Qiang Zhu Enyi Ye zibiao li Xian Jun Loh Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore138634Singapore Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore637371Singapore Institute of Sustainability for Chemicals Energy and Environment(ISCE2)A*STAR(Agency for ScienceTechnology and Research)1 Pesek RoadJurong IslandSingapore627833Singapore

Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance,superior biocompatibility and biodegradation,as well as high loading capability and permeability of *** polymeric patches are classified into microneedles(MNs),hydrogel,microcapsule,microsphere and fiber depending on the formed *** combination of nanomaterials with polymeric patches allows for improved advantages of increased curative efficacy and lowered systemic toxicity,promoting on-demand and regulated drug administration,thus providing the great potential to their clinic *** this review,the category of flexible polymeric patches that are utilized to integrate with nanomaterials is briefly presented and their advantages in bioapplications are further *** applications of nanomaterials embedded polymeric patches in non-cancerous diseases were also systematically reviewed,including diabetes therapy,wound healing,dermatological disease therapy,bone regeneration,cardiac repair,hair repair,obesity therapy and some immune disease ***,the limitations,latest challenges and future perspectives of such biomedical therapeutic devices are addressed.

关键词： Flexible polymeric patches Microneedle Hydrogel Nanomaterials Non-cancer therapy Biomedical scaffolds

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

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Bioactive Materials 2022年第3期7卷 77-91页

作者： Yi Han Lu Jiang Huihui Shi Chenfang Xu Minting liu Qingjian li Lan Zheng Hong Chi Mingyue Wang Zuguo liu Mingliang You Xian Jun Loh Yun-Long Wu zibiao li Cheng li Fujian Provincial Key Laboratory of Ophthalmology and Visual Science&Ocular Surface and Corneal Diseases Eye Institute&Affiliated Xiamen Eye CenterSchool of MedicineXiamen UniversityXiamen361102China Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore138634Singapore School of Chemical Sciences University of Chinese Academy of ScienceBeijing100049China Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Material Technology and EngineeringChinese Academy of ScienceNingbo315201China Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiamen361102China Hangzhou Cancer Institute Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang ProvinceAffiliated Hangzhou Cancer HospitalZhejiang University School of MedicineHangzhou310002China Shandong Provincial Key Laboratory of Molecular Engineering School of Chemistry and Pharmaceutical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan250353China Department of Materials Science and Engineering National University of SingaporeSingapore117575Singapore

Dry eye is a common ocular disease that results in discomfort and impaired vision,impacting an individual’s quality of life.A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from the ocular surface,which limits their therapeutic ***,it is imperative to design a novel drug delivery system that not only improves the water solubility of the drug but also prolongs its retention time on the ocular ***,we develop a copolymer from mono-functional POSS,PEG,and PPG(MPOSS-PEG-PPG,MPEP)that exhibits temperature-sensitive sol-gel transition *** thermo-responsive hydrogel improves the water solubility of FK506 and simultaneously provides a mucoadhesive,long-acting ocular delivery *** addition,the FK506-loaded POSS hydrogel possesses good biocompatibility and significantly improves adhesion to the ocular *** comparison with other FK506 formulations and the PEG-PPG-FK506(F127-FK506)hydrogel,this novel MPOSS-PEG-PPG-FK506(MPEP-FK506)hydrogel is a more effective treatment of dry eye in the murine dry eye ***,delivery of FK506 in this POSS hydrogel has the potential to prolong drug retention time on the ocular surface,which will improve its therapeutic efficacy in the management of dry eye.

关键词： Ocular adhesive Polyhedral oligomeric silsesquioxane FK506 Dry eye

Baiting bacteria with amino acidic and peptidic corona coated defect-engineered antimicrobial nanoclusters for optimized wound healing

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Bioactive Materials 2024年第12期42卷 628-643页

作者： Maonan Wang Houjuan Zhu Yuling Xue Yanxia Duan Hua Tian Qi liu Yuzhu Zhang zibiao li Xian Jun Loh Enyi Ye Gang Yin Xuemei Wang Xianguang Ding David Tai Leong Department of Chemical and Biomolecular Engineering Faculty of EngineeringNational University of SingaporeSingapore117585Singapore Department of Pathology Xiangya HospitalSchool of Basic Medical SciencesCentral South UniversityChangshaChina Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis#08-03Singapore138634Singapore State Key Laboratory of Bioelectronics(Chien-Shiung Wu Lab) School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Nanjing University of Posts&TelecommunicationsNanjing210023China

Keeping steps ahead of the bacteria in the race for more efficacious antibacterial strategies is increasingly difficult with the advent of bacterial resistance ***,we engineered copper sulfide nanoclusters(CuS_(x) NCs)with variable sulfur defects for enhanced dual-treatment of bacterial infections by manipulating photothermal effects and Fenton-like ***,by encasing CuS_(x) NCs with a complex mixture of amino acids and short peptides derived from Luria-Bertani bacterial culture media as a protein corona,we managed to coax *** to take up these CuS_(x) *** a whole,Amino-Pep-CuS_(x) NCs was perceived as a food source and actively consumed by bacteria,enhancing their effective uptake by at least 1.5-fold greater than full length BSA protein BSA-corona CuS_(x) *** strategically using defect-engineering,we successfully fine-tune photothermal effect and Fenton-like capacity of CuS_(x) *** sulfur defects lead to reduced but sufficient heat generation under solar-light irradiation and increased production of toxic hydroxyl *** fine-tuning sulfur defects during synthesis,we achieve CuS_(x) NCs with an optimal synergistic effect,significantly enhancing their bactericidal *** ultra-small and biodegradable CuS_(x) NCs can rapidly break down after treatment for ***,Amino-Pep-CuS_(x) NCs demonstrate effective eradication of bacteria both in vitro and in vivo because of their relatively high uptake,optimal balanced photothermal and chemodynamic *** study offers a straightforward and efficient method to enhance bacterial uptake of next generation of antibacterial agents.

关键词： Defect-engineered Photothermal effect Chemodynamic effect Copper sulfide nanoclusters Protein corona

Polyethylene glycol/polylactic acid block co‐polymers as solid–solid phase change materials

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SmartMat 2023年第3期4卷 108-119页

作者： Xiang YDSoo Joseph K.Muiruri Jayven CCYeo Zhuang MPng Anqi Sng Huiqing Xie Rong Ji Suxi Wang Hongfei liu Jianwei Xu Xian JLoh Qingyu Yan zibiao li Qiang Zhu Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore Institute of Sustainability for Chemicals Energy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)Singapore Department of Chemistry National University of SingaporeSingapore Department of Material Science and Engineering National University of SingaporeSingapore School of Materials Science and Engineering Nanyang Technological UniversitySingapore School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore

Phase change materials(PCMs)are promising thermal energy storage materials due to their high specific latent *** PCMs typically exploit the solid–liquid(s–l)***,leakage and leaching are common issues for solid–liquid PCMs,which have to be addressed before usage in practical *** contrast,solid–solid(s–s)PCMs would naturally overcome these issues due to their inherent form stability and *** this study,we report a new type of s–s PCM based on chemically linked polyethylene glycol(PEG,the PCM portion)with polylactic acid(PLA,the support portion)in the form of a block co‐***‐solid latent heat of up to 56 J/g could be achieved,with melting points of between 44°C and 55°*** comparison,PEG was physically mixed into a PLA matrix to form a PEG:PLA ***,the composite material saw leakage of up to 9%upon heating,with a corresponding loss in thermal storage *** contrast,the mPEG/PLA block co‐polymers were found to be completely homogeneous and thermally stable even when heated above its phase transition temperature,with no observable leakage,demonstrating the superiority of chemical linking strategies in ensuring form stability.

关键词： block co‐polymer chemically linked form‐stable phase change material(PCM),polyethylene glycol(PEG) polylactic acid(PLA) solid–solid transition

Face Masks in the New COVID-19 Normal: Materials, Testing,and Perspectives

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Research 2020年第1期2020卷 1245-1284页

作者： Ming Hui Chua Weiren Cheng Shermin Simin Goh Junhua Kong Bing li Jason Y.Clim Lu Mao Suxi Wang Kun Xue Le Yang Enyi Ye Kangyi Zhang Wun Chet Davy Cheong Beng Hoon Tan zibiao li Ban Hock Tan Xian Jun Loh Institute of Materials Research and Engineering Agency for ScienceTechnology and Research(A∗STAR)2 Fusionopolis WayInnovisSingapore 138634 Department of Infectious Disease Singapore General HospitalSingapore

The increasing prevalence of infectious diseases in recent decades has posed a serious threat to public *** of transmission differ,but the respiratory droplet or airborne route has the greatest potential to disrupt social intercourse,while being amenable to prevention by the humble *** types of masks give different levels of protection to the *** ongoing COVID-19 pandemic has even resulted in a global shortage of face masks and the raw materials that go into them,driving individuals to self-produce masks from household *** the same time,research has been accelerated towards improving the quality and performance of face masks,e.g.,by introducing properties such as antimicrobial activity and *** review will cover mask-wearing from the public health perspective,the technical details of commercial and home-made masks,and recent advances in mask engineering,disinfection,and materials and discuss the sustainability of mask-wearing and mask production into the future.

关键词： details prevention driving

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粗糙集和可信性理论下订单融资风险评估

物流技术 2014年第11期33卷 362-363,484页

作者：李子彪河北工业大学经济管理学院天津300401

利用粗糙集理论与可信理论建立订单融资风险评估模型，然后采用打分的方式对该系统进行评估。最后通过实验验证该方法的可行性，使得对订单融资风险的评估有了一定的依据。

关键词：粗糙集订单融资风险可信性理论风险评估

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