Advances in the design and development of SARS-CoV-2 vaccines

作     者：Xue-Liang Peng Ji-Si-Yu Cheng Hai-Lun Gong Meng-Di Yuan Xiao-Hong Zhao Zibiao Li Dai-Xu Wei Xue?Liang Peng;Ji?Si?Yu Cheng;Hai?Lun Gong;Meng?Di Yuan;Xiao?Hong Zhao;Zibiao Li;Dai?Xu Wei

作者机构：Key Laboratory of Resource Biology and Biotechnology in Western ChinaMinistry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi'an 710069China Institute of Materials Research and EngineeringA*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis WayInnovis#08-03Singapore 138634Singapore. 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2022年第9卷第4期

页      面：484-513页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(31900950) 

主　　题：Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 Vaccine Synthetic biology Nanoscience 

摘      要：Since the end of 2019,coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread *** RNA genome of SARS-CoV-2,which is highly infectious and prone to rapid mutation,encodes both structural and non-structural *** is currently the only effective method to prevent COVID-19,and structural proteins are critical targets for vaccine ***,many vaccines are in clinical trials or are already on the *** review highlights ongoing advances in the design of prophylactic or therapeutic vaccines against COVID-19,including viral vector vaccines,DNA vaccines,RNA vaccines,live-attenuated vaccines,inactivated virus vaccines,recombinant protein vaccines and bionic nanoparticle *** addition to traditional inactivated virus vaccines,some novel vaccines based on viral vectors,nanoscience and synthetic biology also play important roles in combating ***,many challenges persist in ongoing clinical trials.