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Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： zi-Bing Qian Jun-Feng li Wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis liver disease

Synergistically enhanced dielectric, insulating and thermally conductive performances of sandwich PMMA based dielectric films

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Progress in Natural Science:Materials International 2024年第3期34卷 591-597页

作者： Dongmei zhang Yufan li Yuchao li Zhonggui Sun Hanxue Zhu Lujia Yang Yanhu zhan Yankai li Shi Wang Jun-Wei Zha School of Mathematical Sciences Liaocheng University School of Materials Science and Engineering Liaocheng University State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications School of Chemistry and Biological Engineering University of Science and Technology Beijing

A tri-layered(B-G-B) dielectric films were simply prepared by alternatively spin-coating boron nitride/polymethylmethacrylate(BN/PMMA, B) and graphene nanosheets(GNS/PMMA, G) compound solutions. The structure, morphology, thermal conductivity, and particularly the dielectric and relaxation behaviors were systematically studied. Results showed that a good exfoliation and dispersion of BN and GNS can be simply achieved through intensive mechanical compounding with PMMA in the internal mixer. The dielectric constant and breakdown strength of the obtained 1-3-1(B-G-B) sandwich composite film reached 4.3(@1 kHz) and 458.6kV/mm, being 119 % and 113 % higher than that of pure PMMA, respectively. Furthermore, the overall thermal conductivity of sandwich 1-3-1 composite increased by 112 % due to the addition of thermally conductive BN and GNS. The sandwich design strategy provided an effective way of achieving good permittivity, high insulation, and improved thermal conductivity simultaneously, showing potential applications in the miniaturization and integration of electronic devices.

关键词： Breakdown strength Composites Dielectric constant Sandwich structure Thermal conductivity

Oxidation resistant low-alloyed Ti alloys with good ductility

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Rare Metals 2024年第8期43卷 3921-3936页

作者： Meng li zhang-Zhi Shi Jun-Yi Xu Fu-Zhi Dai Xiang-Min li zi-lin li Lu-Ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advance Metals and MaterialsSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Oxidation resistance enhancement of pure Ti often comes at the cost of reduced ductility,which is frequently the problem through alloying with sole Al,Si,W,Mo and *** overcome the short coming of single element alloying,this paper proposes a multi-element low-alloying strategy to take advantage of synergistic effects and resolve the conflict between oxidation resistance and *** demonstrates that the addition of a small quantity of Ta(0.51wt%)can boost both oxidation resistance and ductility in comparison to pure ***,the combined addition of a small amount(0.54 wt%)of Ta,Nb and Si not only preserves good ductility of pure Ti,but also reduces mass gains to 14%-67%of pure Ti during 100 h oxidation at 650-850℃in *** indicates even better oxidation resistance than that obtained through the use of Ta,Nb,or Nb+Ta *** Ta+Nb+Si alloying creates an oxide layer that is less porous and more resistant to stratification and ***,a 3-μm N-rich layer can form in the Ti substrate beneath the oxide scale,in which phase transformation generates coherent Ti_(2)N with(0001)_(Ti)as the habit plane,with N atoms prefers to diffuse along■than along[0001]_(Ti).The completely transformed Ti_(2)N region or partially transformed Ti+Ti_(2)N region can effectively impede oxygen ***,the multielement low-alloying strategy is promising for enhancing both oxidation resistance and mechanical properties of metallic materials in the future.

关键词： Ti alloys Multi-element Co-alloying Oxidation resistance Mechanical properties

Human influence on the duration of extreme temperature events in Asia's hotspot regions

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Advances in Climate Change Research 2024年第2期15卷 312-326页

作者： zi-Meng WANG Hong-Yun MA Wei li Hai-Shan CHEN Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)/Key Laboratory of Meteorological Disaster Ministry of Education(KLME)Nanjing University of Information Science and TechnologyNanjing 210044China

Observations and models indicate that human activities exert a considerable impact on the frequency and intensity of extreme temperature events,which are associated with global ***,changes in the duration of extreme temperature events and their association with human influence have not been considered in most ***,the possible relationship between the observed changes in the warm and cold spell duration(WSDI and CSDI)in hotspot regions during 1960-2014 and human influence was investigated based on the NCEP/NCAR reanalysis version 1 and Coupled Model Inter-comparison Project Phase 6(CMIP6)*** projection based on these attribution results was also *** optimal fingerprinting technique was used to compare observed changes in WSDI and CSDI to simulated changes averaged across eight CMIP6 *** show that anthropogenic(ANT)forcing contributed to the observed increase in WSDI in the three hotspot regions(West Asia,South Asia and Southeast Asia),with the majority of the changes being attributed to greenhouse gas ***,a generally weak ANT signal can be observed in the decreasing trend of CSDI and can be detected in South and Southeast *** influence of aerosol forcing remains undetected in either WSDI or CSDI,which differs from the results for frequency and intensity of extreme *** attribution results revealed that the constrained projection of WSDI is lower than the raw projection for 2015-2100 in West Asia and Southeast ***,no differences in future CSDI changes are found in Southeast Asia between the constrained and raw projections.

关键词： Extreme temperature events Duration Detection attribution Constraint projection Hotspot regions

Anthropogenic influence on the extreme drought in eastern China in 2022 and its future risk

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Atmospheric and Oceanic Science Letters 2024年第1期17卷 21-27页

作者： Yinjun zhang lin Chen Yuqing li zi-An Ge Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environmental Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science and TechnologyNanjingChina

2022年夏季中国东部地区遭遇了一次持续性极端高温干旱事件.本文利用CMIP6检测归因比较计划(DAMIP)数据,量化了人为强迫对类2022年极端干旱事件发生概率的影响,并基于未来不同增暖情景试验给出了此类极端干旱事件的未来变化预估.通过分... 详细信息

2022年夏季中国东部地区遭遇了一次持续性极端高温干旱事件.本文利用CMIP6检测归因比较计划(DAMIP)数据,量化了人为强迫对类2022年极端干旱事件发生概率的影响,并基于未来不同增暖情景试验给出了此类极端干旱事件的未来变化预估.通过分析不同外强迫因子作用下此类极端干旱事件的发生概率变化,发现人为强迫使此类极端干旱事件的发生概率提高约56%,这主要与人为强迫下中国东部平均水汽减少和平均上升运动减弱有关.进一步通过分析此类极端干旱事件对不同温室气体排放情景(SSP1-2.6,SSP2-4.5,SSP5-8.5)的响应,发现在低排放情景下类2022年极端干旱事件的发生概率较当今气候显著下降,这主要与中国东部平均水汽的增加和平均环流的变化有关,而在高排放情景(SSP5-8.5)下,此类极端干旱事件的发生概率较当今气候增加约79%,这主要与高排放情景下平均下沉运动增强有关.该研究表明,人为强迫通过调制气候平均背景场从而引起极端事件发生频次的变化是人类活动影响极端气候事件的重要途径之一,极端干旱事件对温室气体排放量的响应可能是非线性的.

关键词：极端干旱中国东部归因分析人为强迫未来预估

Transforming Adolescent Smiles:Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

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Current Medical Science 2024年第3期44卷 657-666页

作者： Wen-jie FAN Jia-qi zhanG Jia-qi zhan.li HU li-li CHEN Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Wuhan National High Magnetic Field Center Wuhan430074China The Affiliated lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People’s Hospital of lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental *** traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial *** recent years,an invisible orthodontic technique,without brackets,has become increasingly ***,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect *** case report presents an adolescent patient with bimaxillary protrusion and mandibular *** on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular *** patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the *** case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction ***,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

Atomic interface regulation of rare-marth metal single atom catalysts for energy conversion

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Nano Research 2024年第5期17卷 3493-3515页

作者： ziheng zhan Zhiyi Sun zihao Wei Yaqiong li Wenxing Chen Shenghua li Siping Pang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China

Efficient photocatalysis and electrocatalysis in energy conversion have been important strategies to alleviate energy crises and environmental *** recent years,with the rapid development of emerging catalysts,significant progress has been made in photocatalysis for converting solar energy into chemical energy and electrocatalysis for converting electrical energy into chemical ***,their selectivity and efficiency of the products are *** earth(RE)can achieve atomic level fine regulation of catalysts and play an crucial role in optimizing catalyst performance by their unique electronic and orbital ***,there is a lack of systematic review on the atomic interface regulation mechanism of RE and their role in energy conversion *** atom catalysts(SACs)provide clear active sites and 100%atomic utilization,which is conducive to exploring the regulatory mechanisms of ***,this review mainly takes atomic level doped RE as an example to review and discuss the atomic interface regulation role of RE elements in energy ***,a brief introduction was given to the synthesis strategies that can effectively exert the atomic interface regulation effect of RE,with a focus on the atomic interface regulation mechanism of ***,the regulatory mechanisms of RE atoms have been systematically summarized in various energy conversion ***,the challenges faced by RE in energy conversion,as well as future research directions and prospects,were pointed out.

关键词： rare earth elements interface regulation effect single-atom catalyst energy conversion

Large porewater exchange reshapes saltmarsh carbon and greenhouse gas budgets on local and global scales

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Science China Earth Sciences 2024年第7期67卷 2195-2209页

作者： Xiaogang CHEN Isaac RSANTOS Lucheng zhan Yu Yan YAU Yan zhanG ling li Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Department of Marine Sciences University of GothenburgGothenburg 41319Sweden College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210024China

Saltmarshes are carbon-rich ecosystems that play a role in climate regulation by efficiently sequestrating atmospheric CO_(2).Climate change is a major threat to saltmarshes and will impact saltmarsh carbon ***,porewater-derived carbon outwelling emerges as a crucial pathway for carbon sequestration,but it has been largely overlooked in ***,we assessed the drivers of dissolved carbon exports and greenhouse gas emissions in a saltmarsh and placed those observations into a global *** our study site,porewater exchange(PEX)was the major process controlling dissolved carbon and greenhouse gas *** our results with 33 other studies in saltmarshes worldwide,porewater-derived carbon fluxes were equivalent to~48% of average global saltmarsh primary productivity and 2.2 times greater than global organic carbon ***,our local observations and global upscaling demonstrate the major role played by PEX in saltmarsh carbon *** part of dissolved inorganic carbon returns to the atmosphere as CO_(2),the remaining bicarbonate fraction is stored in the ocean over long time *** findings strengthen global blue carbon assessments and build arguments for the use of saltmarshes as nature-based solutions for global climate change.

关键词： Coastal carbon Global carbon budget Carbon neutrality Nature-based solutions Coastal wetlands Submarine groundwater discharge

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Enhancing thermodynamic stability of single-crystal Ni-rich cathode material via a synergistic dual-substitution strategy

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Journal of Energy Chemistry 2024年第1期88卷 428-436,I0010页

作者： Jixue Shen Hui li Haoyu Qi zhan.lin Zeheng li Chuanbo Zheng Weitong Du Hao Chen Shanqing zhang School of Metallurgy Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600JiangsuChina School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Guangdong Laboratory of Chemistry and Fine Chemical Industry Jieyang Center Jieyang 515200GuangdongChina Institute of Sustainable Transformation School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 510006GuangdongChina Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina Centre for Catalysis and Clean Energy School of Environment and ScienceGold Coast CampusGriffith UniversityGold Coast 4222QueenslandAustralia

Nickel(Ni)-rich cathode materials have become promising candidates for the next-generation electrical vehicles due to their high specific ***,the poor thermodynamic stability(including cyclic performance and safety performance or thermal stability)will restrain their wide commercial ***,a single-crystal Ni-rich li Ni_(0.83)Co_(0.12)Mn_(0.05)O_(2) cathode material is synthesized and modified by a dual-substitution strategy in which the high-valence doping element improves the structural stability by forming strong metal–oxygen binding forces,while the low-valence doping element eliminates high li^(+)/Ni^(2+)*** a result,this synergistic dual substitution can effectively suppress H2-H3 phase transition and generation of microcracks,thereby ultimately improving the thermodynamic stability of Ni-rich cathode ***,the dual-doped Ni-rich cathode delivers an extremely high capacity retention of 81%after 250 cycles(***/li+)in coin-type half cells and 87%after 1000 cycles(***/li^(+))in pouch-type full cells at a high temperature of 55℃.More impressively,the dual-doped sample exhibits excellent thermal stability,which demonstrates a higher thermal runaway temperature and a lower calorific *** synergetic effects of this dual-substitution strategy pave a new pathway for addressing the critical challenges of Ni-rich cathode at high temperatures,which will significantly advance the high-energy-density and high-safety cathodes to the subsequent commercialization.

关键词： Ni-rich cathode Single crystalline Dual-substitution strategy High-temperature cathode li-ion batteries