检索结果-南通市图书馆

Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

引用

World Journal of Diabetes 2024年第6期15卷 1263-1271页

作者： Xiang-Yu Gao Chen-Xia Zhou Hong-Mei li Min Cheng Da Chen zi-yi li Bo Feng Jun Song Department of Endocrinology East HospitalTongji University School of MedicineShanghai 200120China Department of Endocrinology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Immunization Program Huangdao District Center for Disease Prevention and ControlQingdao 266400Shandong ProvinceChina

BACKGROUND Cognitive dysfunction is the main manifestation of central *** cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive *** is closely related to neurological abnormalities,while often disregarded in clinical *** in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)*** A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East *** participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(linical data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical ***,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance *** The HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(P<0.05),whereas HOMA-βwas negatively correlated with the HbA1c level(P<0.05).Ordered multiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-

关键词： Type 2 diabetes mellitus Hemoglobin A1c Proton magnetic resonance spectroscopy Neurotransmitters Central neuropathy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Triceps skinfold thickness trajectories and the risk of all-cause mortality:A prospective cohort study

引用

World Journal of Clinical Cases 2024年第15期12卷 2568-2577页

作者： Na Yang li-Yun He zi-yi li Yu-Cheng Yang Fan Ping ling-ling Xu Wei li Hua-Bing Zhang Yu-Xiu li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND The measurement of triceps skinfold(TSF)thickness serves as a noninvasive metric for evaluating subcutaneous fat *** its clinical utility,the TSF thickness trajectories and their correlation with overall mortality have not been thoroughly *** To explore TSF thickness trajectories of Chinese adults and to examine their associations with all-cause *** This study encompassed a cohort of 14747 adults sourced from the China Health and Nutrition *** class trajectory modeling was employed to identify distinct trajectories of TSF *** were classified into subgroups reflective of their respective TSF thickness *** utilized multivariate Cox regression analyses and mediation examinations to explore the link between TSF thickness trajectory and overall mortality,including contributory *** Upon adjustment for multiple confounding factors,we discerned that males in the‘Class 2:Thin-stable’and‘Class 3:Thin-moderate’TSF thickness trajectories exhibited a markedly reduced risk of mortality from all causes in comparison to the‘Class 1:Extremely thin’*** the mediation analyses,the Geriatric Nutritional Risk Index was found to be a partial intermediary in the relationship between TSF thickness trajectories and *** females,a lower TSF thickness pattern was significantly predictive of elevated all-cause mortality risk exclusively within the non-elderly *** In males and non-elderly females,lower TSF thickness trajectories are significantly predictive of heightened mortality risk,independent of single-point TSF thickness,body mass index,and waist circumference.

关键词： Triceps skinfold thickness Trajectory All-cause mortality Body mass index Geriatric Nutritional Risk Index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dipeptidyl peptidase-4 inhibitors and the risk of infection: A systematic review and meta-analysis of cardiovascular outcome trials

引用

World Journal of Diabetes 2024年第5期15卷 1011-1020页

作者： Na Yang li-Yun He Peng liu zi-yi li Yu-Cheng Yang Fan Ping ling-ling Xu Wei li Hua-Bing Zhang Yu-Xiu li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Endocrinology The First Affiliated Hospitaland College of Clinical Medicine of Henan University of Science and TechnologyLuoyang 471000Henan ProvinceChina

BACKGROUND Since adverse events during treatment affect adherence and subsequent glycemic control,understanding the safety profile of oral anti-diabetic drugs is imperative for type 2 diabetes mellitus(T2DM)*** To evaluate the risk of infection in patients with T2DM treated with dipeptidyl-peptidase 4(DPP-4)*** Electronic databases were *** selection criteria included randomized controlled trials focused on cardiovascular *** these studies,the effects of DPP-4 inhibitors were directly compared to those of either other active anti-diabetic treatments or *** trials involving 53616 patients were deemed *** calculated aggregate relative risks employing both random-effects and fixed-effects approaches,contingent upon the *** The application of DPP-4 inhibitors showed no significant link to the overall infection risk[0.98(0.95,1.02)]or the risk of serious infections[0.96(0.85,1.08)],additionally,no significant associations were found with opportunistic infections[0.69(0.46,1.04)],site-specific infections[respiratory infection 0.99(0.96,1.03),urinary tract infections 1.02(0.95,1.10),abdominal and gastrointestinal infections 1.02(0.83,1.25),skin structure and soft tissue infections 0.81(0.60,1.09),bone infections 0.96(0.68,1.36),and bloodstream infections 0.97(0.80,1.18)].CONCLUSION This meta-analysis of data from cardiovascular outcome trials revealed no heightened infection risk in patients undergoing DPP-4 inhibitor therapy compared to control cohorts.

关键词： T2DM drugs treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

哌嗪类新精神活性物质体内检测研究进展

引用

法医学杂志 2024年第3期40卷 276-283页

作者：刘晋廷周莉英相佳宏李子怡谢婉婷贠克明施妍司法鉴定科学研究院上海市法医学重点实验室司法部司法鉴定重点实验室上海市司法鉴定专业技术服务平台上海200063 山西医科大学法医学院山西晋中030600

哌嗪类新精神活性物质是一类具有致幻作用的化合物,通过影响单胺能神经递质的水平进而影响中枢神经系统。滥用该类物质后,会产生刺激和致幻作用并伴头痛、头晕、焦虑、失眠、呕吐、胸痛、心动过速、高血压等不良反应,甚至可能造成心血... 详细信息

哌嗪类新精神活性物质是一类具有致幻作用的化合物,通过影响单胺能神经递质的水平进而影响中枢神经系统。滥用该类物质后,会产生刺激和致幻作用并伴头痛、头晕、焦虑、失眠、呕吐、胸痛、心动过速、高血压等不良反应,甚至可能造成心血管系统损害和多器官衰竭而死亡,严重危害身心健康和公共安全。哌嗪类新精神活性物质的滥用已引起国际社会的广泛关注,对其药理毒理及分析方法的研究成为法医学领域的研究热点。本文综述了已有的哌嗪类新精神活性物质的体内过程、样品处理以及分析方法,以期为法医学鉴定提供参考依据。

关键词：法医毒物化学新精神活性物质哌嗪类体内过程高效液相色谱法气相色谱-串联质谱法液相色谱-质谱法综述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于MaxEnt模型的芦苇中国潜在分布区预测

引用

湖南农业科学 2024年第8期 66-72页

作者：王二国游澜清易自力杜卫红湖南农业大学生物科学技术学院湖南长沙410128 国家能源非粮生物质原料研发中心湖南分中心湖南长沙410128

研究基于338条芦苇分布数据和6个环境变量,利用MaxEnt模型对芦苇在我国的潜在分布区进行模拟,结合环境变量的贡献率、置换重要性、刀切法检验结果以及单变量响应曲线综合分析影响芦苇分布的主要环境变量及其适宜范围。结果表明:MaxEnt... 详细信息

研究基于338条芦苇分布数据和6个环境变量,利用MaxEnt模型对芦苇在我国的潜在分布区进行模拟,结合环境变量的贡献率、置换重要性、刀切法检验结果以及单变量响应曲线综合分析影响芦苇分布的主要环境变量及其适宜范围。结果表明:MaxEnt模型在RM=1、FC=LQHP组合参数下的AUC均值为0.909,表明预测结果准确度极高;芦苇在我国的潜在分布区主要位于甘肃、山西、陕西等地区,其中高、中适生区面积分别为1.25×10^(9)、1.88×10^(9) hm^(2);影响芦苇分布的主要环境变量是年平均气温、最湿月降水量、等温性、最冷季度降水量和年平均气温变化范围;当年平均气温为14~22℃、最湿月降水量为108~284 mm、等温性低于24、最冷季度降水量小于50 mm、年平均气温变化范围低于28.5℃时,芦苇的分布概率较高。

关键词：芦苇 MaxEnt模型环境因子潜在适生区

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Oxidation resistant low-alloyed Ti alloys with good ductility

引用

Rare Metals 2024年第8期43卷 3921-3936页

作者： Meng li Zhang-Zhi Shi Jun-yi Xu Fu-Zhi Dai Xiang-Min li zi-lin li Lu-Ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advance Metals and MaterialsSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Oxidation resistance enhancement of pure Ti often comes at the cost of reduced ductility,which is frequently the problem through alloying with sole Al,Si,W,Mo and *** overcome the short coming of single element alloying,this paper proposes a multi-element low-alloying strategy to take advantage of synergistic effects and resolve the conflict between oxidation resistance and *** demonstrates that the addition of a small quantity of Ta(0.51wt%)can boost both oxidation resistance and ductility in comparison to pure ***,the combined addition of a small amount(0.54 wt%)of Ta,Nb and Si not only preserves good ductility of pure Ti,but also reduces mass gains to 14%-67%of pure Ti during 100 h oxidation at 650-850℃in *** indicates even better oxidation resistance than that obtained through the use of Ta,Nb,or Nb+Ta *** Ta+Nb+Si alloying creates an oxide layer that is less porous and more resistant to stratification and ***,a 3-μm N-rich layer can form in the Ti substrate beneath the oxide scale,in which phase transformation generates coherent Ti_(2)N with(0001)_(Ti)as the habit plane,with N atoms prefers to diffuse along■than along[0001]_(Ti).The completely transformed Ti_(2)N region or partially transformed Ti+Ti_(2)N region can effectively impede oxygen ***,the multielement low-alloying strategy is promising for enhancing both oxidation resistance and mechanical properties of metallic materials in the future.

关键词： Ti alloys Multi-element Co-alloying Oxidation resistance Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microplastic exposure disturbs sleep structure,reduces lifespan,and decreases ovary size in Drosophila melanogaster

引用

Zoological Research 2024年第4期45卷 805-820页

作者： Wei Yan zi-Jie li zi-yi lin Shu-Qin Ji William Ka Fai Tse Zhi-Qiang Meng Chang liu Lei li Shenzhen-Hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Laboratory of Developmental Disorders and Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key Laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and ***,under natural conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila *** indicated that the particles caused gut damage and remained within the digestive *** MP exposure significantly shortened the lifespan of adult *** short-term exposure disrupted sleep patterns,increasing the length of daytime sleep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated *** MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these *** the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related *** the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate ***,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.

关键词： Microplastics Sleep lifespan Reproduction Risk assessment Drosophila melanogaster

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

单壁碳纳米管在阴离子表面活性剂溶液中的分散悬浮和团聚沉降性能研究(英文)

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第8期15卷 624-633页

作者： Kun YANG zi-li yi Qing-feng JING Dao-hui liN Department of Environmental Science Zhejiang University Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control

研究目的:纳米颗粒在水中的悬浮和团聚性能是决定它们在环境中迁移行为及潜在健康和环境风险影响范围的关键。表面活性剂不仅在环境中普遍存在,而且是工业制备纳米颗粒稳定悬浮液的主要分散剂。本文以单壁纳米碳管为代表,研究震荡扰动... 详细信息

研究目的:纳米颗粒在水中的悬浮和团聚性能是决定它们在环境中迁移行为及潜在健康和环境风险影响范围的关键。表面活性剂不仅在环境中普遍存在,而且是工业制备纳米颗粒稳定悬浮液的主要分散剂。本文以单壁纳米碳管为代表,研究震荡扰动及稀释等模拟环境条件下其在阴离子表面活性剂溶液中的分散悬浮和团聚沉降性能,为评价纳米颗粒排放进入环境后的潜在风险提供依据。创新要点:现有研究认为,纳米颗粒由于能在水中稳定悬浮,其排放到环境中会产生长距离迁移并存在造成大范围污染的可能性和生态健康风险。在本文中,震荡扰动及稀释等模拟环境条件的研究表明,单壁碳纳米管在环境中长距离迁移并造成大范围污染的可能性和风险较小。研究方法:通过比较震荡扰动(模拟环境条件)和超声辅助两种分散悬浮方式及有无添加十二烷基苯磺酸钠(SDBS)阴离子表面活性剂条件下的单壁碳纳米管在水中的悬浮性能(图1),研究单壁碳纳米管能否在环境中被分散悬浮。通过研究Na+,K+,Ca2+和Mg2+等环境主要阳离子存在时SDBS稳定悬浮的单壁碳纳米管悬浮性能及与SDBS浓度等的相关性(图6和8),探明稳定悬浮的单壁碳纳米管能否在环境稀释过程中和环境阳离子存在下保持稳定悬浮。重要结论:在超声辅助下,单壁碳纳米管可以在SDBS阴离子表面活性剂溶液中稳定分散悬浮,但不能在水中稳定分散悬浮。在无超声辅助、仅通过机械震荡的情况下,单壁碳纳米管无法在水中和SDBS溶液中稳定分散悬浮。对于已经在SDBS溶液中稳定悬浮的单壁碳纳米管,它们在Na+,K+,Ca2+和Mg2+等环境主要阳离子存在时也会脱稳形成团聚沉降,且该团聚沉降行为取决于悬浮溶液中SDBS的浓度。当SDBS稳定悬浮的单壁碳纳米管在环境中被稀释时,SDBS浓度被稀释降低,会迅速导致单壁碳纳米管团聚沉降。因此,单壁碳纳米管很难在环境中被分散悬浮,即使是已经稳定分散悬浮的单壁碳纳米管,也会在环境稀释和环境阳离子的作用下快速团聚沉降。由此可见,单壁碳纳米管在环境中长距离迁移并造成大范围污染的可能性和风险较小。

关键词：分散悬浮团聚沉降:单壁碳纳米管阴离子表面活性剂超声

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ziF-8 modified by isocyanate as a photocatalytic antibacterial agent

引用

Rare Metals 2024年第6期43卷 2708-2718页

作者： yi-Ning Zhang Zhen Pei zi-Hao Wang Chong-En Wang Fen-Fen liang li-Qiao Wei College of Architecture Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials of Taiyuan University of Technology Ministry of EducationTaiyuan 030024China Department of Materials Science and Engineering Shanxi Institute of TechnologyYangquan 045000China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030000China

Zeolite imidazole skeleton(ziF-8)is a promising option for self-cleaning of building exterior walls due to its large specific surface area,high antibacterial activity and low ***,it suffers from low antibacterial efficiency and yield under visible light *** address the issues,we developed the photocatalytic materials T-ziF-8-TDI(thermally treated-ziF-8-toluene 2,4-diisocyanate)by modifying ziF-8 with thermal oxygen sensitization and chemical *** results show that the yield of T-ziF-8-TDI photocatalytic antibacterial agent is increased to 11.5 times of that of T-ziF-8,while maintaining the crystal structure of T-ziF-8 and thermal stability up to 60℃.Furthermore,T-ziF-8-TDI exhibits extended optical response range to the nearinfrared region,significantly narrowed band gap,improved photogenerated elec tron-hole separation efficiency,reduced recombination rate,and excellent photocatalytic *** the concentration of antibacterial agent is 600 mg·L^(-1),the antibacterial rate of Escherichia coli(***)reaches 99.99%irradiated by visible light for30 min,and when the concentration of antibacterial agent is 200 mg·L^(-1),the antibacterial rate of Staphylococcus aureus(***)reaches 99.99%irradiated by visible light for 25 *** also analyzed the reasons in detail from the aspects of bacterial species and antibacterial mechanism,and proposed the antibacterial mechanism of·O_(2)^(-)and h^(+)as the main active *** findings suggest that T-ziF-8-TDI photocatalytic antibacterial agent has potential for use in self-cleaning of building exterior walls.

关键词： ziF-8 Hot oxygen sensitization Modified by isocyanate Antimicrobial performance Photocatalytic antibacterial mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Azacitidine maintenance therapy for blastic plasmacytoid dendritic cell neoplasm allograft: A case report

引用

World Journal of Clinical Cases 2024年第1期12卷 136-141页

作者： li-li Tao Hui-Ting Wen zi-yi Wang Juan Cheng li Zhao Department of Hematology The First Clinical Medical CollegeLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Hematology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare,highly invasive malignant *** is no universally accepted standard of care because of its rarity and the dearth of prospective *** is still challenging for some patients to achieve persistent clinical remission or cure,despite the success of allogeneic hematopoietic stem cell transplantation(allo-HSCT),indicating that there is still a significant recurrence *** report a case of prevention of BPDCN allograft recurrence by azacitidine maintenance therapy and review the relevant *** SUMMARY We report a 41-year-old man with BPDCN who was admitted to hospital due to skin sclerosis for>5 mo’*** was diagnosed by combined clinical assessment and laboratory *** diagnosis,the patients underwent induction consolidation chemotherapy to achieve the first complete remission,followed by bridging ***-transplantation,azacitidine(75 mg/m2 for 7 d)was administered as maintenance therapy,with repeat administration every 4–6 wk and appropriate extension of the chemotherapy *** 10 cycles,the patient has been disease free for 26 mo after *** assessments of bone marrow morphology,minimal residual disease,full donor chimerism,Epstein–Barr virus,and cytomegalovirus all yielded normal results with no abnormalities *** Azacitidine may be a safe and effective maintenance treatment for BPDCN following transplantation because there were no overt adverse events during the course of treatment.

关键词： Blastic plasmacytoid dendritic cell neoplasm Azacitidine Allogeneic hematopoietic stem cell transplantation Maintenance therapy Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：