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Chronic Kidney Disease Induces Cognitive Impairment in the Early Stage

Current Medical Science 2023年第5期43卷 988-997页

作者： Yu WANG Kai CHEN zi-xuan qiao Xiao-rong BAO Department of Nephrology Jinshan HospitalFudan UniversityShanghai 201508China

Objective Previous research indicates a link between cognitive impairment and chronic kidney disease(CKD),but the underlying factors are not fully *** study aimed to investigate the progression of CKD-induced cognitive impairment and the involvement of cognition-related proteins by developing early-and late-stage CKD models in Sprague-Dawley *** The Morris water maze test and the step-down passive avoidance task were performed to evaluate the cognitive abilities of the rats at 24 weeks after *** examinations were conducted to examine renal and hippocampal ***-time PCR,Western blotting analysis,and immunohistochemical staining were carried out to determine the hippocampal expression of brain-derived neurotrophic factor(BDNF),choline acetyltransferase(ChAT),and synaptophysin(SYP).Results Compared with the control rats,the rats with early-stage CKD exhibited mild renal damage,while those with late-stage CKD showed significantly increased serum creatinine levels as well as apparent renal and brain *** rats with early-stage CKD also demonstrated significantly impaired learning abilities and memory compared with the control rats,with further deterioration observed in the rats with late-stage ***,we observed a significant downregulation of cognition-related proteins in the hippocampus of rats with early-stage CKD,which was further exacerbated with declining renal function as well as worsening brain and renal damage in rats with late-stage *** These results suggest the importance of early screening to identify CKD-induced cognitive dysfunction *** addition,the downregulation of cognition-related proteins may play a role in the progression of cognitive dysfunction.

关键词： chronic kidney disease cognitive impairment Morris water maze test brain-derived neurotrophic factor choline acetyltransferase synaptophysin

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How to estimate isotope fractionations of a Rayleigh-like but diffusion-limited disequilibrium process?

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Acta Geochimica 2023年第1期42卷 24-37页

作者： zi xuan Guan Yun Liu School of Earth and Space Science Peking UniversityBeijing 100871China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China International Center for Planetary Science College of Earth ScienceChengdu University of TechnologyChengdu 610059China CAS Center for Excellence in Comparative Planetology Hefei 230026China

The Rayleigh distillation isotope fractionation(RDIF) model is one of the most popular methods used in isotope geochemistry. Numerous isotope signals observed in geologic processes have been interpreted with this model. The RDIF model provides a simple mathematic solution for the reservoir-limited equilibrium isotope fractionation effect. Due to the reservoir effect, tremendously large isotope fractionations will always be produced if the reservoir is close to being depleted. However, in real situations, many prerequisites assumed in the RDIF model are often difficult to meet. For instance, it requires the relocated materials, which are removed step by step from one reservoir to another with different isotope compositions(i.e., with isotope fractionation), to be isotopically equilibrated with materials in the first reservoir simultaneously. This ‘‘quick equilibrium requirement’’ is indeed hard to meet if the first reservoir is sufficiently large or the removal step is fast. The whole first reservoir will often fail to re-attain equilibrium in time before the next removal *** problem led the RDIF model to fail to interpret isotope signals of many real situations. Here a diffusion-coupled and Rayleigh-like(i.e., reservoir-effect included) separation process is chosen to investigate this problem. We find that the final isotope fractionations are controlled by both the diffusion process and the reservoir effects via the disequilibrium separation process. Due to its complexity, we choose to use a numerical simulation method to solve this problem by developing specific computing codes for the working *** to our simulation results, the classical RDIF model only governs isotope fractionations correctly at the final stages of separation when the reservoir scale(or thickness of the system) is reduced to the order of magnitude of the quotient of the diffusivity and the separation rate. The RDIF model fails in other situations and the isotope fractionations

关键词： Isotope fractionation Reservoir isotope effect Rayleigh-like distillation process Diffusional isotope effect Numerical modeling Disequilibrium process

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Multi-Physics Modeling of Solid Oxide Fuel Cell Fueled by Methane and Analysis of Carbon Deposition

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Chinese Journal of Chemical Physics 2015年第3期28卷 299-307,I0001页

作者： Bao-xuan Wang Jiang Zhu zi-jing Lin Hefei National Laboratory for Physical Sciences at the Microscale & Collaborative Innovation Center of Suzhou Nano Science and Technology University of Science and Technology of China Hefei 230025 China Key Laboratory of Strongly-Coupled Quantum Matter Physics Chinese Academy of Sciences and Department of Physics University of Science and Technology of China Hefei 230025 China

Internal reformation of low steam methane fuel is important for the high efficiency and low cost operation of solid oxide fuel cell. Understanding and overcoming carbon deposition is crucial for the technology development. Here a multi-physics model is established for the relevant experimental cells. Balance of electrochemical potentials for the electrochemical reactions, generic rate expression for the methane steam reforming, dusty gas model in a form of Fick＇s model for anode gas transport are used in the model. Excellent agreement between the theoretical and experimental current-voltage relations is obtained, demonstrating the validity of the proposed theoretical model. The steam reaction order in low steam methane reforming reaction is found to be 1. Detailed information about the distributions of physical quantities is obtained by the numerical simulation. Carbon deposition is analyzed in detail and the mechanism for the coking inhibition by operating current is illustrated clearly. Two expressions of carbon activity are analyzed and found to be correct qualitatively, but not quantitatively. The role of anode diffusion layer on reducing the current threshold for carbon removal is also explained. It is noted that the current threshold reduction may be explained quantitatively with the carbon activity models that are only qualitatively correct.

关键词： Numerical model Methane reforming kinetics Current-voltage relation Carbon activity Diffusion barrier layer

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A mini-review on recent progress of new sensitizers for luminescence of lanthanide doped nanomaterials

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Nano Research 2020年第7期13卷 1795-1809页

作者： Hongxin Zhang zi-Han Chen xuan Liu Fan Zhang Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsState Key Laboratory of Molecular Engineering of Polymers and iChemFudan UniversityShanghai 200433China

Trivalent lanthanide(Ln2+)doped luminescent nanocrystals are promising for applications ranging from biosensor,lasing,super-resolution nanoscopy,information security and so *** the utility prospect is of great attractions,the light absorption of these lanthanide doped nanocrystals is inherently weak due to the electric dipole-forbidden 4f→4f *** worse,the quantum yields of upconverison nanocrystals are very low,which will unavoidably hinder their further *** a typical lanthanide luminescent nanosystem,both sensitizers as light absorption centers and activators as light emitting centers are necessary and important for desired luminescence *** various sensitization systems,only Yb3+and Nd+are considered as the most efficient ***,the corresponding excitation wavelengths are strictly limited around 980 and 808 *** enrich excitation wavelengths and boost luminescence intensity,exploring more sensitization units that possess larger absorption cross section,higher efficiency of energy transfer process and independent excitation is imperative and beneficial for the demands of different applications,such as broadened absorption in near infrared(NIR)region for higher conversion efficiency of solar cells,prolonged excitation wavelength to second near infrared windows region(NIR Ⅱ,1,000-1,700 nm)for in vivo fluorescence imaging with deeper tissue depth and higher spatial resolution,more orthogonal excitations and emissions to improve optical multiplexing,and so ***,in the review,we primarily conclude several major energy transfer mechanisms from sensitizers to *** we present three kinds of sensitizers,including lanthanide ions,organic dyes and quantum dots(QDs),and introduce the newly designed sensitization system that allows us to exploit superior excitation wavelength and amplity luminescence ***,several future challenges and opportunities for the sensitizing strategies are discuss

关键词： lanthanide luminescenee new sensitizers organic dyes quantum dots

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Consensus control of second-order stochastic discrete-time multi-agent systems without velocity transmission

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Control Theory and Technology 2023年第4期21卷 591-601页

作者： zi-xuan Wang Xiaofeng Zong Ling-Jie Gai School of Automation China University of GeosciencesWuhan430074China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems WuhanHubeiChina Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of EducationWuhanHubeiChina

This article studies the almost-sure and the mean-square consensus control problems of second-order stochastic discrete-time multi-agent systems with multiplicative ***,a control law based on the absolute velocity and relative position information is ***,considering the existence of multiplicative noises and nonlinear terms with Lipschitz constants,the consensus control problem is solved through the use of a degenerated Lyapunov ***,for the linear second-order multi-agent systems,some explicit consensus conditions are ***,two sets of numerical simulations are performed.

关键词： Consensus control Multiplicative noises Second-order Discrete-time Multi-agent system

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Dual-targeted treatment for inflammatory bowel disease:Whether fecal microbiota transplantation can be an important part of it

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World Journal of Gastroenterology 2024年第36期30卷 4025-4030页

作者： zi-Ning Zhang Li-xuan Sang Department of Gastroenterology The Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina

Inflammatory bowel disease(IBD)is a chronic gastrointestinal inflammatory *** the emergence of biologics and other therapeutic methods,two biologics or one biologic combined with a novel small-molecule drug has been proposed in recent years to treat *** treatment strategies for IBD are being optimized,their efficacy and risks still warrant further *** editorial explores the current risks associated with dual-targeted treatment for IBD and the great potential that fecal microbiota transplantation(FMT)may have for use in combination therapy for *** are focused on addressing refractory IBD or biologically resistant IBD based on currently available dual-targeted treatment by incorporating FMT as part of this dual-targeted *** this new therapy regimen,FMT represents a promising combination therapy.

关键词： Gut microbiota Inflammatory bowel disease Fecal microbiota transplantation Dual-targeted treatment Combination treatment

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Recent advances of morphology adaptive nanomaterials for anti-cancer drug delivery

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Progress in Natural Science:Materials International 2020年第5期30卷 555-566页

作者： Dongbing Cheng Zengying qiao Lixue xuan Hao Wang School of Chemistry Chemical Engineering & Life Science Wuhan University of Technology CAS Center for Excellence in Nanoscience Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST) Department of Breast Surgery Nation Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Henan Institute of Advanced Technology Zhengzhou University

The morphology of nanomaterials combines the characteristics of their size, shape and spatial structure. Owing to the improved spatiotemporal control of the nanocarriers for anti-cancer drug delivery, the morphology adaptive nanomaterials have received tremendous attention in the field of nanomedicine, while they are able to respond through chemical or physical change. In this review, we summarize the recent advancements of morphology adaptive nanomaterials and their application in anti-cancer drug delivery system, wherein the size, shape and spatial structure of nanocarriers can be changed to adapt the complex living system, thus overcoming the pathological barriers in drug delivery. The overview of the recent examples shows that each step of delivery process can be improved by the morphology adaption, which represents the great potential for clinic translation of morphology adaptive nanomaterials.

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非层状二维γ-In_(2)Se_(3)的各向异性生长及其光学特性

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原子与分子物理学报 2025年第6期42卷 58-65页

作者：雷子煊张文婷夏晓凤王红艳西南交通大学物理科学与技术学院材料先进技术重点实验室成都610031

非层状二维(2D)γ-In_(2)Se_(3)具有优异的光学和电学性能,在超薄柔性器件和光电探测领域具有广泛的应用前景.然而,相较于层状的类石墨烯材料,非层状材料固有的各向同性化学键,使得其二维各向异性生长面临较大的挑战.本研究构建了一种... 详细信息

非层状二维(2D)γ-In_(2)Se_(3)具有优异的光学和电学性能,在超薄柔性器件和光电探测领域具有广泛的应用前景.然而,相较于层状的类石墨烯材料,非层状材料固有的各向同性化学键,使得其二维各向异性生长面临较大的挑战.本研究构建了一种新的化学气相沉积(CVD)生长策略,成功制备了高质量的2Dγ-In_(2)Se_(3).首次选用低熔点的铟粉为前驱体,有效降低了生长温度.此外,生长过程去除了CVD法合成二维硒化物时不可避免的危险气体H_(2),这不仅能有效抑制InSe副产物的形成,还降低了实验危险性.通过探究原料用量、生长温度及时间等参数对样品形貌和厚度的影响,获得了最佳生长窗口.详细表征了2Dγ-In_(2)Se_(3)的微观形貌、化学组分、晶体结构和光学特性等.结果表明,样品具有强烈的光致发光(PL)效应,与γ-In_(2)Se_(3)的直接带隙属性相吻合.随着厚度的减小,PL峰会发生蓝移,说明光学带隙随之增大.Raman光谱显示,不同厚度的样品其特征峰也会发生移动,说明厚度会影响2Dγ-In_(2)Se_(3)的分子振动行为.由此可见,通过生长参数调控2Dγ-In_(2)Se_(3)的厚度,可实现对其光学带隙和分子振动行为的调控,这将为相关的理论研究和光电器件应用提供基本的材料平台.

关键词：非层状材料二维γ-In_(2)Se_(3) 化学气相沉积各向异性生长带隙

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Synthesis and Crystal Structure of a Co(II) Complex with Schiff Base and Imidazole Ligand

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Chinese Journal of Structural Chemistry 2006年第5期25卷 567-571页

作者： WU Lian-Bin HU zi-Qiang LAI Guo-qiao Key Laboratory of Organosilicon Chemistry and Material Technology of Education Ministry Hangzhou Teachers University Hangzhou 310012 China

The title compound, [Co（C3H4N2）2（C22H18N2O4）]·5H2O （Mr = 659.56）, has been prepared and its crystal structure was determined by X-ray diffraction method. The crystal belongs to monoclinic, space group P21/n, a = 9.6808（2）, b = 26.7204（5）, c = 12.7993（3） A, β = 100.9340（10）°, V= 3250.75（12） A^3, Z = 4, Dc = 1.348 g/cm^3,μ = 0.586 mm^-1, F（000） = 1380, S = 1.131, R = 0.0689 and wR = 0.1883 for 4782 observed reflections （Ⅰ 〉 2σ（Ⅰ））. The title crystal consists of Co（Ⅱ） complex and lattice water molecules. The Co（Ⅱ） complex assumes a distorted octahedral coordination geometry, formed by one Schiff base dianion phenylenediamine-3-methoxysali-cylaldehyde and two imidazole ligands. The π-π stacking interaction occurs between nearly parallel benzene rings of the neighboring complexes.

关键词： cobalt(Ⅱ) complex Schiff base crystal structure π-π stacking

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Electrospun N-halamine/ZnO-based platform eradicates bacteria through multimodal antimicrobial mechanism of action

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Rare Metals 2023年第1期42卷 222-233页

作者： Hui-Hui Qu Cong Wang Yi-xuan Guo zi-Ying Zhao Long qiao Jie-Bing Yang Hai-Xia Wu Quan-Shun Li Alideertu Dong College of Chemistry and Chemical Engineering Engineering Research Center of Dairy Quality and Safety Control TechnologyMinistry of EducationInner Mongolia UniversityHohhot010021China Center of Experimental Instrument School of Food Science and TechnologyDalian Polytechnic UniversityDalian116034China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun130012China

The emergence and prevalence of antibiotic-resistant bacteria demands powerful antibacterial tactics to combat infectious *** combinational therapy based on synergistic hybrid antibacterial materials is a promising approach to realize effective sterilization through the rational integration of distinct bactericides into one compact *** this work,we constructed a microfiber-based antibacterial platform(PAM-Cl/ZnO MFs)by electrospinning N-halamine polymers(PAM-Cl)loaded with zinc oxide(ZnO)*** as-designed PAM-Cl/ZnO MFs inherited the intrinsic antibacterial effects of both PAM-Cl microfibers(PAM-Cl MFs)and ZnO microfibers(ZnO MFs),and the material exhibited enhanced synergistic antibacterial performance against Staphylococcus aureus(***)and Escherichia coli(***)in *** bactericidal effect was multimodal and included contact killing based on the N-Cl bond of N-halamine,multiple-release killing,such as reactive oxygen species(ROS)under light irritation,and Zn^(2+)and Cl^(+)acting as antibacterial ***,PAM-Cl/Zno MFs worked on inactivate bacteria even under harsh temperatures and atmospheric ***,PAM-Cl/ZnO MFs exhibited good biocompatibility and performed outstanding acceleration of wound healing with in vivo mouse skin defect models using *** work advances the design of antibacterial hybrid materials with the potency to eradicate bacteria in biological systems in multiple settings through the superiority of multimodal synergistic therapy.

关键词： N-halamine ZnO nanoparticles Electrospinning Synergistic antibacterial therapy Various scenarios

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