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Early prediction and prevention of infected pancreatic necrosis

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World Journal of Gastroenterology 2024年第9期30卷 1005-1010页

作者： cheng Lv zi-Xiong Zhang Lu Ke Department of Critical Care Medicine Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210000Jiangsu ProvinceChina Research Institute of Critical Care Medicine and Emergency Rescue Nanjing UniversityNanjing 210000Jiangsu ProvinceChina

Approximately 20%-30%of patients with acute necrotizing pancreatitis develop infected pancreatic necrosis(IPN),a highly morbid and potentially lethal complication.Early identification of patients at high risk of IPN may facilitate appropriate preventive measures to improve clinical outcomes.In the past two decades,several markers and predictive tools have been proposed and evaluated for this purpose.Conventional biomarkers like C-reactive protein,procalcitonin,lymphocyte count,interleukin-6,and interleukin-8,and newly developed biomarkers like angiopoietin-2 all showed significant association with IPN.On the other hand,scoring systems like the Acute Physiology and Chronic Health Evaluation II and Pancreatitis Activity Scoring System have also been tested,and the results showed that they may provide better accuracy.For early prevention of IPN,several new therapies were tested,including early enteral nutrition,anti-biotics,probiotics,immune enhancement,etc.,but the results varied.Taken together,several evidence-supported predictive markers and scoring systems are readily available for predicting IPN.However,effective treatments to reduce the incidence of IPN are still lacking apart from early enteral nutrition.In this editorial,we summarize evidence concerning early prediction and prevention of IPN,providing insights into future practice and study design.A more homo-geneous patient population with reliable risk-stratification tools may help find effective treatments to reduce the risk of IPN,thereby achieving individualized treatment.

关键词： Acute pancreatitis Infected pancreatic necrosis Biomarker Scoring system Nutrition therapy Selective digestive decontamination Probiotics Antibiotics Immune enhancement therapy

Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： zi-Bing qian Jun-Feng Li Wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic field.Various forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver diseases.In general,more than one form of cell death pathways is responsible for the disease state.Therefore,it is particularly important to study the regulation and interaction of various cell death forms in liver diseases.Data sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver disease.We also used terms such as signal path,inducer,and inhibitor to supplement the query results.Results:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver diseases.Conclusions:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

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Prescribed-Time Fully Distributed Nash Equilibrium Seeking Strategy in Networked Games

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 261-263页

作者： cheng qian Lei Ding the Institute of Advanced Technology for Carbon Neutrality College of Automation&the College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China IEEE

Dear Editor, This letter is concerned with prescribed-time fully distributed Nash equilibrium seeking for networked games under directed graphs. An adaptive algorithm is proposed to ensure the convergence of all players to the Nash equilibrium without requiring any knowledge of global parameters. Moreover, it is theoretically proved that the convergence time of the proposed seeking strategy can be predefined based on practical requirements. Finally, a numerical example is presented to validate the effectiveness of the proposed method.

关键词： parameters seeking prescribed

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Gastric cancer immunotherapy:A scientometric and clinical trial review

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World Journal of Gastroenterology 2024年第2期30卷 196-198页

作者： qian-cheng Du Xin-Yu Wang Hua Yu Thoracic Surgery Shanghai Xuhui Central HospitalShanghai 200031China Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of General Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

This letter is intended to arouse your interest in a recent review of comprehensive scientometrics and clinical trials on immunotherapy for gastric cancer(GC).Our study reviews recent advances in immunotherapy in the field of GC and highlights its new prospects as a treatment for GC.Our research reveals China’s leadership in this field,as well as new therapeutic strategies such as immune checkpoint inhibitors,cellular immunotherapy,and vaccines.The combined findings highlight the potential of immunotherapy to improve survival and quality of life in patients with stomach cancer.We believe that this study will provide important guidance for the future direction of the GC treatment field.

关键词： Gastric cancer Immunotherapy Bibliometrics Comment Therapeutic strategies

Multifaceted role of microRNAs in gastric cancer stem cells: Mechanisms and potential biomarkers

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 300-313页

作者： qian-Hui Sun zi-Yu Kuang Guang-Hui Zhu Bao-Yi Ni Jie Li Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Department of Oncology Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina

MicroRNAs(miRNAs)have received much attention in the past decade as potential key epigenomic regulators of tumors and cancer stem cells(CSCs).The abnormal expression of miRNAs is responsible for different phenotypes of gastric cancer stem cells(GCSCs).Some specific miRNAs could be used as promising biomarkers and therapeutic targets for the identification of GCSCs.This review summarizes the coding process and biological functions of miRNAs and demon-strates their role and efficacy in gastric cancer(GC)metastasis,drug resistance,and apoptosis,especially in the regulatory mechanism of GCSCs.It shows that the overexpression of onco-miRNAs and silencing of tumor-suppressor miRNAs can play a role in promoting or inhibiting tumor metastasis,apart from the initial formation of GC.It also discusses the epigenetic regulation and potential clinical applications of miRNAs as well as the role of CSCs in the pathogenesis of GC.We believe that this review may help in designing novel therapeutic approaches for GC.

关键词： Gastric cancer,Cancer stem cells MicroRNAs Epigenetics Therapeutic target

Mechanical performance of 22SiMn2TiB steel welded with lowtransformation- temperature filler wire and stainless steel filler wire

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Journal of Iron and Steel Research(International) 2024年第4期31卷 967-981页

作者： zi-dong Lin Kai-jie Song Zhen Sun zi-qian Zhu Xue-feng Zhao Constantinos Goulas Wei Ya Xing-hua Yu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China Department of Design Production and Management Faculty of Engineering Technology.University of TwenteEnschede 7500 AETheNetherlands Rotterdam Additive Manufacture Fieldlab(RAMLAB) Rotterdam 3089 JWTheNetherlands

TX-80 low-transformation-temperature(LTT)welding wire was used to replace the traditional ER 307Si welding wire to realize the connection of 22SiMn2TiB armor steel in manual overlay welding.The previously existing issues,such as welding cracks,large welding deformation,and severe welding residual stress,were solved to ensure good strength and ductility requirements.In particular,with the same welding conditions,TX-80 LTT wire eliminates welding cracks.It reduces the welding deformation no matter the base pretreatment of pre-setting angle or no pre-setting angle.By comparison,it was found that the microstructure at the TX-80 weld is mainly composed of martensite and a small amount of retained austenite.In contrast,the microstructure of the ER 307Si weld consists of a large amount of austenite and a small amount of skeleton-like ferrite.The variation trend of residual stress and microhardness from the weld to the base were investigated and compared with the mechanical properties of base materials.The TX-80 and the ER 307Si tensile samples elongation is 6.76%and 6.01%,while the ultimate tensile strengths are 877 and 667 MPa,respectively.The average impact toughness at room temperature of the ER 307Si weld is 143.9 J/cm^(2),much higher than that of the TX-80 weld,which is only 36.7 J/cm^(2).The relationship between impact and tensile properties with microstructure species and distribution was established.In addition,the fracture surface of the tensile and the impact samples was observed and analyzed.Deeper dimples,fewer pores,larger radiation zone,and shear lips of TX-80 samples indicate better tensile ductility and worse impact toughness than those of ER 307Si weld.

关键词： Low-transformation-temperature material 22SiMn2TiB steel Welding deformation Residual stress Martensitic transformation Mechanical property

Limit theorems for supercritical remaining-lifetime age-structured branching processes

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Acta Mathematica Sinica,English Series 2024年

作者： zi Ling cheng School of Mathematical Sciences Beijing Normal University

We study supercritical age-structured branching models starting from a single particle with a random lifetime, where the reproduction law depends on the remaining lifetime of the parent. The lifespan of an individual is decided at its birth and its remaining lifetime decreases at the unit speed. A necessary and sufficient condition is provided for the convergence of the Malthusian normalized random measures. The Malthusian type limit theory in a functional form can be strengthened to hold with probability one under some “L log L” conditions. We further prove a central limit theory with a random normalization factor.

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Spatio-Temporal Service Analysis in Multi-Layer Non-Terrestrial Networks

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Journal of Communications and Information Networks 2024年第1期9卷 43-55页

作者： qian Chen Weixiao Meng Shuai Han cheng Li School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China School of Engineering Science Simon Fraser UniversityBurnabyBC V5A 1S6Canada Department of Electrical and Computer Engineering Memorial UniversitySt.John’sNL A1B 3X5Canada

In the advent of the 6G era, non-terrestrial networks (NTN) with expansive coverage are being increasingly recognized as a vital supplement to cellular networks for facilitating seamless communication. The intricate interplay between network performance and service quality necessitates a thorough investigation into the modeling and analysis of services for efficient construction of NTN.Previous studies on service analysis, predominantly focused on terrestrial networks,fall short in addressing the unique challenges posed by NTN,particularly those related to platform distribution and antenna gain modeling. This deficiency in research,coupled with the varying preferences of users for different network types, forms the basis of this study. This paper explores the spatio-temporal characteristics of services within a multi-layered NTN framework.In this context,the spatial distribution of the platforms is modeled using a binomial point process, and the antennas are characterized by a sectorized beam pattern. We derive the closed-form expressions for the association probability,the number of accessed users, and the arrival rate of services with certain delay requirements towards different types of NTN. Simulation results are provided to evaluate the influence of various parameters on the association probability, the number of accessed users, and the total arrival rate of services. The number of satellites can be determined to achieve the optimal system utility,balancing the accessed services, offloading effects, and launching costs. This initial investigation lays the groundwork for further theoretical progress in the service analysis and platform deployment of NTN.

关键词： association strategy non-terrestrial networks service analysis stochastic geometry system utility

Cross-resistance and genetics of field-evolved resistance to chlorfenapyr in Plutella xylostella

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Insect Science 2024年第2期31卷 533-541页

作者： cheng qian Jialin Li Shuwen Wu Yihua Yang Yidong Wu Xingliang Wang Sanya Institute of Nanjing Agricultural Universty SanyaHainanChinaand College of Plant Protection Nanjing Agricultural UniversNanjingChina

Chlorfenapyr is a broad-spectrum halogenated pyrrole insecticide with a unique mode of action.Due to the misuse and overuse of this chemical,resistance has been reported in several arthropods,including Plutella xylostella,which is one of the most destructive insect pests afflicting crucifers worldwide.A better understanding of the cross-resistance and genetics of field-evolved chlorfenapyr resistance could effectively guide resistance management practices.Here,the chlorfenapyr resistance of a fieldderived population of P xylostella was introgressed into the susceptible IPP-S strain using a selection-assisted multigenerational backcrossing approach.The constructed nearisogenic strain,TH-BCsF2,shared 98.4%genetic background with the recurrent parent IPP-S strain.The TH-BCsF2 strain showed 275-fold resistance to chlorfenapyr,but no significant cross-resistance to spinosad,abamectin,chlorpyrifos,β-cypermethrin,indoxacarb,chlorantraniliprole,or broflanilide(no more than 4.2-fold).Genetic analysis revealed that resistance was autosomal,incompletely dominant,and conferred by 1 major gene or a few tightly linked loci.The synergism of metabolic inhibitors(PBO,DEM,and DEF)to chlorfenapyr was very weak(<1.7-fold),and the metabolic enzyme activities in the TH-BCsF2 strain were not significantly elevated compared with the IPP-S strain.The results enhances our understanding of the genetic traits of chlorfenapyr resistance,and provides essential information for improving resistance management strategies.

关键词： chlorfenapyr cross-resistance mode of inheritance near-isogenic line Plutellaxylostella