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Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis

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Current Medical Science 2024年第3期44卷 623-632页

作者： Ke NI zi-li li Zhi-yong HU li HONG Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan430060China Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Endometrial carcinoma(EC)is a prevalent gynecological malignancy characterized by increasing incidence and mortality *** underscores the critical need for novel therapeutic *** such potential target is cell division cycle 20(CDC20),which has been implicated in *** study investigated the effect of the CDC20 inhibitor Apcin on EC and elucidated the underlying mechanism *** The effects of Apcin on EC cell proliferation,apoptosis,and the cell cycle were evaluated using CCK8 assays and flow *** sequencing(RNA-seq)was subsequently conducted to explore the underlying molecular mechanism,and Western blotting and coimmunoprecipitation were subsequently performed to validate the *** studies were performed to evaluate the antitumor effects in *** analysis was also conducted to identify CDC20 as a potential therapeutic target in *** Treatment with Apcin inhibited proliferation and induced apoptosis in EC cells,resulting in cell cycle *** associated with apoptosis and the cell cycle were activated following treatment with ***,Apcin treatment led to the upregulation of the cell cycle regulator p21,which was verified to interact with CDC20 and consequently decrease the expression of downstream cyclins in EC *** vivo experiments confirmed that Apcin treatment significantly impeded tumor *** CDC20 expression was observed in EC tissue than in nonmalignant tissue,and increased CDC20 expression in EC patients was associated with shorter overall survival and progress free *** CDC20 is a novel molecular target in EC,and Apcin could be developed as a candidate antitumor drug for EC treatment.

关键词： endometrial carcinoma CDC20 apoptosis cell cycle arrest p21 BBC3

Probing multi-physical process and deformation mechanism of a largescale landslide using integrated dual-source monitoring

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Geoscience Frontiers 2024年第2期15卷 417-432页

作者： Hong-Hu Zhu Xiao Ye Hua-Fu Pei Wei Zhang Gang Cheng zi-li li School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China Department of Geotechnical Engineering Dalian University of TechnologyDalian 116024China Civil Structural&Environmental EngineeringSchool of Engineering and ArchitectureUniversity College CorkCorkIreland Department of Civil&Environmental Engineering Massachusetts Institute of TechnologyCambridgeMA 02139-4307United States

The implementation of isolated heterologous monitoring systems for spatially distant borehole deployments often comes with substantial equipment costs,which can limit the effectiveness of geohazard mitigation and georisk management *** address this,we have developed a novel monitoring system that integrates fiber Bragg grating(FBG)and microelectromechanical system(MEMS)techniques to capture soil moisture,temperature,sliding resistance,strain,surface tilt,and deep-seated *** system enables real-time,simultaneous data acquisition and cross-validation analyses,offering a costeffective solution for monitoring critical parameters in geohazard-prone *** successfully applied this integrated monitoring system to the Xinpu landslide,an active super-large landslide located in the Three Gorges Reservoir Area(TGRA)of *** resulting strain profile confirmed the presence of two shallow secondary sliding surfaces at depths of approximately 7 m and 12 m,respectively,in addition to the deep-seated sliding surface at a depth of28 *** lower secondary sliding surface was activated by extreme precipitation,while the upper one was primarily driven by significant changes in reservoir water levels and secondarily triggered by concentrated ***-slide piles have remarkably reinforced the upper moving masses but failed to control the lower *** gap between the pile heads and the soil amplified the rainwater erosion effect,creating a preferential channel for rainwater ***-physical measurements revealed a mixture of seepage-driven and buoyancy-driven behaviors within the *** study offers an integrated dual-source multi-physical monitoring paradigm that enables collaborative management of multiple crucial boreholes on a large-scale landslide,and contributes to the evaluation and improvement of engineering measures in similar geological settings.

关键词： Reservoir landslide Multi-physical process Integrated dual-source monitoring Fiber optic Extreme weather

Self-tuning Information Fusion Kalman Predictor Weighted by Diagonal Matrices and Its Convergence Analysis

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自动化学报 2007年第2期33卷 156-163页

作者： DENG zi-li li Chun-Bo Department of Automation Heilongjiang Uninvesity Harbin 150080 P.R. China

为有未知噪音统计的 multisensor 系统，使用现代时间系列分析方法，基于革新建模的动人的一般水准(麻省)的联机鉴定，并且基于为关联功能的矩阵方程的解决方案，噪音变化的评估者被获得，并且在线性最小的变化下面由斜矩阵加权的最佳... 详细信息

为有未知噪音统计的 multisensor 系统，使用现代时间系列分析方法，基于革新建模的动人的一般水准(麻省)的联机鉴定，并且基于为关联功能的矩阵方程的解决方案，噪音变化的评估者被获得，并且在线性最小的变化下面由斜矩阵加权的最佳的信息熔化标准，一个自我调节的信息熔化 Kalman 预言者被介绍，它认识到自我调节的 dec 基于动态错误系统，一个新集中分析方法为自我调节的 fuser 被介绍。在一条认识的集中的一个新概念被介绍，它是比有概率一的集中弱的。如果 MA 革新模型的参数评价是一致的，那么，自我调节的熔化 Kalman 预言者将在一条认识收敛到最佳的熔化 Kalman 预言者，这严格地被证明，或与概率一，以便它有 asymptotic optimality。它能减少计算负担，并且对实时应用合适。为追踪系统的一个目标的一个模拟例子显示出它的有效性。

关键词：人工智能信息融合集中分析控制理论

Multiple sub-array beamspace CAATI algorithm for multi-beam bathymetry system

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Journal of Marine Science and Application 2007年第1期6卷 47-52页

作者： li zi-sheng li Hai-sen ZHOU Tian YUAN Yan-yi College of Underwater Acoustic Engineering Harbin Engineering University Harbin 150001 China

This paper extends CAATI （Computed Angle-of-Arrival Transient Imaging） technique of Multi-angle Swath Bathymetry Sidesean Sonar （MSBSS） into Multi-Beam Bathymetry Sonar （MBBS） and presents a new Multiple Sub-array Beamspaee - CAATI （MSB-CAATI） algorithm. The method not only can achieve high resolution seafloor mapping in the whole wide swath, but also can work well in complex acoustic environments or geometries. Simulation results and processing results of sea-experiment data prove the validity and superiority of the algorithm.

关键词： MSB-CAATI swath bathymetry high resolution multi-beam

Simulation and photoelectron track reconstruction of soft X-ray polarimeter

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Nuclear Science and Techniques 2021年第7期32卷 1-10页

作者： Xue-Feng Huang Hong-Bang liu Jin Zhang Bo Huang Wen-Jin Xie Huan-Bo Feng Xi-Chen Cai Xi-Wen liu zi-li li Jian-Yu Gu Qian liu Jin li En-Wei liang Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

The soft X-ray polarimeter(SXP)is a detector with a wide energy range,large area,and large field of view.A SXP will be mounted on the Chinese Space Station and will mainly focus on detecting the polarization of transient soft X-ray(2–10 keV)sources,especially gamma-ray bursts(GRBs).In this work,a polarimeter detector unit is taken as an example,and Geant4 and Garfield++software are used to simulate the detection efficiency and track *** improved track reconstruction algorithm is proposed and used to reconstruct two-dimensional images of the *** this method,the initial emission angle of photoelectrons is reconstructed from the initial part of the track by shortening or extending the initial part of the track until the remaining track is straight,and the number of pixels is within an adjustable *** modulation factor of the photoelectronic tracks after reconstruction reaches approximately 57%in the photon energy range of 7–10 keV.

关键词： X-ray Polarimetry Track reconstruction algorithm

Design of detector to monitor the Bragg peak location of carbon ions by means of prompt γ-ray measurements with Geant4

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Nuclear Science and Techniques 2018年第4期29卷 83-91页

作者： Yan Fan Guang-Ming Huang Xiang-Ming Sun Zhen Wang Shu-Guang Zou Jun liu Dong Wang Hui-li Kang Ping Yang Hua Pei Da-Ming Sun zi-li li PLAC Key Laboratory of Quark & Lepton Physics (MOE)Department of Physics Science and Technology Central China Normal University Wuhan 430079 Hubei China

Real-time monitoring of the Bragg peak location of carbon ions is urgently required for the quality control of hadron therapy. In this study, we design an annular detector to monitor the Bragg peak location of carbon ions with Geant4 simulation. This 360° surrounding structure has a high detection efficiency for the small-dose situation. The detector consists of a multilayered collimator system and an Na I scintillator for prompt gamma counting. The multilayered collimator includes a lead layer to prevent unwanted gammas and the paraffin and boron carbide layers to moderate and capture fast neutrons. An inclination of the detector further diminishes the background signal caused by neutrons. The detector, with optimized parameters, is applicable to carbon ions of different energies. In addition, the scintillator is replaced by an improved EJ301 organic liquid scintillator to discriminate gammas and neutrons. Inserting thin Fe slices into the liquid scintillator improves the energy deposition efficiency. The Bragg peak location of 200 Me V/u carbon ions can be monitored by prompt gamma detection with the improved liquid scintillator.

关键词： Braggpeak Carbonion Promptc-ray Geant4

Electronics system for the cosmic X-ray polarization detector

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Nuclear Science and Techniques 2023年第5期34卷 1-12页

作者： Hui Wang Dong Wang Ran Chen Yan-Wei Kui Hong-Bang liu Zong-Wang Fan Huan-Bo Feng Jin li Jun liu Qian liu Shi Chen Yuan-Kang Yang Zhuo Zhou zi-li li Shi-Qiang Zhou Ni Fang PLAC Key Laboratory of Quark&Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China School of Science Huzhou UniversityHuzhou 313000China

This study presents an electronics system for cosmic X-ray polarization detection(CXPD).The CXPD was designed as a high-sensitivity soft X-ray polarimeter with a measurement energy range of 2-10 keV carried by a CubeSat.A stable and functionally complete electronics system under power and space constraints is a key *** complete CXPD electronics system(CXPDES)comprises hardware and *** adopts a three-layer electronic board structure based on functionality and available *** gas pixel detectors(GPDs)were placed on the top layer board,and CXPDES provided the GPDs with voltages up to-4000 *** GPD signal was digitized,compressed,encoded,and stored before being transmitted to the *** CXPDES provided stable and high-speed communication based on a scheme that separated command and data transmission,and it supports the CXPDES in-orbit *** addition,environmental monitors,silicon photomultiplier(SiPM)triggers,power management,GPDs configuration,and mode switches were included in the overall operating logic of the *** results obtained by testing the CXPDES showed that it satisfied all the requirements of *** CXPDES provides design experience and technological readiness for future large-area X-ray polarimetry missions.

关键词： X-ray polarimeter Electronics CubeSat Gas pixel detector FPGA

Novel Zn(Ⅱ) ladder-like coordination polymer constructed from designed ferrocenyl ligand

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Chinese Chemical Letters 2008年第12期19卷 1499-1503页

作者： Hai Fang Zhang zi Feng li Gang li li Peng Wang Jia Bin li Guang Jian Mei Department of Chemistry Zhengzhou University Zhengzhou 450052 China

Reaction of Zn（NO3）2·6H2O with 3-（4-carboxylphenylamino）-l-ferrocenyl-2-butylen-l-one （HL） and 4,4′-bipyfidine （4,4′- bipy） in methanol solution resulted in a novel ladder-like coordination polymer {[Zn2L2（μ2-L）2（4,4′-bipy）2]·MeOH}n （1）. Its crystal structure, thermal and electrochemical properties are presented.

关键词： zinc(Ⅱ) Structure Coordination polymer Designed ferrocenyl ligand Thermal and electrochemical properties

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基于6自由度坐标模型的虚拟智能实体初探

系统仿真学报 2006年第z1期18卷 161-163页

作者：李晖李自力华中科技大学电子与信息工程系武汉430074

虚拟现实技术越来越广泛的研究和应用,参与者希望进行更加智能化的人机交互,这对研究者提出了更高的要求。本文提出了一种基于6自由度坐标模型的虚拟智能实体,利用有限状态机来实现智能判断,以此来增加整个虚拟现实系统的人-机交互智能... 详细信息

虚拟现实技术越来越广泛的研究和应用,参与者希望进行更加智能化的人机交互,这对研究者提出了更高的要求。本文提出了一种基于6自由度坐标模型的虚拟智能实体,利用有限状态机来实现智能判断,以此来增加整个虚拟现实系统的人-机交互智能特性。

关键词：虚拟现实技术 6自由度坐标模型虚拟智能实体有限状态机