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Molecular Plant 2012年第1期5卷 270-280页

作者： zi-yu li Bin li Ai-Wu Dong State Key Laboratory of Genetic Engineering Institute of Plant BiologyDepartment of BiochemistrySchool of Life SciencesFudan UniversityShanghai200433China

Plant cells frequently undergo endoreduplication, a modified cell cycle in which genome is repeatedly rep- licated without cytokinesis. As the key step to achieve final size and function for cells, endoreduplication is prevalent during plant development. However, mechanisms to control the balance between endoreduplication and mitotic cell di- vision are still poorly understood. Here, we show that the Arabidopsis TCP （CINCINNATA-like TEOSINTE BRANCHED1~ CYCLOIDEA-_PCF）-family transcription factor gene AtTCP15 is expressed in trichomes, as well as in rapidly dividing and vascular tissues. Expression of AtTCP15SRDX, AtTCP15 fused with a SRDX repressor domain, induces extra endoredupli- cation in trichomes and cotyledon cells in transgenic Arabidopsis. On the contrary, overexpression of AtTCP15 suppresses endoreduplication in trichomes and other examined cells. Misregulation of AtTCP15 affects the expression of several im- portant genes involved in cell-cycle regulation. AtTCP15 protein binds directly to the promoter regions of CYCA2;3 and RETINOBLASTOMA-RELATED （RBR） genes, which play key roles in endoreduplication. Taken together, AtTCP15 plays an important role in regulating endoreduplication during Arabidopsis development.

关键词： Arabidopsis TCP transcription factor endoreduplication cell cycle gene expression.

Neoadjuvant chemoradiotherapy followed by laparoscopic distal gastrectomy in advanced gastric cancer: A case report and review of literature

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World Journal of Clinical Cases 2021年第11期9卷 2542-2554页

作者： zi-Ning liu Yin-Kui Wang zi-yu li Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

BACKGROUND The laparoscopic technique has been widely applied for early gastric cancer,with the advantages of minimal invasion and quick ***,there is no report about the safety and oncological outcome of laparoscopic gastrectomy with D2 lymph node dissection for patients after neoadjuvant *** SUMMARY A 60-year-old man was diagnosed with advanced distal gastric cancer,cT4aN1M0 stage *** neoadjuvant chemoradiotherapy was performed based on the regimen of gross tumor volume 50G y/25 f and clinical target volume 45 Gy/25 f,as well as concurrent S-160 mg *** laparoscopic distal gastrectomy with D2 lymph node dissection was undertaken successfully for him after achieving partial response evaluated by radiological *** patient recovered smoothly without moderate or severe postoperative *** postoperative pathological stage was ypT3N0M0 with American Joint Committee on Cancer tumor regression grade *** was still in good condition after 5 years of *** Neoadjuvant chemoradiotherapy followed by laparoscopic technique could be applicable and may achieve satisfactory oncological *** finding requires further validation by cohort studies.

关键词： Gastric cancer Neoadjuvant chemoradiotherapy Laparoscopic Distal gastrectomy S-1 Case report

The Synthesis and Characterization of High Molecular Weight Poly(phenylene sulfide/ether)

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Chinese Chemical Letters 2006年第10期17卷 1373-1376页

作者： Ai Qun GU Mei Ju XIE zi li yu Institute of Materials Science ＆ Technology Analytical ＆ Testing Center Sichuan University Chengdu 610064

Poly（phenylene sulfide/ether）（PPSE） was synthesized from 4,4＇-dihydroxydiphenyl sulfide and 4,4＇-dichlorodiphenyl sulfide in solution by nucleophilic substitution reaction. The resulting polymer was characterized by viscosity measurement, elemental analysis, FT-IR, ^1H NMR, X-ray diffraction and thermal analysis. The results showed that the viscosities of the resulting polymer were above 0.68 dL/g, and the linear chain structure of product was confirmed. PPSE had the same reflex indices as poly（p-phenylene sulfide）, an orthorhombic crystalline with unit cell a=0.853, b=0.562, c=1.026nm. The melting temperature, glass transition temperature and initial decomposition temperature were found to be 228℃, 85℃ and 325℃, respectively. The product was soluble in common organic solvents such as NMP, N, N＇-dimethylformamide, N, N＇-dimethylacetamide and 1,2-dichloroethane.

关键词： Poly(phenylene sulfide/ether) (PPSE) synthesis characterization.

Extracellular vesicles in anti-tumor drug resistance: Mechanisms and therapeutic prospects

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Journal of Pharmaceutical Analysis 2024年第7期14卷 940-954页

作者： Hao-Yang Cheng Guang-liang Su yu-Xuan Wu Gang Chen zi-li yu State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhan430079China Department of Oral and Maxillofacial Surgery School and Hospital of StomatologyWuhan UniversityWuhan430079China TaiKang Center for life and Medical Sciences Wuhan UniversityWuhan430071China Frontier Science Center for Immunology and Metabolism Wuhan UniversityWuhan430071China

Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor *** research has illuminated reasons behind drug resistance,including increased drug efflux,alterations in drug targets,and abnormal activation of oncogenic ***,there's a need for deeper investigation into the impact of drug-resistant cells on parental tumor cells and intricate crosstalk between tumor cells and the malignant tumor microenvironment(TME).Recent studies on extracellular vesicles(EVs)have provided valuable *** are membrane-bound particles secreted by all cells,mediating cell-to-cell *** contain functional cargoes like DNA,RNA,lipids,proteins,and metabolites from mother cells,delivered to other ***,EVs are increasingly recognized as regulators in the resistance to anti-cancer *** review aims to summarize the mechanisms of EV-mediated anti-tumor drug resistance,covering therapeutic approaches like chemo-therapy,targeted therapy,immunotherapy and even *** Ev-based biomarkers to predict drug resistance assists in bypassing anti-tumor drug ***,targeted inhibition of EV biogenesis and secretion emerges as a promising approach to counter drug *** highlight the importance of conducting in-depth mechanistic research on EVs,their cargoes,and functional ap-proaches specifically focusing on EV *** efforts will significantly advance the devel-opment of strategies to overcome drug resistance in anti-tumor therapy.

关键词： Extracellular vesicle Anti-Tumor therapy Drug resistance Mechanisms Prospects

Complex proximal femoral fracture in a young patient followed up for 3 years: A case report

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World Journal of Clinical Cases 2022年第1期10卷 283-288页

作者： zi-yu li Wen-Dan Cheng Lei Qi Shui-Sheng yu Jue-Hua Jing Department of Orthopaedics The Second Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Department of Orthopaedics The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina

BACKGROUND Ipsilateral femoral neck and intertrochanteric fractures in young patients are extremely rare,and there is no reference for fracture classification and treatment *** SUMMARY We report a 27-year-old male patient who sustained ipsilateral femoral neck and intertrochanteric fractures and was treated with a proximal femoral locking compression plate(PFLCP).The literature on these fractures was also *** the last follow-up three years after surgery,the patient had no obvious pain in the hip,and the range of motion in the hip joint was slightly limited,but met the normal life and work *** were no complications such as necrosis of the femoral *** The PFLCP can be used to treat these complex proximal femoral fractures,and selection should be based on the patient's specific fractures.

关键词： Young patients Complex proximal femoral fracture Reduction Locking compression plate Case report

Comparison of tumor regression grading systems for locally advanced gastric adenocarcinoma after neoadjuvant chemotherapy

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2161-2179页

作者： zi-Ning liu Yin-Kui Wang li Zhang Yong-Ning Jia Shan Fei Xiang-Ji Ying Yan Zhang Shuang-Xi li yu Sun zi-yu li Jia-Fu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterPeking University Cancer Hospital and InstituteBeijing 100142China Department of Pathology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Current tumor regression grade(TRG)evaluations are based on various systems which brings confusion for oncologists and pathologists when interpreting *** recent six-tier system(JGCA2017-TRG)recommended by the Japanese Gastric Cancer Association(JGCA)is worth investigating,as four-tier TRG systems are favored in various parts of the *** To compare the predictive accuracies of five published TRG *** Data were retrospectively collected from patients with locally advanced gastric cancer(LAGC)who underwent neoadjuvant chemotherapy followed by D2 Lymphadenectomy between January 2005 and January 2014 at our *** were overall survival(OS)and disease-free survival(DFS),which were evaluated separately using the following TRG systems:JGCA2017,JGCA,Becker,AJCC/CAP,and *** All five published TRG systems were independent predictors for OS and *** indices of the JGCA2017,JGCA,Becker,AJCC/CAP-TRG,and Mandard systems were 0.651/0.6480.652/0.649,0.693/0.695,0.688/0.685,and 0.674/0.675 for OS and DFS,*** four-tier Becker system showed the highest c-index,which was significantly greater than that of the six-tier JGCA2017 and five-tier JGCA systems(P<0.05 in OS and DFS).When residual tumor percentages were reset as:“no residual tumor”,<10%,<100%,and“no response”,the rearranged cutoff values achieved a maximum c-index with 0.728 for OS and 0.737 for DFS,which was superior to the other five *** The newly introduced six-tier JGCA-TRG system cannot increase prognostic *** four-tier Becker system is more suitable for LAGC patients.A population-based study is warranted to define the optimal criterion for TRG in LAGC patients.

关键词： Gastric cancer Neoadjuvant chemotherapy Tumor regression grade Survival Concordance index

Feasibility of differentiating T3 from T4a gastric cancer in different Lauren classification by determining serosa invasion：Diagnostic performance of high enhanced serosa sign

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Chinese Journal of Cancer Research 2018年第2期30卷 263-271页

作者： Rui-Jia Sun Lei Tang Ying Chen Xiao-Ting li yu Sun zi-yu li Ying-Shi Sun Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Radiology Beijing 100142 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Departrnent of Pathology Beijing 100142 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Beijing 100142 China

Objective： To study the value of high enhanced serosa sign on contrast-enhanced computed tomography（CT）in differentiating T3 from T4a gastric cancer in different Lauren ***： This study included 276 consecutive patients with surgically confirmed p T3 or p T4a gastric *** pre-operative CT images were reviewed by two radiologists blinded. The demonstration of the high enhanced serosa on CT between T3 and T4a was compared with chi-square test. The diagnostic performance of this sign on CT in the differentiation of T4a from T3 in different Lauren classification was ***： The accuracy, sensitivity, specificity, positive predictive value（PPV） and negative predictive value（NPV） for the judgement of serosa invasion using the high enhanced serosa sign on CT was 74.6%, 63.7%, 83.6%,76.0% and 73.8% by one radiologist and 76.4%, 66.1%, 84.9%, 78.1% and 75.4% by the other *** to the intestinal-type, the sensitivity of the judgement of serosa invasion using the high enhanced serosa sign on CT in diffuse-type was significant higher（80% in both readers）, while the specificity trended to be lower（65.9% and 80.5%, respectively）. There is no significant difference in the accuracy of diagnosis between intestinaltype and diffuse-type of gastric cancers（the P-values of two radiologists were 0.968, 0.591, respectively）. The combination of the high enhanced serosa sign with conventional CT signs is significant different in diagnosis of T3 and T4a（P〈0.001）. The diagnostic accuracy was increased in both radiologists after the combination. The two readers achieved substantial agreement, with Kappa coefficient of 0.63, P〈***： The high enhanced serosa sign on CT is associated with serosa involvement. The sensitivity of the judgement of serosa invasion using this sign on CT in diffuse-type was significant higher than that in intestinal-type.

关键词： Computed tomography gastric cancer staging serosa invasion imaging

Imatinib mesylate in clinically suspected gastric stromal tumors

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Chinese Journal of Cancer Research 2013年第5期25卷 600-602页

作者： zi-yu li Lei Tang Shuang-Xi li Fei Shan Zhao-De Bu Jia-Fu Ji Department of Gastrointestinal Surgery Beijing Cancer Hospital and InstitutePeking University School of OncologyKey laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Beijing Cancer Hospital and InstitutePeking University School of OncologyKey laboratory of Carcinogenesis and Translational Research (Ministry of Education)

Gastrointestinal stromal tumors （GISTs） occur most frequently in the *** of gastric GIST is not always clear before *** endoscopy may suggest the nature of the lesion （a bulky tumor with preserved mucosa）; however,biopsy is rarely ***,diagnostic medication with safe drugs may provide a feasible way under such conditions after an informed consent is *** on the excellent efficacy of imatinib mesylate （IM） in the treatment of GIST,we successfully applied it in the diagnostic medication of two patients with clinically suspected gastric stromal *** conclusion,the diagnostic medication with IM can be an alternative option for patients with suspected GIST that can not be confirmed pathologically.

关键词： Gastrointestinal stromal tumors (GISTs) imatinib mesylate (IM) magnetic resonance imaging (MRI)

Effect of acacetin on inhibition of apoptosis in Helicobacter pyloriinfected gastric epithelial cell line

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3624-3634页

作者： Qi-Xi Yao zi-yu li Hou-Le Kang Xin He Min Kang Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Orthopaedics The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Emergency Luzhou People’s HospitalLuzhou 646000Sichuan ProvinceChina

BACKGROUND Helicobacter pylori(***)infection can cause extensive apoptosis of gastric epithelial cells,serving as a critical catalyst in the progression from chronic gastritis,gastrointestinal metaplasia,and atypical gastric hyperplasia to gastric *** eradication of *** is paramount for ameliorating the pathophysiological conditions associated with chronic inflammation of the gastric mucosa and the primary prevention of gastric ***,which has multifaceted pharmacological activities such as anti-cancer,anti-inflammatory,and antioxidative properties,has been extensively investigated across various ***,the impact and underlying mechanisms of action of acacetin on ***-infected gastric mucosal epithelial cells remain *** To explore the defensive effects of acacetin on apoptosis in ***-infected GES-1 cells and to investigate the underlying *** GES-1 cells were treated with *** and acacetin in *** viability was assessed using the CCK-8 assay,cell mortality rate via lactate dehydrogenase assay,alterations in cell migration and healing capacities through the wound healing assay,rates of apoptosis via flow cytometry and TUNEL staining,and expression levels of apoptosis-associated proteins through western blot *** *** infection led to decreased GES-1 cell viability,increased cell mortality,suppressed cell migration,increased rate of apoptosis,increased expressions of Bax and cle-caspase3,and decreased Bcl-2 ***,acacetin treatment enhanced cell viability,mitigated apoptosis induced by *** infection,and modulated the expression of apoptosis-regulatory proteins by upregulating Bcl-2 and downregulating Bax and cleaved *** Acacetin significantly improved GES-1 cell viability and inhibited apoptosis in ***-infected GES-1 cells,thereby exerting a protective effect on gastric mucosal epithelial cells.

关键词： Gastric epithelial GES-1 cells Helicobacter pylori Infection Acacetin Antibiotic resistance Apoptosis

M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury

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Neural Regeneration Research 2022年第5期17卷 1072-1079页

作者： Shui-Sheng yu zi-yu li Xin-Zhong Xu Fei Yao Yang Luo Yan-Chang liu li Cheng Mei-Ge Zheng Jue-Hua Jing Department of Orthopedics The Second Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

After spinal cord injury(SCI),astrocytes gradually migrate to and surround the lesion,depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar,which limits the spread of inflammation but hinders axon ***,microglia gradually accumulate at the lesion border to form microglial scar and can polarize to generate a pro-inflammatory M1 phenotype or an anti-inflammatory M2 ***,the effect of microglia polarization on astrocytes is ***,we found that both microglia(CX3 CR1^(+))and astrocytes(GFAP^(+))gathered at the lesion border at 14 days post-injury(dpi).The microglia accumulated along the inner border of and in direct contact with the astrocytes.M1-type microglia(i NOS^(+)CX3 CR1^(+))were primarily observed at 3 and 7 dpi,while M2-type microglia(Arg1^(+)CX3 CR1^(+))were present at larger numbers at 7 and 14 *** growth factor-β1(TGFβ1)was highly expressed in M1 microglia in vitro,consistent with strong expression of TGFβ1 by microglia in vivo at 3 and 7 dpi,when they primarily exhibited an M1 ***,conditioned media from M1-type microglia induced astrocytes to secrete chondroitin sulfate proteoglycan in *** effect was eliminated by knocking down sex-determining region Y-box 9(SOX9)in astrocytes and could not be reversed by treatment with TGFβ*** together,our results suggest that microglia undergo M1 polarization and express high levels of TGFβ1 at 3 and 7 dpi,and that M1-type microglia induce astrocytes to deposit chondroitin sulfate proteoglycan via the TGFβ1/SOX9 *** study was approved by the Institutional Animal Care and Use Committee of Anhui Medical University,China(approval ***20160052)on March 1,2016.

关键词： astrocytes astrocytic scar chondroitin sulfate proteoglycan M1/M2 polarization microglia sex-determining region Y-box 9 spinal cord injury transforming growth factor-β1