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A V-Folded Digital Laser for On-Demand Vortex Beams by Astigmatic Transformation of Hermite–Gaussian Modes

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Chinese Physics Letters 2019年第12期36卷 32-35页

作者： Sen-Sen Liu Xu-Dong chen Ji-Xiong Pu Zhi-Li Lin zi-yang chen Fujian Key Laboratory of Light Propagation and Transformation College of Information Science and EngineeringHuaqiao UniversityXiamen 361021

A V-folded digital laser using a spatial light modulator(SLM)for intra-cavity loss shaping is exploited to generate Hermite-Gaussian modes with on-demand mode *** aπ/2 astigmatic mode converter,vortex beams carrying on-demand orbital angular momentum(OAM)with a tunable range from-11h to 12 h are *** mode order of the HG mode,hence the OAM of the vortex beam,is digitally switched by changing the phase pattern imposed on the SLM without requiring any mechanic alignment of the *** work has great potential applications in various OAM-tunable vortex beams.

关键词： tunable modulator switched

Vanadium nitride nanoparticles embedded in carbon matrix with pseudocapacitive behavior for high performance lithium-ion capacitors

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Rare Metals 2022年第7期41卷 2460-2469页

作者： Jin-Hui Zhang zi-yang chen Tie-Zhu Xu Liu-Feng Ai Ying-Hong Xu Xiao-Gang Zhang Lai-Fa Shen Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies College of Material Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016China

Lithium-ion capacitors(LICs)have attracted wide attention due to their potential of achieving merits of high-power output as well as high energy ***-ever,the key issue of kinetics mismatch between anode and cathode hinders the electrochemical performance of ***,a vanadium nitride composite with nanoparti-cles embedded in carbon matrix(VN-C)was prepared as an efficiently pseudocapacitive anode material with high electronic conductivity and fast Li-ion diffusion *** VN-C composites were synthesized through one-step ammonia heating treatment at different temperatures among which the sample annealed at 600℃exhibits high specific capacity(513 mAh·g^(-1)at 0.1 A·g^(-1)),outstanding rate performance(~300 mAh·g^(-1)at 10 A·g^(-1)),and excellent cyclic steadiness(negligible capacity decay over 2000 cycles)in half-cell devices.A high-performance lithium-ion capacitor device was also fabricated by using VN-C-600 as the anode and activated carbon as the cath-ode,delivering a maximum energy density of 112.6 Wh·kg^(-1)and an extreme power density of 10 kW·kg^(-1).

关键词： Vanadium nitride Carbon matrix Pseudocapacitive behavior Lithium-ion capacitor

Application of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging in recurrent anastomotic tumors after surgery in digestive tract tumors

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2474-2483页

作者： Deng-Feng Ge Hao Ren zi-chen yang Shou-Xiang Zhao Zhen-Ting cheng Da-Da Wu Bin Zhang Department of Cardiothoracic Surgery Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Gastrointestinal Surgery Shanghai Sixth People’s HospitalShanghai 250063China

BACKGROUND This study was to investigate the application value of whole-body dynamic ^(18)F-fluorodeoxyglucose(FDG)positron emission tomography/computed tomogra-phy(PET/CT)imaging in recurrent anastomotic tumors of digestive tract after gastric and esophageal cancer *** patients with gastric and esophageal cancer have a high risk of tumor recurrence,and traditional imaging methods have certain limitations in early detection of recurrent ***-body dynamic ^(18)F-FDG PET/CT imaging,due to its high sensitivity and specifi-city,can provide comprehensive information on tumor metabolic activity,which is expected to improve the early diagnosis rate of postoperative recurrent tumors,and provide an important reference for clinical treatment *** A retrospective analysis was performed on 53 patients with upper digestive tract tumors after operation and systemic dynamic ^(18)F-FDG PET/CT imaging indi-cating abnormal FDG uptake by anastomosis,including 29 cases of gastric cancer and 24 cases of esophageal *** to the follow-up results of gas-troscopy and other imaging examinations before and after PET/CT examination,the patients were divided into an anastomotic recurrence group and anastomotic inflammation *** multi-parameter analysis software was used to obtain the metabolic rate(MRFDG),volume of distribution maximum(DVmax)of anastomotic lesions,and MRmean and DVmean of normal liver *** lesion/background ratio(LBR)was calculated by dividing the MRFDG and DVmax of the anastomotic lesion by the MRmean and DVmean of the normal liver tissue,respectively,to obtain LBR-MRFDG and *** independent sample t test was used for statistical analysis,and a receiver operating characteristic curve was used to analyze the differential diagnostic efficacy of each parameter for anastomotic recurrence and *** The dynamic ^(18)F-FDG PET/CT imaging parameters MRFDG,DVmax,LBR-MRFDG,and LBR-DVmax of post

关键词： Gastric cancer Esophageal cancer Anastomosis Dynamic positron emission tomography Differential diagnosis Metabolic rate

Effects of Dendrobium candidum polysaccharides on microRNA-125b and mitogen-activated protein kinase signaling pathways in diabetic cataract rats

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Traditional Medicine Research 2021年第5期6卷 43-48页

作者： zi-yang chen Qian Lan Sheng chen Yan-Hong Hu Fa-Jie Ke Jun Hu Chun-Yan Feng Ming-Xin Qi Xiu-Rong Huang Comprehensive Clinic of Fujian Academy of Chinese Medicine Fuzhou 350003China Fujian University of Traditional Chinese Medicine Fuzhou 350122China Department of Opthalmology The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityFuzhou 350003China

Background:Diabetic cataract is a common complication and a lens disorder in ***,Dendrobium officinale polysaccharide(DOP)is found to alleviate diabetes ***,microRNA-125b and mitogen-activated protein kinase signaling pathways play significant roles in ***,the mechanism and the effect of DOP on diabetic cataract remains ***:Wistar male rats were randomly assigned to the control,model,and DOP *** was induced with ***,DOP was orally given for 12 *** Lens Opacities Classification System III was used to evaluate lens opacity by slit-lamp *** lens was then harvested for testing the mRNA expression of microRNA-125b,ERK1,ERK2,Raf and Ras using reverse transcription-polymerase chain *** protein expression of ERK1,ERK2,Raf,and Ras was detected using the Western blot *** targets of microRNA-125b were predicted in miRWalk *** targets were obtained from the Kyoto Encyclopedia of Genes and Genomes ***:The lens opacities of the rats in the control group were almost at ***,the majority of the lens opacities in the model group were C3 to C4 and N1 to N2,and were mostly at C1 to C2 and N0 to N1 in the DOP *** difference was statistically significant(P<0.05).Furthermore,the microRNA-125b expression in the model group is significantly higher compared with the control ***,the microRNA-125b expression in the DOP group is significantly decreased(all P<0.05).The mRNA expression of ERK1,ERK2,Raf,and Ras in the model groups were upregulated compared with those of the control ***,the ERK1 and Raf mRNA expressions of the DOP group were lower compared with the model group(all P<0.05).The protein expression of ERK1,Raf,and Ras in the model group was significantly increased compared with those of the control *** protein expression of ERK1,Raf,and Ras in the DOP group was significantly lower compared with

关键词： Dendrobium officinale polysaccharide microRNA-125b mitogen-activated protein kinase diabetic cataract

Analysis of the action mechanism of Si-Jun-zi decoction in cataract by network pharmacology

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Medical Data Mining 2020年第4期3卷 177-184页

作者： zi-yang chen Zhao-Da Ye Li-Jin You Yan-Hong Hu Comprehensive Clinic of Fujian Academy of Traditional Chinese Medicine Fujian 350001China Fujian University of Traditional Chinese Medicine Fujian 350122China Second People’s Hospital of Fujian University of Traditional Chinese Medicine Fujian 350001China

Background:To explore the action mechanism of the classic ancient prescription Si-Jun-zi decoction in slowing down cataract process by network ***:In Traditional Chinese Medicines for Systems Pharmacology Database and Analysis Platform Database,screening the chemical components and functional targets of the classic ancient prescription Si-Jun-zi decoction,and the targets of cataract disease were obtainded through GeneCards and the Online Mendelian Inheritance in Man *** the STRING database,the protein-protein interaction network was *** network visualization were created in *** genetic ontology and Kyoto Gene and Genome Encyclopedia pathways of key proteins were enriched via the DAVID data ***:Ninety-six active components and 33 key targets were obtained in this *** protein-protein interaction network consisted of 33 *** were 33 genetic ontology entries and 72 Kyoto Gene and Genome Encyclopedia pathway enrichment ***:This work provided a new means to understand the pathogenesis of cataract and revealed the action mechanisms of the classic ancient prescription Si-Jun-zi decoction.

关键词： Network pharmacology Cataract Si-Jun-zi decoction Action target Genetic ontoloy

Mechanism of Liangxue Huayu decoction in treatment of age-related macular degeneration based on network pharmacology and clinical validation

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Drug Combination Therapy 2022年第3期4卷 1-7页

作者： zi-yang chen Ying-Ying Lin Yi-Huang Zheng Fa-Jie Ke Sheng chen Yan-Hong Hu Eye Hospital of Chinese Academy of Traditional Chinese Medicine Beijing 100040China The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine Fujian 350001China

Background:This paper investigates the mechanism of Liangxue Huayu decoction treating age-related macular degeneration through network pharmacology and clinical ***:The potential targets of Liangxue Huayu decoction were retrieved by the BATMAN-TCM database,and age-related macular degeneration-related disease targets were collected using the OMIM,GeneCards,and CTD *** intersection of targets for Liangxue Huayu decoction for age-related macular degeneration was performed using the online tool ***-protein interaction network was drawn using the String *** core targets were obtained with the CytoNCA *** gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed using the Metascape ***,targets of Liangxue Huayu decoction for age-related macular degeneration were identified in clinical ***:In this study,832 potential action targets and 9,475 age-related macular degeneration-related disease targets were screened,and 575 intersection targets of Liangxue Huayu decoction and age-related macular degeneration were ***-protein interaction network analysis showed that 15 core targets include chemokine 8,interleukin 1,histone deacetylase 2,estrogen receptor 2,and glutamate ionotropic receptor NMDA type subunit 1,et *** ontology enrichment analysis included 2,727 biological processes,434 molecular functions,and 206 cellular *** Encyclopedia of Genes and Genomes enrichment analysis selected 107 signaling *** validation showed that peripheral blood chemokine 8 and interleukin 1 levels were significantly lower after age-related macular degeneration patients compared with before treatment,and the difference was statistically significant(t chemokine 8=12.684,t interleukin 1=11.405,all P<0.001).Conclusion:By treating age-related macular degeneration with multiple targets and multiple pathways,Liangxue Huayu decoction can down-re

关键词： Liangxue Huayu decoction age-related macular degeneration network pharmacology interleukin-1β chemokines 8

Real-World Study on the Treatment of Macular Edema in Central Retinal Vein Occlusion Using Traditional Chinese Medicine(TCM)and Its Medication Guidelines

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Drug Combination Therapy 2023年第3期5卷 14-20页

作者： zi-yang chen Hang Yuan Xiao-Yan Zhang Li-Ke Xie Xiao-Feng Hao Department of Cataract and Ocular Diseases Ophthalmology Hospital of Chinese Academy of Traditional Chinese MedicineBeijing 100040China

Object:The aim is to evaluate how effective Traditional Chinese Medicine(TCM)is in treating patients who have central retinal vein occlusion with macular edema(CRVO-ME)in a real-world ***,the objective of the research was to examine the TCM prescription trends in the management of ***:A single-center real-world study(RWS)was carried out over a span of 19 years,following the established *** study encompassed 113 patients diagnosed with *** of these,74 patients received TCM treatment,while the remaining individuals underwent a combined therapy involving TCM and anti-VEGF drugs through intravitreal *** patients were matched using propensity score matching(PSM).The result measured in the RWS was *** oral prescriptions for CRVO-ME that led to observable and effective outcomes were *** and the TCM Inheritance Auxiliary Platform V2.5 were utilized to optimize mutual information,hierarchical clustering based on entropy,and other techniques to extract medication regulations and ***:After applying PSM,each group comprised 29 *** groups exhibited improved BCVA following treatment;however,there was no statistically significant distinction in BCVA or effectiveness between the two groups(all P>0.05).Apart from the analysis of oral prescriptions for CRVO-ME,the investigation pinpointed the most frequently used TCMs,namely Flos Carthami,Semen Persicae,Radix Angelica sinensis,Radix Rehmanniae,and Radix et Rhizoma *** utilized medications tended to possess cold,warm,or mild attributes and exhibited a taste profile that was either bitter or *** primary meridians associated with the medicines employed in treating CRVO-ME were liver,spleen,stomach,heart,and *** the application of association rule analysis,it was discerned that there were 195 commonly employed combinations of ***,a complex system entropy cluster analysis unveiled 13 key combinations o

关键词： Traditional Chinese Medicine central vein occlusion macular edema vascular endothelial growth factor real-world study

Protective effect of Liangxue Huayu decoction on human retinal pigment epithelial cell(ARPE-19)injury induced by hypoxia through autophagy pathway

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Pharmacology Discovery 2024年第1期4卷 44-50页

作者： Han-Ran Zheng Yi-Tong Lin Sheng chen zi-yang chen Jun-Chang Cao Zhao-Da Ye Yan-Hong Hu College of graduate Fujian University of Traditional Chinese MedicineFujian 350122China Department of Ophthalmology The Second People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFujian 350003China Comprehensive Outpatient Department Fujian Academy of Traditional Chinese Medicine SciencesFujian 350003China

Background:Exploring the protective mechanism of the Liangxue Huayu(LXHY)decoction on human retinal pigment epithelial(RPE)cells induced by hypoxia through the autophagy ***:The appropriate LXHY decoction concentration was determined by ***-19 cells were divided into the normal control group(A group),CoCl_(2)group(B group),3-Methyladenine(3-MA)group(treated with 3-MA(the inhibition of autophagy pathway))(C group),blank serum(BS)group(D group),LXHY drug-contained serum(DCS)group(E group),and Rapamycin(RAP)group[treated with LXHY drug-contained serum combined with rapamycin group(the activation of autophagy pathway)](F group).Counting the number of autophagosomes and autolysosomes in each group of cells under transmission electron *** infection of cells in each group by mRFP-GFP-LC3 fusion protein adenovirus,the strength of autophagic flux was *** mRNA expression levels of LC3 and Beclin-1 were detected by ***:CCK-8 assay results showed that LXHY DCS could inhibit the cell proliferation of ARPE-19 under hypoxia(all P<0.05).As the transmission electron microscopy assay result showed,compared with the normal control group,the number of autolysosomes was significantly increased in the CoCl_(2)group(P<0.05).Compared with CoCl_(2)group,the number of autolysosomes was significantly reduced the 3-Methyladenine group,blank serum group and LXHY drug-contained serum group(all P<0.001).As autophagic flux assay result showed,compared with the normal control group,the level of autophagosomes and autolysosomes were significantly risen in CoCl_(2)group(all P<0.001).Compared with the CoCl_(2)group,the level of autophagosomes and autolysosomes were significantly fell down in 3-Methyladenine group,blank serum group and LXHY drug-contained serum group(all P<0.05).The level of autolysosomes in the LXHY drug-contained serum group was lower than in the blank serum group(P<0.05).Compared with the LXHY drug-contained serum group,the levels o

关键词： Liangxue Huayu decoction age-related macular degeneration autophagy lysosome autophagosomes

Nomogram for overall survival in ampullary adenocarcinoma using the surveillance,epidemiology,and end results database and external validation

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World Journal of Clinical Oncology 2025年第2期16卷 36-51页

作者： Jia yang zi-Yi Wang Jing chen Yao Zhang Lei chen Department of Gastroenterology The First Affiliated Hospital of Army Medical UniversityChongqing 400038China Department of Epidemiology College of Preventive MedicineArmy Medical UniversityChongqing 400038China

BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal ***,only a few cases have been reported,resulting in limited information on *** To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary *** Data were sourced from the surveillance,epidemiology,and end results stat *** patients in the database were randomized in a 7:3 ratio into training and validation *** Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the *** nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical *** For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the *** area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific *** internal and external validation cohorts indicated good consistency of the *** The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.

关键词： Ampullary adenocarcinoma Dynamic nomogram Gastrointestinal tract Surveillance Epidemiology End results database Survival rate