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First platelet transfusion refractoriness in a patient with acute myelocytic leukemia: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7156-7161页

作者： Sheng-Ke Tu Hong-Jie Fan zi-wei shi Xiao-Lan Li Min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Platelet transfusion is of great significance in the treatment of thrombocytopenia caused by myelosuppression during intensive chemotherapy in patients with acute *** recent years,with platelet transfusion increasing,ineffective platelet transfusion has become increasingly *** speaking,platelet antibodies can be produced after repeated transfusion,thus rendering subsequent platelet transfusion *** report a case of first platelet transfusion refractoriness(PTR)in a patient with acute myelocytic leukemia(AML).Due to the rarity of such cases in clinical practice,there have been no relevant case reports so *** SUMMARY A 51-year-old female patient attended the hospital due to throat pain and abnormal blood cells for 4 *** diagnosis was acute myelocytic leukemia[M2 type Fms related receptor tyrosine kinase 3,Isocitrate Dehydrogenase 1,Nucleophosmin 1,Neuroblastoma RAS viral oncogene homolog(+)high-risk group].She was treated with"IA"(IDA 10 mg day 1-3 and Ara-C 0.2 g day 1-5)*** her condition improved,the patient was discharged from the hospital,instructed to take medicine as prescribed by the doctor after discharge,and returned to the hospital for further chemotherapy on *** We report a rare case of first platelet transfusion failure in a patient with AML during induction chemotherapy,which may be related to the production of platelet antibodies induced by antibiotics and excessive tumor *** also suggests that we should consider the influence of antibiotics when the rare situation of first platelet transfusion failure occurs in patients with *** platelet antibodies are produced,immunoglobulins can be used to block antibodies,thereby reducing platelet *** patients with PTR,both immune and non-immune factors need to be considered and combined in clinical practice along with individualized treatment to effectively solve the problem.

关键词： Acute myelocytic leukemia First platelet transfusion refractoriness Myelosuppression Nonimmune causes Immune-mediated causes Case report

Applying dynamic light scattering to investigate the self-assembly process of DNA nanostructures

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Chinese Chemical Letters 2024年第3期35卷 316-320页

作者： wei Yuan Gui-Zhi Dong Hui Ning Xiang-Xiang Guan Jia-Feng Cheng zi-wei shi Xiu-Ji Du Si-Wen Meng Dong-Sheng Liu Yuan-Chen Dong CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Dandong Bettersize Instruments Ltd. Dandong 118000China Key Laboratory of Organic Optoelectronics&Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Department of Chemistry Renmin University of ChinaBeijing 100872China

Understanding the dynamic assembly process of DNA nanostructures is important for developing novel strategy to design and construct functional *** this work,temperature-controlled dynamic light scattering(DLS)strategy has been applied to study the global assembly process of DNA origami and DNA *** the temperature dependent size and intensity profiles,the self-assembly process of various DNA nanostructures with different morphologies have been well-studied and the temperature transition ranges could be *** advantage of the DLS information,rapid preparation of the DNA origami and the brick assembly has been realized through a constant temperature *** results demonstrate that the DLS-based strategy provides a convenient and robust tool to study the dynamic process of forming hieratical DNA structures,which will benefit understanding the mechanism of self-assembly of DNA nanostructures.

关键词： Dynamic light scattering Self-assembly process DNA nanostructures Temperature transition ranges Rapid preparation

MSP430-based single-phase sine wave inverter

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MSP430-based single-phase sine wave inverter

教育部中南地区高等学校电子电气基础课教学研究会第二十届学术年会

作者： Liu zi-xi,shi wei,Luo Jin-wei (School of Information Engineering,Wuhan University of Technology,Wuhan 430070,China)

This paper describes a MSP430 microcontroller based SPWM inverter *** the boost section and the SPWM inverter section,it can give high-quality AC whose frequency and voltage has been *** design is based on Boost topology principle and uses high-performance voltage PWM control chip TL494 to drive the MOS tube in main ***430 microcontroller is the center of the whole *** cooperates with the 12-bit high-precision D/A module to control the output voltage *** system has a good over-current protection and can detect load conditions *** SCM technology to control this power makes the whole system more simple and achieves digital *** provides a kind of high-quality AC power for equipments with high performance requirements.

关键词： Inverters MSP430 single chip sinusoidal pulse width modulation voltage negative feedback

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多元整合元分析法评介

心理科学进展 2010年第3期18卷 505-510页

作者：叶子菁石伟西南大学文化与社会发展学院重庆400715

在传统元分析中,每个研究只能提取一个效果量,以满足各效果量相互独立的条件。若出现单个研究多效果量的情况,就需要采用多元元分析技术予以处理。多元元分析主要包括多元线性模型法和多元整合法,其中,多元整合法是应用最为广泛的一种方... 详细信息

在传统元分析中,每个研究只能提取一个效果量,以满足各效果量相互独立的条件。若出现单个研究多效果量的情况,就需要采用多元元分析技术予以处理。多元元分析主要包括多元线性模型法和多元整合法,其中,多元整合法是应用最为广泛的一种方法,可较为有效地解决多效果量非独立性问题,还可借助传统元分析的固定效应模型和混合效应模型进行统计分析。但多元整合法在应用中还存在着统计软件的开发问题、同质性Q检验显著性的稳定问题、不同质混合效果量的同质性检验的可行性问题。

关键词：多元整合法多元元分析效果量非独立性混合效果量

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu zi-Ling shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

国产新冠疫苗使用效果评价、面临的挑战与对策建议

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医学新知 2022年第1期32卷 53-57页

作者：石梓薇黄娇魏晟华中科技大学同济医学院公共卫生学院武汉430030 武汉大学中南医院循证与转化医学中心武汉430071

新冠疫情暴发以来,我国新冠疫苗的研发进程在国际上始终处于第一梯队,为世界抗疫提供了有力的支持。当前国产新冠疫苗在临床试验和真实世界的研究中均表现出较好的保护效力和安全性,但由于疫苗保护效力持续时间的不确定性以及多种变异... 详细信息

新冠疫情暴发以来,我国新冠疫苗的研发进程在国际上始终处于第一梯队,为世界抗疫提供了有力的支持。当前国产新冠疫苗在临床试验和真实世界的研究中均表现出较好的保护效力和安全性,但由于疫苗保护效力持续时间的不确定性以及多种变异毒株的出现,国产疫苗仍面临诸多挑战。利用同源疫苗加强免疫可提高疫苗的保护效果,但长期来看应加快研发包含多种变异毒株的多价疫苗以及新冠病毒通用疫苗,同时尽快开展科学规范的新冠疫苗安全性的主动监测,科学评估新冠疫苗的长期安全性。

关键词：新型冠状病毒肺炎国产新冠疫苗效果挑战应对策略

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-wei Li Jian-Hong shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

低能As_2^+注入与快速退火形成n^+—p超浅结的研究

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微电子学与计算机 1989年第10期6卷 7-8页

作者：林成鲁方子韦邹世昌中科院上海冶金所离子束开放研究实验室

本文研究了As_2^+注入硅的辐射损伤及退火行为。以能量为10～30keV、剂量为1×10^(13)～5×10^(15)cm^(-2)的As_2^+注入p型〈100〉硅形成浅掺杂层,用快速退火激活注入杂质并控制其再分布。结果表明,可以获得结深为700～1500 (?)的n^+—... 详细信息

本文研究了As_2^+注入硅的辐射损伤及退火行为。以能量为10～30keV、剂量为1×10^(13)～5×10^(15)cm^(-2)的As_2^+注入p型〈100〉硅形成浅掺杂层,用快速退火激活注入杂质并控制其再分布。结果表明,可以获得结深为700～1500 (?)的n^+—p浅结,相应的薄层电阻值为60Ω/口。

关键词： VLSI As2^+ 退火 n^+-p结

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1