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Reversal of complete atrioventricular block in dialysis patients following parathyroidectomy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1313-1319页

作者： shan-shan Xu li-Hai Hao Yan-Meng Guan Hemodialysis Center Weifang People’s HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic *** calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular *** case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular *** SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus *** developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular ***,she underwent parathyroidectomy(PTX)with ***,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was *** This case revealed that metastatic cardiac calcification can result in complete atrioventricular *** parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular *** is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.

关键词： Secondary hyperparathyroidism Ectopic calcification Atrioventricular block Reversal Case report

Analytical evaluation of steady-state solute distribution in through- diffusion and membrane behavior test under non-perfectly flushing boundary conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 258-267页

作者： Guannian Chen Yuchao li Kristin MSample-Lord shan Tong School of Civil&Environmental Engineering and Geography Science Ningbo UniversityNingbo315211China MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Ningbo ZCONE High-tech Company limited Ningbo315000China Department of Civil and Environmental Engineering Villanova UniversityVillanovaPAUSA

The through-diffusion and membrane behavior testing procedure using a closed-system apparatus has been widely used for concurrent measurement of diffusion and membrane efficiency coefficients of low-permeability clay-based barrier ***,the common assumption of perfectly flushing conditions at the specimen boundaries could induce errors in analyses of the diffusion coefficients and membrane *** this study,an innovative pseudo three-dimensional(3D)analytical method was proposed to evaluate solute distribution along the boundary surfaces of the soil-porous disks system,considering the non-perfectly flushing *** results were consistent with numerical models under two scenarios considering different inflow/outflow *** proposed model has been demonstrated to be an accurate and reliable method to estimate solute distributions along the *** calculated membrane efficiency coefficient and diffusion coefficient based on the proposed analytical method are more accurate,resulting in up to 50%less relative error than the traditional approach that adopts the arithmetic mean value of the influent and effluent *** retar-dation factor of the clay specimen also can be calculated with a revised cumulative mass ***,the simulated transient solute transport matched with experimental data from a multi-stage through-diffusion and membrane behavior test,validating the accuracy of the proposed method.

关键词： Diffusion testing Membrane behavior Coupled transport Clay barrier Transport modeling

Use of curcumin and its nanopreparations in the treatment of inflammatory bowel disease

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World Journal of Gastroenterology 2024年第3期30卷 280-282页

作者： zi-Wen Meng Bing Chang li-Xuan Sang Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Gastroenterology the First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

Inflammatory bowel disease(IBD)is a nonspecific inflammatory disease of the intestine that includes Crohn’s disease and ulcerative *** IBD is difficult to heal and easily relapses,it could worsen patient quality of life and increase economic ***(CUR)is a bioactive component derived from the rhizome of turmeric(Curcuma longa).Many basic and clinical studies have shown that CUR can efficiently treat IBD by decreasing the activity of proinflammatory cytokines by communicating with transcription factors and signaling ***,due to the limitations of being almost insoluble in aqueous solutions and having low oral bioavailability,it is important to select appropriate pharmaceutical preparations.

关键词： Curcumin Inflammatory bowel disease Bioavailability Nanotherapeutics

Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： zi-Bing Qian Jun-Feng li Wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis liver disease

Molecular mechanism for the unusual enhancement of the second-step chemiluminescence production from the carcinogenic tetrabromohydroquinone and H2O_(2)

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Journal of Environmental Sciences 2024年第7期141卷 330-342页

作者： zi-Han Wang Chun-Hua Huang Zhi-Sheng liu li Mao Ben-Zhan Zhu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Environment and Resources University of Chinese Academy of SciencesBeijing 100049China

We have found recently that two-step intrinsic hydroxyl radical(·OH)-dependent chemiluminescence(CL)could be produced by carcinogenic tetrahaloquinone and H_(2)O_(2).However,the first-step CL was too fast to clearly detect the stepwise generation of·OH and CL,and to distinguish the exact dividing point between the first-step and second-step *** we found that,extremely clear two-step intrinsic CL could be produced by the relative slow reaction of tetrabromohydroquinone(TBHQ)with H_(2)O_(2),which was directly dependent on the two-step·OH ***,the second-step,but not the first-step CL production of TBHQ/H_(2)O_(2)(CRET donor)was markedly enhanced by fluorescein(a typical xanthene dye,CRET acceptor)through a unique chemiluminescence resonance energy transfer(CRET)*** novel CRET system of TBHQ/H_(2)O_(2)/fluorescein was successfully applied for the sensitive detection of TBHQ with the detection limit as low as 2.5μmol/*** findings will help to develop more sensitive and highly efficient CL or CRET systems and specific CL sensor to detect the carcinogenic haloquinones,which may have broad environmental applications.

关键词： Two-step chemiluminescence Bromohydroquinone Hydrogen peroxide Hydroxyl radical CRET

Oxidation resistant low-alloyed Ti alloys with good ductility

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Rare Metals 2024年第8期43卷 3921-3936页

作者： Meng li Zhang-Zhi Shi Jun-Yi Xu Fu-Zhi Dai Xiang-Min li zi-lin li Lu-Ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advance Metals and MaterialsSchool of Materials Science and Engineering University of Science and Technology Beijing Institute of Materials Intelligent Technology Liaoning Academy of Materials

Oxidation resistance enhancement of pure Ti often comes at the cost of reduced ductility,which is frequently the problem through alloying with sole Al,Si,W,Mo and *** overcome the short coming of single element alloying,this paper proposes a multi-element low-alloying strategy to take advantage of synergistic effects and resolve the conflict between oxidation resistance and *** demonstrates that the addition of a small quantity of Ta（0.51wt%） can boost both oxidation resistance and ductility in comparison to pure ***,the combined addition of a small amount（0.54 wt%） of Ta,Nb and Si not only preserves good ductility of pure Ti,but also reduces mass gains to 14%-67% of pure Ti during 100 h oxidation at 650-850℃ in *** indicates even better oxidation resistance than that obtained through the use of Ta,Nb,or Nb+Ta *** Ta+Nb+Si alloying creates an oxide layer that is less porous and more resistant to stratification and ***,a 3-μm N-rich layer can form in the Ti substrate beneath the oxide scale,in which phase transformation generates coherent Ti2N with（0001）Tias the habit plane,with N atoms prefers to diffuse along ■ than along [0001]*** completely transformed Ti2N region or partially transformed Ti+Ti2N region can effectively impede oxygen ***,the multielement low-alloying strategy is promising for enhancing both oxidation resistance and mechanical properties of metallic materials in the future.

关键词： Ti alloys Multi-element Co-alloying Oxidation resistance Mechanical properties

Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

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Current Medical Science 2024年第3期44卷 475-484页

作者： Min-shan li Xiang-hong WANG Heng WANG Department of Otolaryngology-Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute of Allergy and Clinical Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Clinical Research Center for Nasal Inflammatory Diseases Wuhan430030China

Proton-activated G protein-coupled receptors(GPCRs),initially discovered by Ludwig in 2003,are widely distributed in various *** receptors have been found to modulate the immune system in several inflammatory diseases,including inflammatory bowel disease,atopic dermatitis,and ***-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular *** detection triggers downstream signaling pathways within the cells,ultimately influencing the function of immune *** this review,we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

关键词： proton-activated G protein-coupled receptors inflammation immunomodulation disease

Unbound^(28)O,the heaviest oxygen isotope observed:a cutting-edge probe for testing nuclear models

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Nuclear Science and Techniques 2024年第2期35卷 1-2页

作者： Jian-Guo li Bai-shan Hu Shuang Zhang Fu-Rong Xu School of Physics and State Key Laboratory of Nuclear Physics and TechnologyPeking UniversityBeijing 100871China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

The beyond-dripline oxygen isotopes^(27,28)O were recently observed at RIKEN,and were found to be unbound decaying into^(24)O by emitting *** unbound feature of the heaviest oxygen isotope,^(28)O,provides an excellent test for stateof-the-art nuclear *** atomic nucleus is a self-organized quantum manybody system comprising specific numbers of protons Z and neutrons N.

关键词： testing quantum system

Anthropogenic influence on the extreme drought in eastern China in 2022 and its future risk

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Atmospheric and Oceanic Science Letters 2024年第1期17卷 21-27页

作者： Yinjun Zhang lin Chen Yuqing li zi-An Ge Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environmental Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science and TechnologyNanjingChina

2022年夏季中国东部地区遭遇了一次持续性极端高温干旱事件.本文利用CMIP6检测归因比较计划(DAMIP)数据,量化了人为强迫对类2022年极端干旱事件发生概率的影响,并基于未来不同增暖情景试验给出了此类极端干旱事件的未来变化预估.通过分... 详细信息

2022年夏季中国东部地区遭遇了一次持续性极端高温干旱事件.本文利用CMIP6检测归因比较计划(DAMIP)数据,量化了人为强迫对类2022年极端干旱事件发生概率的影响,并基于未来不同增暖情景试验给出了此类极端干旱事件的未来变化预估.通过分析不同外强迫因子作用下此类极端干旱事件的发生概率变化,发现人为强迫使此类极端干旱事件的发生概率提高约56%,这主要与人为强迫下中国东部平均水汽减少和平均上升运动减弱有关.进一步通过分析此类极端干旱事件对不同温室气体排放情景(SSP1-2.6,SSP2-4.5,SSP5-8.5)的响应,发现在低排放情景下类2022年极端干旱事件的发生概率较当今气候显著下降,这主要与中国东部平均水汽的增加和平均环流的变化有关,而在高排放情景(SSP5-8.5)下,此类极端干旱事件的发生概率较当今气候增加约79%,这主要与高排放情景下平均下沉运动增强有关.该研究表明,人为强迫通过调制气候平均背景场从而引起极端事件发生频次的变化是人类活动影响极端气候事件的重要途径之一,极端干旱事件对温室气体排放量的响应可能是非线性的.

关键词：极端干旱中国东部归因分析人为强迫未来预估