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Pregnancy outcomes of the first thawing cycle in"freeze-all"strategy of infertility patients with fever during oocyte recruitment:a matched-pair study

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Chinese Medical Journal 2021年第7期134卷 800-805页

作者： Ming-Mei Lin zi-ru niu Hua Zhang Rong Li Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Beijing 100191China Beijing Key Laboratory of Assisted Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Research Center of Clinical Epidemiology Peking University third hospitalBeijing 100191China.

Background:It is currently unknown whether patients with a fever after controlled ovulation during egg retrieval could increase the risk of pelvic infection or not,and fever itself may affect endometrial receptivity or embryo quality with poor pregnancy *** aim of this study was to analyze the outcomes of patients with fever during oocyte retrieval after the first frozen-thawed embryo transfer(FET)***:This was a 1:3 retrospective paired study matched for *** this study,58 infertility patients(Group 1)had a fever during the control ovulation,and the time of the oocyte retrieval was within 72 hours,they underwent ovum pick up and whole embryo freezing("freeze-all"strategy).The control subjects(Group 2)are 174 patients matched for age who underwent whole embryo freezing for other *** baseline characteristics,clinical data of ovarian stimulation,and outcomes,such as the clinical pregnancy rate,ongoing clinical pregnancy rate were compared between the two groups in the subsequent FET ***:All patients had no pelvic inflammatory disease after oocyte ***-Mullerian hormone(AMH)levels(4.2 vs.2.2,P<0.001)were higher in group 2,and the number of oocytes retrieved,and fertilization rate were lower in group 1(P<0.001),but the endometrial thickness,the number of embryo transfers,and the type of luteal support supplementation were similar between the two *** pregnancy outcomes in the subsequent FET cycle,the implantation rate,clinical pregnancy rate,early spontaneous rate,ectopic pregnancy rate,and ongoing pregnancy rate were all not significantly *** regression analyses showed that the clinical pregnancy rate and ongoing pregnancy rate were also not significantly ***:Transvaginal ultrasound-guided follicular puncture for oocyte retrieval is a safe and minimally invasive method for patients with ***,the fever had almost no effect on embryo quality.

关键词： Fever Oocyte retrieval Infertility Pregnancy outcomes

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Chinese Medical Journal 2021年第12期134卷 1405-1415页

作者： rui Yang zi-ru niu Li-Xue Chen Ping Liu Rong Li Jie Qiao Center for Reproductive Medicine Peking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Beijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Background:More and more scholars have called for the cumulative live birth rate(CLBR)of a complete ovarian stimulation cycle as a key indicator for assisted reproductive *** research aims to study the CLBR of the first ovarian hyperstimulation cycles and analyze the related prognosis factors that might affect the ***:Our retrospective study included first in vitro fertilization or intracytoplasmic sperm injection(IVF/ICSI)cycles performed between January 2013 to December 2014.A total of 17,978 couples of first ovarian hyperstimulation IVF/ICSI cycles were *** study was followed up for 4 years to observe the *** multivariable logistic regression model was used to analyze the prognosis factor,P value of<0.05 was considered statistically ***:The cumulative pregnancy rate was 58.14%(10,452/17,978),and the CLBR was 49.66%(8928/17,978).The female age was younger in the live birth group when compared with the non-live birth group(30.81±4.05 vs.33.09±5.13,P<0.001).The average duration of infertility was shorter than the non-live birth cohort(4.22±3.11 vs.5.06±4.08,P<0.001).The preliminary gonadotropin used and the total number of gonadotropin used were lower in the live birth group when compared with the non-live birth group(both P<0.001).Meanwhile,the number of oocytes retrieved and transferrable embryos were both significantly higher in the live birth group(15.35±7.98 vs.11.35±7.60,P<0.001;6.66±5.19 vs.3.62±3.51,P<0.001,respectively).Conclusions:The women's age,body mass index,duration of infertility years,infertility factors,controlled ovarian hyperstimulation protocol,the number of acquired oocytes,and number of transferrable embryos are the prognosis factors that significantly affected the CLBR.

关键词： Cumulative live birth rates IVF ICSI Controlled ovarian hyperstimulation In vitro fertilization Intracytoplasmic sperm injection

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Potential use of large language models for mitigating students’problematic social media use:ChatGPT as an example

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World Journal of Psychiatry 2024年第3期14卷 334-341页

作者： Xin-Qiao Liu zi-ru Zhang School of Education Tianjin UniversityTianjin 300350China

The problematic use of social media has numerous negative impacts on individuals'daily lives,interpersonal relationships,physical and mental health,and ***,there are few methods and tools to alleviate problematic social media,and their potential is yet to be fully *** large language models(LLMs)are becoming increasingly popular for providing information and assistance to people and are being applied in many aspects of *** mitigating problematic social media use,LLMs such as ChatGPT can play a positive role by serving as conversational partners and outlets for users,providing personalized information and resources,monitoring and intervening in problematic social media use,and *** this process,we should recognize both the enormous potential and endless possibilities of LLMs such as ChatGPT,leveraging their advantages to better address problematic social media use,while also acknowledging the limitations and potential pitfalls of ChatGPT technology,such as errors,limitations in issue resolution,privacy and security concerns,and potential *** we leverage the advantages of LLMs to address issues in social media usage,we must adopt a cautious and ethical approach,being vigilant of the potential adverse effects that LLMs may have in addressing problematic social media use to better harness technology to serve individuals and society.

关键词： Problematic use of social media Social media Large language models ChatGPT Chatbots

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The Astrometric Performance of the China Space Station Telescope(CSST) Sky Survey in Extending the Gaia Celestial Reference Frame

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Research in Astronomy and Astrophysics 2024年第8期24卷 135-142页

作者： Jun Yao Jia-Cheng Liu niu Liu zi Zhu Zhen-Wei Wang School of Astronomy and Space Science Key Laboratory of Modern Astronomy and Astrophysics (Ministry of Education)Nanjing University University of Chinese Academy of Sciences

The multi-color imaging sky survey conducted by the China Space Station Telescope (CSST) holds significant promise for advancing the development of the celestial reference *** this study,we focus on assessing the astrometric performance of the CSST celestial reference frame (CSST-CRF) in extending the Gaia Celestial Reference Frame 3 (Gaia-CRF3).First,the orientation precision of the CSST reference frame is evaluated using a simulated set of extragalactic sources with CSST g magnitudes ranging from 18 to 25 *** estimated orientation uncertainty caused by random error insignificantly affects the alignment between Gaia-CRF3 and the ***,the systematic effect of incomplete CSST sky coverage on the alignment between CSST-CRF and Gaia-CRF3 is discussed by analyzing the differences between the subset of Gaia-CRF3 in the CSST observation region (Gaia-CRF3′) and Gaia-CRF3 as a *** the third International Celestial Reference Frame (ICRF3) S/X band as an intermediate reference frame,the orientation offset between Gaia-CRF3′and GaiaCRF3 is estimated to be 20μ*** offset is marginally larger than the orientation offset between Gaia-CRF3 and the ICRF3,approximately 15μ*** residual spin and glide rate of Gaia-CRF3′are derived from the proper motions,consistent with that of Gaia-CRF3 within the formal ***,we explore the role of CSST in establishing a multi-band celestial reference frame by comparing its limiting magnitude and observation accuracy with existing catalogs in the infrared and ultraviolet *** to its broad wavelength coverage and highprecision measurements,CSST is well-positioned to make significant contributions to the development of a multiband celestial reference frame.

关键词： astrometry reference systems surveys

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Nomogram to predict pregnancy outcomes of emergency oocyte freeze-thaw cycles

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Chinese Medical Journal 2021年第19期134卷 2306-2315页

作者： Yang Wang zi-ru niu Li-Yuan Tao Xiao-Ying Zheng Yi-Feng Yuan Ping Liu Rong Li Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Beijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China

Background:Existing clinical prediction models for in vitro fertilization are based on the fresh oocyte cycle,and there is no prediction model to evaluate the probability of successful thawing of cryopreserved mature *** research aims to identify and study the characteristics of pre-oocyte-retrieval patients that can affect the pregnancy outcomes of emergency oocyte freeze-thaw ***:Data were collected from the Reproductive Center,Peking University Third Hospital of *** logistic regression model was used to derive the *** model performance was assessed by examining the discrimination and calibration in the development and validation *** ability was assessed using the area under the receiver operating characteristic curve(AUC),and calibration was assessed using the Hosmer–Lemeshow goodness-of-fit test and calibration ***:The predictors in the model of“no transferable embryo cycles”are female age(odds ratio[OR]=1.099,95%confidence interval[CI]=1.003–1.205,P=0.0440),duration of infertility(OR=1.140,95%CI=1.018–1.276,P=0.0240),basal follicle-stimulating hormone(FSH)level(OR=1.205,95%CI=1.051–1.382,P=0.0084),basal estradiol(E2)level(OR=1.006,95%CI=1.001–1.010,P=0.0120),and sperm from microdissection testicular sperm extraction(MESA)(OR=7.741,95%CI=2.905–20.632,P<0.0010).Upon assessing predictive ability,the AUC for the“no transferable embryo cycles”model was 0.799(95%CI:0.722–0.875,P<0.0010).The Hosmer–Lemeshow test(P=0.7210)and calibration curve showed good calibration for the prediction of no transferable embryo *** predictors in the cumulative live birth were the number of follicles on the day of human chorionic gonadotropin(hCG)administration(OR=1.088,95%CI=1.030–1.149,P=0.0020)and endometriosis(OR=0.172,95%CI=0.035–0.853,P=0.0310).The AUC for the“cumulative live birth”model was 0.724(95%CI:0.647–0.801,P<0.0010).The Hosmer–Lemeshow test(P=0.5620)and calibration curve showed good cali

关键词： Nomogram Oocyte freeze-thaw In vitro fertilization Pregancy outcome

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Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358patients

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World Journal of Clinical Cases 2020年第1期8卷 54-67页

作者： Peng-Fei Cui Xiao-Feng Cong Feng Gao Jia-Xin Yin zi-ru niu Song-Chen Zhao zi-Ling Liu Cancer Center the First Hospital of Jilin University

BACKGROUND Distant metastasis,particularly visceral metastasis(VM),represents an important negative prognostic factor for prostate cancer(PCa)***,due to the lower rate of occurrence of VM,studies on these patients are relatively ***,studies focusing on prognostic factors associated with PCa patients with VM are highly *** To investigate the prognostic factors for overall survival(OS)in PCa patients with lung,brain,and liver metastases,respectively,and evaluate the impact of site-specific and number-specific VM on *** Data on PCa patients with VM were extracted from the Surveillance,Epidemiology,and End Results database between 2010 and *** and multivariate Cox regression analyses were used to analyze the association between clinicopathological characteristics and survival of patients with different site-specific ***-Meier analyses and Log-rank tests were performed to analyze the differences among the *** A total of 1358 PCa patients with site-specific VM were identified from 2010 to *** age(>70 years)(P8)(P70 years)(P=0.010)and higher Gleason score(>8)(P=0.001)were associated with shorter OS in PCa patients with liver *** patients with isolated lung metastases exhibited significantly better survival outcomes compared with PCa patients with other single sites of VM(P<0.001).PCa patients with a single site of VM exhibited a superior OS compared with PCa patients with multiple sites of VM(P<0.001).CONCLUSION This is the first Surveillance,Epidemiology,and End Results-based study to determine prognostic factors affecting OS in PCa patients with different si

关键词： Prognostic factors Overall survival Prostate cancer Visceral metastases

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Carbon uptake by cement in China:Estimation and contribution to carbon neutrality goals

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Science China Earth Sciences 2024年第6期67卷 2056-2067页

作者： Mingjing MA zi HUANG Jiaoyue WANG Le niu Wenfeng ZHANG Xiaowei XU Fengming XI Zhu LIU Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Department of Earth System Science Tsinghua UniversityBeijing 100084China Department of Engineering Science University of OxfordOxfordOX13UK

Cement is a widely used construction material *** manufacturing contributes to anthropogenic CO_(2)emissions ***,its alkaline compounds can absorb CO_(2)from the surrounding environment and engage in a carbonation reaction,thereby functioning as a carbon *** a major cement producer and consumer,China has an important responsibility to rigorously investigate and accurately account for cement carbon *** study presents a comprehensive analytical model of cement carbon uptake from China,revealing a substantial increase in carbon uptake from 1930 to 2021,peaking at 426.77 Mt CO_(2)(95% Confidence Interval:317.67-874.33 Mt CO_(2))in *** uptake accounts for 8.10% to 45.40% of China’s annual land sink and 2.51% to 4.54% of the global land *** cumulative carbon uptake by cement is approximately 7.06 Gt CO_(2)(95%CI:5.22–9.44 Gt CO_(2))during this period,offsetting 50.7% of the total emissions(13.91 Gt CO_(2),95%CI:12.44–17.00 Gt CO_(2))from the cement ***,cement mortar contributed to most absorption(65.64%).From a life cycle perspective,the service stage of cement materials is the period where the largest CO_(2)sink is formed,accounting for 90.03% of the ***,the potential for carbon sequestration in cement materials and their waste is ***,the model improves the accuracy of cement carbon accounting,supporting both China and global carbon neutrality ***,it is crucial for China to achieve its carbon neutrality goals sooner by prioritizing the environmental benefits of cement materials and wastes,and accelerating the development and commercialization of CO_(2)sequestration technologies for cement and its by-products.

关键词： Cement Carbon uptake Life cycle assessment Carbon emission reduction Carbon neutrality

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Surgical treatment of an old avulsion fracture of the ischial tuberosity and ischial ramus: A case report

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World Journal of Orthopedics 2024年第1期15卷 94-100页

作者： zi-ru Chen Shi-Jie Liao Fu-Chun Yang Department of Orthopedic Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Avulsion fracture of the ischial tuberosity is a relatively clinically rare type of trauma that is mainly incurred by adolescents during competitive sports *** to previous literature,the most commonly involved sports are soccer,sprinting,and gymnastics,in descending ***-induced avulsion fracture of the ischial tuberosity and ischial ramus is extremely clinically *** SUMMARY A case of a neglected avulsion fracture of the ischial tuberosity and ischial ramus was diagnosed in a young female dancer who complained of pain and restricted movement of her right *** stated that she had suffered the injury while performing a split leap during a dance performance 9 mo ***,she underwent surgery and obtained satisfactory treatment *** Early diagnosis of these fractures is important to ensuring early proper treatment towards a quicker *** old fractures with nonunion and chronic buttock pain,surgery is a preferred therapeutic choice with good treatment outcomes.

关键词： Ischial tuberosity Ischial ramus Avulsion fracture Delayed diagnosis Splitleap injury Case report

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Ethanol extract of Abelmoschus manihot suppresses endoplasmic reticulum stress in contrast-induced nephropathy

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 17-27,I0002,I0003页

作者： Xin Lin Xin Lu Yun-He Zhao Yi-Bei Wang ru-Ge niu Xiao-Hu Chen Department of Cardiology Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210004China

Objective:To explore the efficacy and potential mechanisms of the ethanol extract of Abelmoschus manihot(L.)Medic in contrast-induced nephropathy(CIN).Methods:CIN rat models and human renal proximal tubular cells(HK-2)with iopromide-induced injury were employed to mimic CIN *** effect of Abelmoschus manihot extract on the rat models and HK-2 cells was *** rat models,kidney function,histology,oxidative stress and apoptosis were *** HK-2 cells,cell viability,apoptosis,mitochondrial membrane potential,and endoplasmic reticulum stress were ***:Abelmoschus manihot extract significantly improved structural and functional impairments in the kidneys of CIN ***,the extract effectively mitigated the decline in cellular viability and reduced iopromide-induced oxidative stress and lipid *** investigations revealed that Abelmoschus manihot extract prominently attenuated acute endoplasmic reticulum stress-mediated apoptosis by downregulating GRP78 and CHOP protein ***:Abelmoschus manihot extract can be used as a promising therapeutic and preventive agent in the treatment of CIN.

关键词： Contrast-induced nephropathy Abelmoschus manihot extract ER stress Apoptosis GRP78 CHOP

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Climate warming is likely to weaken the performance of two-phase closed thermosyphon on the Qinghai-Tibet Plateau

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Advances in Climate Change Research 2024年第1期15卷 90-100页

作者： Guan-Li JIANG zi-Teng FU Xin-Yu MEN Hong-Ting ZHAO Si-ru GAO Yong-Zhi LI Qing-Bai WU State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Beiluhe Observation and Research Station on Frozen Soil Engineering and Environment in the Qinghai-Tibet Plateau Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Muli Field Scientific Observation and Research Station for Gas Hydrate China Geological SurveyBeijing 100083China University of Chinese Academy of Sciences Beijing 100049China School of Civil Engineering and Architecture Jiaxing Nanhu UniversityJiaxing 314001China

Over the years,numerous geotechnical approaches have been implemented to mitigate the adverse effects of climate warming on various infrastructures in the permafrost region of the Qinghai-Tibet Plateau(QTP),such as the Qinghai-Tibet Highway and Railway,and achieved the expected engineering ***,little attention has been given to whether the performance of these geotechnical approaches has changed during the ongoing process of climate *** investigate the performance variation of one of these geotechnical approaches,which is two-phase closed thermosyphon(TPCT),during sustained climate warming,we conducted a statistical analysis of soil temperature monitoring data in 2003-2020 from eight regular embankments and six TPCT embankments in our permafrost monitoring *** results indicate that TPCT undeniably has a cooling effect on the permafrost beneath embankments,even rapidly eliminated previously formed taliks beneath ***,further analysis reveals that the performance of TPCT has been weakening during sustained climate warming,which has confirmed by the re-forming of the taliks beneath embankment where they had been previously *** on the current understanding,we attributed the weakening of thermosyphon performance to a significant reduction in the air temperature freezing index caused by ongoing climate *** this study,we aimed to draw attention to the evolving performance of geotechnical approaches in permafrost regions amid climate warming,prompting necessary engineering innovations to address this situation and ensure the sustainable development of the permafrost region on the QTP.

关键词： Two-phase closed thermosyphon Climate warming Supra-permafrost talik Permafrost degradation Qinghai-Tibet Highway

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