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Over-expression of programmed death-ligand 1 and programmed death-1 on antigen-presenting cells as a predictor of organ dysfunction and mortality during early sepsis: a prospective cohort study

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World Journal of Emergency Medicine 2023年第3期14卷 179-185页

作者： Jia-bao Li Miao-rong Xie Mei-li Duan Ya-nan Yu Chen-chen Hang zi-ren tang Chun-sheng Li Department of Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Emergency and Critical Care Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND:This study aimed to explore the changes of programmed death-ligand 1(PDL1)and programmed death-1(PD-1)expression on antigen-presenting cells(APCs)and evaluate their association with organ failure and mortality during early ***:In total,40 healthy controls and 198 patients with sepsis were included in this *** blood was collected within the first 24 h after the diagnosis of *** expression of PDL1 and PD-1 was determined on APCs,such as B cells,monocytes,and dendritic cells(DCs),by flow *** in plasma,such as interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),IL-6,IL-10,and IL-17A were determined by Luminex ***:PD-1 expression decreased significantly on B cells,monocytes,myeloid DCs(mDCs),and plasmacytoid DCs(pDCs)as the severity of sepsis ***-1 expression was also markedly decreased in non-survivors compared with *** contrast,PD-L1 expression was markedly higher on mDCs,pDCs,and monocytes in patients with sepsis than in healthy controls and in non-survivors than in *** PD-L1 expression on APCs(monocytes and DCs)was weakly related to organ dysfunction and infl *** area under the receiver operating characteristic curve(AUC)of the PD-1 percentage of monocytes(monocyte PD-1%)+APACHE II model(0.823)and monocyte PD-1%+SOFA model(0.816)had higher prognostic value than other parameters *** PD-1%was an independent risk factor for 28-day ***:The severity of sepsis was correlated with PD-L1 or PD-1 over-expression on ***-L1 in monocytes and DCs was weakly correlated with infl ammation and organ dysfunction during early *** combination of SOFA or APACHE II scores with monocyte PD-1%could improve the prediction ability for mortality.

关键词： Infl ammation Programmed death-ligand 1 Programmed death-1 Antigen-presenting cells

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Development and evaluation of a predictive nomogram for survival in heat stroke patients: a retrospective cohort study

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World Journal of Emergency Medicine 2022年第5期13卷 355-360页

作者： Fei Shao Xian Shi Shu-hua Huo Qing-yu Liu Ji-xue Shi Jian Kang Ping Gong Sheng-tao Yan Guo-xing Wang Li-jie Qin Fei Wang Ke Feng Feng-ying Chen Yong-jie Yin Tao Ma Yan Li Yang Wu Hao Cui Chang-xiao Yu Song Yang Wei Gan Sai Wang Liu-ye-zi Du Ming-chen Zhao zi-ren tang Shen Zhao Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Emergency Medicine Hebei Yanda HospitalLangfang 065201China Department of Emergency Medicine Beijing Huairou HospitalBeijing 101400China Department of Emergency Medicine the Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Emergency Medicine the Second Affi liated Hospital of Shandong First Medical UniversityTai’an 271000China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine China-Japan Friendship HospitalBeijing 100029China Department of Emergency Medicine Beijing Friendship HospitalBeijing 100050China Department of Emergency Medicine Henan Provincial People’s HospitalZhengzhou 450003China Department of Emergency Medicine Beijing Tsinghua Changung HospitalBeijing 102218China Department of Emergency Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004China Department of Emergency Medicine the Affi liated Hospital of Inner Mongolia Medical UniversityHohhot 010050China Department of Emergency Medicine the Second Hospital of Jilin UniversityChangchun 130021China Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Department of Emergency Medicine the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Big Data Research Goodwill Hessian Health Technology Co.Ltd.Beijing 100085China School of Public Health Peking UniversityBeijing 100083China Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing 100020China Department of Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND:This study aimed to establish an eff ective nomogram to predict the survival of heat stroke(HS)based on risk ***:This was a retrospective,observational multicenter cohort *** analyzed patients diagnosed with HS,who were treated between May 1 and September 30,2018 at 15 tertiary hospitals from 11 cities in Northern ***:Among the 175 patients,32 patients(18.29%)died before hospital *** the univariate analysis,mechanical ventilation,initial mean arterial pressure<70 mmHg,maximum heart rate,lab results on day 1(white blood cell count,alanine aminotransferase,creatinine),and Glasgow admission prediction score were included in multivariate *** Cox regression showed that invasive ventilation,initial mean arterial pressure<70 mmHg(1 mmHg=0.133 kPa),and Glasgow admission prediction score were independent risk factors for *** nomogram was established for predicting 7-d and 14-d survival in the training *** nomogram exhibited a concordance index(C-index)of 0.880(95%confidence interval[95%CI]0.831-0.930)by bootstrapping validation(B=1,000).Furthermore,the nomogram performed better when predicting 14-d survival,compared to 7-d *** prognostic index cut-off value was set at 2.085,according to the operating characteristic curve for overall survival *** model showed good calibration ability in the internal and external validation ***:A novel nomogram,integrated with prognostic factors,was proposed;it was highly predictive of the survival in HS patients.

关键词： Heat stroke Nomogram Survival Prognosis

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Bronchiectasis is one of the indicators of severe coronavirus disease 2019 pneumonia

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Chinese Medical Journal 2021年第20期134卷 2486-2488页

作者： Peng Peng Feng Wang zi-ren tang Xiao Liu zi-Hao Zhang Huan Song Bei-Lin Zhu Shi Liu Yong Liu Xiao-Guang Xu Meng-Hua Liu Le-Fei Zhou Tao Jiang Department of Radiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Respiratory and Critical Care Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Emergency Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Respiratory and Critical Care Medicine Zhoukou Central HospitalZhoukouHenan 466000China Department of Respiratory and Critical Care Medicine Affiliated Hospital of Jilin Medical UniversityJilinJilin 132013China Department of Respiratory Medicine Taiyuan Municipal No.2 People’s HospitalTaiyuanShanxi 030002China

Since 2019,an epidemic of pneumonia of unknown cause occurred around the world.[1]The analysis of respiratory tract samples led to the identification of a novel coronavirus,which was named 2019 novel coronavirus(2019-nCoV).Epidemiological data showed that 2019-nCoV could spread rapidly from person to person and cause coronavirus disease-19(COVID-19).The high infectivity of COVID-19 has led to a rapid increase in the number of cases and caused a global *** date,2019-nCoV has infected millions of people and caused hundreds of thousands of deaths *** numbers are updated every day and are expected to increase further at a great ***-19 has now become a serious threat to public health worldwide.

关键词： pneumonia respiratory hundreds

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Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue tang Mansheng Chu Quan Shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue ren Ying tang Qi Yang Tian-Tian Meng Song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

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Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 24-31页

作者： Tiantian tang Jiaying He Huihang Sun Jingjia Luo Institute for Climate and Application Research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information Science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo Li Fu tang Jingkai Zhang Yuetong Kang Hean Zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

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Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da Wan Shuwei tang Shulin Bai Xiaodong Li Peng Ai Wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

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