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Over-expression of programmed death-ligand 1 and programmed death-1 on antigen-presenting cells as a predictor of organ dysfunction and mortality during early sepsis: a prospective cohort study

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World Journal of Emergency Medicine 2023年第3期14卷 179-185页

作者： Jia-bao Li Miao-rong Xie Mei-li Duan Ya-nan Yu Chen-chen Hang zi-ren tang Chun-sheng Li Department of Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Emergency and Critical Care Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND:This study aimed to explore the changes of programmed death-ligand 1(PDL1)and programmed death-1(PD-1)expression on antigen-presenting cells(APCs)and evaluate their association with organ failure and mortality during early sepsis.METHODS:In total,40 healthy controls and 198 patients with sepsis were included in this study.Peripheral blood was collected within the first 24 h after the diagnosis of sepsis.The expression of PDL1 and PD-1 was determined on APCs,such as B cells,monocytes,and dendritic cells(DCs),by flow cytometry.Cytokines in plasma,such as interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),IL-6,IL-10,and IL-17A were determined by Luminex assay.RESULTS:PD-1 expression decreased significantly on B cells,monocytes,myeloid DCs(mDCs),and plasmacytoid DCs(pDCs)as the severity of sepsis increased.PD-1 expression was also markedly decreased in non-survivors compared with survivors.In contrast,PD-L1 expression was markedly higher on mDCs,pDCs,and monocytes in patients with sepsis than in healthy controls and in non-survivors than in survivors.The PD-L1 expression on APCs(monocytes and DCs)was weakly related to organ dysfunction and infl ammation.The area under the receiver operating characteristic curve(AUC)of the PD-1 percentage of monocytes(monocyte PD-1%)+APACHE II model(0.823)and monocyte PD-1%+SOFA model(0.816)had higher prognostic value than other parameters alone.Monocyte PD-1%was an independent risk factor for 28-day mortality.CONCLUSION:The severity of sepsis was correlated with PD-L1 or PD-1 over-expression on APCs.PD-L1 in monocytes and DCs was weakly correlated with infl ammation and organ dysfunction during early sepsis.The combination of SOFA or APACHE II scores with monocyte PD-1%could improve the prediction ability for mortality.

关键词： Infl ammation Programmed death-ligand 1 Programmed death-1 Antigen-presenting cells

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Development and evaluation of a predictive nomogram for survival in heat stroke patients: a retrospective cohort study

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World Journal of Emergency Medicine 2022年第5期13卷 355-360页

作者： Fei Shao Xian Shi Shu-hua Huo Qing-yu Liu Ji-xue Shi Jian Kang Ping Gong Sheng-tao Yan Guo-xing Wang Li-jie Qin Fei Wang Ke Feng Feng-ying Chen Yong-jie Yin Tao Ma Yan Li Yang Wu Hao Cui Chang-xiao Yu Song Yang Wei Gan Sai Wang Liu-ye-zi Du Ming-chen Zhao zi-ren tang Shen Zhao Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Emergency Medicine Hebei Yanda HospitalLangfang 065201China Department of Emergency Medicine Beijing Huairou HospitalBeijing 101400China Department of Emergency Medicine the Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Emergency Medicine the Second Affi liated Hospital of Shandong First Medical UniversityTai’an 271000China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine China-Japan Friendship HospitalBeijing 100029China Department of Emergency Medicine Beijing Friendship HospitalBeijing 100050China Department of Emergency Medicine Henan Provincial People’s HospitalZhengzhou 450003China Department of Emergency Medicine Beijing Tsinghua Changung HospitalBeijing 102218China Department of Emergency Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004China Department of Emergency Medicine the Affi liated Hospital of Inner Mongolia Medical UniversityHohhot 010050China Department of Emergency Medicine the Second Hospital of Jilin UniversityChangchun 130021China Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Department of Emergency Medicine the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Big Data Research Goodwill Hessian Health Technology Co.Ltd.Beijing 100085China School of Public Health Peking UniversityBeijing 100083China Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing 100020China Department of Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND:This study aimed to establish an eff ective nomogram to predict the survival of heat stroke(HS)based on risk factors.METHODS:This was a retrospective,observational multicenter cohort study.We analyzed patients diagnosed with HS,who were treated between May 1 and September 30,2018 at 15 tertiary hospitals from 11 cities in Northern China.RESULTS:Among the 175 patients,32 patients(18.29%)died before hospital discharge.After the univariate analysis,mechanical ventilation,initial mean arterial pressure<70 mmHg,maximum heart rate,lab results on day 1(white blood cell count,alanine aminotransferase,creatinine),and Glasgow admission prediction score were included in multivariate analysis.Multivariate Cox regression showed that invasive ventilation,initial mean arterial pressure<70 mmHg(1 mmHg=0.133 kPa),and Glasgow admission prediction score were independent risk factors for HS.The nomogram was established for predicting 7-d and 14-d survival in the training cohort.The nomogram exhibited a concordance index(C-index)of 0.880(95%confidence interval[95%CI]0.831-0.930)by bootstrapping validation(B=1,000).Furthermore,the nomogram performed better when predicting 14-d survival,compared to 7-d survival.The prognostic index cut-off value was set at 2.085,according to the operating characteristic curve for overall survival prediction.The model showed good calibration ability in the internal and external validation datasets.CONCLUSION:A novel nomogram,integrated with prognostic factors,was proposed;it was highly predictive of the survival in HS patients.

关键词： Heat stroke Nomogram Survival Prognosis

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Bronchiectasis is one of the indicators of severe coronavirus disease 2019 pneumonia

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Chinese Medical Journal 2021年第20期134卷 2486-2488页

作者： Peng Peng Feng Wang zi-ren tang Xiao Liu zi-Hao Zhang Huan Song Bei-Lin Zhu Shi Liu Yong Liu Xiao-Guang Xu Meng-Hua Liu Le-Fei Zhou Tao Jiang Department of Radiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Respiratory and Critical Care Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Emergency Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Respiratory and Critical Care Medicine Zhoukou Central HospitalZhoukouHenan 466000China Department of Respiratory and Critical Care Medicine Affiliated Hospital of Jilin Medical UniversityJilinJilin 132013China Department of Respiratory Medicine Taiyuan Municipal No.2 People’s HospitalTaiyuanShanxi 030002China

Since 2019,an epidemic of pneumonia of unknown cause occurred around the world.[1]The analysis of respiratory tract samples led to the identification of a novel coronavirus,which was named 2019 novel coronavirus(2019-nCoV).Epidemiological data showed that 2019-nCoV could spread rapidly from person to person and cause coronavirus disease-19(COVID-19).The high infectivity of COVID-19 has led to a rapid increase in the number of cases and caused a global pandemic.To date,2019-nCoV has infected millions of people and caused hundreds of thousands of deaths worldwide.These numbers are updated every day and are expected to increase further at a great rate.COVID-19 has now become a serious threat to public health worldwide.

关键词： pneumonia respiratory hundreds

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Antiviral treatment standards for hepatitis B:An urgent need for expansion

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World Journal of Gastroenterology 2024年第4期30卷 418-420页

作者： zi-Hong Bao Zhi-Kun Dai Hao-Xian tang Department of Infectious Diseases The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Medical College Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Cardiology The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The present letter to the editor is related to the review with the title“Past,present,and future of long-term treatment for hepatitis B virus.”Chronic hepatitis B(CHB)represents an important and pressing public health concern.Timely identification and effective antiviral therapy hold the potential to reduce liver-related mortality attributable to chronic infection with hepatitis B virus(HBV)substantially.However,the current global treatment rates for CHB remain conspicuously low,with the excessively stringent treatment criteria advocated by national CHB guidelines being a contributing factor to these low rates.Nevertheless,recent strides in comprehending this malady and the emergence of novel antiviral agents prompt the imperative re-evaluation of treatment standards to extend the sphere of potential beneficiaries.An impending need arises for a novel paradigm for the classification of patients with CHB,the expansion of antiviral treatment eligibility for HBV-infected individuals,and even the streamlining of the diagnostic process for CHB to amplify cost-effectiveness and augment survival prospects.

关键词： Hepatitis B virus Chronic hepatitis B Antiviral treatment criteria Serum alanine aminotransferase Liver-related mortality Letter to the Editor

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High-precision modeling of tide-induced 3-D magnetic field and analysis of geomagnetic satellite orbit requirements

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Science China Earth Sciences 2024年第1期67卷 165-178页

作者： Zhengyong ren Cong YANG Hongbo YAO Xu tang Jingtian tang Keke ZHANG Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of Education Central South UniversityChangsha 410083China Hunan Key Laboratory of Nonferrous Resources and Geological Hazards Exploration Changsha 410083China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China

Ground-based magnetic observatories and geomagnetic satellites can observe the induced magnetic field generated by the motion of seawater containing sodium and chlorine ions.Calculating the three-dimensional(3-D)spatial distribution of tide-induced magnetic fields(TIMF)is crucial for inverting the electrical conductivity structure of the oceanic lithosphere.It also serves as an essential basis for designing optimal geomagnetic observatories and satellite orbits.However,existing methods for simulating TIMF suffer from limitations in inaccurately modeling realistic coastlines,heterogeneous land and sea surface properties,and complex deep Earth structures,thereby the interpretational level of TIMF data is reduced.To overcome this issue,we developed a tetrahedral-based finite element method for simulating TIMF,which can efficiently approximate realistic coastlines,heterogeneous land and sea surface properties,and complex deep Earth structures.Firstly,we derived the boundary value problem for the seawater motion-induced electromagnetic field,which was solved using the vector finite element method based on tetrahedral elements.Secondly,using the latest ocean depth and seafloor sediment layer models,we constructed a 3-D conductivity model of the Earth,which includes realistic coastlines,heterogeneous land and sea conductivity distributions.We then computed the TIMF using the M_(2)tidal source as an example and validated our method by comparing it with results obtained from spherical harmonic finite element and integral equation methods.Finally,utilizing the computed high-precision M_(2),N_(2),and O1 TIMF signals,we marked global observatories capable of observing strong M_(2),N_(2),and O1 TIMF signals and predicted alternative stations suitable for tide signal observations.Additionally,we calculated TIMF at heights of 450 and 200 km for the Macao Science Satellite 1 and its subsequent satellites.The results indicate that the amplitude of the tidal-induced magnetic field at 200 km is approximately twice that at 450 km.Th

关键词： Ocean motional induction Electromagnetic induction Ocean tides Geomagnetic satellite Macao Science Satellite 1

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Investigating the elliptic anisotropy of identified particles in p-Pb collisions with a multi-phase transport model

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Nuclear Science and Techniques 2024年第2期35卷 160-169页

作者： Si-Yu tang Liang Zheng Xiao-Ming Zhang ren-Zhuo Wan School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Mathematics and Physics China University of Geosciences(Wuhan)Wuhan 430074China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China Hubei Key Laboratory of Digital Textile Equipment Wuhan Textile UniversityWuhan 430200China School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|<0.8)was investigated in p-Pb collisions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculatio... 详细信息

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|rential v_(2)based on the advanced flow extraction method of light flavor hadrons(pions,kaons,protons,andΛ)in small collision systems were extended to a wider transverse momentum(p_(T))range of up to 8 GeV/c for the first time.The string-melting version of the AMPT model provides a good description of the measured p_(T)-differential v_(2)of the mesons but exhibits a slight deviation from the baryon v_(2).In addition,we observed the features of mass ordering at low p_(T)and the approximate number-of-constituentquark(NCQ)scaling at intermediate p_(T).Moreover,we demonstrate that hadronic rescattering does not have a significant impact on v_(2)in p-Pb collisions for different centrality selections,whereas partonic scattering dominates in generating the elliptic anisotropy of the final particles.This study provides further insight into the origin of collective-like behavior in small collision systems and has referential value for future measurements of azimuthal anisotropy.

关键词： Azimuthal anisotropy Small collision systems Transport model

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Efflcient machining of a complex blisk channel using a disc cutter

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Chinese Journal of Aeronautics 2024年第1期37卷 414-437页

作者： Xiangyu LI Zhaoyu LI Dong HE Junxue ren Qian FENG Kai tang Department of Mechanical and Aerospace Engineering Hong Kong University of Science and TechnologyHong Kong 999077China Key Laboratory of High Performance Manufacturing for Aero Engine(Northwestern Polytechnical University) Ministry of Industry and Information TechnologyXi’an 710072China Xi’an Sanhang Power Technology Co. LtdXi’an 710000China HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute FutianShenzhen 518057China HKUST Shenzhen Research Institute Shenzhen 518057China

For rough machining of a complex narrow cavity,e.g.,a complex blisk channel on an aero-engine,the typically used cutting tools are the slender cylindrical cutter and conical cutter.Nevertheless,as neither of the two is particularly suited for rough machining,wherein the main purpose is to remove a large volume as quickly as possible,the machining efficiency is low,especially when the part materials are of hard-to-cut types(e.g.,Titanium-alloy)for which it often takes days to rough machine a blisk.Fortunately,disc machining provides a new and efficient roughing solution,since a disc cutter with a large radius enables a much larger cutting speed and thus a larger material removal rate.However,due to the large radius of the disc cutter,its potential collision with narrow and twisted channels becomes a serious concern.In this paper,we propose a novel twophase approach for efficiently machining a complex narrow cavity workpiece using a disc-shaped cutter,i.e.,3+2-axis disc-slotting of the channel by multiple layers(rough machining)+five-axis disc-milling of the freeform channel side surfaces(semi-finish machining).Both simulation and physical cutting experiments are conducted to assess the effectiveness and advantages of the proposed method.The experimental results show that,with respect to a same cusp-height threshold on the channel side surfaces,the total machining time of the tested part by the proposed method is about only 36%of that by the conventional approach of plunging-milling(for roughing)plus milling by a slender cylindrical cutter(for semi-finishing).

关键词： Blisk channel CNC machining Disc cutter Roughing efficiency Tool path planning

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Visual Semantic Segmentation Based on Few/Zero-Shot Learning:An Overview

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1106-1126页

作者： Wenqi ren Yang tang Qiyu Sun Chaoqiang Zhao Qing-Long Han Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China National Key Laboratory of Air-Based Information Perception and Fusion Aviation Industry Corporation of ChinaLuoyang 471000China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia

Visual semantic segmentation aims at separating a visual sample into diverse blocks with specific semantic attributes and identifying the category for each block,and it plays a crucial role in environmental perception.Conventional learning-based visual semantic segmentation approaches count heavily on largescale training data with dense annotations and consistently fail to estimate accurate semantic labels for unseen categories.This obstruction spurs a craze for studying visual semantic segmentation with the assistance of few/zero-shot learning.The emergence and rapid progress of few/zero-shot visual semantic segmentation make it possible to learn unseen categories from a few labeled or even zero-labeled samples,which advances the extension to practical applications.Therefore,this paper focuses on the recently published few/zero-shot visual semantic segmentation methods varying from 2D to 3D space and explores the commonalities and discrepancies of technical settlements under different segmentation circumstances.Specifically,the preliminaries on few/zeroshot visual semantic segmentation,including the problem definitions,typical datasets,and technical remedies,are briefly reviewed and discussed.Moreover,three typical instantiations are involved to uncover the interactions of few/zero-shot learning with visual semantic segmentation,including image semantic segmentation,video object segmentation,and 3D segmentation.Finally,the future challenges of few/zero-shot visual semantic segmentation are discussed.

关键词： Visual segmentation separating

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Decreased human leukocyte antigen-D-related expression on CD14^(+)monocytes in patients with out-of-hospital cardiac arrest provided target temperature management therapy:a prospective observational study

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Emergency and Critical Care Medicine 2024年第1期4卷 16-21页

作者： Huan Shao Wei Yuan ziren tang Zhijiang Qi Le An Qiang Zhang Chunsheng Li Department of Emergency Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina.

Background:Post–cardiac arrest syndrome involves systemic inflammation,which causes subsequent neurological impairments.We investigated the influence of targeted temperature management(TTM)therapy in patients with out-of-hospital cardiac arrest(OHCA)after return of spontaneous circulation(ROSC)by observing the changes in circulating CD14^(+)monocytes and the expression of human leukocyte antigen D–related(HLA-DR)and programmed cell death ligand 1(PD-L1)in CD14^(+)monocytes.Methods:Adult patients admitted to the emergency department of Beijing Chao-Yang Hospital after OHCA between January 2017 and March 2018 were included in this study.Thirty control subjects,10 patients with OHCA,and 37 patients with OHCA who received 72 hours of TTM therapy were enrolled.Peripheral blood samples of patients in the OHCA and TTM groups were collected on Days 1 and 3(D1 and D3)after ROSC and evaluated for HLA-DR and PD-L1 expression on CD14^(+)monocytes using flow cytometry.Results:Compared with control subjects,the percentage of circulating CD14^(+)monocytes,HLA-DR+/CD14^(+)monocyte ratios,and mean fluorescence intensity were significantly decreased in patients with OHCA.After ROSC,HLA-DR expression in CD14^(+)monocytes in the TTM group was lower than that in patients with OHCA.However,there were no significant differences in the percentage of PD-L1+/CD14^(+)monocytes or the mean fluorescence intensity between patients with OHCA and healthy volunteers.Conclusion:After ROSC,circulating CD14^(+)monocytes and HLA-DR+/CD14^(+)monocyte ratios decreased significantly in patients with OHCA.Human leukocyte antigen D–related expression in CD14^(+)monocytes was lower in patients treated with TTM.

关键词： Human leukocyte antigen D-related Monocytes Out-of-hospital cardiac arrest Target temperature management

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Efficacy and safety of Y- 2 sublingual tablet for patients with acute ischaemic stroke: protocol of a phase III randomised double- blind placebo- controlled multicentre trial

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Stroke & Vascular Neurology 2024年第1期9卷 90-95页

作者： Yu Fu renhong tang Rong Chen Anxin Wang Jinsheng ren Shunwei Zhu Xiaofei Feng Dongsheng Fan Deparment of Neurology Peking University Third HospitalBeijingChina State Key Laboratory of Neurology and Oncology Drug Development NanjingJiangsuChina Simcere Pharmaceutical Group Limited NanjingJiangsuChina Neurodawn Pharmaceutical Co. LtdNanjingJiangsuChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Clinical studies have demonstrated that edaravone dexborneol can improve the functional outcomes in patients with acute ischaemic stroke(AIS).The present clinical trial aimed at testing the efficacy and safety of Y-2 sublingual tablet on 90-day functional outcome in patients with AIS.Methods and design This is a randomised,double-blind,placebo-controlled,multicentre,parallel-group trial of Y-2 sublingual tablet on patients with AIS.An estimated 914 patients at age of 18–80 years with AIS within 48 hours after symptom onset from 40 hospitals will be randomly assigned to receive Y-2 sublingual tablet or placebo for 14 days.Patients are at score 6–20 points on National Institutes of Health Stroke Scale(NIHSS)and had a modified Rankin Scale(mRS)≤1 before this stroke,except mechanical thrombectomy and neuroprotective agents treatment.Study outcomes The primary outcome is the proportion of patients with mRS≤1 on day 90 after randomisation.Secondary efficacy outcomes include mRS score on day 90,the proportion of patients with mRS≤2 on day 90;the change of NIHSS score from baseline to day 14 and the proportion of patients with NIHSS score≤1 at the days 14,30 and 90.Discussion This trial will provide valuable evidence for the efficacy and safety of Y-2 sublingual table for improving 90 days the functional outcomes in patients with AIS.Trial registration number NCT04950920.

关键词： patients protective centre

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