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Screening and regulatory network analysis of survival-related genes of patients with colorectal cancer

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Science China(Life Sciences) 2014年第5期57卷 526-531页

作者： qi lu DING Yanqing Department of Pathology School of Basic Medical SciencesSouthern Medical University Department of Pathology Nanfang HospitalSouthern Medical University

The purpose of this study was to screen key survival-related genes from patients with colorectal cancer and explore signal transduction network of the involved *** a previous study,survival-related genes of patients with colorectal cancer were selected by colorectal cancer-related expression data GSE17538 using the Significance Analysis of Microarrays(SAM3.01)software,and 235 genes related to the survival of patients with colorectal cancer were ***,the following screening and analysis were conducted on these 235 genes in this ***,the enrichment analysis of transcription factor binding sites was conducted on the 235 *** with more than seven transcription factor binding sites were ***,these genes and upregulated genes in colorectal cancer were ***,survival analysis and regulatory network analysis were conducted on the screened *** allowed clarification of the relationship between these genes and the survival of patients with colorectal cancer and the signaling network involving these genes in the cell signal transduction network of colorectal *** the above analysis,six upregulated genes in colorectal cancer related to the survival of colorectal cancer patients and highly regulated by transcription factors were selected,namely STX2,PODXL,KLK6,GRB10,EHBP1 and *** genes are involved in signal regulatory networks related to colorectal cancer metastasis-related signaling ***,the survival of patients with colorectal cancer is closely correlated with colorectal cancer *** six survival-related genes affect the survival of patients by regulating colorectal cancer metastasis-associated signaling pathways.

关键词： survival time colorectal cancer transcription factor bioinformatics

Dry electrode technology for scalable and flexible high-energy sulfur cathodes in all-solid-state lithium-sulfur batteries

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Journal of Energy Chemistry 2022年第8期31卷 612-618,I0017页

作者： Jiang-Kui Hu Hong Yuan Shi-Jie Yang Yang lu Shuo Sun Jia Liu Yu-Long Liao Shuai Li Chen-zi Zhao Jia-qi Huang School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing 100083China

All-solid-state lithium-sulfur batteries(ASSLSBs)employing sulfide solid electrolytes are one of the most promising next-generation energy storage systems due to their potential for higher energy density and ***,scalable fabrication of sheet-type sulfur cathodes with high sulfur loading and excellent performances remains *** this work,sheet-type freestanding sulfur cathodes with high sulfur loading were fabricated by dry electrode *** unique fibrous morphologies of polytetrafluoroethylene(PTFE)binders in dry electrodes not only provides excellent mechanical properties but also uncompromised ionic/electronic *** employed with thickened dry cathodes with high sulfur loading of 2 mg cm^(-2),ASSLSBs still exhibit outstanding rate performance and cycle ***,the all-solid-state lithium-sulfur monolayer pouch cells(9.2 m Ah)were also demonstrated and exhibited excellent safety under a harsh test *** work verifies the potential of dry electrode technology in the scalable fabrication of thickened sulfur cathodes and will promote the practical applications of ASSLSBs.

关键词： All-solid-state lithium-sulfur batteries Sulfide solid electrolytes Sheet-type electrodes Composite sulfur cathode Dry electrode technology

Real-time toxicity prediction of Aconitum stewing system using extractive electrospray ionization mass spectrometry

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Acta Pharmaceutica Sinica B 2020年第5期10卷 903-912页

作者： zi-Dong qiu Jin-Long Chen Wen Zeng Ying Ma Tong Chen Jin-Fu Tang Chang-Jiang-Sheng Lai lu-qi Huang State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesState Key Laboratory Breeding Base of Dao-di HerbsBeijing 100700China

Due to numerous obstacles such as complex matrices,real-time monitoring of complex reaction systems(e.g.,medicinal herb stewing system)has always been a challenge though great values for safe and rational use of ***,facilitated by the potential ability on the tolerance of complex matrices of extractive electrospray ionization mass spectrometry,a device was established to realize continuous sampling and real-time quantitative analysis of herb stewing system for the first time.A complete analytical strategy,including data acquisition,data mining,and data evaluation was proposed and implemented with overcoming the usual difficulties in real-time mass spectrometry *** complex Fuzi(the lateral root of Aconitum)-meat stewing systems were real-timely monitored in150 min by qualitative and quantitative analysis of the nine key alkaloids *** results showed that the strategy worked perfectly and the toxicity of the systems were evaluated and predicated *** with trotters effectively accelerated the detoxification of Fuzi soup and reduced the overall toxicity to 68%,which was recommended to be used practically for treating rheumatic arthritis and enhancing *** established strategy was versatile,simple,and accurate,which would have a wide application prospect in real-time analysis and evaluation of various complex reaction systems.

关键词： Real-time extractive electrospray ionization mass spectrometry Toxic alkaloids Data mining Aconitine Aconitum--meat stewing system Toxicity prediction

Early prediction and prevention of infected pancreatic necrosis

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World Journal of Gastroenterology 2024年第9期30卷 1005-1010页

作者： Cheng Lv zi-Xiong Zhang lu Ke Department of Critical Care Medicine Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210000Jiangsu ProvinceChina Research Institute of Critical Care Medicine and Emergency Rescue Nanjing UniversityNanjing 210000Jiangsu ProvinceChina

Approximately 20%-30%of patients with acute necrotizing pancreatitis develop infected pancreatic necrosis(IPN),a highly morbid and potentially lethal *** identification of patients at high risk of IPN may facilitate appropriate preventive measures to improve clinical *** the past two decades,several markers and predictive tools have been proposed and evaluated for this *** biomarkers like C-reactive protein,procalcitonin,lymphocyte count,interleukin-6,and interleukin-8,and newly developed biomarkers like angiopoietin-2 all showed significant association with *** the other hand,scoring systems like the Acute Physiology and Chronic Health Evaluation II and Pancreatitis Activity Scoring System have also been tested,and the results showed that they may provide better *** early prevention of IPN,several new therapies were tested,including early enteral nutrition,anti-biotics,probiotics,immune enhancement,etc.,but the results *** together,several evidence-supported predictive markers and scoring systems are readily available for predicting ***,effective treatments to reduce the incidence of IPN are still lacking apart from early enteral *** this editorial,we summarize evidence concerning early prediction and prevention of IPN,providing insights into future practice and study design.A more homo-geneous patient population with reliable risk-stratification tools may help find effective treatments to reduce the risk of IPN,thereby achieving individualized treatment.

关键词： Acute pancreatitis Infected pancreatic necrosis Biomarker Scoring system Nutrition therapy Selective digestive decontamination Probiotics Antibiotics Immune enhancement therapy

Preparation of CF/Ni-Fe/CNT/silicone layered rubber for aircraft sealing and electromagnetic interference shielding applications

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Chinese Journal of Aeronautics 2021年第10期34卷 91-102页

作者： Wanying luAN qin WANG qi SUN Yinxiang lu Department of Materials Science Fudan UniversityShanghai 200433China

To meet the needs of preventing information leakage in space engineering and military industry,an efficient method was introduced to obtain layered electromagnetic shielding sealing *** carbon fiber,Ni-Fe coating,and Carbon Nano Tube(CNT)were combined by chemical plating and in-situ polymerization to obtain a lightweight(0.14 g/cm^(2))and thin(1 mm thick)Carbon fiber Fabric(CF)/Ni-Fe/CNT/silicone layered electromagnetic shielding *** layered material obtained by adjusting the electroless plating time exhibited a high Shielding Efficiency(SE)of 60.2–85.5 d B in the range of 0–4800 MHz,which can be used for aviation electromagnetic *** fibers and carbon nanotubes mainly attenuated electromagnetic waves through absorption loss,while the nickel-iron alloy coating through reflection loss interacted with the magnetic vector of incident Electro Magnetic(EM)radiation and magnetic dipoles,therefore,the EM Interference(EMI)shielding composite attenuated EM waves with the“absorptionreflection-absorption”cooperative ***,the flexible fabric substrate adhered with silicone rubber possessed a breaking elongation of 52.3%,which can be utilized as a good sealing ***,the outstanding exothermicity(67.2℃ under the applied voltage of 5 V)makes it possible to be applied in electric heating *** electromagnetic shielding composites prepared in this paper have good potential in the fields of precision electronic equipment and aviation systems.

关键词： Electroless plating Electromagnetic interference shielding Heating effects Nickel-iron(Ni-Fe)coating Sealing rubber

基于纳秒LIBS的氢气/空气火焰混合分数测量研究

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光谱学与光谱分析 2025年第1期45卷 24-29页

作者：刘子晗刘艳韩磊单沅鲁政高强李帅瑶李博天津大学内燃机燃烧学国家重点实验室天津300072 中国科学院工程热物理研究所北京100190

在双碳政策和化石能源短缺的背景下,氢能作为高效环保的清洁能源,受到广大研究人员的关注。氢气/空气混合燃烧作为推动氢能规模化应用的重要途径,其燃烧机理和关键参数的测量技术成为目前研究的热点。燃空当量比是表征燃烧过程中燃料与... 详细信息

在双碳政策和化石能源短缺的背景下,氢能作为高效环保的清洁能源,受到广大研究人员的关注。氢气/空气混合燃烧作为推动氢能规模化应用的重要途径,其燃烧机理和关键参数的测量技术成为目前研究的热点。燃空当量比是表征燃烧过程中燃料与氧化剂混合程度的重要参数,直接影响燃烧的开始、自持以及燃烧化学反应的活跃程度。因此,对燃烧过程中的局部当量比实时在线监测,对于改善燃烧效率、控制燃烧过程具有重要意义。目前,可以实时测量氢气/空气火焰当量比的方法相对较少,激光光谱技术作为一种非侵入式的测量方法,不仅具有实时在线测量的能力,还具有快速、原位、远程分析、多元素同时在线监测等特点,在燃烧测量领域具有重要的应用潜力。采用纳秒激光诱导击穿光谱技术对氢气和空气燃烧场的燃空当量比进行测量研究。氢气和空气在管内混合后,由射流口喷出形成射流燃烧火焰场。激光通过透镜聚焦到射流燃烧场中击穿并产生等离子体,其等离子体的发射光谱由光谱仪采集,实验发现光谱中H 656 nm和O 777 nm具有很强的发射强度,且光谱强度随着当量比的变化,呈现规律性变化趋势。因此,采用H 656 nm和O 777 nm的光谱分别标示氢气和空气,并将其比值作为燃空当量比的测量参量。实验在氢气空气混合均匀的低速流场中测量了不同当量比下H 656 nm与O 777 nm的光谱强度比值,并与当量比建立标定曲线,实验发现该标定曲线对燃烧场和非燃烧场同样适用。基于标定曲线,我们研究了存在外界掺混情况下,射流燃烧场的局部燃空当量比情况。在当量比1.0,流场速度为20 m·s^(-1)的射流燃烧场中,测量了射流中心位置不同高度的燃空当量比变化情况,并在相同工况下进行了数值模拟。模拟结果与实验测量吻合较好,验证了纳秒激光诱导击穿光谱技术测量氢气/空气混合气的燃空当量比的可行性。该方法可为氢气燃烧基础研究及数值模拟提供技术支持。

关键词：激光诱导击穿光谱氢能当量比模拟

Global Regularity for a 2D Model of Electro-Kinetic Fluid in a Bounded Domain

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Acta Mathematicae Applicatae Sinica 2018年第2期34卷 398-403页

作者： Miao-chao CHEN Sheng-qi lu qi-lin LIU School of Applied Mathematics Chaohu University Anhui 238000 China Department of Mathematics and Physics Sanjiang University Jiangsu 210012 China School of Mathematics Southeast University Jiangsu 211189 China

In this paper, we consider an initial boundary value problem for a 2D model of electro-kinetic fluid in a smooth and bounded domain. We prove that the model has a unique global-in-time smooth solution.

关键词： euler equations electro-hydrodynamics global regularity

An endoparasitoid uses its egg surface proteins to regulate its host immune response

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Insect Science 2022年第4期29卷 1030-1046页

作者： zi-Wen Teng Hui-zi Wu Xin-Hai Ye qi Fang Hong-Xu Zhou Gong-Yin Ye China-Australia Cooperation Base of Crop Health and Invasive Species China-Australia Joint Institute of Agricultural and Environmental HealthCollege of Plant Health and MedicineQingdao Agricultural UniversityQingdaoShandong ProvinceChina State Key Laboratory of Rice Biology Ministry of Agricultural and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and InsectsKey Laboratory of Biology of Crop Pathogens and Insects of Zhejiang ProvinceInstitute of Insect SciencesZhejiang UniversityHangzhouChina

With proteomic analysis,we identified 379 egg surface proteins from an endoparasitoid,Cotesia *** containing conserved enzymatic domains constitute a large proportion of egg surface *** proteins,such as superoxidase dismutase,homolog of *** 32-kDa protein,and immunoevasive protein-2A,are classical parasitism factors that have known functions in host immunity *** assays revealed that a novel egg surface protein,*** egg surface serpin domain-containing protein had the same function as a *** venom serpin,as both suppressed host melanization in a dose-dependent *** egg surface serpin domain-containing protein is mainly transcribed in *** oocytes with follicular cells,and it is located on both the anterior and posterior sides of the mature egg ***,we used LC-MS/MS to identify 586 binding proteins sourced from *** plasma located on the eggshell surface of ***,which included some immunity-related *** results not only indicate that *** uses its egg surface proteins to reduce the immune response of its host but also imply that endoparasitoid egg surface proteins might be a new parasitism factor involved in host immune regulation.

关键词： egg surface protein immune regulation melanization parasitism factor parasitoid wasp

Techniques for increasing the yield of stem cell-derived exosomes:what factors may be involved?

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Science China(Life Sciences) 2022年第7期65卷 1325-1341页

作者： zi-Yuan Feng qing-Yi Zhang Jie Tan Hui-qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Exosomes are nano-scale extracellular vesicles secreted by cells and constitute an important part in the cell-cell *** main contents of the exosomes include proteins,micro RNAs,and *** mechanism and safety of stem cell-derived exosomes have rendered them a promising therapeutic strategy for regenerative ***,limited yield has restrained full explication of their functions and clinical *** address this,various attempts have been made to explore the up-and down-stream manipulations in a bid to increase the production of *** review has recapitulated factors which may influence the yield of stem cell-derived exosomes,including selection and culture of stem cells,isolation and preservation of the exosomes,and development of artificial exosomes.

关键词： exosome stem cell yield therapy