Screening and regulatory network analysis of survival-related genes of patients with colorectal cancer

作     者：QI Lu DING YanQing 

作者机构：Department of PathologySchool of Basic Medical SciencesSouthern Medical University Department of PathologyNanfang HospitalSouthern Medical University 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第5期

页      面：526-531页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Joint Funds of the National Natural Science Foundation of China(U1201226) the National Natural Science Foundation of China(30670967) 

主　　题：survival time colorectal cancer transcription factor bioinformatics 

摘      要：The purpose of this study was to screen key survival-related genes from patients with colorectal cancer and explore signal transduction network of the involved *** a previous study,survival-related genes of patients with colorectal cancer were selected by colorectal cancer-related expression data GSE17538 using the Significance Analysis of Microarrays(SAM3.01)software,and 235 genes related to the survival of patients with colorectal cancer were ***,the following screening and analysis were conducted on these 235 genes in this ***,the enrichment analysis of transcription factor binding sites was conducted on the 235 *** with more than seven transcription factor binding sites were ***,these genes and upregulated genes in colorectal cancer were ***,survival analysis and regulatory network analysis were conducted on the screened *** allowed clarification of the relationship between these genes and the survival of patients with colorectal cancer and the signaling network involving these genes in the cell signal transduction network of colorectal *** the above analysis,six upregulated genes in colorectal cancer related to the survival of colorectal cancer patients and highly regulated by transcription factors were selected,namely STX2,PODXL,KLK6,GRB10,EHBP1 and *** genes are involved in signal regulatory networks related to colorectal cancer metastasis-related signaling ***,the survival of patients with colorectal cancer is closely correlated with colorectal cancer *** six survival-related genes affect the survival of patients by regulating colorectal cancer metastasis-associated signaling pathways.