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Anterior vs conventional approach right hepatic resection for large hepatocellular carcinoma:A systematic review and meta-analysis

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World Journal of Gastroenterology 2017年第44期23卷 7917-7929页

作者： Jian-Xin Tang Jin-Jun Li Rui-Hui Weng zi-ming liang Nan Jiang Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat-sen University Department of Neurology The Third Affiliated Hospital of Sun Yat-sen University

AIM To compare the clinical outcomes of right hepatectomy for large hepatocellular carcinoma via the anterior and conventional *** We comprehensively performed an electronic search of Pub Med, EMBASE, and the Cochrane Library for randomized controlled trials(RCTs) or controlled clinical trials(CCTs) published between January 2000 and May 2017 concerning the anterior approach(AA) and the conventional approach(CA) to right hepatectomy. Studies that met the inclusion criteria were included, and their outcome analyses were further assessed using a fixed or random effects *** This analysis included 2297 patients enrolled in 16 studies(3 RCTs and 13 CTTs). Intraoperative blood loss [weighted mean difference =-255.21; 95% confidence interval(95%CI):-371.3 to-139.12; P < 0.0001], intraoperative blood transfusion [odds ratio(OR) = 0.42; 95%CI: 0.29-0.61; P < 0.0001], mortality(OR = 0.59; 95%CI: 0.38-0.92; P = 0.02), morbidity(OR = 0.77; 95%CI: 0.62-0.95; P = 0.01), and recurrencerate(OR = 0.62; 95%CI: 0.47-0.83; P = 0.001) were significantly reduced in the AA group. Patients in the AA group had better overall survival(hazard ratio [HR] = 0.71; 95%CI: 0.50-1.00; P = 0.05) and disease-free survival(HR = 0.67; 95%CI: 0.58-0.79; P < 0.0001) than those in the CA *** The AA is safe and effective for right hepatectomy for large hepatocellular carcinoma and could accelerate postoperative recovery and achieve better survival outcomes than the CA.

关键词： Anterior approach Conventional approach Right hepatectomy Hepatocellular carcinoma Postoperative complication Survival

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Topological approach of liver segmentation based on 3D visualization technology in surgical planning for split liver transplantation

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World Journal of Gastrointestinal Surgery 2022年第10期14卷 1141-1149页

作者： Dong Zhao Kang-Jun Zhang Tai-Shi Fang Xu Yan Xin Jin zi-ming liang Jian-Xin Tang Lin-Jie Xie Department of Liver Surgery and Organ Transplantation Center The Third People's Hospital of ShenzhenThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

BACKGROUND Split liver transplantation(SLT)is a complex *** left-lateral and right tri-segment splits are the most common surgical approaches and are based on the Couinaud liver segmentation ***,the liver surface following right trisegment splits may exhibit different degrees of ischemic changes related to the destruction of the local portal vein blood flow *** is currently no consensus on preoperative evaluation and predictive strategy for hepatic segmental necrosis after *** To investigate the application of the topological approach in liver segmentation based on 3D visualization technology in the surgical planning of *** Clinical data of 10 recipients and 5 donors who underwent SLT at Shenzhen Third People’s Hospital from January 2020 to January 2021 were retrospectively *** surgery,all the donors were subjected to 3D modeling and *** on the 3D-reconstructed models,the liver splitting procedure was simulated using the liver segmentation system described by Couinaud and a blood flow topology liver segmentation(BFTLS)*** addition,the volume of the liver was also *** indexes mainly included the hepatic vasculature and expected volume of split grafts evaluated by 3D models,the actual liver volume,and the ischemia state of the hepatic segments during the actual *** Among the 5 cases of split liver surgery,the liver was split into a left-lateral segment and right trisegment in 4 cases,while 1 case was split using the left and right half liver *** operations were successfully implemented according to the preoperative *** to Couinaud liver segmentation system and BFTLS methods,the volume of the left lateral segment was 359.00±101.57 mL and 367.75±99.73 mL,respectively,while that measured during the actual surgery was 397.50±37.97 *** volume of segment IV(the portion of ischemic liver lobes)allocated to the right tri-segment was 136.31±86.10 mL

关键词： Three-dimensional visualization Couinaud liver segmentation Blood flow topology liver segmentation Split liver transplantation Surgical planning

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NUDT5 promotes the growth,metastasis,and Warburg effect of IDH wild-type glioblastoma multiforme cells by upregulating TRIM47

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 82-92页

作者： zi-Fa Zhang Shu-ming Liu Neurosurgery Department Shanxi Bethune HospitalTaiyuanShanxi Province030022China Shanxi Academy of Medical Sciences TaiyuanShanxi province030022China Emergency Department Taiyuan People’s HospitalTaiyuanShanxi Province030021China

Objective:To explore the regulatory mechanism of NUDT5 in glioblastoma multiforme(GBM).Methods:GEPIA database was used to predict the expressions of NUDT5 and tripartite motif family proteins 47(TRIM47)in GBM ***-qPCR and Western blot analyses were performed to examine NUDT5 expression in GBM ***-229 cell proliferation,migration as well as invasion were estimated by CCK-8,colony formation,wound healing,and Transwell assays following interference with *** assay,L-lactic acid kit,glucose detection kit,and ATP detection kit were applied for the detection of glycolysis-related ***-immunoprecipitation experiment was carried out to verify the relationship between NUDT5 and ***:GEPIA database showed that NUDT5 expression was significantly increased in GBM *** the expression of NUDT5 in GBM cells significantly suppressed the viability,proliferation,invasion,migration,and glycolysis of GBM ***,TRIM47 was highly expressed in GBM cells and interacted with *** of TRIM47 partially reversed the inhibitory effect of NUDT5 downregulation on the proliferation,metastasis,and glycolysis of GBM ***:NUDT5 promotes the growth,metastasis,and Warburg effect of GBM cells by upregulating *** NUDT5 and TRIM47 can be used as targets for GMB treatment.

关键词： Glioblastoma multiforme NUDT5 TRIM47 Growth Metastasis Warburg effect

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Reconstructing the portal vein through a posterior pancreatic tunnel:New choice for portal vein thrombosis during liver transplantation

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World Journal of Gastrointestinal Surgery 2022年第10期14卷 1131-1140页

作者： Dong Zhao Yi-ming Huang zi-ming liang Kang-Jun Zhang Tai-Shi Fang Xu Yan Xin Jin Yi Zhang Jian-Xin Tang Lin-Jie Xie Xin-Chen Zeng Department of Liver Surgery and Organ Transplantation Center The Third People’s Hospital of ShenzhenThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

BACKGROUND Thrombectomy and anatomical anastomosis(TAA)has long been considered the optimal approach to portal vein thrombosis(PVT)in liver transplantation(LT).However,TAA and the current approach for non-physiological portal reconstructions are associated with a higher rate of complications and mortality in some *** To describe a new choice for reconstructing the portal vein through a posterior pancreatic tunnel(RPVPPT)to address cases of unresectable *** Between August 2019 and August 2021,245 adult LTs were ***-five(18.4%)patients were confirmed to have PVT before surgery,among which seven underwent PV reconstruction via the RPVPPT *** retrospectively analyzed the surgical procedure and postoperative complications of these seven recipients that underwent PV reconstruction due to *** During the procedure,PVT was found in all the seven cases with significant adhesion to the vascular wall and could not be *** portal vein proximal to the superior mesenteric vein was damaged in one case when attempting thrombolectomy,resulting in massive *** was successfully performed in all patients with a mean duration of 585 min(range 491-756 min)and mean intraoperative blood loss of 800 mL(range 500-3000 mL).Postoperative complications consisted of chylous leakage(n=3),insufficient portal venous flow to the graft(n=1),intra-abdominal hemorrhage(n=1),pulmonary infection(n=1),and perioperative death(n=1).The remaining six patients survived at 12-17 mo *** The RPVPPT technique might be a safe and effective surgical procedure during LT for complex ***,follow-up studies with large samples are still warranted due to the relatively small number of cases.

关键词： Liver transplantation Portal vein thrombosis Portal vein reconstruction Retropancreatic tunnel Computer tomography angiography Three-dimensional visualization

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Outcomes of ABO-incompatible liver transplantation in end-stage liver disease patients co-infected with hepatitis B and human immunodeficiency virus

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World Journal of Gastroenterology 2023年第11期29卷 1745-1756页

作者： Jian-Xin Tang Kang-Jun Zhang Tai-Shi Fang Rui-Hui Weng zi-ming liang Xu Yan Xin Jin Lin-Jie Xie Xin-Chen Zeng Dong Zhao Department of Liver Surgery and Organ Transplantation Center The Third People's Hospital of Shenzhen(The Second Affiliated Hospital of Southern University of Science and Technology)Shenzhen 518000Guangdong ProvinceChina Department of Neurology The Third People’s Hospital of Shenzhen(The Second Affiliated Hospital of Southern University of Science and Technology)Shenzhen 518000Guangdong ProvinceChina Department of Liver Surgery and Organ Transplantation Center National Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-positive patients coinfected with hepatitis B virus(HBV)are eligible for liver transplantation(LT)in Africa and Southeast Asia,particularly ***,the outcome of HIV-HBV coinfected patients referred for ABO-incompatible LT(ABOi-LT)is *** To clarify the outcome of ABOi-LT for HIV-HBV coinfected patients with endstage liver disease(ESLD).METHODS We report on two Chinese HIV-HBV coinfected patients with ESLD who underwent A to O brain-dead donor LT and reviewed the literature on HIV-HBV coinfected patients treated with ABO-compatible *** pretransplantation HIV viral load was undetectable,with no active opportunistic *** therapy consisted of two sessions of plasmapheresis and a single dose of rituximab in two split doses,followed by an intraoperative regimen of intravenous immunoglobulin,methylprednisolone,and ***-transplant maintenance immunosuppressive agents consisted of tacrolimus and mycophenolate mofetil,and *** At the intermediate-term follow-up,patients showed undetectable HIV viral load,CD4(+)T cell counts greater than 150 cells/μL,no HBV recurrence,and stable liver function.A liver allograft biopsy showed no evidence of acute cellular *** patients survived at 36-42 mo of *** This is the first report of ABOi-LT in HIV-HBV recipients with good intermediate-term outcomes,suggesting that ABOi-LT may be feasible and safe for HIV-HBV coinfected patients with ESLD.

关键词： ABO incompatibility liver transplantation Human immunodeficiency virus Hepatitis B virus End-stage liver disease Immunosuppression

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Bearing mechanism of roof and rib support structure in automatically formed roadway and its support design method

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Journal of Central South University 2024年第7期31卷 2467-2487页

作者： JIANG Bei WANG ming-zi WANG Qi XIN Zhong-xin XING Xue-yang DENG Yu-song YAO liang-di State Key Laboratory for Tunnel Engineering China University of Mining and Technology-BeijingBeijing 100083China Research Center of Geotechnical and Structural Engineering Shandong UniversityJi􀆳nan 250061China College of Civil Engineering and Architecture Shandong University of AeronauticsBinzhou 256600China

Non-pillar mining technology with automatically formed roadway is a new mining method without coal pillar reservation and roadway *** stability control of automatically formed roadway is the key to the successful application of the new *** order to realize the stability control of the roadway surrounding rock,the mechanical model of the roof and rib support structure is established,and the influence mechanism of the automatically formed roadway parameters on the compound force is *** this basis,the roof and rib support structure technology of confined lightweight concrete is proposed,and its mechanical tests under different eccentricity are carried *** results show that the bearing capacity of confined lightweight concrete specimens is basically the same as that of ordinary confined concrete *** bearing capacity of confined lightweight concrete specimens under different eccentricities is 1.95 times higher than those of U-shaped steel *** comparing the test results with the theoretical calculated results of the confined concrete,the calculation method of the bearing capacity for the confined lightweight concrete structure is *** design method of confined lightweight concrete support structure is established,and is successfully applied in the extra-large mine,Ningtiaota Coal Mine,China.

关键词： automatically roadway with non-pillar confined lightweight concrete roof and rib support mechanical model bearing behaviour

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Uniqueness on Difference Operators of Meromorphic Functions of Infinite Order

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Acta Mathematica Sinica,English Series 2024年第2期40卷 511-527页

作者： Hui LI ming liang FANG Xiao YAO School of Science China University of Mining and TechnologyBeijing 100083P.R.China Institute of Mathematics Academy of Mathematics and System SciencesChinese Academy of SciencesBeijing 100190P.R.China School of Sciences Hangzhou Dianzi UniversityHangzhou 310012P.R.China School of Mathematical sciences and LPMC Nankai UniversityTianjin 300071P.R.China

We investigate the uniqueness problems of meromorphic functions and their difference operators by using a new *** is proved that if a non-constant meromorphic function f shares a non-zero constant and ∞ counting multiplicities with its difference operators Δcf(z) and Δ_(c)^(2)f(z), thenΔcf(z)≡Δ_(c)^(2)f(z).In particular,we give a difference analogue of a result of *** method has two distinct features:(ⅰ) It converts the relations between functions into the corresponding *** makes it possible to deal with the uniqueness problem by linear algebra and combinatorics.(ⅱ) It circumvents the obstacle of the difference logarithmic derivative lemma for meromorphic functions of infinite order,since this method does not depend on the growth of the ***,the idea in this paper can also be applied to the case for several variables.

关键词： Uniqueness meromorphic functions difference operators infinite order

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Signifying quantum uncertainty relations by optimal observable sets and the tightest uncertainty constants

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 43-50页

作者： Xiao-Bin liang Bo Li Shao-ming Fei School of Mathematics and Computer Science Shangrao Normal UniversityShangrao 334001China Quantum Information Research Center Shangrao Normal UniversityShangrao 334001China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China

Quantum uncertainty relations constrain the precision of measurements across multiple non-commuting quantum mechanical ***,we introduce the concept of optimal observable sets and define the tightest uncertainty constants to accurately describe these measurement *** any quantum state,we establish optimal sets of three observables for both product and summation forms of uncertainty relations,and analytically derive the corresponding tightest uncertainty *** demonstrate that the optimality of these sets remains consistent regardless of the uncertainty relation ***,the existence of the tightest constants excludes the validity of standard real quantum mechanics,underscoring the essential role of complex numbers in this ***,our findings resolve the conjecture posed in[***.118,180402(2017)],offering novel insights and potential applications in understanding preparation uncertainties.

关键词： uncertainty relation the tightest uncertainty constants optimal observable sets

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Supramolecular polymer network constructed by a functionalized polyimidazolium salt derived from metal-carbene template approach

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Science China Chemistry 2024年第4期67卷 1224-1228页

作者： ming-ming Gan zi-En Zhang Yi-Fan Zhang Heng Zhang Li-Ying Sun Ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China

In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane *** strategy involves the formation of metal-carbene templates,photochemical cycloaddition,and subsequent demetallation of metal *** by the host-guest chemistry between crown ether units and ammonium salts,we successfully fabricated a supramolecular polymer SPN1,which features imidazolium receptors and cyclobutane *** obtained SPN1 demonstrates outstanding reversible stimulus-response,antibacterial behavior and conductivity.

关键词： metal-carbene template crown ether polyimidazolium salt host-guest chemistry

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Intelligent geochemical interpretation of mass chromatograms:Based on convolution neural network

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Petroleum Science 2024年第2期21卷 752-764页

作者： Kai-ming Su Jun-Gang Lu Jian Yu zi-Xing Lu Shi-Jia Chen Hubei Key Laboratory of Petroleum Geochemistry and Environment Wuhan430100HubeiChina College of Resources and Environment Yangtze UniversityWuhan430100HubeiChina School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500SichuanChina Changqing Oilfield Company PetroChinaXi'an710021ShaanxiChina

Gas chromatography-mass spectrometry(GC-MS)is an extremely important analytical technique that is widely used in organic *** is the only approach to capture biomarker features of organic matter and provides the key evidence for oil-source correlation and thermal maturity ***,the conventional way of processing and interpreting the mass chromatogram is both timeconsuming and labor-intensive,which increases the research cost and restrains extensive applications of this *** overcome this limitation,a correlation model is developed based on the convolution neural network(CNN)to link the mass chromatogram and biomarker features of samples from the Triassic Yanchang Formation,Ordos Basin,*** this way,the mass chromatogram can be automatically *** research first performs dimensionality reduction for 15 biomarker parameters via the factor analysis and then quantifies the biomarker features using two indexes(*** and PMI)that represent the organic matter thermal maturity and parent material type,***,training,interpretation,and validation are performed multiple times using different CNN models to optimize the model structure and hyper-parameter setting,with the mass chromatogram used as the input and the obtained MI and PMI values for supervision(label).The optimized model presents high accuracy in automatically interpreting the mass chromatogram,with R2values typically above 0.85 and0.80 for the thermal maturity and parent material interpretation results,*** significance of this research is twofold:(i)developing an efficient technique for geochemical research;(ii)more importantly,demonstrating the potential of artificial intelligence in organic geochemistry and providing vital references for future related studies.

关键词： Organic geochemistry Biomarker Mass chromatographic analysis Automated interpretation Convolution neural network Machine learning

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