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Extracorporeal continuous portal diversion plus temporal plasmapheresis for “small-for-size” syndrome

World Journal of Gastroenterology 2013年第33期19卷 5464-5472页

作者： Peng Hou Chao Chen Yu-Liang Tu zi-man zhu Jing-Wang Tan Institute of Gastroenterology The First Affiliated Hospital of Chinese PLA General Hospital Institute of Hepatobiliary Surgery The First Affiliated Hospital of Chinese PLA General Hospital

AIM:To investigate the effect of plasmapheresis via the portal vein for"small-for-size"syndrome(SFSS)aided by extracorporeal continuous portal diversion(ECPD).METHODS:Extensive or total hepatectomy in the pig is usually adopted as a postoperative liver failure(PLF)or SFSS *** this study,animals which underwent85%-90%hepatectomy were randomized into either the Systemic group(n=7)or the Portal group(n=7).In the Systemic group,all pigs received temporal plasmapheresis(PP)via the extracorporeal catheter circuit(systemic to systemic circulation)from 24 to 30 h posthepatectomy(PH);in the Portal group,all pigs received ECPD to divert partial portal vein flow(PVF)to the systemic circulation after hepatectomy,then converted to temporal PP from 24 to 30 h PH,and subsequently converted to ECPD again until 48 h *** the Portal group,the PVF was preserved at 3.0-3.3 times that of the baseline value,similar to that following 70%hepatectomy,which was regarded as the optimal PVF to the hypertrophic liver *** 48 h PH,all pigs were re-opened and the portal vein pressure(PVP),PVF,and HAF(hepatic artery flow)were measured,and then diversion of the portal venous flow was ***1 h the PVP,PVF,and HAF were *** portal hemodynamic changes,liver injury,liver regeneration and bacterial/lipopolysaccharide(LPS)translocation were evaluated in the two ***:The PVP in the Portal group was significantly lower than that in the Systemic group during the time period from 2 to 49 h PH(P<0.05).Serum alanine aminotransferase(ALT),total bilirubin(TB)and ammonia were significantly reduced in the Portal group compared with the Systemic group from 24 to 48 h PH(P<0.05).The Portal group may have attenuated sinusoidal endothelial injury and decreased the level of HA compared with the Systemic *** the Systemic group,there was significant sinusoidal dilation,hydropic changes in hepatocytes and hemorrhage into the hepatic parenchyma,and the sinusoidal endothelial

关键词： Small-for-size syndrome Postoperative liver failure Extracorporeal portal diversion Plasmapheresis Hepatectomy

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Impact of mesocaval shunt on safe minimal liver remnant:Porcine model

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World Journal of Gastroenterology 2013年第31期19卷 5076-5084页

作者： Yu-Liang Tu Xuan Wang Da-Dong Wang zi-man zhu Jing-Wang Tan Department of Hepatobiliary Surgery the First Affiliated Hospital Chinese PLA General Hospital Department of Hepatobiliary Surgery Chinese PLA No. 81 Hospital

AIM: To investigate the capacity of shunts to relieve portal hypertension and decrease the safe minimal liver remnant in ***: A subtotal hepatectomy with < 60 mL blood loss and without hepatic pedicle occlusion was *** mesenteric venous inflow was diverted through a mesocaval shunt(MCS) constructed using the prepared left renal vein with an end-to-side running suture of 5-0 *** 21 animals that underwent subtotal hepatectomy and/or MCS were divided into three *** the 15% group,the residual volume was 14%-19% of total liver volume(TLV);in the 15%+ S group,the residual volume was also 14%-19% of TLV with a mesocaval shunt(MCS);and in the 10%+ S group,the residual volume was 8%-13% of TLV with an *** the three groups,the intraoperative portal vein pressure(PVP) and portal vein flow(PVF) were monitored and compared at laparotomy and 1 h *** survival rate,sinusoidal endothelial damage,tissue analysis,and serum analysis were investigated among the three ***: The percentage residual liver volume was 15.9%,16.1% and 11.8% in the 15%,15%+ S,10%+ S groups,*** hepatectomy,PVF and portal-to-arterial flow ratio in the 15%+ S group significantly decreased and hepatic artery flow(HAF) per unit volume significantly increased,compared to those in the 15% *** PVP in the 15%+ S group and 10%+ S group increased slightly from that measured at laparotomy;however,in the 15% group,the PVP increased immediately and significantly above that observed in the other two *** 14-d survival rates were 28.5%,85.6%,and 14.2% in the 15%,15%+ S,and 10%+ S groups,*** the 15%+ S group,the shunts effectively attenuated injury to the sinusoidal endothelium,and the changes in the serum and tissue analysis results were significantly reduced compared to those in the 15% and 10%+ S ***: MCS can decompress the portal vein and so attenuate liver injury from hyperperfusion,and make extreme or margin

关键词： Hepatectomy Safe minimal remnant volume Mesocaval shunt Pigs

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Should temporary extracorporeal continuous portal diversion replace meso/porta-caval shunts in “small-for-size” syndrome in porcine hepatectomy?

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World Journal of Gastroenterology 2015年第3期21卷 888-896页

作者： Da-Dong Wang Yong Xu zi-man zhu Xiang-Long Tan Yu-Liang Tu Ming-Ming Han Jing-Wang Tan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chinese PLA General Hospital

AIM:To investigate the feasibility of temporary extracorporeal continuous porta-caval diversion(ECPD) to relieve portal hyperperfusion in "small-for-size" syndrome following massive hepatectomy in ***:Fourteen pigs underwent 85%-90% liver resection and were then randomly divided into thecontrol group(n = 7) and diversion group(n = 7).In the diversion group,portal venous blood was aspirated through the portal catheter and into a tube connected to a centrifugal *** filtration,the blood was returned to the pig through a double-lumen catheter inserted into the internal jugular or subclavian *** the conversion pump,portal venous inflow was partially diverted to the inferior vena cava through a catheter inserted via the gastroduodenal vein at 100-130 m L/*** hemodynamics,injury,and regeneration in the liver remnant were compared between the two ***:Compared to the control group,porta-caval diversion via ECPD significantly mitigated excessive portal venous flow and portal vein pressure(PVP); the portal vein flow(PVF),hepatic artery flow(HAF),and PVP in the two groups were not significantly different at baseline; however,the PVF(431.8 ± 36.6 vs 238.8 ± 29.3,P manent meso/porta-caval shunts in "smallfor-size" synd

关键词： small-for-size syndrome Extracorporeal continuous

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Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation:a case-control study

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Neural Regeneration Research 2022年第5期17卷 1051-1058页

作者： Pei-Ling Huang Song-Jian Wang Rui-Feng Sun zi-man zhu Xiao-Ling Li Wen-Shan Li Meng-Yue Wang Meng Lin Wei-Jun Gong Department of Neurological Rehabilitation Beijing Rehabilitation Hospital of Capital Medical UniversityBeijingChina Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application School of Biomedical EngineeringCapital Medical UniversityBeijingChina Department of Neurological Rehabilitation Beijing Rehabilitation Medicine AcademyCapital Medical UniversityBeijingChina

Repetitive transcranial magnetic stimulation(r TMS)has been shown to effectively improve impaired swallowing in Parkinson's disease(PD)patients with ***,little is known about how r TMS affects the corresponding brain regions in this patient *** this casecontrol study,we examined data from 38 PD patients with dysphagia who received treatment at Beijing Rehabilitation Medicine Academy,Capital Medical *** patients received high-frequency r TMS of the motor cortex once per day for 10 successive *** in brain activation were compared via functional magnetic resonance imaging in PD patients with dysphagia and healthy *** results revealed that before treatment,PD patients with dysphagia showed greater activation in the precentral gyrus,supplementary motor area,and cerebellum compared with healthy controls,and this enhanced activation was weakened after ***,before treatment,PD patients with dysphagia exhibited decreased activation in the parahippocampal gyrus,caudate nucleus,and left thalamus compared with healthy controls,and this activation increased after *** addition,PD patients with dysphagia reported improved subjective swallowing sensations after r *** findings suggest that swallowing function in PD patients with dysphagia improved after r TMS of the motor *** may have been due to enhanced activation of the caudate nucleus and parahippocampal *** study protocol was approved by the Ethics Committee of Beijing Rehabilitation Hospital of Capital Medical University(approval No.2018 bkky017)on March 6,2018 and was registered with Chinese Clinical Trial Registry(registration *** CTR 1800017207)on July 18,2018.

关键词： brain regions caudate clinical trial dysphagia functional magnetic resonance imaging parahippocampal gyrus Parkinson's disease precentral gyrus repetitive transcranial magnetic stimulation saliva swallowing task

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Feasibility and safety of “bridging” pancreaticogastrostomy for pancreatic trauma in Landrace pigs

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World Journal of Gastrointestinal Surgery 2021年第5期13卷 419-428页

作者： Jian Feng Hang-Yu Zhang Li Yan zi-man zhu Bin Liang Peng-Fei Wang Xiang-Qian Zhao Yong-LiangChen Department of Hepatopancreatobiliary Surgery Peking University Shougang HospitalBeijing 100144China Faculty of Hepato-Pancreato-Biliary Surgery Institute of Hepatobiliary Surgery of Chinese PLAKey Laboratory of Digital Hepetobiliary SurgeryChinese PLA General HospitalBeijing 100853China

BACKGROUND In recent years,we created and employed a new anastomosis method,“bridging”pancreaticogastrostomy,to treat patients with extremely severe pancreatic *** surgery has advantages such as short length of surgery,low secondary trauma,rapid construction of shunts for pancreatic fluid,preventing second surgeries,and achieving good treatment outcomes in clinical ***,due to the limited number of clinical cases,there is a lack of strong evidence to support the feasibility and safety of this surgical ***,we carried out animal experiments to examine this procedure,which is reported *** To examine the feasibility and safety of a new rapid method of pancreaticogastrostomy,“bridging”*** Ten Landrace pigs were randomized into the experimental and control groups,with five pigs in each group.“Bridging”pancreaticogastrostomy was performed in the experimental group,while routine mucosa-to-mucosa pancreaticogastrostomy was performed in the control *** surgery,the general condition,amylase levels in drainage fluid on Days 1,3,5,and 7,fasting and 2-h postprandial blood glucose 6 mo after surgery,fasting,2-h postprandial peripheral blood insulin,and portal vein blood insulin 6 mo after surgery were *** was carried out at 1 and 6 mo after the former one to examine the condition of the abdominal cavity and firmness and tightness of the pancreaticogastric anastomosis and *** After surgery,the general condition of the animals was *** in the control group did not gain weight 6 mo after surgery,whereas significant weight gain was present in the *** were significant differences on Days 1 and 3 after surgery between the two groups but no differences on Days 5 and *** were no differences in fasting and 2-h postprandial blood glucose and fasting and 2-h insulin values of postprandial peripheral blood and portal vein blood 6 mo after surgery between the two ***

关键词： Pancreatic trauma Damage control surgery “Bridging”pancreaticogastrostomy Severe pancreatic injury Safety

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Silencing phospholipid scramblase 1 expression by RNA interference in colorectal cancer and metastatic liver cancer

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 393-400页

作者： Wei Cui,Shi-Yong Li,Jun-Feng Du,zi-man zhu and Ping An Department of General Surgery,General Surgery Center of the PLA,General Hospital of Beijing Military Command,Beijing 100700,China Department of Hepatobiliary Surgery,First Affiliated Hospital,General Hospital of the PLA,Beijing 100037,China [a] Department of General Surgery General Surgery Center of the PLA General Hospital of Beijing Military Command Beijing 100700 China [b] Department of Hepatobiliary Surgery First Affiliated Hospital General Hospital of the PLA Beijing 100037 China

BACKGROUND:Phospholipid scramblase 1(PLSCR1) not only participates in the transbilayer movement of phospholipids,but also plays a role in the pathogenesis and progression of *** present study aimed to evaluate the effect of silencing PLSCR1 expression by RNA interference in colorectal cancer(CRC) and metastatic liver ***:The expression of PLSCR1 in CRC and metastatic liver cancer samples was assessed by *** cultured cells with the highest expression were selected for subsequent *** designed three siRNA oligonucleotide segments targeted at *** transfection was *** biological behavior of the cells in proliferation,adhesion,migration and invasion was ***:PLSCR1 protein expression increased significantly in the majority of CRC and metastatic liver cancer samples compared with normal *** cells had the highest expression of *** siRNA-390 oligonucleotide segment had the best silencing *** transfection,Lovo cell proliferation was significantly inhibited compared with the controls in the MTT *** and fibronectin adhesion assays showed Lovo cell adhesion was also significantly *** the migration assay,the number of migrating cells in the PLSCR1 siRNA-390 group was 50±12,significantly lower than the number in the siRNA-N group(115±28) and in the control group(118±31).In an invasion test,the number of invading cells in the PLSCR1 siRNA-390 group was 60±18,significantly lower than that in the siRNA-N group(97±26) and the control group(103±24).CONCLUSIONS:PLSCR1 is overexpressed in CRC and metastatic liver *** of PLSCR1 by siRNA inhibits the proliferation,adhesion,migration and invasion of Lovo cells,which suggests that PLSCR1 contributes to the tumorigenesis and tumor progression of ***1 may be a potential gene therapy target for CRC and associated metastatic liver cancer.

关键词： phospholipid scramblase 1 colorectal cancer metastatic liver cancer RNA interference

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Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO_(2) Nanoparticles for Tetracycline Degradation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 42-48页

作者： XU Rongqi MI Jianxin WANG Shulin XU man zhu Li BAI Lei TANG Dandan LEI Yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710100China

Cu-Mn co-doped CeO_(2) photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO_(2) without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO_(2) nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18%and maintained a stable cycling performance.

关键词： photocatalyst co-doped charge separation water treatment

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T7 RNA聚合酶催化的荧光扩增技术检测人CEA

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世界华人消化杂志 2007年第27期15卷 2927-2930页

作者：朱自满李世拥安萍白雪于波北京军区总医院全军普通外科中心 100700

目的:建立检测人癌胚抗原(CEA)的T7 RNA聚合酶催化的荧光扩增技术(fluorescent amplification catalyzed by T7 polymerase technique,FACTT).方法:以亲和素作为连接分子,连接生物素化的检测抗体和生物素化的DNA,加入T7RNA聚合酶进行转... 详细信息

目的:建立检测人癌胚抗原(CEA)的T7 RNA聚合酶催化的荧光扩增技术(fluorescent amplification catalyzed by T7 polymerase technique,FACTT).方法:以亲和素作为连接分子,连接生物素化的检测抗体和生物素化的DNA,加入T7RNA聚合酶进行转录扩增反应,对生成的RNA产物进行荧光检测,并同时进行夹心酶联接免疫吸附剂测定(ELISA)方法检测人CEA.结果:成功的建立了检测人CEA的T7 RNA聚合酶催化的荧光扩增技术,其检测CEA的灵敏度达2×10^(-3)mg/L,比夹心ELISA方法灵敏度(0.25 mg/L)高125倍.结论:T7 RNA聚合酶催化的荧光扩增技术较夹心ELISA方法具有更高的敏感性,有可能作为一种新的检测方法用于临床的早期诊断.

关键词： T7 RNA聚合酶荧光扩增技术癌胚抗原酶联接免疫吸附剂测定

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Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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Science China Chemistry 2025年

作者： zhuozhou Xie zhu zhuo zi-Ang Nan Qing Li Xiufang Li zi-Xiu Lu Linzhe Lü Jin Liu Luyao Liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui Huang State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

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温度和水分对寒温带典型森林类型土壤有机碳矿化的影响

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东北林业大学学报 2025年第2期53卷 127-136页

作者：李雪朱宾宾满秀玲东北林业大学哈尔滨150040 内蒙古呼伦贝尔市林业和草原事业发展中心

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0 详细信息

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0

关键词：寒温带白桦林兴安落叶松林土壤有机碳矿化温度敏感性

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