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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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淫羊藿苷对大鼠正畸牙移动过程中牙槽骨改建的影响

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上海口腔医学 2017年第5期26卷 465-470页

作者：杨盼盼王旭霞陈云汪倩倩王英姿张君山东大学口腔医学院正畸科山东济南250012 山东省口腔生物医学重点实验室山东济南250012 山东大学口腔医学院口腔颌面外科山东济南250012 南京医科大学附属口腔医院儿童牙病科江苏南京210029

目的:研究淫羊藿苷对大鼠正畸牙移动过程中牙槽骨改建的作用机制。方法:48只雄性Sprague-Dawley(SD)大鼠,建立正畸牙移动模型,随机分为对照组和淫羊藿苷组,每组分为4个亚组,每个亚组6只。实验组以灌胃方式给予大鼠淫羊藿苷20 mg/(kg·d)... 详细信息

目的:研究淫羊藿苷对大鼠正畸牙移动过程中牙槽骨改建的作用机制。方法:48只雄性Sprague-Dawley(SD)大鼠,建立正畸牙移动模型,随机分为对照组和淫羊藿苷组,每组分为4个亚组,每个亚组6只。实验组以灌胃方式给予大鼠淫羊藿苷20 mg/(kg·d),对照组给予等体积溶剂。各组大鼠在7、14、21、28 d处死,分离出上颌骨作为标本,测量上颌第一磨牙近中移动距离。所有标本做脱钙处理,制成上颌牙周组织切片,分别采用H-E染色、抗酒石酸酸性磷酸酶(tartrate resistant acid phosphatase,TRAP)染色观察移动牙周围牙周膜及牙槽骨的改建情况。采用SPSS16.0软件包对数据进行统计学分析。结果:淫羊藿苷组牙移动距离显著大于对照组(P<0.05)。光镜下显示,淫羊藿苷组压力侧破骨细胞数目在第7天时达到高峰,显著高于对照组;在第14天时与对照组持平,至28 d时低于对照组。结论:淫羊藿苷通过促进牙槽骨的改建而加速正畸牙移动。

关键词：淫羊藿苷破骨细胞正畸牙移动骨改建

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Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai zhang Pei-Zhi Liu Yan-Bo Li Qi zhang jun-Zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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竞争环境下双目标零售平台销售模式选择

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管理工程学报 2025年第1期39卷 227-242页

作者：张冲朱祎宋君南京邮电大学管理学院江苏南京210003

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求... 详细信息

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求自身利润最大化,另外一个零售平台追求自身利润和消费者剩余的线性组合最大化,即考虑双目标最优。本文具体考虑两个零售平台分别选择转售模式或代理模式共四种情形,进而研究双目标零售平台销售模式选择问题,及其对供应链成员最优决策和供应链整体绩效的影响。结果表明:(1)在一定条件下,双目标零售平台能获得比竞争对手更高的利润;(2)当双目标零售平台选择转售模式时,无论其竞争对手选择哪种销售模式,其双目标策略都能使供应链总体利润得到优化;(3)当双目标零售平台的竞争对手选择代理模式时,其自身根据不同情况选择转售模式或者代理模式可以使两个零售平台的销售模式选择形成均衡。

关键词：双目标企业社会责任零售平台销售模式双渠道

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Turning point of organoid transplantation:first-in-human trial of iPSC-derived retinal organoid grafting in patients with retinitis pigmentosa

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Science China(Life Sciences) 2024年第5期67卷 1082-1084页

作者： Chang-jun zhang zi-Bing Jin Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

The discovery of induced pluripotent stem cells(iPSCs)has revolutionized the field of disease research,providing a promising platform for studying various *** the last decade,significant progress has been made in combining iPSCs with other cutting-edge technologies to investigate disease mechanisms and develop potential treatments.

关键词： conditions patients retinitis

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Accuracy and Consistency of the Explicit-Invariant Energy Quadratization Approach for the Cahn-Hilliard Equation

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Journal of Mathematical Research with Applications 2025年第1期 84-104页

作者： jun zhang Fangying SONG Yu zhang Computational Mathematics Research Center Guizhou University of Finance and Economics School of mathematics and statistics Guizhou University of Finance and Economics School of Mathematics and Stastistics Fuzhou University

It is well known that the explicit-invariant energy quadratization (EIEQ) approach can generate fully decoupled, linear and unconditionally energy-stable numerical schemes, so it is favored by many researchers. However, the undeniable fact is that the numerical method obtained by EIEQ approach preserves the “modified” energy law instead of the original *** is mainly due to the introduction of some auxiliary variables in EIEQ scheme, and the truncation error will make the auxiliary variables deviate from the original definition in the process of numerical calculation. The primary objective of this paper is to address this gap by providing the accuracy and consistency of the EIEQ method in the context of the CahnHilliard equation. We introduce a relaxation technique for auxiliary variables and construct two numerical schemes based on EIEQ. The analysis results show that the newly constructed schemes are not only unconditionally energy stable, linear and fully decoupled, but also can effectively correct the errors introduced by auxiliary variables and follow the original energy ***, several 2D and 3D numerical examples illustrate the accuracy and efficiency of the newly constructed numerical schemes.

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基于2018-2022年国家自然科学基金结题项目分析干细胞研究现状

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中国组织工程研究 2025年第19期29卷 4145-4150页

作者：蒋君张玢中国医学科学院医学信息研究所北京市100005

背景:目前大多数研究从国家自然科学基金资助论文和项目申请角度出发,对干细胞某一方面进行深入分析,或者验证某种评价方法,缺乏对干细胞领域国家自然科学基金已结题项目的全面分析。目的:了解2018-2022年干细胞领域国家自然科学基金结... 详细信息

背景:目前大多数研究从国家自然科学基金资助论文和项目申请角度出发,对干细胞某一方面进行深入分析,或者验证某种评价方法,缺乏对干细胞领域国家自然科学基金已结题项目的全面分析。目的:了解2018-2022年干细胞领域国家自然科学基金结题项目资助情况及研究热点,为后续研究提供参考。

关键词：干细胞国家自然科学基金聚类分析研究热点文献计量学

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Transient Appearance of Double Spontaneous-Snakes in EAST H Mode Plasma

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Chinese Physics Letters 2014年第3期31卷 96-98页

作者： XU Li-Qing HU Li-Qun zhang zi-jun Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031

Transient lasting of double spontaneous snakes is observed in energy confinement improved plasma on the EAST tokamak. The destabilization of snakes with superb particle confinement can lower plasma energy confinement and slow plasma toroidal rotation. The non-monotonic q profile with double q=1 surface, slightly above unity in central, is constructed. The prevailing harmonic modes are susceptible to the nearly zero magnetic shear. Finally, the role of anomalous particle transport and the formation of off-axis peaking electron profile on the excitation of double snakes are discussed.

关键词： Magnetoplasma

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Cold Model Study on Mg Desulfurization of Hot Metal Under Mechanical Stirring

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Journal of Iron and Steel Research International 2013年第12期20卷 1-6页

作者： LIU Yan zhang zi-mu LIU Jian-nan zhang jun-hua Masamichi Sano zhang jun Key Laboratory of Ecological Utilization of Multi-metal Intergrown Ores of Ministry of Education School of Materials and MetallurgyNortheastern University Beijing Institute of Technology Dalian University of Technology Nagoya University

The new method of in-situ desulfurization with mechanical stirring of new type impellers was introduced, in which the bubble＇s dispersion and disintegration of magnesium vapor were the key to boosting the desulfurization efficiency and increasing the utilization rate of magnesium. Effects of different new type of impellers on bubble dis persion and disintegration were studied through bubble image analysis, gas-liquid mass transfer, and power con- sumption levels of different impeller structures. The results showed that the sloped swept-back blade impeller-2 pro- duces optimal bubble＇s dispersion and disintegration, as well as higher volumetric mass transfer coefficient and CO2 gas utilization while consuming the least power. Numerical simulation result with Fluent software also showed that the sloped swept-back blade impeller-2 has higher turbulent kinetic energy and better velocity distribution than the other two impellers.

关键词： gas injection refining eccentric mechanical stirring bubble disintegration bubble dispersion volumetric mass transfer coefficient Mg desulfurization hot metal

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