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Detection of k-ras gene point mutation in fine needle aspiration and pancreatic juice by sequence special primer method and its clinical significance

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World Journal of Gastroenterology 2000年第6期6卷 917-919页

作者： Xun Liang liu Cun Cai Dai Yi Miao jing Hui Du Zhao Song Zhang Shu Zhen Chen Department of General Surgery the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210024Jiangsu ProvinceChina The Molecular Biology Research Center of Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina

INTRODUCTIONThe point mutation rate of k-ras gene at codon 12 inpancreatic adenocarcinoma is reported to be as highas 90%,and with no mutations in normalpancreas tissues or other pancreatic *** detected the presence o... 详细信息

关键词： pancreatic neoplasms/diagnosis polymerase chain reaction biopsy needle genes ras pancreatic diseases pancreatic juice gene amplification cytodiagnosis

Current understanding of metal ions in the pathogenesis of Alzheimer’s disease

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Translational Neurodegeneration 2020年第2期9卷 105-117页

作者： Lu Wang Ya-Ling Yin Xin-zi liu Peng Shen Yan-Ge Zheng Xin-Rui Lan Cheng-Biao Lu Jian-Zhi Wang Key Laboratory of Brain Research of Henan Province Sino-UK Joint Laboratory of Brain Function and Injury of Henan ProvinceDepartment of Physiology and NeurobiologyXinxiang Medical UniversityXinxiang453003China Department of Pathophysiology School of Basic MedicineKey Laboratory of Ministry of Education of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background The homeostasis of metal ions,such as iron,copper,zinc and calcium,in the brain is crucial for maintaining normal physiological *** have shown that imbalance of these metal ions in the brain is closely related to the onset and progression of Alzheimer’s disease(AD),the most common neurodegenerative disorder in the *** body Erroneous deposition/distribution of the metal ions in different brain regions induces oxidative *** metal ions imbalance and oxidative stress together or independently promote amyloid-β(Aβ)overproduction by activatingβ-orγ-secretases and inhibitingα-secretase,it also causes tau hyperphosphorylation by activating protein kinases,such as glycogen synthase kinase-3β(GSK-3β),cyclin-dependent protein kinase-5(CDK5),mitogen-activated protein kinases(MAPKs),etc.,and inhibiting protein phosphatase 2A(PP2A).The metal ions imbalances can also directly or indirectly disrupt organelles,causing endoplasmic reticulum(ER)stress;mitochondrial and autophagic dysfunctions,which can cause or aggravate Aβand tau aggregation/accumulation,and impair synaptic *** worse,the metal ions imbalance-induced alterations can reversely exacerbate metal ions misdistribution and *** vicious cycles between metal ions imbalances and Aβ/tau abnormalities will eventually lead to a chronic neurodegeneration and cognitive deficits,such as seen in AD *** The metal ions imbalance induces Aβand tau pathologies by directly or indirectly affecting multiple cellular/subcellular pathways,and the disrupted homeostasis can reversely aggravate the abnormalities of metal ions transportation/***,adjusting metal balance by supplementing or chelating the metal ions may be potential in ameliorating AD pathologies,which provides new research directions for AD treatment.

关键词： Metal ions Alzheimer's disease Amyloid-β Tau Oxidative stress Autophagy Synapses

Versatile fluidity test model for cast superalloys and comparison between IN718 and IN939

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 2881-2888页

作者： Jun ZHANG zi-qi JIE Miao-nan liu Min GUO State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China School of Materials Science and Chemical Engineering Xi’an Technological UniversityXi’an 710021China

A spiral fluidity test model of superalloys with 10 mm in height and 3 mm in thickness was designed to evaluate the fluidity of two distinct Ni-based superalloys IN718 and *** factors influencing fluidity are ascertained through comparative analysis utilizing methodologies such as JMat Pro,differential scanning calorimetry and high-temperature confocal laser scanning *** results show that under identical testing conditions,the fluidity of the IN939 superalloy surpasses that of the IN718 *** subjected to the same temperature,the melt viscosity and surface tension of IN939 superalloy are considerably reduced relative to those of IN718 superalloy,which is beneficial to improving the melt ***,the liquidus temperature and solidification range for the IN939 superalloy are both smaller compared with those of the IN718 *** condition proves advantageous in delaying dendrite coherency,thereby improving fluidity.

关键词： fluidity solidification range superalloys surface tension viscosity

Transanal total mesorectal excision combined with intersphincteric resection has similar long-term oncological outcomes to laparoscopic abdominoperineal resection in low rectal cancer:a propensity score-matched cohort study

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Gastroenterology Report 2022年第1期10卷 377-385页

作者： Zhi-Hang liu zi-Wei Zeng Hai-Qing Jie Liang Huang Shuang-Ling Luo Wen-Feng Liang Xing-Wei Zhang Liang Kang Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background Transanal total mesorectal excision(taTME)or intersphincteric resection(ISR)has recently proven to be a valid and safe surgical procedure for low rectal ***,studies focusing on the combination of these two technologies are *** study aimed to evaluate perioperative results,long-termoncologic outcomes,and anorectal functions of patients with low rectal cancer undergoing taTME combined with ISR,by comparing with those of patients undergoing laparoscopic abdominoperineal resection(laAPR).Methods After 1:1 propensity score matching,200 patients with low rectal cancer who underwent laAPR(n=100)or taTME combined with ISR(n=100)between September 2013 and November 2019 were *** demographics,clinicopathological characteristics,oncological outcomes,and anal functional results were *** Patients in the taTME-combined-with-ISR group had less intraoperative blood loss(79.6672.6 vs 107.3665.1 mL,P=0.005)and a lower rate of post-operative complications(22.0%vs 44.0%,P<0.001)than those in the laAPR *** overall local recurrence rates were 7.0%in both groups within 3 years after *** 3-year disease-free survival rates were 86.3%in the taTME-combined-with-ISR group and 75.1%in the laAPR group(P=0.056),while the 3-year overall survival rates were 96.7%and 94.2%,respectively(P=0.319).There were 39 patients(45.3%)in the taTME-combined-with-ISR group who developed major low anterior resection syndrome,whereas 61 patients(70.9%)had good post-operative anal function(Wexner incontinence score≤10).Conclusion We found similar long-term oncological outcomes for patients with low rectal cancer undergoing laAPR and those undergoing taTME combined with *** receiving taTME combined with ISR had acceptable post-operative anorectal function.

关键词： rectal cancer transanal totalmesorectal excision laparoscopic abdominoperineal resection oncological outcomes

A　CONVERGENT　SYNTHESIS　OF（E．E，E）－3，7，13－TRIMETHYL－6－（i－PROPENYL）－7，14－DIHYDROXY－2，8，12－TETRADECATRIEN－1－METHYLAL

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Chinese Chemical Letters 1996年第2期7卷 109-110页

作者： Yi qian Wan jing Yu SU Qing liu Long Mei Zeng(Department of Chemistry,Zhongshan University,Guangzhou 510275) ZHONGSHAN UNIV DEPT CHEMGUANGZHOU 510275PEOPLES R CHINA

Starting form geanial a new Synthetic route for compound 6, (E,E,E)-3,7-13-trimethy1-6-(i-propenyl)-7,14-dihydydroxy1-2,8,12-tetradecatrien-1-methylal,a key intermediate in the synthesis of diterpene epi-mayol is desc...

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High-Power Raman Soliton Generation at 1.7 μm in All-Fiber Polarization-Maintaining Erbium-Doped Amplifier

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Chinese Physics Letters 2024年第5期41卷 35-39页

作者：徐子鹏王萱姚传飞杨林京李平雪 Institute of Ultrashort Pulsed Laser and Application Beijing University of TechnologyBeijing 100124China

An all-fiber polarization maintaining high-power laser system operating at 1.7 μm based on the Ramaninduced soliton self-frequency shifting effect is demonstrated. The entirely fiberized system is built by erbiumdoped oscillator and two-stage amplifiers with polarization maintaining commercial silica fibers and devices, which can provide robust and stable soliton generation. High-power soliton laser with the average power of 0.28 W,the repetition rate of 42.7 MHz, and pulse duration of 515 fs is generated directly from the main *** experiment provides a feasible method for high-power all-fiber polarization maintaining femtosecond laser generation working at 1.7 μm.

关键词： polarization fiber amplifier

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自动化决策拒绝权的整体主义实现

华中科技大学学报（社会科学版） 2024年第2期38卷 99-111页

作者：崔靖梓中国政法大学人权研究院

个体主义范式的自动化决策拒绝权以人的主体性为价值内核,依靠个人的理性和自主控制能力,以个人的自我保护为主展开。在此范式下形成的自动化决策二分法和个人自主检视模式难以使自动化决策拒绝权充分实现,无法对数智化社会的自动化决... 详细信息

个体主义范式的自动化决策拒绝权以人的主体性为价值内核,依靠个人的理性和自主控制能力,以个人的自我保护为主展开。在此范式下形成的自动化决策二分法和个人自主检视模式难以使自动化决策拒绝权充分实现,无法对数智化社会的自动化决策风险进行有效回应。整体主义将事物整体作为基本分析单位,强调事物之间的系统性关联,与我国自动化决策拒绝权构建的基本逻辑相契合,能够为自动化决策拒绝权提供方法论基础。整体主义要求自动化决策拒绝权在价值内核上坚持人的主体价值与共同善的统一,在适用条件上强调基于整体思维的组织结构标准,在实现方式上基于先在规制对义务体系进行重塑。

关键词：自动化决策拒绝权个体主义范式整体主义个人信息保护法

Automation in road distress detection,diagnosis and treatment

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Journal of Road Engineering 2024年第1期4卷 1-26页

作者： Xu Yang Jianqi Zhang Wenbo liu Jiayu jing Hao Zheng Wei Xu School of Future Transportation Chang'an UniversityXi'an 710064China School of Highway Chang'an UniversityXi'an 710064China School of Information Engineering Chang'an UniversityXi'an 710064China

Road transportation plays a crucial role in society and daily life,as the functioning and durability of roads can significantly impact a nation's economic *** the whole life cycle of the road,the emergence of disease is unavoidable,so it is necessary to adopt relevant technical means to deal with the *** study comprehensively reviews the advancements in computer vision,artificial intelligence,and mobile robotics in the road domain and examines their progress and applications in road detection,diagnosis,and treatment,especially asphalt ***,it analyzes the research progress in detecting and diagnosing surface and internal road distress and related techniques and algorithms are *** addition,also introduces various road gover-nance technologies,including automated repairs,intelligent construction,and path planning for crack *** their proven effectiveness in detecting road distress,analyzing diagnoses,and planning maintenance,these technologies still confront challenges in data collection,parameter optimization,model portability,system accuracy,robustness,and real-time ***,the integration of multidisciplinary technologies is imperative to enable the development of an integrated approach that includes road detection,diagnosis,and *** paper addresses the challenges of precise defect detection,condition assessment,and unmanned *** the same time,the efficiency of labor liberation and road maintenance is achieved,and the automation level of the road engineering industry is improved.

关键词： Road detection Road diagnosis Road treatment Deep learning Intelligent maintenance

Engineering CuMn Prussian blue analog-shelled nanobox for efficient electrochemical reduction of nitrate to ammonia

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Tungsten 2024年第4期6卷 833-844页

作者： zi-Yi Yang Yu-Dong Li Dan liu Mao-Sen Song Yang Gao Qing-Ping Wu En-Shan Han Yan-Zhen He Xiao-Hui Yang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300130China Key Laboratory of Bio-Based Material Science and Technology Northeast Forestry UniversityHarbin150040China Institute of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und EnergieHahn-Meitner-Platz 114109BerlinGermany Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing400714China

Electrocatalytic nitrate reduction reaction(ENRR)for ammonia synthesis is a promising strategy to relieve nitration contamination,as well as an alternative to the Haber-Bosch *** blue analogs(PBAs)are expected to be an electrocatalytic material with superior performance owing to their abundant active sites and open channel ***,most reported PBA materials possess low nitrate conversion and ammonia yield rates,which has led to a hindrance in their research of ***,CuMn-PBA-shelled nanoboxes(CuMn-PBA SNBs)synthesized through tannic acid etching and cation exchange approaches are demonstrated for efficient ammonia *** optimal CuMn-PBA SNBs electrode achieves a high nitrate conversion of 91.33%and ammonia selectivity of 98.87%in a 0.2 mol·L^(-1)Na_(2)SO_(4) solution with100×10^(-6) NO_(3)^(-)-N at-1.4 V ***,the CuMn-PBA SNB s electrode exhibits exceptional stability throughout a 30 h electrocatalytic *** outstanding electrochemical performance is attributed to the unique hollow nanobox structure with abundant active sites and high-throughput transport pathways for ions'aspects.

关键词： Electrocatalytic nitrate reduction Ammonia synthesis Prussian blue analogs Acid etching Cation exchange Nanobox