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Peptide Cy_(RL-QN15)accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor

Zoological Research 2024年第6期45卷 1287-1299页

作者： Yu-Tong Wu Ze-Qiong Ru Ying Peng Zhe Fu Qiu-Ye Jia zi-jian kang Yuan-Sheng Li Yu-Bing Huang Sai-Ge Yin Kun Guo Nai-Xin Liu Cheng-An Feng Jing Tang Bai-Yu Zhang Zhi Yang Ying Wang Xin-Wang Yang Department of Anatomy and Histology&Embryology Faculty of Basic Medical ScienceKunming Medical UniversityKunmingYunnan 650500China Key Laboratory of Chemistry in Ethnic Medicinal Resources&Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes State Ethnic Affairs Commission&Ministry of EducationSchool of Ethnic MedicineYunnan Minzu UniversityKunmingYunnan 650504China Department of Biochemistry and Molecular Biology Faculty of Basic Medical ScienceKunming Medical UniversityKunmingYunnan 650500China Department of Urology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650500China Dermatology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650500China Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunmingYunnan 650500China

Individuals with diabetes frequently face serious challenges,including delayed wound healing and increased risk of ***,the regeneration of hair follicles plays a crucial role in accelerating diabetic skin damage repair,reducing the risk of infection,and enhancing overall skin *** has predominantly emphasized the re-epithelialization of diabetic wounds,with a paucity of in-depth studies on hair follicle *** the current study,we explored the effects of a bioactive amphibian-derived peptide,Cy_(RL-QN15),on promoting hair regeneration in a diabetic skin *** vivo experiments demonstrated that local treatment with Cy_(RL-QN15)not only accelerated wound healing of scalded skin on the backs of diabetic Kunming(KM)mice but also improved growth of damaged hair ***,back-shaved diabetic C57BL/6 mice showed a significant increase in the growth of newly formed hair after 28 days of continuous Cy_(RL-QN15)*** analysis indicated that the hairregenerating effects of Cy_(RL-QN15)were closely associated with the proliferation and migration of hair follicle stem cells(HFSCs).Cy_(RL-QN15)enhanced intracellularβ-catenin expression by binding to the Frizzled-7 receptor on the surface of *** up-regulation inβ-catenin modulated the levels of downstream proteins,such as cMYC,Cyclin D1,and Lef1,ultimately inducing hair *** study not only reveals the robust effects of the bioactive peptide Cy_(RL-QN15)in hair follicle regeneration but also provides novel avenues for the development of more targeted and effective therapeutics for diabetic wound healing in the future.

关键词： CyRL-QN15 Hair follicle stem cells(HFSCs) β-catenin Frizzled-7

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发展绿色畜产品是垦区实现可持续畜牧业的必由之路

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现代化农业 2005年第2期 37-39页

作者：姜文秀訾健康黑龙江省农垦总局宝泉岭分局环保局萝北154211 黑龙江省农垦科学院测试化验中心

中国加入WTO后,意味着中国融入经济全球化的速度和深度逐渐加大,不容质疑地将对中国畜牧业的发展产生深远的影响.当前,我国畜产品存在质量不高、药物残留严重、微生物超标等问题,成为制约我国畜产品出口的主要瓶颈.因此研究和探索绿色... 详细信息

中国加入WTO后,意味着中国融入经济全球化的速度和深度逐渐加大,不容质疑地将对中国畜牧业的发展产生深远的影响.当前,我国畜产品存在质量不高、药物残留严重、微生物超标等问题,成为制约我国畜产品出口的主要瓶颈.因此研究和探索绿色畜产品对垦区乃至我国畜牧业的可持续发展有着重要的意义.

关键词：中国畜牧业绿色畜产品垦区 WTO 必由之路发展药物残留中国深度

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao zi-jian Wang Xiu-Liang Xu jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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基于EEF模型的港口生态评价方法研究

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水道港口 2017年第2期38卷 198-201页

作者：郭子坚崔维康彭云张祺大连理工大学建设工程学部大连116024

基于能值理论(emergy theory),在分析港口资源消费和污染等生态足迹的基础上,考虑船舶在港作业期间对生态环境的影响,提出基于EEF模型(emergy-ecological footprint)的港口生态评价方法,将港口生态承载力分析计算扩展为自然资源生态承... 详细信息

基于能值理论(emergy theory),在分析港口资源消费和污染等生态足迹的基础上,考虑船舶在港作业期间对生态环境的影响,提出基于EEF模型(emergy-ecological footprint)的港口生态评价方法,将港口生态承载力分析计算扩展为自然资源生态承载力和社会经济虚拟承载力两类账户。以北方某港区为例计算了2009~2014年的生态足迹与生态承载力,结果表明港区历年生态承载力指数均大于1,处于生态不可持续状态,能源足迹与污染足迹是港口生态足迹的主要来源。港口经济虚拟生态承载力账户对港区生态承载力的贡献高于自然资源生态承载力账户,可有效控制生态赤字规模。

关键词： EEF模型能值理论港口生态足迹港口生态承载力

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单一干酪乳杆菌KL1发酵益生菌酸奶工艺条件的研究

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食品工业科技 2017年第21期38卷 104-109页

作者：张敏张子豪康建依刘慧谢远红易欣欣高秀芝北京农学院食品科学与工程学院农产品有害微生物及农残安全检测与控制北京市重点实验室食品质量与安全北京实验室微生态制剂关键技术开发北京市工程实验室北京102206

应用单因素实验及正交实验,确定单一干酪乳杆菌KL1发酵酸奶的最佳原料乳,并对其益生菌酸奶发酵工艺条件进行优化。筛选得到的最佳原料乳为M_2,同时通过添加M_6改善酸奶的色泽与组织状态;采用三因素三水平L_9(3~4)正交实验优化酸奶的发... 详细信息

应用单因素实验及正交实验,确定单一干酪乳杆菌KL1发酵酸奶的最佳原料乳,并对其益生菌酸奶发酵工艺条件进行优化。筛选得到的最佳原料乳为M_2,同时通过添加M_6改善酸奶的色泽与组织状态;采用三因素三水平L_9(3~4)正交实验优化酸奶的发酵工艺条件,接种量是影响KL1发酵酸奶品质的最主要因素,确定干酪乳杆菌KL1发酵酸奶的优化条件如下:接种量为6.0%,M_6添加量1.0%,葡萄糖添加量1.5%,37℃下发酵酸奶22 h,优化后的益生菌酸奶的活菌数量较对照组高10倍。

关键词：益生菌酸奶干酪乳杆菌KL1 正交实验感官评定

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高效抑制大肠埃希氏菌的芽孢杆菌的发酵培养基及发酵条件优化

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食品工业科技 2018年第19期39卷 114-118页

作者：张子豪康建依谢远红易欣欣刘慧侯爽马祎高秀芝北京农学院食品科学与工程学院食品质量与安全北京实验室农产品有害微生物及农残安全检测与控制北京市重点实验室微生态制剂关键技术开发北京市工程实验室北京102206

本研究从土壤中筛选对大肠埃希氏菌具有高抑菌活性的芽孢杆菌,采用单因素实验与正交试验,对发酵培养基及发酵条件进行优化。结果表明,经筛选得到一株对大肠埃希氏菌具有显著抑菌活性的芽孢杆菌G3E,经菌种鉴定为解淀粉芽孢杆菌植物亚种(B... 详细信息

本研究从土壤中筛选对大肠埃希氏菌具有高抑菌活性的芽孢杆菌,采用单因素实验与正交试验,对发酵培养基及发酵条件进行优化。结果表明,经筛选得到一株对大肠埃希氏菌具有显著抑菌活性的芽孢杆菌G3E,经菌种鉴定为解淀粉芽孢杆菌植物亚种(Bacillus amyloliquefaciens ***); G3E表达抑菌物质的最佳发酵培养基配方为:淀粉10 g/L、氯化钙4 g/L、酵母浸出物4 g/L、胰蛋白胨4 g/L、尿素2 g/L;最佳发酵条件为:发酵温度40℃,发酵时间40 h,pH=7.0,此时,抑菌圈直径可达(25.5±0.5) mm。

关键词：解淀粉芽孢杆菌发酵培养基发酵条件抑菌活性大肠埃希氏菌

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Momentum Space Quantum Monte Carlo on Twisted Bilayer Graphene

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Chinese Physics Letters 2021年第7期38卷 130-135页

作者： Xu Zhang Gaopei Pan Yi Zhang jian kang zi Yang Meng Department of Physics and HKU-UCAS Joint Institute of Theoretical and Computational Physics The University of Hong KongPokfulam RoadHong Kong SARChina Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Kavli Institute for Theoretical Sciences University of Chinese Academy of SciencesBeijing 100190China School of Physical Science and Technology and Institute for Advanced Study Soochow UniversitySuzhou 215006China

We report an implementation of the momentum space quantum Monte Carlo(QMC)method on the interaction model for the twisted bilayer graphene(TBG).The long-range Coulomb repulsion is treated exactly with the flat bands,spin and valley degrees of freedom of electrons taking into *** prove the absence of the minus sign problem for QMC simulation when either the two valleys or the two spin degrees of freedom are *** taking the realistic parameters of the twist angle and interlayer tunnelings into the simulation,we benchmark the QMC data with the exact band gap obtained at the chiral limit,to reveal the insulating ground states at the charge neutrality point(CNP).Then,with the exact Green's functions from QMC,we perform stochastic analytic continuation to obtain the first set of single-particle spectral function for the TBG model at *** momentum space QMC scheme therefore offers the controlled computation pathway for systematic investigation of the electronic states in realistic TBG model at various electron fillings.

关键词： momentum exact twisted

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Three-dimensional numerical simulation and earth pressure analysis on double-row piles with consideration of spatial effects

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第10期12卷 758-770页

作者： zi-han WANG jian ZHOU Department of Geotechnical Engineering Tongji University Shanghai 200092 China

As a new kind of technology in retaining structures, the characteristics of double-row piles are significantly affected by spatial effects. In this paper, double-row piles as a retaining structure are simulated numerically in three-dimension by finite element software PLAXIS 3D FOUNDATION. The behavior differences of piles in different positions around the foundation pit are analyzed. By changing the parameters, including the length-width ratio, the excavation depth, the distance between rows and the diameter of piles, the variations of the lateral deformation, the bending moment and the earth pressure around the piles are determined. The reasonable values of parameters and some suggestions with consideration of earth pressure are proposed for the design of double-row piles as a retaining structure. The results show that the lateral deformation and bending moment are the largest in the middle of long side of the foundation pit, which is identified as the most unfavorable position. It is indicated that the earth pressure between rows above pit bottom is close to active earth pressure, while the earth pressure between rows under pit bottom is close to static earth pressure. It is suggested that 1/2-2/3 of pile length, 0.6-1.2 m, 3d-6d, and 2d-2.5d be chosen as embedded depth of piles, diameter of piles, distance between rows, and distance between piles, respectively, where d is the pile diameter.

关键词： Double-row piles Retaining structure Spatial effect Finite element Earth pressure

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Chinese Physics B 2021年第1期30卷 1-13页

作者： Yuan-Da Liao Xiao-Yan Xu zi-Yang Meng jian kang Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Department of Physics University of California at San DiegoLa JollaCalifornia 92093USA Department of Physics and HKU-UCAS Joint Institute of Theoretical and Computational Physics The University of Hong KongPokfulam RoadHong Kong SARChina Songshan Lake Materials Laboratory Dongguan 523808China School of Physical Science and Technology&Institute for Advanced Study Soochow UniversitySuzhou 215006China

We review analytical and numerical studies of correlated insulating states in twisted bilayer graphene, focusing on real-space lattice models constructions and their unbiased quantum many-body solutions. We show that by constructing localized Wannier states for the narrow bands, the projected Coulomb interactions can be approximated by interactions of cluster charges with assisted nearest neighbor hopping terms. With the interaction part only, the Hamiltonian is SU(4)symmetric considering both spin and valley degrees of freedom. In the strong coupling limit where the kinetic terms are neglected, the ground states are found to be in the SU(4) manifold with degeneracy. The kinetic terms, treated as perturbation, break this large SU(4) symmetry and propel the appearance of intervalley coherent state, quantum topological insulators, and other symmetry-breaking insulating states. We first present the theoretical analysis of moiré lattice model construction and then show how to solve the model with large-scale quantum Monte Carlo simulations in an unbiased manner. We further provide potential directions such that from the real-space model construction and its quantum many-body solutions how the perplexing yet exciting experimental discoveries in the correlation physics of twisted bilayer graphene can be gradually understood. This review will be helpful for the readers to grasp the fast growing field of the model study of twisted bilayer graphene.

关键词： twisted bilayer graphene correlated insulator quantum Monte Carlo simulation

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Microstructural evolution of ECAPed 1050 alloy under magnetic annealing

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International Journal of Minerals,Metallurgy and Materials 2014年第12期21卷 1205-1214页

作者： Yi-heng Cao Pin-feng Jia kang Wang Li-zi He Ping Wang jian-zhong Cui Key Lab of Electromagnetic Processing of Materials Ministry of Education Northeastern University

Hardness and microstructure evolutions in 1050 aluminum alloy prepared by equal-channel angular pressing （ECAP） were inves- tigated by hardness testing, optical microscopy, and transmission electron microscopy after samples were annealed at different temperatures for 1 h both in the absence and presence of a 12-T magnetic field. The results showed that the hardness of samples after magnetic annealing were lower than that of samples after normal annealing at 150-250℃, but it was higher than that of samples after normal annealing at 〉250℃. During annealing, the rate of softening was faster, and the grains were more homogeneous in 8-ECAPed samples than in 2-ECAPed samples. A rapid grain growth occurred when 2-ECAPed samples were annealed at high temperature （〉300℃）. The magnetic field enhanced the mobility of dislocations and grain boundaries. A more homogeneous grain size was observed in samples prepared under an applied magnetic field.

关键词： aluminum alloys magnetic annealing equal channel angular pressing microstructural evolution grain growth

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