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Bowel preparation protocol for hospitalized patients ages 50 years or older:A randomized controlled trial

World Journal of Gastrointestinal Endoscopy 2024年第1期16卷 18-28页

作者： Yu He Qi Liu Yi-Wen Chen Li-Jian Cui Kai Cao zi-hao guo Department of Geriatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Gastroenterology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND The incidence and mortality rate of colorectal cancer progressively increase with age and become particularly prominent after the age of 50 years.Therefore,the population that is≥50 years in age requires long-term and regular colonoscopies.Uncomfortable bowel preparation is the main reason preventing patients from undergoing regular colonoscopies.The standard bowel preparation regimen of 4-L polyethylene glycol(PEG)is effective but poorly tolerated.AIM To investigate an effective and comfortable bowel preparation regimen for hospitalized patients≥50 years in age.METHODS Patients were randomly assigned to group 1(2-L PEG+30-mL lactulose+a lowresidue diet)or group 2(4-L PEG).Adequate bowel preparation was defined as a Boston bowel preparation scale(BBPS)score of≥6,with a score of≥2 for each segment.Non-inferiority was prespecified with a margin of 10%.Additionally,the degree of comfort was assessed based on the comfort questionnaire.RESULTS The proportion of patients with a BBPS score of≥6 in group 1 was not significantly different from that in group 2,as demonstrated by intention-to-treat(91.2%vs 91.0%,P=0.953)and per-protocol(91.8%vs 91.0%,P=0.802)analyses.Furthermore,in patients≥75 years in age,the proportion of BBPS scores of≥6 in group 1 was not significantly different from that in group 2(90.9%vs 97.0%,P=0.716).Group 1 had higher comfort scores(8.85±1.162 vs 7.59±1.735,P<0.001),longer sleep duration(6.86±1.204 h vs 5.80±1.730 h,P<0.001),and fewer awakenings(1.42±1.183 vs 2.04±1.835,P=0.026)than group 2.CONCLUSION For hospitalized patients≥50 years in age,the bowel preparation regimen comprising 2-L PEG+30-mL lactulose+a low-residue diet produced a cleanse that was as effective as the 4-L PEG regimen and even provided better comfort.

关键词： Aged 50 years or older Hospitalized 2-L polyethylene-glycol+30-mL lactulose+a low-residue diet Comfort

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Ultralight Iontronic Triboelectric Mechanoreceptor with High Specific Outputs for Epidermal Electronics

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Nano-Micro Letters 2022年第6期14卷 1-14页

作者： Hai Lu Wang zi hao guo Xiong Pu Zhong Lin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China CUSTech Institute of Technology Wenzhou 325024ZhejiangPeople’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The pursuit to mimic skin exteroceptive ability has motivated the endeavors for epidermal artificial mechanoreceptors.Artificial mechanoreceptors are required to be highly sensitive to capture imperceptible skin deformations and preferably to be self-powered,breathable,lightweight and deformable to satisfy the prolonged wearing demands.It is still struggling to achieve these traits in single device,as it remains difficult to minimize device architecture without sacrificing the sensitivity or stability.In this article,we present an all-fiber iontronic triboelectric mechanoreceptor(ITM)to fully tackle these challenges,enabled by the high-output mechano-to-electrical energy conversion.The proposed ITM is ultralight,breathable and stretchable and is quite stable under various mechanical deformations.On the one hand,the ITM can achieve a superior instantaneous power density;on the other hand,the ITM shows excellent sensitivity serving as epidermal sensors.Precise health status monitoring is readily implemented by the ITM calibrating by detecting vital signals and physical activities of human bodies.The ITM can also realize acoustic-to-electrical conversion and distinguish voices from different people,and biometric application as a noise dosimeter is demonstrated.The ITM therefore is believed to open new sights in epidermal electronics and skin prosthesis fields.

关键词： Ultralight Iontronic Triboelectric mechanoreceptor Power density Epidermal electronics

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Recent Progresses in Liquid-Free Soft Ionic Conductive Elastomers

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Chinese Journal of Chemistry 2023年第7期41卷 835-860页

作者： Chuan Luo Zhenkai Huang zi-hao guo Kan Yue South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhouGuangdong510640 China School of Materials Science and Hydrogen Energy Foshan UniversityFoshanGuangdong528000 China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhouGuangdong510640 China

Comprehensive Summary With the rapid growth of soft electronic and ionotronic devices such as artificial tissues,soft luminescent devices,soft robotics,and human-machine interfaces,there is a demanding need to accelerate the development of soft ionic conductive materials.To date,the first-generation ionotronic devices are mainly based on hydrogels or ionogels.However,due to their intrinsic drawbacks,such as freezing or volatilization at extreme temperatures,and the leakage problem under external mechanical forces,the reliability of ionotronic devices under harsh conditions remains a great challenge.The advent of liquid-free ionic conductive elastomers(ICEs)has the potentials to solve the issues related to the gel-type soft conductive materials.The free ions shuttling within the ion-dissolvable polymer network enable liquid-free ICEs to exhibit unparalleled ionic conductivity and elasticity.Moreover,by tuning the composition and structure of the polymeric network,it is also feasible to integrate other desirable properties,such as self-healing ability,transparency,biocompatibility,and stimulus responsiveness,into liquid-free ICE materials.In this review,we summarize the design strategies of recently reported liquid-free ICEs,and further explore the methods to introduce multifunctionality,which originate from the rational molecular design and/or the synergy with other materials.Moreover,we highlight the representative applications of liquid-free ICEs in soft ionotronics.It is believed that liquid-free ICEs might provide a unique material platform for the next-generation ionotronics.

关键词： Liquid-free Elastomer lonic conductorSoft materials lonotronics

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Stretchable iontronics with robust interface bonding between dielectric and ion-conducting elastomers

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Nano Research 2023年第9期16卷 11862-11870页

作者： Zhongpeng Li Panpan Zhang Yangshi Shao zi-hao guo Xiong Pu School of Chemistry and Chemical Engineering Center on Nanoenergy ResearchSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China

Dry ion-conducting elastomers(ICEs)are emerging stretchable and ionic conductive materials that are demonstrated with excellent thermal stability and great promise in multifunctional iontronic devices.Nevertheless,the poor interface between the ICEs and the dielectric material is one of the issues hindering the application of the stretchable iontronic device.Herein,a polydimethylsiloxane(PDMS)based ion-conducting elastomer with dynamic crosslinking structures is reported,which achieves the stretchability of 475%and healing efficiency of 99%.More importantly,a robust interface bonding can be generated between the electrode and the dielectric material,which is beneficial to enhance the performance and lifespan of the flexible iontronic devices.Using this PDMS based ICE as the electrode and PDMS as the dielectric material,two stretchable iontronic devices(triboelectric nanogenerator and capacitive pressure sensor)are realized with overall self-healing and stretchable capabilities.These findings provide a promising strategy to achieve integrate stretchable iontronics or electronics with a robust interface between the electrode and dielectric materials.

关键词： ion-conducting elastomers robust interface iontronics triboelectric nanogenerator pressure sensor

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Templated synthesis of patterned gold nanoparticle assemblies for highly sensitive and reliable SERS substrates

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Nano Research 2023年第4期16卷 5056-5064页

作者： Jianping Peng Peijiang Liu Yutong Chen zi-hao guo Yanhui Liu Kan Yue South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510640China National Key Laboratory for Reliability Physics and Its Application Technology of Electrical Component the 5th Electronics Research Institute of the Ministry of Information IndustryGuangzhou 510610China College of Textiles&Clothing Laboratory of New Fiber Materials and Modern TextileState Key laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao 266000China

Formation of plasmonic structure in closely packed assemblies of metallic nanoparticles(NPs)is essential for various applications in sensing,renewable energy,authentication,catalysis,and metamaterials.Herein,a surface-enhanced Raman scattering(SERS)substrate is fabricated for trace detection with ultrahigh sensitivity and stability.The SERS substrate is constructed from a simple yet robust strategy through in situ growth patterned assemblies of Au NPs based on a polymer brush templated synthesis strategy.Benefiting from the dense and uniform distribution of Au NPs,the resulting Au plasmonic nanostructure demonstrates a very strong SERS effect,while the outer polymer brush could restrict the excessive growth of Au NPs and the patterned design could achieve uniform distribution of Au NPs.As results,an ultra-low limit of detection(LOD)of 10^(−15)M,which has never been successfully detected in other work,is determined for 4-acetamidothiophenol(4-AMTP)molecules and the Raman signals in the random region show good signal homogeneity with a low relative standard deviation(RSD)of 7.2%,indicating great sensitivity and reliability as a SERS substrate.The LOD values of such Au plasmonic nanostructures for methylene blue,thiram,and R6G molecules can also reach as low as 10^(−10)M,further indicating that the substrate has a wide range of applicability for SERS detection.With the help of finite difference time domain simulations(FDTD)calculation,the electric field distribution of the Au plasmonic nanostructures is simulated,which quantitatively matches the experimental observations.Moreover,the Au plasmonic nanostructures show good shelf stability for at least 10 months of storage in an ambient environment,indicating potentials for practical applications.

关键词： templated synthesis patterned Au nanostructures surface-enhanced Raman scattering polymer brush plasmonic nanostructures

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Advanced inorganic/polymer hybrid electrolytes for all-solid-state lithium batteries

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Journal of Advanced Ceramics 2022年第6期11卷 835-861页

作者： Xiaoyu JI Yiruo ZHANG Mengxue CAO Quanchao GU Honglei WANG Jinshan YU zi-hao guo Xingui ZHOU Science and Technology on Advanced Ceramic Fibers and Composites Laboratory College of Aerospace Science and EngineeringNational University of Defense TechnologyChangsha 410073China South China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China Department of Chemical and Environmental Engineering Yale UniversityNew Haven 06511USA

Solid-state batteries have become a frontrunner in humankind’s pursuit of safe and stable energy storage systems with high energy and power density.Electrolyte materials,currently,seem to be the Achilles’heel of solid-state batteries due to the slow kinetics and poor interfacial wetting.Combining the merits of solid inorganic electrolytes(SIEs)and solid polymer electrolytes(SPEs),inorganic/polymer hybrid electrolytes(IPHEs)integrate improved ionic conductivity,great interfacial compatibility,wide electrochemical stability window,and high mechanical toughness and flexibility in one material,having become a sought-after pathway to high-performance all-solid-state lithium batteries.Herein,we present a comprehensive overview of recent progress in IPHEs,including the awareness of ion migration fundamentals,advanced architectural design for better electrochemical performance,and a perspective on unconquered challenges and potential research directions.This review is expected to provide a guidance for designing IPHEs for next-generation lithium batteries,with special emphasis on developing high-voltage-tolerance polymer electrolytes to enable higher energy density and three-dimensional(3D)continuous ion transport highways to achieve faster charging and discharging.

关键词： solid-state electrolytes(SSEs) hybrid electrolytes energy density electrical energy storage(EES) lithium batteries

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A Wearable Multidimensional Motion Sensor for AI-Enhanced VR Sports

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Research 2023年第3期2023卷 105-115页

作者： zi hao guo ziXuan Zhang Kang An Tianyiyi He Zhongda Sun Xiong Pu Chengkuo Lee Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400People's Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBejing 100049People's Republic of China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144People's Republic of China

Regular exercise paves the way to a healthy life.However,conventional sports events are susceptible to weather conditions.Current motion sensors for home-based sports are mainly limited by operation power consumption,single-direction sensitivity,or inferior data analysis.Herein,by leveraging the 3-dimensional printing technique and triboelectric effect,a wearable self-powered multidimensional motion sensor has been developed to detect both the vertical and planar movement trajectory.By integrating with a belt,this sensor could be used to identify some low degree of freedom motions,e.g.,waist or gait motion,with a high accuracy of 93.8%.Furthermore,when wearing the sensor at the ankle position,signals generated from shank motions that contain more abundant information could also be effectively collected.By means of a deep learning algorithm,the kicking direction and force could be precisely differentiated with an accuracy of 97.5%.Toward practical application,a virtual reality-enabled fitness game and a shooting game were successfully demonstrated.This work is believed to open up new insights for the development of future household sports or rehabilitation.

关键词： integrating printing Regular

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Graphene-based dual-function acoustic transducers for machine learning-assisted human-robot interfaces

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InfoMat 2023年第2期5卷 66-79页

作者： hao Sun Xin Gao Liang-Yan guo Lu-Qi Tao zi hao guo Yangshi Shao Tianrui Cui Yi Yang Xiong Pu Tian-Ling Ren Institute of Microelectronics and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijingPeople's Republic of China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijingPeople's Republic of China State Key Laboratory of Power Transmission Equipment and System Security and New Technology School of Electrical EngineeringChongqing UniversityChongqingPeople's Republic of China School of Computer Science&Technology Beijing Institute of TechnologyBeijingPeople's Republic of China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijingPeople's Republic of China

Human–robot interface(HRI)electronics are critical for realizing robotic intelligence.Here,we report graphene-based dual-function acoustic transducers for machine learning-assisted human–robot interfaces(GHRI).The GHRI functions both an artificial ear through the triboelectric acoustic sensing mechanism and an artificial mouth through the thermoacoustic sound emission mechanism.The success of the integrated device is also attributed to the multifunctional laser-induced graphene,as either triboelectric materials,electrodes,or thermoacoustic sources.By systematically optimizing the structure parameters,the GHRI achieves high sensitivity(4500 mV Pa^(–1))and operating durability(1000000 cycles and 60 days),capable of recognizing speech identities,emotions,content,and other information in the human speech.With the assistance of machine learning,30 speech categories are trained by a convolutional neural network,and the accuracy reaches 99.66%and 96.63%in training datasets and test datasets.Furthermore,GHRI is used for artificial intelligence communication based on recognized speech features.Our work shows broad prospects for the development of robotic intelligence.

关键词： human-robot interface laser-induced graphene machine learning thermoacoustic triboelectric nanogenerator

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Comparison of α particle detectors based on single-crystal diamond films grown in two types of gas atmospheres by microwave plasma-assisted chemical vapor deposition

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International Journal of Minerals,Metallurgy and Materials 2020年第5期27卷 703-712页

作者： Yan-zhao guo Jin-long Liu Jiang-wei Liu Yu-ting Zheng Yun Zhao Xiao-lu Yuan zi-hao guo Li-fu Hei Liang-xian Chen Jun-jun Wei Jian-peng Xing Cheng-ming Li Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Optical and Electronic Materials Unit National Institute for Materials Science(NIMSIbaraki 305-0044Japan Key Laboratory of Microelectronic Device and Integration Technology Institute of Microelectronics of the Chinese Academy of SciencesBeijing 100029China

Chemical vapor deposition(CVD)-grown diamond films have been developed as irradiation-resistant materials to replace or upgrade current detectors for use in extreme radiation environments. However, their sensitivity in practical applications has been inhibited by space charge stability issues caused by defects and impurities in pure diamond crystal materials. In this study, two high-quality CVD-grown single-crystal diamond(SCD) detectors with low content of nitrogen impurities were fabricated and characterized. The intrinsic properties of the SCD samples were characterized using Raman spectroscopy, stereomicroscopy, and X-ray diffraction with the rocking curve mode, cathode luminescence(CL), and infrared and ultraviolet-visible-near infrared spectroscopies. After packaging the detectors, the dark current and energy resolution under α particle irradiation were investigated. Dark currents of less than 5 pA at 100 V were obtained after annealing the electrodes, which is comparable with the optimal value previously reported. The detector that uses a diamond film with higher nitrogen content showed poor energy resolution, whereas the detector with more dislocations showed poor charge collection efficiency(CCE). This demonstrates that the nitrogen content in diamond has a significant effect on the energy resolution of detectors, while the dislocations in diamond largely contribute to the poor CCE of detectors.

关键词： single-crystal diamond nitrogen impurity detector αparticle

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Exploring natural gas hydrates toward a carbon-neutral world

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China Geology 2022年第2期5卷 197-200页

作者： zi-guo hao Development and Research Center of China Geological Survey Ministry of Natural ResourcesBeijing 100037China

The energy revolution is the foundation and driving force for the progress of human civilization.The discovery and utilization of fossil energy,which has greatly increased labor productivity and transformed society from a civilization based on farming into an industrial civilization,is a global energy revolution.Over the past two centuries,industrial civilization has brought about substantial progress but has also caused increasingly severe environmental and climate problems.Given these issues,governments around the world have successively formulated specific indices and deadlines for peak carbon dioxide emissions and carbon neutrality.

关键词： neutral carbon successively

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