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Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney,and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways

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World Journal of Diabetes 2024年第3期15卷 502-518页

作者： zi-Ang Ma Li-Xin Wang Hui Zhang han-Zhou Li Li Dong Qing-Hai Wang Yuan-Song Wang Bao-ChaoPan Shu-Fang Zhang Huan-Tian Cui Shu-Quan Lv Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese MedicineCangzhou 061000Hebei ProvinceChina School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 300000China The First School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 065000Yunnan ProvinceChina Department of Endocrinology Hebei Cangzhou Hospital of Integrative MedicineCangzhou 061000Hebei ProvinceChina

BACKGROUND Jianpi Gushen Huayu Decoction(JPGS)has been used to clinically treat diabetic nephropathy(DN)for many ***,the protective mechanism of JPGS in treating DN remains *** To evaluate the therapeutic effects and the possible mechanism of JPGS on *** We first evaluated the therapeutic potential of JPGS on a DN mouse *** then investigated the effect of JPGS on the renal metabolite levels of DN mice using non-targeted ***,we examined the effects of JPGS on c-Jun N-terminal kinase(JNK)/P38-mediated apoptosis and the inflammatory responses mediated by toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/NOD-like receptor family pyrin domain containing 3(NLRP3).RESULTS The ameliorative effects of JPGS on DN mice included the alleviation of renal injury and the control of inflammation and oxidative *** metabolomic analysis revealed that JPGS altered the metabolites of the kidneys in DN mice.A total of 51 differential metabolites were *** analysis results indicated that nine pathways significantly changed between the control and model groups,while six pathways significantly altered between the model and JPGS *** related to cysteine and methionine metabolism;alanine,tryptophan metabolism;aspartate and glutamate metabolism;and riboflavin metabolism were identified as the key pathways through which JPGS affects *** experimental validation showed that JPGS treatment reduced the expression of TLR4/NF-κB/NLRP3 pathways and JNK/P38 pathway-mediated apoptosis related *** JPGS could markedly treat mice with streptozotocin(STZ)-induced DN,which is possibly related to the regulation of several metabolic pathways found in ***,JPGS could improve kidney inflammatory responses and ameliorate kidney injuries in DN mice via the TLR4/NF-κB/NLRP3 pathway and inhibit JNK/P38 pathwaymediated apoptosis in DN mice.

关键词： Diabetic nephropathy Jianpi Gushen Huayu Decoction Oxidative stress Inflammation Untargeted metabolomics Toll-like receptor 4/nuclear factor-kappa B/NOD-like receptor family pyrin domain containing 3 pathway c-Jun N-terminal kinase/P38-mediated apoptosis

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SEM视角下人民币汇率风险影响因素研究

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亚太经济 2024年第1期 65-72,119页

作者：蔡梓涵叶琪新加坡南洋理工大学公共管理研究生院新加坡639798 福建师范大学经济学院福州350001

基于SEM视角,结合我国宏观经济特征与制度背景,运用Granger检验方法选取影响人民币汇率风险的备选指标,使用探索性因子对影响因素进行KMO和Bartlett检验,采用方差极大法对因子载荷矩阵实行正交旋转,构建汇率风险测度因子分析模型,并用SE... 详细信息

基于SEM视角,结合我国宏观经济特征与制度背景,运用Granger检验方法选取影响人民币汇率风险的备选指标,使用探索性因子对影响因素进行KMO和Bartlett检验,采用方差极大法对因子载荷矩阵实行正交旋转,构建汇率风险测度因子分析模型,并用SEM模型绘制出人民币汇率风险影响路径系数图,分析影响人民币汇率风险的主要因素,为人民币汇率风险测度提供科学依据。

关键词：汇率风险测度影响因素结构方程模型

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考虑锚胫作用下拖曳锚在成层土中的嵌入机制

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岩土力学 2024年第5期45卷 1495-1504页

作者：熊树森黄蕴晗赖莹浙江大学超重力研究中心浙江杭州310058 江苏海洋大学土木与港海工程学院江苏连云港222002 浙江大学建筑工程学院浙江杭州310058

深水系泊系统及其系泊基础的开发已成为发展清洁能源“海上风电”项目的关键课题。拖曳锚由于其较大的承载力和易安装等诸多优势而具有较好的发展前景。基于极限塑性上限分析法,建立了考虑锚胫作用的拖曳锚在成层土中的嵌入轨迹、姿态... 详细信息

深水系泊系统及其系泊基础的开发已成为发展清洁能源“海上风电”项目的关键课题。拖曳锚由于其较大的承载力和易安装等诸多优势而具有较好的发展前景。基于极限塑性上限分析法,建立了考虑锚胫作用的拖曳锚在成层土中的嵌入轨迹、姿态以及承载力预测模型。利用已有模型试验对本模型进行验证,结果表明:考虑锚胫作用模型轨迹预测误差控制在13.5%,轨迹和角度预测误差相比于未考虑锚胫作用的模型分别降低了78.32%和36.9%。硬土层的强度、厚度和深度共同制约着拖曳锚的嵌入能力。首先,强度比影响最明显,强度比越大,嵌入深度越小,直至无法穿透硬土层;其次,是深度影响,深度越大,承载力越大。能够穿透硬土层的条件下深度对轨迹和角度影响不明显,不能够穿透硬土层条件下深度越大,嵌入深度越大,最终角度越小;最后,是厚度影响,硬土层厚度越大,嵌入过程中承载力越大。

关键词：拖曳锚预测模型成层土锚胫作用轨迹

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相空间重构与改进SMA优化SVR的网络流量预测

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计算机工程与设计 2024年第9期45卷 2796-2804页

作者：董洁韩子扬沈阳建筑大学电气与控制工程学院辽宁沈阳110168 沈阳建筑大学计算机科学与工程学院辽宁沈阳110168

为提高网络流量预测精度,提出结合相空间重构与改进黏菌优化支持向量回归的预测模型。为解决黏菌算法收敛慢、易得局部最优的不足,引入3种形态对立学习对种群进行初始化,提高种群多样性;利用非线性反馈因子更新机制,均衡全局搜索与局部... 详细信息

为提高网络流量预测精度,提出结合相空间重构与改进黏菌优化支持向量回归的预测模型。为解决黏菌算法收敛慢、易得局部最优的不足,引入3种形态对立学习对种群进行初始化,提高种群多样性;利用非线性反馈因子更新机制,均衡全局搜索与局部开发;设计柯西-高斯混合变异对最优解变异,扩展搜索空间,避免陷入局部最优。利用改进黏菌算法对支持向量回归优化调参,有效解决超参初值敏感缺陷,提高学习精度和收敛速度,以此构建网络流量预测模型。实验结果表明,改进模型预测误差更小,能够实现高精度和实时性预测要求。

关键词：网络流量预测黏菌算法支持向量机对立学习混合变异相空间重构预测误差

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产业政策与跨境并购:政策导向还是创新驱动?

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科学学研究 2024年第1期42卷 54-66页

作者：吴先明马子涵武汉大学经济与管理学院湖北武汉430072

本文以2008-2018年进行国内并购和跨境并购的中国A股上市公司为研究对象,实证检验了产业政策对企业跨境并购倾向的影响。研究结果表明,产业政策对跨境并购倾向具有显著的正向影响。产业政策主要通过获得政府补助和提高商业信用进而影响... 详细信息

本文以2008-2018年进行国内并购和跨境并购的中国A股上市公司为研究对象,实证检验了产业政策对企业跨境并购倾向的影响。研究结果表明,产业政策对跨境并购倾向具有显著的正向影响。产业政策主要通过获得政府补助和提高商业信用进而影响企业跨境并购倾向。行业竞争环境、市场化程度、环境不确定性、企业创新能力和高管薪酬粘性会影响产业政策的实施效果。产业政策没有显著影响跨境并购的交易金额,但提高了跨境并购的股权水平和完成率;同时,战略资产寻求动因能够显著增强产业政策对跨境并购交易金额和股权水平的影响。揭示了产业政策对企业跨境并购倾向的独特作用,不仅丰富了产业政策对跨境并购影响机制的研究,同时也为如何更好地运用产业政策提升跨境并购的效果提供了政策参考。

关键词：产业政策跨境并购投资偏好

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Employing a random forest model to forecast the likelihood of coronary artery lesions in Kawasaki disease: a study centered on four biomarkers

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Medical Data Mining 2024年第3期7卷 1-7页

作者： Chu-xiong Gong Yue-Wen Li Ya-Min Li zi-Yu Wang Hui-Qing Gao Xiao-Mei Liu Department of Infectious Diseases Children’s Hospital Affiliated of Kunming Medical UniversityKunming Children’s HospitalKunming 650228China Department of Rehabilitation and Palliative Medicine The Third Affiliated Hospital of Kunming Medical UniversityKunming 650000China

Background:Kawasaki disease is an acute immune vasculitis,which is more common in children under 5 years *** disease mainly affects the cardiovascular system,especially the coronary *** coronary artery damage occurs,it can significantly impact the patient’s ***,in some countries and regions,Kawasaki disease has become a common acquired heart ***:First,univariate analysis was conducted on each predictive ***,Least Absolute Shrinkage and Selection Operator and random forest algorithms were used to screen all predictive factors,and the prediction model was evaluated using receiver operating characteristic curve,calibration curve,and Decision Curve ***:This study,based on data from 228 Kawasaki disease patients,utilized a random forest model to identify four predictive factors:white blood cell count,creatine kinase isoenzyme MB,albumin,and neutrophil *** factors were used to construct a prediction model,which achieved an area under the curve of ***:We developed a forest plot based on white blood cell count,creatine kinase isoenzyme MB,albumin,and neutrophil count to effectively predict the occurrence of coronary artery lesions in Kawasaki disease.

关键词： Kawasaki disease coronary artery lesions nomogram machine learning

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A 256 Gb/s electronic−photonic monolithically integrated transceiver in 45 nm CMOS

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Journal of Semiconductors 2024年第7期45卷 7-10页

作者： Ang Li Qianli Ma Yujun Xie Yongliang xiong Yingjie Ma han Liu Ye Jin Menghan Yang Guike Li Haoran Yin Minye Zhu Yang Qu Peng Wang Daofa Wang Wei Li Liyuan Liu Nan Qi Ming Li Key Laboratory of Optoelectronic Materials and Devices Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

With the explosive development of artificial intelligence(AI),machine learning(ML),and high-performance comput-ing(HPC),the ever-growing data movement is asking for high density interconnects with higher bandwidth(BW),lower power and lower latency[1−3].The optical I/O leverages silicon photonic(SiPh)technology to enable high-density large-scale integrated photonics.

关键词： Gb/s transceiver monolithic

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Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： Luo-Xi XIAO zi-Yu WANG Jiang-Tao LI Hai-Mei WANG Yi-Ming HAO Pan ZHOU Yu-Lin HUANG Qiu-Ju DENG Yong-Chen HAO Na YANG Li-Zhen han Zhao YANG Ping-Ping JIA Yue QI Jing LIU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

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基于像素对比学习的图像超分辨率算法

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自动化学报 2024年第1期50卷 181-193页

作者：周登文刘子涵刘玉铠华北电力大学控制与计算机工程学院北京102206

目前,深度卷积神经网络(Convolutional neural network,CNN)已主导了单图像超分辨率(Single image superresolution,SISR)技术的研究,并取得了很大进展.但是,SISR仍是一个开放性问题,重建的超分辨率(Super-resolution,SR)图像往往会出现模糊、纹理细节丢失和失真等问题.提出一个新的逐像素对比损失,在一个局部区域中,使SR图像的像素尽可能靠近对应的原高分辨率(High-resolution,HR)图像的像素,并远离局部区域中的其他像素,可改进SR图像的保真度和视觉质量.提出一个组合对比损失的渐进残差特征融合网络(Progressive residual feature fusion network,PRFFN).主要贡献有:1)提出一个通用的基于对比学习的逐像素损失函数,能够改进SR图像的保真度和视觉质量;2)提出一个轻量的多尺度残差通道注意力块(Multi-scale residual channel attention block,MRCAB),可以更好地提取和利用多尺度特征信息;3)提出一个空间注意力融合块(Spatial attention fuse block,SAFB),可以更好地利用邻近空间特征的相关性.实验结果表明,PRFFN显著优于其他代表性方法.

关键词：图像超分辨率卷积神经网络对比学习注意力机制

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Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification:a review

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Traditional Medicine Research 2024年第9期9卷 21-31页

作者： han-Qing Zhang Shuang Wu Xin Chen Ya-Xuan Fang Qiu-Mei Lan zi-Jun Zhou Yan-Heng Qiao Jie Li Yan-Ru Zhao Ming Pei Bo Yang Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease *** medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often *** plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated *** this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关键词： chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers

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