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The evaluation of next-generation probiotics on broiler growth performance,gut morphology,gut microbiome,nutrient digestibility,in addition to enzyme production of Bacillus *** vitro

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Animal Nutrition 2024年第3期18卷 133-144页

作者： Jacoba I.Bromfield Shahram Niknafs Xiaojing Chen Juhani von Hellens Darwin Horyanto Baode Sun Lei yu Viet Hai Tran Marta Navarro Eugeni Roura Bioproton Pty Ltd Acacia RidgeBrisbaneQueenslandAustralia Centre for Nutrition and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandBrisbaneQueenslandAustralia Centre for Animal Science Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandBrisbaneQueenslandAustralia

Considerable research has been conducted into the efficacy of individual probiotics in broiler production,however information on the most effective combinations of synergistic Bacillus probiotic is *** study investigated the impact of different Bacillus strain combinations in broiler chickens,as well as in vitro enzyme *** experiment one,a total of 576 Ross 308 broilers at 1 d old were grown for 21 d across 6 treatments of maize-soybean diets(n=12 pens per treatment)to compare three different strain combinations(formulation 1[F1]:3 strains Bacillus amyloliquefaciens;F2:Bacillus coagulans and 2 strains ***;F3:***,Bacillus licheniformis and 2 strains ***;F5:Bacillus subtilis,*** and 2 strains ***),positive control(PC),and a negative control antibiotic treatment group(NC).In Exp.2,a total of 360 one-day-old ROSS308 broilers were used to test five treatments(n=9)including PC,NC,F1 and F5(selected from Exp.1),and F4(Bacillus pumilis and 2 strains ***)in a maize-soybean *** F1 demonstrated a significant improvement in feed conversion ratio(FCR)compared to F2 at d 14(1.49 vs 2.10;P=0.038)and the body weight(BW)at d 21(847.0 g vs 787.4 g)compared to other combinations(P=0.027).The FCR at d 21 tended to be lower in birds fed F1(1.46 vs 1.66)compared to the control(P=0.068).Probiotic treatments had significantly improved nutrient digestibility compared to the PC and ***,probiotic treatments supported the growth of Streptococcus,a common commensal genus and reduced the abundance of genera that correlated with low weight gain such as *** two revealed that F4 improved FCR(P<0.001)and BW at 28 d(P=0.014).In vitro testing showed a high production of protease and amylase by ***,the addition of Bacillus probiotics,particularly containing *** strains and Bacillus pumilus,into the diet of broiler chickens improves

关键词： Broiler Probiotic Bacillus Gut health Microbial profile

基于RS和BCH码的SRAM-PUF密钥提取方法及性能分析

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计算机工程 2024年第7期50卷 187-193页

作者：周昱于宗光中国电子科技集团公司第五十八研究所江苏无锡214072

物理不可克隆函数(PUF)是芯片制造过程中随机偏差形成的唯一和不可复制的物理指纹,使用这个特征可以鉴别各个芯片,然而PUF芯片因环境变化会影响输出,导致在认证应用时可能失败。介绍了模糊提取器的密钥提取方法,通过在静态随机存取存储... 详细信息

物理不可克隆函数(PUF)是芯片制造过程中随机偏差形成的唯一和不可复制的物理指纹,使用这个特征可以鉴别各个芯片,然而PUF芯片因环境变化会影响输出,导致在认证应用时可能失败。介绍了模糊提取器的密钥提取方法,通过在静态随机存取存储器(SRAM)-PUF芯片中加入里德-所罗门(RS)硬解码,在认证系统中加入BCH软解码模块,纠正PUF在一定范围内变化来确保通过认证,并对SRAM-PUF电路在三温下进行实验分析。实验结果表明,SRAM-PUF电路的PUF点分布有较好的均衡性,在常温时可靠性接近100%,在低温条件下可靠性范围为98.84%~100%,在高温条件下,可靠性范围为97.77%~99%,当RS码和BCH码设计的纠错能力大于PUF可靠性时能够通过认证。

关键词：物理不可克隆函数静态随机存取存储器模糊提取器里德-所罗门码 BCH码

Robust THP Design with the Presence of Errors in CSIT Acquisition

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China Communications 2010年第2期7卷 78-86页

作者： Wang Xuzhen niu Kai He Zhiqiang yu Guangwei Li Hui Inforrnation Theoryand Technology Education and Research Center Beijing University of Posts and Telecommunications Beijing 100876 China The Pilot College Beijing University of Technology Beijing 101101 China

In this paper, a robust THP is proposed for broadcast channel in multi-user multi-input multi-output (MU-MIMO) system, in which the channel uncertainty caused by feedback delay and mobile speed is taken into account. In order to acquire the imperfect channel state information at transmitter (CSIT), a dynamic CSIT model is introduced where the channel temporal and spatial correlations are considered. By utilizing the unchanged channel statistics and accurate outdated feedback channel information jointly, the imperfect CSIT is obtained as the channel estimate and error covariance. Based on the obtained imperfect CSIT, a Minimum Mean-Square Error (MMSE) Tomlinsion-Harashima precoding (THP) is designed and the closed-form solution is derived by the Lagrangian multiplier approach under total power constraint. Simulation results are provided to indicate the preferable performances of the robust THP. Performance analysis with respect to feedback delay and mobile speed is also given.

关键词： MU-MIMO channel estimate imperfect channel state

日粮添加蚕豆皮对湖羊空肠屏障相关基因表达、消化酶活性和微生物菌群的影响

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南京农业大学学报 2024年第1期47卷 142-150页

作者：刘静王钊于昊夏雨婷李鹏牛伟强万永杰茆达干南京农业大学动物科技学院江苏南京210095 启东瑞鹏牧业有限公司江苏南通226000

[目的]本试验旨在研究日粮添加蚕豆皮对湖羊空肠屏障相关基因表达、消化酶活性和微生物菌群的影响。[方法]30只4月龄体重相近[(27±2.0)kg]的雄性湖羊分为2组,分别饲喂基础日粮(对照组,CON)和添加30%蚕豆皮日粮(蚕豆皮组,BBS)。预饲期10... 详细信息

[目的]本试验旨在研究日粮添加蚕豆皮对湖羊空肠屏障相关基因表达、消化酶活性和微生物菌群的影响。[方法]30只4月龄体重相近[(27±2.0)kg]的雄性湖羊分为2组,分别饲喂基础日粮(对照组,CON)和添加30%蚕豆皮日粮(蚕豆皮组,BBS)。预饲期10 d,正式期50 d。试验结束后采集空肠组织及食糜(n=5),通过RT-qPCR检测黏膜屏障相关基因的表达,生化试剂盒检测消化酶活性,高通量测序分析食糜微生物菌群。[结果]与对照组相比,BBS组空肠黏膜细胞连接基因Claudin-1、Occludin、MUC-2和ZO-1,促炎因子IL-6、IL-10和TNF-α mRNA水平无显著变化(P>0.05),而IL-1β mRNA水平显著降低(P0.05)。BBS组食糜微生物Shannon、Chao1和Observed_otus指数显著降低(P<0.05);门水平上,BBS组变形菌门(Proteobacteria)相对丰度显著升高(P<0.05),厚壁菌门(Firmicutes)、髌骨细菌门(Patescibacteria)相对丰度和F/B值显著降低(P<0.05);属水平上,BBS组克里斯滕森氏菌R7菌群(Christensenellaceae_R-7_group)、未分类厚壁菌属(Firmicutes_unclassified)、糖单胞菌属(Candidatus_Saccharimonas)、糖酵解菌属(Saccharofermentans)、毛螺科NK3A20菌群(Lachnospiraceae_NK3A20_group)和聚乙酸菌属(Acetitomaculum)的相对丰度显著下降(P<0.05)。16S rDNA基因组的PICRUSt 2功能预测结果显示,空肠微生物差异菌群主要富集在三羧酸循环、脂肪酸β氧化、原儿茶酸降解和L-亮氨酸降解通路。[结论]日粮添加30%蚕豆皮可降低空肠黏膜炎症因子IL-1β mRNA表达量,改变空肠食糜微生物菌群多样性和相对丰度,调节肠道发酵环境。研究结果为蚕豆皮在养羊业发展中的应用提供参考。

关键词：蚕豆皮湖羊空肠屏障功能消化酶活性微生物菌群

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High Precision Prediction of Rolling Force Based on Fuzzy and Nerve Method for Cold Tandem Mill

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Journal of Iron and Steel Research International 2008年第2期15卷 23-27页

作者： JIA Chun-yu SHAN Xiu-ying niu Zhao-ping College of Mechanical Engineering Yanshan University Qinhuangdao 066004 Hebei China

The rolling force model for cold tandem mill was put forward by using the Elman dynamic recursive network method,based on the actual measured ***,a good assumption is put forward,which brings a full universe of discourse self-adjusting factor fuzzy control,closed-loop adjusting,based on error feedback and expertise into a rolling force prediction model,to modify prediction outputs and improve prediction precision and *** simulated results indicate that the method is highly effective and the prediction precision is better than that of the traditional *** relative error is less than ±4%,so the prediction is high precise for the cold tandem mill.

关键词： Elman dynamic recursive network fuzzy control cold tandem mill rolling force prediction

Acute coronary syndrome in a patient with gastric cancer treated by immune checkpoint inhibitor: A case report

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Malignancy Spectrum 2024年第2期1卷 136-140页

作者： Bin Guan Lingyun Zhang Shan yu Department of Medical Oncology Jinshan HospitalFudan UniversityShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Department of Medical Oncology Shanghai Geriatric Medical CenterShanghaiChina Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghaiChina

Objective:To highlight the incidence and management of acute coronary syndrome(ACS)in patients with gastric cancer undergoing immune checkpoint inhibitor(ICI)therapy,emphasizing the need for early detection and intervention in this high-risk *** and methods:We presented a case of a 71-year-old male patient with poorly differentiated adenocarcinoma of the gastric antrum,clinical stage cT4N2M0,phase III,with no prior history of chronic diseases or cardiovascular risk *** patient was treated with a combination of ICI therapy(sintilimab)and chemotherapy using the albumin-bound paclitaxel combined with S1 *** therapy,he developed symptoms and diagnostic findings consistent with ACS,which was managed with percutaneous coronary ***:The patient's presentation with ACS during ICI therapy underscored the potential cardiovascular risks associated with cancer treatments,particularly in patients without traditional cardiovascular risk *** involved collaboration between oncologists and cardiologists,leading to successful coronary stenting and continuation of antitumor ***:ACS is a significant risk in patients with malignancies undergoing ICI therapy,even in those without prior cardiovascular *** recognition and management of ACS in this context are crucial to enable the continuation of cancer treatment and improve patient *** case underscores the importance of interdisciplinary collaboration in managing complex patients with concurrent cancer and cardiovascular disease.

关键词： gastric cancer acute coronary syndrome immune checkpoint inhibitor

Exploring the Lagged Correlation Between Baidu Index and Influenza-Like Illness-China,2014-2019

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China CDC weekly 2024年第26期6卷 629-634页

作者： Xuan Han Jiao Yang Yan Luo Dazhu Huo Xuya yu Xuancheng Hu Ling Xin Liuyang Yang Hualei Xin Ting Zhang Zhongjie Li Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollegeBeijingChina School of Health Policy and Management Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of management science and information system Faculty of Management and EconomicsKunming University of Science and TechnologyKunming CityYunnan ProvinceChina

Introduction:This study investigated the lagged correlation between Baidu Index for influenza-related keywords and influenza-like illness percentage(ILI%)across regions in *** aim is to establish a scientific foundation for utilizing Baidu Index as an early warning tool for influenza-like illness ***:In this study,data on ILI%and Baidu Index were collected from 30 provincial-level administrative divisions(PLADs)spanning April 2014 to March *** Baidu Index was categorized into Overall Index,Ordinary Index,Prevention Index,Symptom Index,and Treatment Index based on search query *** lagged correlation between the Baidu Index and ILI%was examined through the cross-correlation function(CCF)***:Correlating the Baidu Overall Index of 30 PLADs with ILI%revealed CCF values ranging from 0.46 to 0.86,with a median lag of 0.5 *** analysis indicated that the Prevention Index and Symptom Index exhibited quicker responses to ILI%,with median lags of−9 and−0.5 days,respectively,compared to 0 and 3 days for the Ordinary and Treatment *** median lag days between the Baidu Index and the ILI%were earlier in the northern PLADs compared to the southern ***:The Prevention and Symptom Indexes show promising predictive capabilities for influenzalike illness epidemics.

关键词： utilizing illness Baidu

策略梯度的超启发算法求解带容量约束车辆路径问题

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控制理论与应用 2024年第6期41卷 1111-1122页

作者：张景玲孙钰粟赵燕伟余孟凡蒋玉勇浙江工业大学特种装备制造及先进加工技术教育部重点实验室浙江杭州310014

有容量车辆路径问题是组合优化问题中比较热门的问题,它属于经典的NP-hard问题并且时间复杂度高.本文提出了一种基于策略梯度的超启发算法,将强化学习中的确定性策略梯度算法引入到超启发算法的高层策略中的底层算法选择策略,确定性策... 详细信息

有容量车辆路径问题是组合优化问题中比较热门的问题,它属于经典的NP-hard问题并且时间复杂度高.本文提出了一种基于策略梯度的超启发算法,将强化学习中的确定性策略梯度算法引入到超启发算法的高层策略中的底层算法选择策略,确定性策略梯度算法采用Actor-Critic框架,另外为了能够在后续计算和神经网络参数更新中引用历史经验数据,在确定性策略梯度算法中设计了经验池用于存储状态转移数据.在超启发算法解的接受准则方面,文中通过实验对比了3种接受准则的效果,最终选择了自适应接受准则作为高层策略中解的接受准则.通过对有容量车辆路径问题标准算例的计算,并将求解结果与其他算法对比,验证了所提算法在该问题求解上的有效性和稳定性.

关键词：车辆路径问题强化学习关策略梯度算法神经网络超启发算法

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“机械灌注+”应用于扩大标准供肝移植--肝尽其用

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Engineering 2024年第1期32卷 29-40页

作者： Zhoucheng Wang Jack Martin Jiongjie yu Kai Wang Kourosh Saeb-Parsy Xiao Xu Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Department of Surgery Cambridge University Hospitals&NHS Foundation TrustCambridge CB22QQ UK Department of Surgery University of Cambridge&NIHR Cambridge Biomedical Research CentreCambridge CB22QQUK Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China

Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor *** criteria donor(ECD)liver grafts are increasingly utilized in clinical practice to mitigate this ***,impaired ischemic tolerance of these grafts jeopardizes organ viability during cold *** perfusion(MP)was designed to improve organ preservation and reduce posttransplant ***,it is increasingly evident that MP alone may not preserve ECD grafts *** emphasis has thus been placed on modified MP strategies,including the use of different perfusates,modified perfusion modalities,and different therapeutic ***,we introduce a novel term,"MP Plus,"denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of ECD *** this review,we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different ECD grafts in clinical settings.

关键词： Liver transplantation Extended criteria donor Machine perfusion plus Organ shortage