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Different ENSO Impacts on Eastern China Precipitation Patterns in Early and Late Winter Associated with Seasonally-Varying Kuroshio Anticyclonic Anomalies

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Advances in Atmospheric Sciences 2024年第9期41卷 1691-1703页

作者： Jingrui YAN Wenjun ZHANG Suqiong HU feng JIANG Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science and TechnologyNanjing 210044China

Winter precipitation over eastern China displays remarkable interannual variability,which has been suggested to be closely related to El Niño-Southern Oscillation(ENSO).This study finds that ENSO impacts on eastern China precipitation patterns exhibit obvious differences in early(November-December)and late(January-February)*** early winter,precipitation anomalies associated with ENSO are characterized by a monopole spatial distribution over eastern *** contrast,the precipitation anomaly pattern in late winter remarkably changes,manifesting as a dipole spatial *** noteworthy change in precipitation responses from early to late winter can be largely attributed to the seasonally varying Kuroshio anticyclonic *** the early winter of El Niño years,anticyclonic circulation anomalies appear both over the Philippine Sea and Kuroshio region,enhancing water vapor transport to the entirety of eastern China,thus contributing to more precipitation *** the late winter of El Niño years,the anticyclone over the Philippine Sea is further strengthened,while the one over the Kuroshio dissipates,which could result in differing water vapor transport between northern and southern parts of eastern China and thus a dipole precipitation *** the opposite anomalies of circulation and precipitation are displayed during La Niña *** analysis suggests that the seasonally-varying Kuroshio anticyclonic anomalies are possibly related to the enhancement of ENSO-related tropical central-eastern Pacific convection from early to late *** results have important implications for the seasonal-tointerannual predictability of winter precipitation over eastern China.

关键词： precipitation eastern China ENSO early winter late winter Kuroshio anticyclone

An overview of potential cardioprotective benefits of xanthophylls in atherosclerosis:an evidence-based review

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Food Science and Human Wellness 2024年第4期13卷 1739-1755页

作者： Yuting Su feng Chen Jiehua Chen Mingfu Wang Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced StudyShenzhen UniversityShenzhen 518060China Institution for Innovative Development of Food Industry Shenzhen UniversityShenzhen 518060China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Food Nutrition and Health Shenzhen UniversityShenzhen 518060China

Atherosclerosis,as the most prevalent form of cardiovascular disease,is characterized by oxidized lowdensity lipoprotein(ox-LDL)accumulation in the vascular wall,increased inflammation of the large arteries,dysfunction of the endothelial cells(ECs)and vascular smooth muscle cells(VSMCs),which may eventually lead to the formation of ***,one of the main groups of carotenoids,have been proposed as preventive agents or adjunct therapies to prevent and slow the progression of atherosclerosis due to their cardioprotective ***,the underlying preventive mechanism of action of xanthophylls on the pathogenesis of atherosclerosis remains unclear,and clinical evidence of the effect of xanthophylls on atherosclerosis have not yet been summarized and critically *** this regard,we conducted a comprehensive literature search in four scientific databases(Pub Med,Google Scholar,Science Direct and Web of Science)and carefully analyzed the existing evidence to provide meaningful insights on the association between xanthophylls and atherosclerosis from various *** on the evidence from in vitro and in vivo studies,we explored several potential mechanisms,including antioxidant effect,anti-inflammatory effect,regulation of lipid metabolism,and modulation of ECs and VSMCs dysfunction,and we found that a clear picture of regulatory pathways of xanthophylls on atherosclerosis prevention and treatment is still *** addition,epidemiological studies suggested the possible relationship among high dietary intake of xanthophylls,high plasma/serum xanthophylls and a reduced risk of *** evidence from interventional studies investigating the effect of xanthophylls on atherosclerosis is very sparse,whilst indirect clinical evidence was only limited to astaxanthin and ***,well-designed long-term randomized controlled trials(RCTs)are highly recommended for future studies to investigate the effective dose of different

关键词： Atherosclerosis Xanthophylls Antioxidant Anti-inflammation Lipid metabolism

Synergistic integration of self-supported 1T/2H-WS_(2) and nitrogendoped rGO on carbon cloth for pH-universal electrocatalytic hydrogen evolution

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Nano Research 2024年第3期17卷 1267-1280页

作者： feng Ming Yap Jian Yiing Loh Wee-Jun Ong School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Gulei Innovation Institute Xiamen UniversityZhangzhou 363200China Shenzhen Research Institute of Xiamen University Shenzhen 518057China

Hydrogen economy based on electrochemical water splitting exemplified one of the most promising means for overcoming the rapid consumption of fossil fuels and the serious deterioration of global *** development of earth-abundant,efficient,and durable electrocatalysts for hydrogen evolution reaction(HER)plays a vital role in the commercialization of water ***,the self-supported electrode with unique nitrogen-doped reduced graphene oxide(N-rGO)nanoflakes and WS_(2) hierarchical nanoflower that were grown directly on carbon cloth(CC)substrate(WS_(2)/N-rGO/CC)was successfully synthesized using a facile dual-step hydrothermal *** as-synthesized 50%1T/2H-WS_(2)/N-rGO/CC(WGC),which possessed high metallic 1T phase of 57%not only efficiently exposed more active sites and accelerated mass/charge diffusion,but also endowed excellent structural lustiness,robust stability,and durability at a high current *** a result,the 50%WGC exhibited lower overpotentials and Tafel slopes of 21.13 mV(29.55 mV∙dec^(-1))and 80.35 mV(137.02 mV∙dec^(-1))as compared to 20%Pt-C/CC,respectively for catalyzing acidic and alkaline hydrogen evolution ***,the as-synthesized 50%WGC also depicted long-term stability for more than 8 h in the high-current-density regions(100 and 220 mA∙cm^(-2)).In brief,this work reveals a self-supported electrode as an extraordinary alternative to Pt-based catalysts for HER in a wide pH range,while paving a facile strategy to develop advanced electrocatalysts with abundant heterointerfaces for practical applications in energy-saving hydrogen production.

关键词： self-supported electrocatalyst carbon-based substrate phase engineering pH-universal water splitting

NHC-derived carbon-centered luminescent radicals with shortwavelength emission via suppression of Kasha's rule

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Science China Chemistry 2024年第8期67卷 2679-2685页

作者： Can Chen Xin Li Xinhua Ouyang Ying-feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China College of Material Engineering Fujian Agriculture and Forestry University Fuzhou 350108China

Luminescent organic radicals have garnered increasing attention owing to their versatile applications in sensing, imaging, and organic light-emitting diodes(OLEDs), attributed to their unique emission properties originating from the doublet spin ***, the natural narrow bandgap of organic free radicals typically limits their emission to the long-wavelength *** luminescent organic radicals with short-wavelength emission remains a significant challenge. Herein, a series of carbon-centered radicals with short-wavelength emission(383–476 nm) by combining N-heterocyclic carbenes with various polycyclic aromatic hydrocarbons(PAHs)(2-naphthyl, 2a~Ⅰ and 2b~Ⅰ;2-phenanthryl, 2a~Ⅱand 2b~Ⅱ;2-anthryl, 2a~Ⅲand 2b~Ⅲ;3-phenanthryl, 2a~Ⅳand 2b~Ⅳ). Theoretical calculations reveal that the introduction of PAHs significantly increases the ΔE_(D2-D1) in 2a^(Ⅰ–Ⅲ)and 2b^(Ⅰ–Ⅲ)compared to that in phenyl-derived radical congeners. Consequently, the internal transition from D2 to D1 is impeded, leading to a high yield of D2 emission and a suppressed Kasha's rule, thereby overcoming the limitations imposed by their narrow bandgap. For 2a~Ⅳ and 2b~Ⅳ, despite a moderately large ΔED2-D1value, the ΔED3-D1value exceeds 1 e V, indicating that their emission likely originates from the D3 state. Furthermore, we utilized 2a~Ⅲand 2b~Ⅲ as emissive materials in OLEDs,resulting in blue emissions with external quantum efficiencies of 7.5% and 6.5%, respectively.

关键词： N-heterocyclic carbenes luminescent organic molecules carbon-centered radicals short-wavelength emission

Targeting RAF dimers in RAS mutant tumors:From biology to clinic

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1895-1923页

作者： Huanhuan Yin Qiulin Tang Hongwei Xia feng Bi Division of Abdominal Cancer Department of Medical OncologyCancer Center and Laboratory of Molecular Targeted Therapy in OncologyWest China HospitalSichuan UniversityChengdu 610041China

RAS mutations occur in approximately 30%of tumors worldwide and have a poor prognosis due to limited *** targeting of KRAS G12C has achieved significant success in recent years,but there is still a lack of efficient therapeutic approaches for tumors with non-G12C KRAS mutations.A highly promising approach is to target the MAPK pathway downstream of RAS,with a particular focus on RAF ***-generation RAF inhibitors have been authorized to treat BRAF mutant tumors for over a ***,their use in RAS-mutated tumors is not recommended due to the paradoxical ERK activation mainly caused by RAF *** address the issue of RAF dimerization,type II RAF inhibitors have emerged as leading *** clinical studies have shown the initial effectiveness of these agents against RAS mutant ***,type II RAF inhibitors in combination with MEK or ERK inhibitors have demonstrated impressive efficacy in RAS mutant *** review aims to clarify the importance of RAF dimerization in cellular signaling and resistance to treatment in tumors with RAS mutations,as well as recent progress in therapeutic approaches to address the problem of RAF dimerization in RAS mutant tumors.

关键词： RAS mutations RAF dimerization RAF inhibitors Cancer therapy Drug resistance

Automated Vulnerability Detection of Blockchain Smart Contacts Based on BERT Artificial Intelligent Model

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China Communications 2024年第7期21卷 237-251页

作者： feng Yiting Ma Zhaofeng Duan Pengfei Luo Shoushan School of Cyberspace Security Beijing University of Posts and TelecommunicationsBeijing 100876China

The widespread adoption of blockchain technology has led to the exploration of its numerous applications in various *** algorithms and smart contracts are critical components of blockchain *** the benefits of virtual currency,vulnerabilities in smart contracts have resulted in substantial losses to *** researchers have identified these vulnerabilities and developed tools for detecting them,the accuracy of these tools is still far from satisfactory,with high false positive and false negative *** this paper,we propose a new method for detecting vulnerabilities in smart contracts using the BERT pre-training model,which can quickly and effectively process and detect smart *** specifically,we preprocess and make symbol substitution in the contract,which can make the pre-training model better obtain contract *** evaluate our method on four datasets and compare its performance with other deep learning models and vulnerability detection tools,demonstrating its superior accuracy.

关键词： BERT blockchain smart contract vulnerability detection

Convolutional neural network adaptation and optimization method in SIMT computing mode

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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 105-112页

作者： feng Zhenfu Zhang Yaying Yang Lele Xing Lidong School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121China

For studying and optimizing the performance of general-purpose computing on graphics processing units(GPGPU)based on single instruction multiple threads(SIMT)processor about the neural network application,this work contributes a self-developed SIMT processor named Pomelo and correlated assembly *** parallel mechanism of SIMT computing mode and self-developed Pomelo processor is briefly introduced.A common convolutional neural network(CNN)is built to verify the compatibility and functionality of the Pomelo *** computing flow with task level and hardware level optimization is adopted on the Pomelo processor.A specific algorithm for organizing a Z-shaped memory structure is developed,which addresses reducing memory access in mass data computing *** the above-combined adaptation and optimization strategy,the experimental result demonstrates that reducing memory access in SIMT computing mode plays a crucial role in improving performance.A 6.52 times performance is achieved on the 4 processing elements case.

关键词： parallel computing single instruction multiple threads(SIMT) convolutional neural network(CNN) memory optimization

Which Neighborhoods Have Easier Access to Online Home Delivery Services?A Spatiotemporal Accessibility Analysis in Nanjing,China

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Chinese Geographical Science 2024年第4期34卷 722-738页

作者： KONG Yu ZHEN feng ZHANG Shanqi SHEN Lizhen School of Architecture and Urban Planning Nanjing UniversityNanjing 210093China Provincial Engineering Research Center of Smart City Planning and Digital Governance Nanjing 210093China

The rise in online home delivery services(OHDS)has had a significant impact on how urban services are supplied and used in recent *** on the spatial accessibility of OHDS are emerging,but few is known about the temporal dimension of OHDS accessibility as well as the geographic and socioeconomic differences in the spatiotemporal accessibility of *** study measures the spatiotemporal accessibility of four types of OHDS,namely leisure,fresh and convenient,medical,and catering *** geographic and socioeconomic disparities in the spatiotemporal accessibility of these four types of OHDS are then identified using spatial statistical methods and the Kruskal-Wallis test(K-W test).The case study in Nanjing,China,suggests that:1)spatiotemporal accessibility better reflects the temporal variation of OHDS accessibility and avoids overestimation of OHDS accessibility when only considering its spatial dimension.2)The spatiotemporal accessibility of OHDS varies geographically and *** located in the main city or neighborhoods with higher housing prices,higher population density,and higher point of interest(POI)mix have better OHDS spatiotemporal *** study contributes to the understanding of OHDS accessibility from a spatiotemporal perspective,and the empirical insights can assist policymakers in creating intervention plans that take into account variations in OHDS spatiotemporal accessibility.

关键词： online home delivery services(OHDS) spatiotemporal accessibility neighborhoods accessibility differences Nanjing City China

New quantification of symmetry energy from neutron skin thicknesses of 48Ca and 208Pb

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Nuclear Science and Techniques 2024年第10期35卷 217-225页

作者： Rong An Shuai Sun Li-Gang Cao feng-Shou Zhang School of Physics Ningxia University Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal University Key Laboratory of Beam Technology of the Ministry of Education Institute of Radiation TechnologyBeijing Academy of Science and Technology Center of Theoretical Nuclear Physics National Laboratory of the Heavy Ion Accelerator of Lanzhou

Precise knowledge of the nuclear symmetry energy can be tentatively calibrated using multimessenger *** neutron skin thickness of a heavy nucleus is one of the most sensitive indicators for probing the isovector components of effective interactions in asymmetric nuclear *** studies have suggested that the experimental data from the CREX and PREX2 collaborations are not mutually compatible with existing nuclear *** this study,we review the quantification of the slope parameter of the symmetry energy L from the neutron skin thicknesses of48Ca *** energy density functionals classified by various isoscalar incompressibility coefficients K were employed to evaluate the bulk properties of finite *** calculated results suggest that the slope parameter L deduced from208Pb is sensitive to the compression modulus of symmetric nuclear matter,but not that *** effective parameter sets classified by K=220 MeV can provide an almost overlapping range of L from48Ca and208Pb.

关键词： Energy density functional Neutron skin thickness Nuclear symmetry energy