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Regulating the microenvironment with nanomaterials:Potential strategies to ameliorate COVID-19

药学学报:英文版 2023年第9期13卷 3638-3658页

作者： Zhicheng Liu zhuolei han Xin Jin Jusung An Jaewon Kim Wenting Chen Jong Seung Kim Ji Zheng Jun Deng Department of Urology Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China Department of Urology Urological Surgery Research InstituteSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Burn Research Southwest HospitalState Key Lab of TraumaBurn and Combined InjuryChongqing Key Laboratory for Disease ProteomicsThird Military Medical University(Army Medical University)Chongqing 400038China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of Chemistry Korea UniversitySeoul 02841South Korea Department of Rheumatology and Clinical Immunology Army Medical CenterThird Military Medical University(Army Medical University)Chongqing 400042China

COVID-19,caused by SARS-CoV-2,has resulted in serious economic and health *** treatments remain inadequate to extinguish the epidemic,and efficient therapeutic approaches for COVID-19 are urgently being ***,accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in *** addition,recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection,providing new insight into COVID-19 *** literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 *** fill this gap,this review systematically discusses alterations of homeostasis in COVID-19 patients and potential ***,advances in nanotechnology-based strategies for promoting homeostasis restoration are ***,we discuss the challenges and prospects of using nanomaterials for COVID-19 *** review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders.

关键词： Coronavirus disease 19 Severe acute respiratory syndrome coronavirus 2 Therapeutic approaches Nanotechnology Nanomaterial technologies Microenvironment Microenvironmental disorder Altered homeostasis

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Hollow Bio-derived Polymer Nanospheres with Ordered Mesopores for Sodium-Ion Battery

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Nano-Micro Letters 2020年第3期12卷 1-11页

作者： Yan Ai Yuxiu You Facai Wei Xiaolin Jiang zhuolei han Jing Cui Hao Luo Yucen Li Zhixin Xu Shunqi Xu Jun Yang Qinye Bao Chengbin Jing Jianwei Fu Jiangong Cheng Shaohua Liu State Key Laboratory of Precision Spectroscopy and Department of Materials School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241People’s Republic of China Department of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Center for Advancing Electronics Dresden(cfaed)and Department of Chemistry and Food Chemistry Technische Universität Dresden01062 DresdenGermany School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450052People’s Republic of China State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050People’s Republic of China

Bio-inspired hierarchical self-assembly provides elegant and powerful bottom-up strategies for the creation of complex ***,the current self-assembly approaches for natural bio-compounds often result in materials with limited diversity and complexity in architecture as well as ***,we develop a novel coordination polymerization-driven hierarchical assembly of micelle strategy,using phytic acid-based natural compounds as an example,for the spatially controlled fabrication of metal coordination bio-derived *** resultant ferric phytate polymer nanospheres feature hollow architecture,ordered meso-channels of^12 nm,high surface area of 401 m2 g−1,and large pore volume of 0.53 cm3 g−*** an advanced anode material,this bio-derivative polymer delivers a remarkable reversible capacity of 540 mAh g−1 at 50 mA g−1,good rate capability,and cycling stability for sodium-ion *** study holds great potential of the design of new complex bio-materials with supramolecular chemistry.

关键词： Self-assembly Biomimetic synthesis Mesoporous polymer Ferric phytate Sodium-ion battery

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眼科疾病中细胞表型转化的研究进展

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医学综述 2020年第15期26卷 2924-2929页

作者：韩雪冯卓蕾哈尔滨医科大学附属第一医院眼科哈尔滨150001

细胞表型转化是指在特定条件下细胞从一种细胞类型转变为另一种细胞类型的生理病理过程。细胞表型转化与全身疾病联系密切,而细胞表型转化作为多种眼病的发病机制,近年来受到广泛关注。多种眼部疾病与细胞表型转化相关,包括Fuchs角膜内... 详细信息

细胞表型转化是指在特定条件下细胞从一种细胞类型转变为另一种细胞类型的生理病理过程。细胞表型转化与全身疾病联系密切,而细胞表型转化作为多种眼病的发病机制,近年来受到广泛关注。多种眼部疾病与细胞表型转化相关,包括Fuchs角膜内皮营养不良、组织创伤修复、白内障及青光眼术后并发症以及新生血管形成等。有多种因子参与细胞表型转化进而参与眼科疾病的调节,明确相关因子及细胞转化类型可为以后的治疗提供新的切入点。

关键词：细胞表型转化 Fuchs角膜内皮营养不良组织创伤修复术后并发症新生血管形成

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