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Current strategies for preventing the recurrence of hepatocellular carcinoma after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 145-149页

作者： zhuo-yi wang Lei Geng Shu-Sen Zheng Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND：Liver transplantation is the optimal treatment for a selected group of patients with moderate to severe cirrhosis and hepatocellular carcinoma（HCC）.Despite the strict selection of candidates,post-transplant recurrence often occurs and markedly reduces the long-term survival of patients with *** present review focuses on the current strategies on preventing the recurrence of HCC after liver *** SOURCES： Relevant articles were identified by exten- sive searching of PubMed using the keywords ＂hepatocellular carcinoma＂, ＂recurrence＂ and ＂liver transplantation＂ between January 1996 and January 2014. Additional papers were searched manually from the references in key articles. RESULTS： The current theories of HCC recurrence after liver transplantation are：（i） the growth of pre-transplant occult metastases; （ii） the engraftment of circulating tumor cells released at the time of transplantation. Pre-transplant treatment aims to control local tumor by radiofrequency ablation, transarterial embolization and transarterial chemoembolization. The main objective during the operation is to prevent tumor cell dissemination. Post-transplant treatment includes systemic anticancer therapy, antiviral therapy, and most recently, immunotherapy. These strategies concentrate on the control of the tumor when the patients are waiting for transplant, to reduce the release of HCC cells during surgical procedures and to dear the occult HCC cells after ***： Much can be done to prevent HCC recurrence after liver transplantation. In future, effort is likely to be di- rected towards combining multidisciplinary approaches and various treatment modalities.

关键词： hepatocellular carcinoma recurrence liver transplantation

Enhanced recovery after surgery in perioperative period of liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 594-596页

作者： Jiang-Juan He Lei Geng zhuo-yi wang Shu-Sen Zheng Department of Infection Management the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China

End-stage liver disease(ESLD)usually causes multi-organ dys-function which increases the risk for perioperative complications and mortality[1].Liver transplantation is the only curative ther-apy for ***,liver transplantation is a major and chal-lenging surgery with a great level of complexity as a result of the interaction between donor and recipient ***,this procedure brings a high risk of complications that significantly affect 1-year mortality and graft loss[2].In addition,immuno-suppressant applications are required *** factors make perioperative care of patients with liver disease complicated,and the risk of poor patient prognosis increases *** perioperative management strategies benefit the patient rehabilitation and prolong *** recovery after surgery(ERAS)is a multimodal and evidence-based program of care to minimize the surgical stress,reduce perioperative morbid-ity and hospital stay[3].

关键词： perioperative surgery mortality

Natural killer/T-cell lymphoma with intracranial infiltration and Epstein-Barr virus infection: A case report

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World Journal of Clinical Cases 2020年第15期8卷 3284-3290页

作者： Nan Li yi-zhuo wang yi Zhang Wei-Ling Zhang Yan Zhou Dong-Sheng Huang Pediatric Department Beijing Tongren Hospital Affiliated to Capital Medical UniversityBeijing 100176China

BACKGROUND Because of atypical clinical symptoms,lymphoma is easily confused with infectious *** nasal-type natural killer/T-cell lymphoma(NKTL)is more common,and there are few cases of eyelid site onset and intracranial infiltration,which increases the difficulty of *** disease usually has a very poor prognosis and there are few reports of *** SUMMARY A 3-year-old boy was admitted to our hospital due to an initial misdiagnosis of"eyelid cellulitis"and failed antibiotic *** was characterized by fever,right eyeball bulging,convulsions,and abnormal liver *** blood Epstein-Barr virus(EBV)DNA was positive(8.798×10^4 copies/mL),and remained positive for about half a *** cranial imaging examination suggested a space-occupying lesion in the right eyelid,with the right temporal lobe and meninges *** boy underwent ocular mass *** pathological diagnosis was *** was diagnosed as having NKTL with intracranial infiltration,combined with chronic active EBV infection(CAEBV).Then he underwent systemic chemotherapy and intrathecal *** boy suffered from abnormal blood coagulation,oral mucositis,diarrhea,liver damage,and severe bone marrow suppression but ***,the tumor was completely relieved and his blood EBV-DNA level turned *** current follow-up has been more than 2 years and his condition is *** This case suggests that chemotherapy combined with intrathecal injection may have a good effect on intracranial infiltrating lymphoma and CAEBV,which deserves further study and discussion.

关键词： Natural killer/T-cell lymphoma Intracranial infiltration Chronic active Epstein-Barr virus infection Eyelid cellulitis Chemotherapy Case report

Lower tacrolimus trough levels in the late period after living donorliver transplantation contribute to improvements in long-term clinicaloutcomes

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 204-209页

作者： lei geng li-dong wang jun-jie huang tian shen zhuo-yi wang bing-yi lin yu-fu ye shu-sen zheng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Combined Multi-organ Transplantation Ministry of Public HealthKey Laboratory of Organ TransplantationHangzhou 310003China Key Laboratory of Organ Transplantation Hangzhou 310003China Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases Hangzhou 310003China

Background： Previous studies have emphasized the need to reduce tacrolimus （TAC） trough levels in theearly post-liver transplantation （LT） period. However, whether late-period TAC trough levels influence the long... 详细信息

关键词： Liver transplantation Complications Immunosuppression

Synchronous concomitant pancreatic acinar cell carcin and gastric adenocarcinoma:A case report and review of literature

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World Journal of Clinical Cases 2021年第28期9卷 8509-8517页

作者： Tian Fang Ting-Ting Liang yi-zhuo wang Hai-Tao Wu Shu-Han Liu Chang wang Department of Oncology First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Multiple primary malignant tumors are two or more malignancies in an individual without any relationship between the *** recent years,an increasing number of cases have been ***,concomitant primary gastric and pancreatic cancer reported a relatively small incidence,involving no pancreatic acinar cell carcinoma ***,we present the first case of concomitant pancreatic acinar cell carcinoma and gastric *** SUMMARY A 69-year-old male presented to our department with a history of vomiting,epigastric pain,and weight *** revealed space-occupying lesions in the stomach and the tail of the pancreas,*** patient underwent laparo-scopic radical gastrectomy and pancreatectomy *** pathologies of surgical specimens were completely different:The resected gastric specimen was moderate to poorly differentiated adenocarcinoma,whereas the pancreatic tumor was consistent with acinar cell *** patient was treated with six cycles of oxaliplatin and S-1 *** of March 2021,the patient was healthy without any recurrence or *** thoroughly reviewing the literature on simultaneous pancreatic and gastric cancers at home and abroad,we discussed the clinical characteristics of these rare synchronous double *** of the cases had undergone surgery and adjuvant chemotherapy,and all of the cases were pathologically confirmed by the postoperative *** Synchronous pancreatic acinar cells and gastric adenocarcinoma can occur and should be considered when tumors are found in these organs.

关键词： Synchronous concomitant cancers Pancreatic neoplasms Stomach neoplasms Pancreatic acinar cell carcinoma Surgical procedures Case report

A modified protocol with rituximab and intravenous immunoglobulin in emergent ABO-incompatible liver transplantation for acute liver failure

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 395-401页

作者： Tian Shen Bing-yi Lin Jun-Jun Jia zhuo-yi wang Li wang Qi Ling Lei Geng Sheng Yan Shu-Sen Zheng Key Lab of Combined Multi-organ Transplantation Ministry of Public Health Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND： The established procedure for ABO-incompatible liver transplantation（ABO-I LT） was too complicated to be used in case of emergency. We developed a protocol consisting of rituximab and intravenous immunoglobulin（IVIG） for ABO-I LT in patients with acute liver failure（ALF）.METHODS： The data from 101 patients who had undergone liver transplantation（LT） for ALF were retrospectively *** patients were divided into two groups： ABO-compatible liver transplantation group（ABO-C LT, n=66） and ABO-I LT group（n=35）. All the patients in the ABO-I LT group received a single dose of rituximab（375 mg/m2） and IVIG（0.4 g/kg per day） at the beginning of the operation. IVIG was administered for 10 consecutive days after LT. Plasma exchange, splenectomy and graft local infusion were omitted in the *** immunosuppressive therapy including basiliximab,corticosteroids, tacrolimus and mycophenolatemofetil was used to reinforce ***： The 3-year cumulative patient survival rates in the ABO-I LT and ABO-C LT groups were 83.1% and 86.3%,respectively（P〉0.05）, and the graft survival rates were 80.0%and 86.3%, respectively（P〉0.05）. Two patients（5.7%） suffered from antibody-mediated rejection in the ABO-I LT *** complications such as acute cellular rejection, biliary complication and infection displayed no significant differences between the two ***： The simplified treatment consisting of rituximab and IVIG prevented antibody-mediated rejection for LT of blood-type incompatible patients. With this treatment, the patients did not need plasma exchange, splenectomy and graft local infusion. This treatment was safe and efficient for LT of the patients with ALF.

关键词： ABO-incompatible liver transplantation rituximab intravenous immunoglobulin acute liver failure

Non-synchronous vibration of rotor blade in a six-stage transonic compressor

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Chinese Journal of Aeronautics 2024年第8期37卷 36-48页

作者： Ronghui CHENG zhuo wang Huawei YU Lin DU yi ZHANG Xiaofeng SUN Aeroengine Research Institute Beihang UniversityBeijing 102206China School of Energy and Power Engineering Beihang UniversityBeijing 102206China

This paper presents an experimental study on the Non-Synchronous Vibration(NSV)in a six-stage transonic *** first part of the paper describes the NSV phenomenon of Rotor 1,which occurs when both Stator 1(S1)and Stator 2(S2)or S1 only are *** measurements and analysis are carried out for the former case through the unsteady wall pressure and the Blade Strain(BS).The spinning mode theory used in the rotor/stator interaction noise is employed to explain the relation between the circumferential wave number of the aerodynamic disturbance and the Nodal Diameter(ND)of the blade *** variations of the vibration amplitudes of different blades and the Inter-Blade Phase Angles(IBPAs)at different moments suggest that the evolution of NSV is a highly nonuniform phenomenon along the circumferential *** addition,the difference between the wall-pressure spectra generated by the NSV and the classic flutter has been *** the second part,the variations of aerodynamic loading due to the adjustment of the staggers of the Inlet Guide Vane(IGV),S1 and S2 have been *** is found that closing S1 only can result in a great fluctuation to the performance of the front stages,which might be detrimental to the flow organization and increase the risk of *** contrast,the effect of closing S2 only on the performance of the first two stages appears to be slighter relatively.

关键词： Transonic compressor Non-synchronous vibration Modal analysis Aerodynamic loading Nodal diameter

Selective deposition of a MOF at the spikes of Au nanostars for SERS detection

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Nano Research 2024年第10期17卷 9166-9173页

作者： yi Liu Ka Kit Chui Xinyue Xia Han Zhang Xiaolu zhuo Jianfang wang School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China Department of Physics The Chinese University of Hong KongShatinHong Kong 999077China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310000China

In the pursuit of advancing molecular sensing through surface-enhanced Raman spectroscopy(SERS),the combination of plasmonic nanoparticles and metal-organic frameworks(MOFs)has emerged as a highly effective approach to enhance the sensitivity and selectivity of SERS ***,most prior investigations have predominantly focused on MOF-coated plasmonic nanoparticles in core@shell or layer-by-layer configurations,leaving a notable knowledge gap in exploring alternative *** we present a facile method to construct a particle-on-mirror architecture by selectively coating a MOF,zeolitic imidazolate framework-8(ZIF-8),onto the tips of Au nanostars and subsequently depositing the resultant nanoparticles onto a Au *** design integrates the electric field enhancement at the sharp tips and nanogaps,along with the molecular enrichment function within the porous MOF immobilized at the tips and nanogaps,leading to a substantial boost in the SERS signal *** a unique SERS platform enables consistent and outstanding SERS performance for analytes of different *** work opens up a promising strategy for constructing multifunctional nanostructures for sensitive SERS detection in real-life scenarios.

关键词： electric field enhancement gold nanostars metal-organic frameworks molecular enrichment plasmon coupling surfaceenhanced Raman spectroscopy(SERS)substrates

Safety and efficacy of an integrated endovascular treatment strategy for early hepatic artery occlusion after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 524-531页

作者： Heng-Kai Zhu Li Zhuang Cheng-Ze Chen Zhao-Dan Ye zhuo-yi wang Wu Zhang Guo-Hong Cao Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgerythe First Affiliated HospitalZhejiang University School of Medicine79 Qingchun RoadHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic CancerCAMSHangzhou 310003China Key Laboratory of Organ Transplantation Zhejiang Provincial Research Center for Diagnosis and Treatment of Hepatobiliary DiseasesHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Intensive Care Unit Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Radiology Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China

Background:Hepatic artery occlusion(HAO)after liver transplantation(LT)is typically comprised of hepatic artery thrombosis(HAT)and stenosis(HAS),both of which are severe complications that coexist and *** study aimed to evaluate an integrated endovascular treatment(EVT)strategy for the resolution of early HAO and identify the risk factors associated with early HAO as well as the procedural challenge encountered in the treatment ***:Consecutive orthotopic LT recipients(n=366)who underwent transplantation between June 2017 and December 2018 were retrospectively *** was performed using an integrated strategy that involved thrombolytic therapy,shunt artery embolization plus vasodilator therapy,percutaneous transluminal angioplasty,and/or stent *** EVT was defined as the clinical resolution of HAO by one round of EVT with thrombolytic therapy and/or shunt artery embolization plus vasodilator ***,it was defined as complex ***:Twenty-six patients(median age 52 years)underwent EVT for early HAO that occurred within 30 days *** median interval from LT to EVT was 7(6–16)*** time(OR=1.027;95%CI:1.005–1.050;P=0.018)and the need for conduit(OR=3.558;95%CI:1.241–10.203,P=0.018)were independent predictors for early *** was diagnosed in eight patients,and four out of those presented with concomitant *** achieved 100%technical success and recanalization by performing simple EVT in 19 patients(3 HAT+/HAS-and 16 HAT-/HAS+)and by performing complex EVT in seven patients(1 HAT+/HAS-,4 HAT+/HAS+,and 2 HAT-/HAS+),without major *** primary assisted patency rates at 1,6,and 12 months were all 100%.The cumulative overall survival rates at 1,6,and 12 months were 88.5%,88.5%,and 80.8%,*** transfusion<600 mL(94.74%vs.42.86%,P=0.010)and interrupted suture for hepatic artery anastomosis(78.95%vs.14.29%,P=0.005)were more prevalent in simple ***

关键词： Liver transplantation Hepatic artery occlusion Hepatic artery thrombosis Hepatic artery stenosis Endovascular treatment