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Anatomical retroperitoneoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell tumors： initial operative experience

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Asian Journal of Andrology 2014年第1期16卷 136-139页

作者： Kai Yao Zai-Shang Li Fang-Jian Zhou Zi-Ke Qin zhuo-wei liu Yong-Hong Li Hui Han Department of Urology Cancer Center Sun Yat-Sen University State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Guangzhou China.

To introduce the technique of anatomical retroperitoneoscopic retroperitoneal lymph node dissection （ARRPLND） was performed in 12 consecutive patients with a clinical stage I nonseminomatous germ-cell tumor （NSGCT） between February 2008 and October 2010. All procedures were performed using a modified template nerve-sparing approach. The retroperitoneal space was adequately expanded using double gasbags. After the retroperitoneal fat was cleared, two relatively bloodless planes were entered consecutively to expose the lymph node and permit dissection. Dissection proceeded first in the plane between the anterior renal fascia and posterior peritoneum, and secondly in the avascular plane between the posterior renal fascia and transversalis fascia. The proximal spermatic vein was clipped at the initial stage. En bloc resection of the lymph tissue and fat between the anterior renal fascia and posterior renal fascia were performed. Three patients （25%） had pathologic stage IIA disease and received adjuvant chemotherapy. No recurrence was observed during follow-up ranging from 26 to 58months. The median operative time was 205min （range： 165-430min） and median estimated blood loss was 320ml （range： 100-1200ml）. There were two intraoperative complications （Clavien grade II） and one open conversion due to perforation of the peritoneum. Postoperative complications （Clavien I） developed in three patients. Normal antegrade ejaculation recovered by 1 month following the operation. Our preliminary results indicate that ARRPLND is technically feasible and associated with satisfactory clinical outcomes for clinical stage I NSGCT. Further studies are necessary to evaluate this technique.

关键词： nonseminomatous retroperitoneoscopic retroperitoneal lymph node testicular cancer

Complications of radical nephrectomy for renal cell carcinoma: a retrospective study comparing transperitoneal and retroperitoneal approaches using a standardized reporting methodology in two Chinese centers

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Chinese Journal of Cancer 2013年第8期32卷 461-468页

作者： Zhi-Ling Zhang Yong-Hong Li Jun-Hang Luo zhuo-wei liu Kai Yao Pei Dong Hui Han Zi-Ke Qin wei Chen Fang-Jian Zhou State Key Laboratory of Oncology in South China Department of Urology Sun Yat-sen University Cancer Center Department of Urology the First Affiliated Hospital of Sun Yat-sen University

The reporting of complications following transperitoneal and retroperitoneal open radical nephrectomy (RN) is nonstandardized. This study aimed to compare early complications between the two approaches using a standardized reporting methodology in a large contemporary cohort. Between 1996 and 2009, 558 patients underwent open RN for renal cell carcinoma (RCC) in our two centers (424 from Sun Yat-sen University Cancer Center and 134 from the First Affiliated Hospital of Sun Yat-sen University). Records were reviewed for clinicopathologic features and complications. Complications were graded using the Clavien system based on the severity of impact. One hundred and five patients (18.8%) had one or more early complications (168 complications overall). The overall rates of grades I to V complications were 5.6%, 10.8%, 2.2%, 0.4%, and 0.2%, respectively. Patients who underwent transperitoneal RN did not experience more overall or procedure-related complications than those who underwent retroperitoneal RN (P=0.911 and P=0.851, respectively). On subgroup analysis, neither grade I/II nor grades III-V complications were significantly different between the transperitonal RN and retroperitoneal RN groups. Multivariate analysis showed that for any grade of complication, age (P=0.016) and estimated blood loss (P=0.001) were significant predictors. We concluded that open RN is a safe procedure associated with low rates of serious morbidity and mortality. Compared with retroperitoneal RN, transperitoneal RN was not associated with more complications. Older patient and more blood loss at surgery were independent predictors for higher early postoperative complication rates.

关键词：并发症肾细胞切除术标准化腹膜癌症中国中山大学

Biochar-based materials as remediation strategy in petroleum hydrocarbon-contaminated soil and water:Performances,mechanisms,and environmental impact

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Journal of Environmental Sciences 2024年第4期138卷 350-372页

作者： zhuo wei Yiwei Yang liu Shuai Niu Yaxi Xu Jong-Hwan Park Jim J.Wang Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China School of Plant Environment&Soil SciencesLouisiana State University AgCenter.Baton RougeLA 70803USA Department of Life Resources Industry Dong-A University37Nakdong-daero 550 beon-gilSaha-guBusan 49315South Korea

Petroleum contamination is considered as a major risk to the health of humans and *** as low-cost and eco-friendly carbon materials,have been widely used for the removal of petroleum hydrocarbon in the *** purpose of this paper is to review the performance,mechanisms,and potential environmental toxicity of biochar,modified biochar and its integration use with other materials in petroleum contaminated soil and ***,the use of biochar in oil-contaminated water and soil as well as the factors that could influence the removal ability of biochar were systematically *** addition,the modification and integrated use of biochar for improving the removal efficiency were summarized from the aspects of sorption,biodegradation,chemical degradation,and ***,the functional impacts and associated ecotoxicity of pristine and modified biochars in various environments were ***,some shortcoming of current approaches,and future research needs were provided for the future direction and challenges of modified biochar ***,this paper gain insight into biochar application in petroleum remediation from the perspectives of performance enhancement and environmental sustainability.

关键词： Petroleum contamination Adsorbent Bioremediation Biochar modification Ecotoxicity

Radical cystectomy for bladder cancer: oncologic outcome in 271 Chinese patients

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Chinese Journal of Cancer 2014年第3期33卷 165-171页

作者： Zhi-Ling Zhang Pei Dong Yong-Hong Li zhuo-wei liu Kai Yao Hui Han Zi-Ke Qin Fang-Jian Zhou Department of Urology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine

Few large scale studies have reported the oncologic outcome of radical cystectomy for treating bladder cancer in China; hence, we lack long-term prognostic information. The aim of the current study was to determine the survival rate and prognostic factors of patients who underwent radical cystectomy for bladder cancer in a Chinese medical center. We retrospectively analyzed clinicopathologic data from 271 bladder cancer patients who underwent radical cystectomy between 2000 and 2011. Univariate and multivariate analyses were conducted to identify independent prognostic predictors for this cohort. Median follow-up was 31.7 months(range, 0.2–139.1 months). Thirty-day mortality was(1.4%). The 5-year recurrence-free survival, cancer-specific survival(CSS), and overall survival rates were 61.6%, 72.9%, and 68.0%, respectively. The 5-year CSS rates of patients with T1–T4 disease were 90.7%, 85.0%, 51.0%, and 18.0%, respectively. Patients with organ-confined disease had a higher 5-year CSS rate than those with extravesical disease(81.4% vs. 34.9%, P < 0.001). For the 38 patients(14%) with lymph node involvement, the 5-year CSS rate was 27.7%—significantly lower than that of patients without lymph node metastasis(P < 0.001). The 5-year CSS rate was much higher in patients with low grade tumor than in those with high grade tumor(98.1% vs. 68.1%, P < 0.001). Multivariate Cox regression showed that patient age(hazard ratio, 2.045; P = 0.013) and T category(hazard ratio, 2.213; P < 0.001) were independent predictors for CSS. These results suggest that radical cystectomy is a safe and effective method for treating bladder cancer in Chinese patients. Old age and high T category were associated with poor prognosis in bladder cancer patients who underwent radical cystectomy.

关键词： Bladder cancer radical cystectomy prognosis

Intraarterial chemotherapy with gemcitabine and cisplatin in locally advanced or recurrent penile squamous cell carcinoma

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Chinese Journal of Cancer 2013年第11期32卷 619-623页

作者： Jian-Ye liu Yong-Hong Li zhuo-wei liu Zhi-Ling Zhang Yun-Lin Ye Kai Yao Hui Han Zi-Ke Qin Fang-Jian Zhou State Key Laboratory of Oncology in South China Department of Urology Sun Yat-sen University Cancer Center

The prognosis of locally advanced or recurrent squamous cell carcinoma(SCC) of the penis after conventional treatment is dismal. This study aimed to evaluate the therapeutic effects of intraarterial chemotherapy with gemcitabine and cisplatin on locally advanced or recurrent SCC of the penis. Between April 1999 and May 2011, we treated 5 patients with locally advanced penile SCC and 7 patients with recurrent disease with intraarterial chemotherapy. The response rate and toxicity data were analyzed, and survival rates were calculated. After 2 to 6 cycles of intraarterial chemotherapy with gemcitabine and cisplatin, 1 patients with locoregionally advanced disease achieved a complete response, and 4 achieved partial response. Of the 7 patients with recurrent disease, 2 achieved complete response, 3 achieved partial response, 3 had stable disease, and 1 developed progressive disease. An objective tumor response was therefore achieved in 10 of the 12 patients. The median overall survival for the patients was 24 months(range, 10-50 months). Three out of 10 patients who responded were long-term survivors after intraarterial chemotherapy. Intraarterial chemotherapy with gemcitabine and cisplatin may be effective and potentially curative in locoregionally advanced or recurrent penile SCC. The contribution of this therapy in the primary management of advanced or recurrent penile SCC should be prospectively investigated.

关键词：鳞状细胞癌治疗效果复发阴茎晚期化疗动脉灌注

Survival analysis of children with stage Ⅱ testicular malignant germ cell tumors treated with surgery or surgery combined with adjuvant chemotherapy

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Chinese Journal of Cancer 2015年第2期34卷 86-93页

作者： Su-Ying Lu Xiao-Fei Sun Zi-Jun Zhen Zi-Ke Qin zhuo-wei liu Jia Zhu Juan Wang Fei-Fei Sun State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Pediatric Oncology Sun Yat sen University Cancer Center Department of Urology Sun Yat sen University Cancer Center

For children with stage II testicular malignant germ cell tumors(MGCT), the survival is good with surgery and adjuvant chemotherapy. However, there is limited data on surgical results for cases in which there was no imaging or pathologic evidence of residual tumor, but in which serum tumor markers either increased or failed to normalize after an appropriate period of half-life time post-surgery. To determine the use of chemotherapy for children with stage II germ cell tumors, we analyzed the outcomes(relapse rate and overall survival) of patients who were treated at the Sun Yat-sen University Cancer Center between January 1990 and May 2013. Twenty-four pediatric patients with a median age of 20 months(range, 4 months to 17 years) were enrolled in this study. In 20 cases(83.3%), the tumors had yolk sac histology. For definitive treatment, 21 patients underwent surgery alone, and 3 patients received surgery and adjuvant chemotherapy. No relapse was observed in the 3 patients who received adjuvant chemotherapy, whereas relapse occurred in 16 of the 21 patients(76.2%) treated with surgery alone. There were a total of 2 deaths. Treatment was stopped for 1 patient, who died 3 months later due to the tumor. The other patient achieved complete response after salvage treatment, but developed lung and pelvic metastases 7 months later and died of the tumor after stopping treatment. For children treated with surgery alone and surgery combined with adjuvant chemotherapy, the 3-year event-free survival rates were 23.8% and 100%, respectively(P = 0.042), and the 3-year overall survival rates were 90.5% and 100%, respectively(P = 0.588). These results suggest that adjuvant chemotherapy can help to reduce the recurrence rate and increase the survival rate for patients with stage II germ cell tumors.

关键词：肿瘤标记物手术治疗生殖细胞化疗儿童生存分析恶性睾丸

Traditional Chinese Medicine Erhuang Suppository for Treatment of Persistent High-risk Human Papillomavirus Infection and Its Impact on Transcriptome of Uterine Cervix

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Current Medical Science 2024年第4期44卷 841-853页

作者： Zi-zhuo WANG Hui-li WANG wei XIONG Juan DU Rong liu Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Pharmacology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective High-risk human papillomavirus(HR-HPV)infection is the chief cause of cervical intraepithelial neoplasia(CIN)and cervical *** Erhuang suppository(EHS)is a traditional Chinese medicine(TCM)prepared from realgar(As2S2),Coptidis rhizoma,alumen,and borneolum syntheticum and has been used for antiviral and antitumor ***,whether EHS can efficiently alleviate HR-HPV infection remains *** study was conducted to evaluate the efficacy of EHS for the treatment of persistent HR-HPV infection in the uterine *** In this study,we evaluated the therapeutic efficacy of EHS in a randomized controlled clinical trial with a 3-month ***,70 patients with persistent HR-HPV infection were randomly assigned to receive intravaginal administration of EHS or *** DNA,ThinPrep cytologic test(TCT),colposcopy,and safety evaluation were carried out after *** analysis was performed to compare transcriptome profiles before and after EHS treatment.A K14-HPV16 mouse model was generated to confirm the efficiency of *** After 3 months,74.3%(26/35)of the patients in the treatment group were HPV negative,compared to 6.9%(2/29)in the placebo ***-throughput microarrays revealed distinct transcriptome profiles after *** differentially expressed genes were significantly enriched in complement activation,immune response,and apoptotic *** K14-HPV16 mouse model also validated the remarkable efficacy of *** This study demonstrated that EHS is effective against HR-HPV infection and cervical ***,no obvious systemic toxicity was observed in patients during the *** superior efficacy and safety of EHS demonstrated its considerable value as a potential cost-effective drug for the treatment of HPV infection and HPV-related cervical diseases.

关键词： Traditional Chinese Medicine Erhuang suppository human papillomavirus cervical diseases transcriptomics

High-performance Si/VO_(2)-nanorod heterojunction photodetector based on photothermoelectric effect for detecting human radiation

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Rare Metals 2024年第3期43卷 1177-1185页

作者： Fu-Hai Guo Lan-Zhong Hao wei-zhuo Yu Si-Qi Li Guan-Chu liu Jing-Yi Hao Yun-Jie liu College of Science China University of PetroleumQingdao266580China School of Materials Science and Engineering China University of PetroleumQingdao266580China

As a typical candidate of optoelectronic materials,vanadium dioxide(VO_(2))has wide applications in photodetectors(PDs),but is still challenging in largely enhancing the photodetecting performance for low-power human ***,high-performance Si/VO_(2)nanorods(NRs)heterojunction PDs based on the photothermoelectric(PTE)effect are *** uniform VO_(2)-NRs array films were deposited on Si by using magnetron sputtering technique,and a Si/VO_(2)heterojunctions were *** device exhibits a four-stage photoresponse and broadband photoresponse from ultraviolet to long-wavelength *** from the unique nanorods structure and the strong PTE effect,the fabricated device exhibits a large enhancement of the photodetecting performance,showing an ultrahigh photodetectivity of 1.6×10^(13)Jones and ultrafast response rates with a risingedge time of~65.0μs,three orders of magnitude higher than other VO_(2)-based ***,the device exhibits unique abilities to detect human radiation even when the human fingers are far away from the device surface up to 10.0 ***,the fabricated Si/VO_(2)devices can also be applied as breath sensors to distinguish different breathing *** results supply an effective route to design high-performance photodetectors toward detecting human thermal radiation and respiration.

关键词： Vanadium dioxide Heterojunction Photodetector Photothermoelectric Human radiation and respiration sensing

Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy

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Chinese Journal of Natural Medicines 2024年第2期22卷 127-136页

作者： WANG wei liu Lijuan YANG zhuo LU Chuanjian TU Pengfei ZHAO Ruizhi ZENG Kewu State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006China

Psoriasis,a prevalent inherited skin condition,involves an inflammatory response as a key pathogenic *** Optimized Yinxieling Formula(OYF),rooted in traditional Chinese medicine,is extensively utilized in clinical settings to treat *** previous studies have demonstrated OYF’s significant anti-inflammatory effects in psoriasis,its potential molecular targets and active components remain *** study aimed to unveil the anti-psoriasis molecular targets and active components of *** findings indicated that OYF extract markedly reduced the production of several inflammatory mediators,including IL-23,nitric oxide,TNF-α,and IL-1β,in LPS-induced RAW264.7 *** synthesized OYF extract-crosslinked beads to isolate pharmacological targets from RAW264.7 lysates using an affinity purification strategy,known as Target *** enriched target proteins were subsequently identified via LC-MS/MS,followed by bioinformatics analysis to map the psoriasis-associated pathway-gene *** identified a total of 76 potential target proteins,which were highly associated with mRNA transcription *** particular,pathway-gene network analysis revealed that the IL-23 inflammatory pathway was involved in the anti-psoriasis effect of OYF *** further utilized a target protein-based affinity capture strategy,combined with LC-MS and SPR analysis,to globally screen OYF’s active components,focusing on the mRNA transcription regulator,fused in sarcoma(FUS).This process led to the identification of umbelliferone,vanillic acid,protocatechuic acid,gentisic acid,and echinacoside as key compounds targeting FUS to inhibit IL-23 ***,we formulated a compound cocktail(CpdC),which significantly reduced psoriasis area and severity index(PASI)scores and the expressions of IL-23 and Ki67 in an imiquimod(IMQ)-induced psoriasis mouse ***,our study elucidates the primary molecular targets and active components of OYF,offeri

关键词： Psoriasis Optimized Yinxieling Formula(OYF) FUS protein Molecular targets Affinity-purified strategy