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Perforation optimization of layer-penetration fracturing for commingling gas production in coal measure strata

Petroleum Science 2022年第4期19卷 1718-1734页

作者： Bing Hou zhuang cui Ji-Hui Ding Feng-Shou Zhang Li zhuang Derek Elsworth State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BejingBejing102249China MOE Key Laboratory of Petroleum Engineering in China University of Petroleum Beijing 102249China Department of Geophysics Stanford University397 Panama MallStanfordCA94305USA Department of Geotechnical Engineering Tongji UniversityShanghai200092China Korea Institute of Civil Engineering and Building Technology Goyang10223South Korea The Pennsylvania State University University ParkPA16802USA

Optimization of fracturing perforation is of great importance to the commingling gas production in coal measure strata.In this paper,a 3 D lattice algorithm hydraulic fracturing simulator was employed to study the effects of perforation position and length on hydraulic fracture propagation in coal measures of the Lin-Xing block,China.Based on field data,three lithologic combinations are simulated:1)a thick section of coal seam sandwiched by sandstones;2)a thin coal seam layer overlay by gas-bearing tight sandstone;3)two coal seams separated by a thin layer of sandstone.Our simulation shows that perforation position and length in multi-layer reservoirs play a major role in hydraulic fracture propagation.Achieving maximum stimulated volume requires consideration of lithologic sequence,coal seam thickness,stress states,and rock properties.To improve the combined gas production in coal measure strata,it is possible to simultaneously stimulate multiple coal seams or adjacent gas-bearing sandstones.In these cases,perforation location and length also significantly impact fracture propagation,and therefore should be carefully designed.Our simulation results using 3 D lattice algorithm are qualitatively consistent with laboratory physical simulation.3 D lattice models can be used to effectively simulate the fracture propagation through layers in coal measure strata.The numerical results provide guidance for perforation optimization in the hydraulic fracturing of coal measure strata.

关键词： Coal measure strata Combined production 3D lattice algorithm Perforation scheme optimization Fracture propagation

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Lactobacillus levels and prognosis of patients with acute myocardial infarction

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Journal of Geriatric Cardiology 2022年第2期19卷 101-114页

作者： Jing-Jing CAI Yin LIU Jie WANG Jing-Xian WANG Yuan WANG Shi-Bo XU zhuang cui Jing GAO Graduate School Tianjin Medical UniversityTianjinChina Department of Cardiology Xing’anmeng People’s HospitalInner MongoliaChina Clinical School of Thoracic Tianjin Medical UniversityTianjinChina Department of Cardiology Tianjin Chest HospitalTianjinChina School of Public Health Tianjin Medical UniversityTianjinChina Cardiovascular Institute Tianjin Chest HospitalTianjinChina

OBJECTIVE To explore the relationship between Lactobacillus and prognosis of acute myocardial infarction(AMI)patients treated by percutaneous coronary intervention(PCI)and its correlation with clinical parameters.METHODS Consecutive patients with AMI in the coronary care unit of Tianjin Chest Hospital in China who received emergency PCI between July 2017 and December 2018 were enrolled.Subjects’fecal 16 S r DNA gene sequencing data were analyzed and subjects were categorized into low,medium and high level groups according to stool Lactobacillus measurements.The primary endpoints were major adverse cardiac events.Cox regression analysis was used to analyze the relationship between Lactobacillus and prognosis.Spearman correlation analysis and trend tests were used to assess the relationship between Lactobacillus and the clinical indicators.RESULTS The data of 254 patients were included in the analysis.Mean age was 65.90±11.56 years,and 152 patients(59.84%)were male.Follow-up time was 652(548.25-753.00)days.Multivariate Cox regression analysis showed a significantly lower risk of major adverse cardiac events in patients with Lactobacillus>7.1 copies/g[adjusted hazard ratio(HR)=0.216,95%CI:0.094-0.493,P<0.001]compared to patients with Lactobacillus≤3.6 copies/g.Statistically significant differences were shown in ST-segment elevation myocardial infarction(STEMI)(HR=0.217,95%CI:0.085-0.551,P=0.001).Lactobacillus was a protective factor for male smokers aged over 60 years whose brain natriuretic peptide was over 1,000 pg/m L.Spearman correlation analysis showed that Lactobacillus correlated negatively with white blood cells,neutrophils,high-sensitivity C-reactive protein,Troponin T,creatine kinase,creatine kinase-MB and brain natriuretic peptide(downward trend),and correlated positively with left ventricular ejection fraction(upward trend).CONCLUSIONS This study is the first to reveal the correlation between Lactobacillus and inflammation and myocardial damage after STEMI.STEMI patients,especially male smokers aged over

关键词： patients infarction prognosis

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Economic Evaluation of the Comprehensive AIDS Prevention and Control Program—Tianjin Municipality,China,2011-2022

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China CDC weekly 2023年第48期5卷 1067-1072页

作者： Maohe Yu Jianping Wang Jinhua Zhao Yan Guo Jianyun Bai Zhongquan Liu Hui Gong Tielin Ning Minna Zheng Jinyu Hou zhuang cui STD&AIDS Control and Prevention Section Tianjin Centers for Disease Control and PreventionTianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjinChina Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjinChina

What is already known about this topic?Acquired immunodeficiency syndrome(AIDS)represents a significant public health challenge globally,not only inflicting harm on the health of individuals but also placing a considerable economic strain on society.What is added by this report?This study represents the inaugural report on the potential reduction in economic burden attributable to human immunodeficiency virus(HIV)prevention strategies in Tianjin.Between 2011 and 2022,it is estimated that effective measures could prevent 2,965 new HIV infections and avert 658 deaths,resulting in an economic benefit of approximately 14.437 billion Chinese Yuan.What are the implications for public health practice?The findings of this study offer valuable evidence to inform the development of localized HIV prevention and control strategies,as well as to guide public health policymaking.

关键词： prevention globally Tianjin

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深层页岩巴西劈裂破坏力学行为数值模拟研究

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石油钻探技术 2024年第2期52卷 218-228页

作者：崔壮侯冰油气资源与工程全国重点实验室(中国石油大学(北京)) 北京102249 石油工程教育部重点实验室(中国石油大学(北京)) 北京102249 中国石油大学(北京)克拉玛依校区石油学院新疆克拉玛依834000

为揭示页岩纹理特征与破坏强度之间的作用机理,利用黏聚力单元法建立了巴西劈裂三维数值模型,研究了纹理角度和纹理强度对页岩破坏模式和抗拉强度的影响,并利用声发射分布特征精确分析了裂纹演化过程。研究结果表明:巴西劈裂数值模拟结... 详细信息

为揭示页岩纹理特征与破坏强度之间的作用机理,利用黏聚力单元法建立了巴西劈裂三维数值模型,研究了纹理角度和纹理强度对页岩破坏模式和抗拉强度的影响,并利用声发射分布特征精确分析了裂纹演化过程。研究结果表明:巴西劈裂数值模拟结果与试验结果基本一致,利用黏聚力单元法可以准则预测页岩破坏行为;纹理角度和纹理强度耦合作用下页岩试样破坏模式分为6种;中心破坏的页岩试样,声发射能量–位移曲线以单峰值分布型为主,拉伸剪切复合破坏的页岩试样,声发射能量–位移曲线以多峰值分布型为主;页岩试样抗拉强度各向异性显著,相同纹理角度下,纹理强度越高,主裂纹越接近加载直径方向,试样抗拉强度越大。研究结果进一步揭示了深层页岩破坏机制,为页岩储层压裂设计提供了理论依据。

关键词：深层页岩巴西劈裂数值模拟破坏模式抗拉强度

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Endothelial PDGF-BB/PDGFR-βsignaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation

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Bone Research 2022年第4期10卷 852-866页

作者： zhuang cui Hangtian Wu Ye Xiao Ting Xu Junjie Jia Hancheng Lin Rongmin Lin Kun Chen Yihuang Lin Kaiqun Li Xiaohu Wu Changjun Li Bin Yu Division of Orthopaedics and Traumatology Department of OrthopaedicsNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Bone and Cartilage Regeneration Medicine Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunan 410008China Department of Sleep Medicine Center Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis(OA)remain unknown.No pharmacological intervention can currently prevent the progression of osteoarthritis.Accumulating evidence has shown that subchondral bone deterioration is a primary trigger for overlying cartilage degeneration.We previously found that H-type vessels modulate aberrant subchondral bone formation during the pathogenesis of OA.However,the mechanism responsible for the elevation of H-type vessels in OA is still unclear.Here,we found that PDGFR-βexpression,predominantly in the CD31^(hi)Emcn^(hi) endothelium,was substantially elevated in subchondral bones from OA patients and rodent OA models.A mouse model of OA with deletion of PDGFR-βin endothelial cells(ECs)exhibited fewer H-type vessels,ameliorated subchondral bone deterioration and alleviated overlying cartilage degeneration.Endothelial PDGFR-βpromotes angiogenesis through the formation of the PDGFR-β/talin1/FAK complex.Notably,endothelium-specific inhibition of PDGFR-βby local injection of AAV9 in subchondral bone effectively attenuated the pathogenesis of OA compared with that of the vehicle-treated controls.Based on the results from this study,targeting PDGFR-βis a novel and promising approach for the prevention or early treatment of OA.

关键词： degeneration osteoarthritis angiogenesis

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Association of cumulative resting heart rate exposure with rapid renal function decline:a prospective cohort study with 27,564 older adults

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老年心脏病学杂志:英文版 2023年第9期20卷 673-683页

作者： Xi JIANG Xian SHAO Xing LI Pu-Fei BAI Hong-Yan LIU Jia-Mian CHEN Wei-Xi WU zhuang cui Fang HOU Chun-Lan LU Sai-Jun ZHOU Pei YU NHC Key Laboratory of Hormones and Development Chu Hsien-I Memorial Hospital and Tianjin Institute of EndocrinologyTianjin Medical UniversityTianjinChina Tianjin Key Laboratory of Metabolic Diseases Tianjin Medical UniversityTianjinChina Ordos Center Hospital OrdosInner MongoliaSudu StreetKangbashi DistrictOrdos CityChina Department of Epidemiology and Health Statistics Tianjin Medical UniversityHeping DistrictTianjinChina Community Health Service Center Jiefang RoadTanggu StreetBinhai New DistrictTianjinChina

OBJECTIVE To evaluate the prospective association between cumulative resting heart rate(cumRHR)and rapid renal function decline(RRFD)in a cohort of individuals aged 60 and older.METHODS In the Tianjin Chronic Kidney Disease Cohort Study,the individuals who underwent three consecutive physical examinations between 2014 and 2017,with estimated glomerular filtration rate(eGFR)greater than 60 mL/min per 1.73 m2 and aged 60 years or older were enrolled.A total of 27,564 patients were prospectively followed up from January 1,2017 to December 31,2020.The 3-year cumRHR was calculated.The primary outcome was RRFD,defined as an annualized decline in eGFR of 5 mL/min per 1.73 m2 or greater.Logistic and restricted spline regression models and subgroup analysis were used to investigate the association of cumRHR with RRFD after adjusting for all confounders.RESULTS During a median follow-up of 3.2 years,a total of 4,347(15.77%)subjects developed RRFD.In fully-adjusted models,compared with the lowest quartile of cumRHR,the odds ratio(OR)for the highest was 1.44(1.28–1.61),P<0.001.Furthermore,each 1-standard deviation(27.97 beats/min per year)increment in cumRHR was associated with a 17%(P<0.001)increased risk of RRFD,with a linear positive correlation(P for non-linear=0.803).Participants with a 3-year cumRHR≥207(beats/min)*year(equivalent to≥69 beats/min per year in 3 years)were found to be at a higher risk of RRFD.CONCLUSIONS The cumRHR is significantly associated with a higher risk of RRFD among older adults.These results might provide an effective goal for managing and delaying the decline of renal function in the older adults.

关键词： prospective Kidney function

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Status of glycosylated hemoglobin and prediction of glycemic control among patients with insulin-treated type 2 diabetes in North China:a multicenter observational study

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Chinese Medical Journal 2020年第1期133卷 17-24页

作者： Jiao Wang Meng-Yang Wang Hui Wang Hong-Wei Liu Rui Lu Tong-Qing Duan Chang-Ping Li zhuang cui Yuan-Yuan Liu Yuan-Jun Lyu Jun Ma Department of Health Statistics College of Public HealthTianjin Medical UniversityTianjin 300070China Department of Endocrinology Tianjin HospitalTianjin 300211China.

Background:Blood glucose control is closely related to type 2 diabetes mellitus(T2DM)prognosis.This multicenter study aimed to investigate blood glucose control among patients with insulin-treated T2DM in North China and explore the application value of combining an elastic network(EN)with a machine-learning algorithm to predict glycemic control.Methods:Basic information,biochemical indices,and diabetes-related data were collected via questionnaire from 2787 consecutive participants recruited from 27 centers in six cities between January 2016 and December 2017.An EN regression was used to address variable collinearity.Then,three common machine learning algorithms(random forest[RF],support vector machine[SVM],and back propagation artificial neural network[BP-ANN])were used to simulate and predict blood glucose status.Additionally,a stepwise logistic regression was performed to compare the machine learning models.Results:The well-controlled blood glucose rate was 45.82%in North China.The multivariable analysis found that hypertension history,atherosclerotic cardiovascular disease history,exercise,and total cholesterol were protective factors in glycosylated hemoglobin(HbAlc)control,while central adiposity,family history,T2DM duration,complications,insulin dose,blood pressure,and hypertension were risk factors for elevated HbAlc.Before the dimensional reduction in the EN,the areas under the curve of RF,SVM,and BP were 0.73,0.61,and 0.70,respectively,while these figures increased to 0.75,0.72,and 0.72,respectively,after dimensional reduction.Moreover,the EN and machine learning models had higher sensitivity and accuracy than the logistic regression models(the sensitivity and accuracy of logistic were 0.52 and 0.56;RF:0.79,0.70;SVM:0.84,0.73;BP-ANN:0.78,0.73,respectively).Conclusions:More than half of T2DM patients in North China had poor glycemic control and were at a higher risk of developing diabetic complications.The EN and machine learning algorithms are alternative choices,in addition to the traditional logistic

关键词： Type 2 diabetes Blood glucose HbAlc Elastic network Machine learning

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阿克达拉PM_(2.5)演变特征及与气象要素的相关性分析

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四川环境 2024年第1期43卷 8-15页

作者：王红顾张杰王丹庄晓翠阿勒泰地区气象局新疆阿勒泰市836000

为深入了解阿克达拉PM_(2.5)颗粒物污染,利用阿克达拉国家大气本底站颗粒物监测仪器GRIMM180观测的2010~2019年PM_(2.5)数浓度及台站的常规气象观测资料,用z-score法对PM_(2.5)数据标准化进行时间变化趋势分析,利用SPSS进行Pearson系数... 详细信息

为深入了解阿克达拉PM_(2.5)颗粒物污染,利用阿克达拉国家大气本底站颗粒物监测仪器GRIMM180观测的2010~2019年PM_(2.5)数浓度及台站的常规气象观测资料,用z-score法对PM_(2.5)数据标准化进行时间变化趋势分析,利用SPSS进行Pearson系数相关分析,能够客观反映出颗粒物浓度与气象要素间的共变趋势程度。结果表明:(1)10年中PM_(2.5)浓度整体上升7.15%。季节变化表现为冬季>春季>秋季>夏季的特征。秋季为明显右偏态分布其余季节对称分布,且冬季的变化性最大。月变化周期为13个月,呈现出“U”形起伏的变化规律。日变化呈现单峰的型式,且采暖期为非采暖期浓度2倍,呈现白天堆积晚上扩散的周期。(2)PM_(2.5)与风速、相对湿度和日照时长相关性最好,且在冬季表现最为显著。PM_(2.5)最高浓度风向为正南,阿克达拉主要污染物成分主要来自西北、偏西方向。风速为10m/s时为PM_(2.5)浓度明显转折点。夏季PM_(2.5)有降水时无降水。日照有助于加速颗粒物运动速度,促进污染物扩散。

关键词：阿克达拉 PM_(2.5) 气象要素相关性

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基于COVID-19相关基因的肝细胞癌分子分型及预后模型构建与验证

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天津医科大学学报 2024年第1期30卷 15-22页

作者：元喆悦白易童文张晓雨崔壮天津医科大学公共卫生学院天津300070 天津市第一中心医院肝胆胰外科天津300192 天津医科大学临床医学系天津300070

目的:基于新型冠状病毒肺炎(COVID-19)相关基因对肝细胞癌进行分子分型,并建立预后模型。方法:收集GeneCard数据库中COVID-19相关基因,分析其在肝细胞癌患者癌与癌旁组织的基因表达量差异,通过一致聚类分析进行分子分型。使用limma包计... 详细信息

目的:基于新型冠状病毒肺炎(COVID-19)相关基因对肝细胞癌进行分子分型,并建立预后模型。方法:收集GeneCard数据库中COVID-19相关基因,分析其在肝细胞癌患者癌与癌旁组织的基因表达量差异,通过一致聚类分析进行分子分型。使用limma包计算不同分子亚型之间差异表达基因并进行功能富集分析。使用R软件包“ESTIMATE”评估不同分子亚型的免疫评分。使用Cox比例风险回归模型和lasso回归构建多基因预后模型,并在其他数据库进行外部验证。结果:基于28个COVID-19相关基因将TCGA的365个肝细胞癌(LIHC)样本分成3个亚型,预后较差的C2亚型具有更高的免疫评分。多因素Cox回归分析结果说明5基因模型是肝细胞癌患者的独立预后危险因素。细胞周期、同源重组等肿瘤相关通路随着风险评分的升高而增加,提示高风险组具有更强的侵袭性。结论:构建了基于COVID-19相关基因的肝细胞癌分子亚型,并开发了预后相关的5基因模型(VEGFA、CD14、CD209、REN、PSMD1)。

关键词：肝细胞癌 COVID-19基因分子分型基因标记预后

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可穿戴设备评估帕金森病患者丘脑底核脑深部电刺激术后短期步态变化

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中风与神经疾病杂志 2024年第5期41卷 459-463页

作者：何婧杜危崔壮杨玉明陈海波苏闻北京医院神经内科国家老年医学中心中国医学科学院老年医学研究院北京100730 北京医院神经外科国家老年医学中心中国医学科学院老年医学研究院北京100730

目的应用可穿戴设备评估帕金森病患者丘脑底核脑深部电刺激术后短期的步态变化。方法在未服药/未开机、服药/未开机和未服药/开机3种不同的治疗状态下,让患者佩戴可穿戴传感器完成计时起立行走测试,收集并分析时空运动参数。结果共13例... 详细信息

目的应用可穿戴设备评估帕金森病患者丘脑底核脑深部电刺激术后短期的步态变化。方法在未服药/未开机、服药/未开机和未服药/开机3种不同的治疗状态下,让患者佩戴可穿戴传感器完成计时起立行走测试,收集并分析时空运动参数。结果共13例平均病程(8.00±1.38)年的接受双侧丘脑底核脑深部电刺激的帕金森病患者被纳入研究。与未服药/未开机状态相比,脑深部电刺激使患者的起立行走测试总用时由(30.63±17.58)s缩短至(19.50±5.78)s(P=0.003),步长由(39.44±14.34)cm增加至(49.46±13.41)cm(P=0.004)、步速由(0.68±0.27)m/s增加至(0.91±0.25)m/s(P=0.005),躯干前倾最大角度由(-25.32°±10.83°)减少至(-17.32°±12.49°)(P=0.047),躯干后倾最大角度由(-22.03°±11.24°)减少至(-13.16°±12.83°)(P=0.022),差异均有统计学意义。结论在术后短期内,丘脑底核脑深部电刺激可以缩短帕金森病患者起立行走测试用时,显著增加患者步长及步速,减少患者行走过程中躯干前倾角度。

关键词：可穿戴设备帕金森病脑深部电刺激步态

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