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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu deng Mingbo Nie Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

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拔尖创新实验班学生的学习投入情况研究--基于某高校CCSS项目数据的分析

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南京理工大学学报（社会科学版） 2016年第5期29卷 75-80页

作者：朱敏邓莉高蓓蕾魏亚南京理工大学高等教育研究所江苏南京210094 南京理工大学教务处江苏南京210094

回应国家拔尖创新人才培养计划,许多研究型大学设立了相应的拔尖创新实验班,国家和学校都投入了大量的人财物保障拔尖创新人才的培养质量。那么,这些投入的效果如何,我们从受众的角度,选取实验班学生的学习性投入情况进行研究,使用"中... 详细信息

回应国家拔尖创新人才培养计划,许多研究型大学设立了相应的拔尖创新实验班,国家和学校都投入了大量的人财物保障拔尖创新人才的培养质量。那么,这些投入的效果如何,我们从受众的角度,选取实验班学生的学习性投入情况进行研究,使用"中国大学生学习与发展追踪研究"的数据,通过实验班和普通学院学生的对比,发现二者差别不大,许多指标上实验班的数据显示不如普通学院。针对此,应从培养方案、教学方法、学者型教师配备、教学评价等多方面对实验班加以改革。

关键词：拔尖创新人才学习性投入研究性教学

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Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu deng Jie Shen Jinxing Lu Chuqiang Huang zhuoyuan Chen Feng Peng Yunpeng liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

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邻苯二甲酸二甲酯免疫层析快速检测试纸的研制

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现代食品科技 2017年第3期33卷 279-284页

作者：朱帆邓丽华朱彬杨金易徐振林孙远明王弘沈玉栋华南农业大学食品学院广东省食品质量安全重点实验室广东广州510642

邻苯二甲酸酯类塑化剂是一类具有生殖毒性的环境激素类物质,通过违规添加或迁移而造成食品污染问题颇为严峻,开发适合现场的塑化剂快速监测方法非常重要。本研究以邻苯二甲酸二甲酯(DMP)为对象,建立了DMP的胶体金标记免疫层析检测试纸... 详细信息

邻苯二甲酸酯类塑化剂是一类具有生殖毒性的环境激素类物质,通过违规添加或迁移而造成食品污染问题颇为严峻,开发适合现场的塑化剂快速监测方法非常重要。本研究以邻苯二甲酸二甲酯(DMP)为对象,建立了DMP的胶体金标记免疫层析检测试纸方法。采用柠檬酸三钠还原氯金酸制备了胶体金,将其标记DMP多克隆抗体,制备了金标抗体;采用棋盘法和单因素试验确定最佳包被浓度和二抗浓度分别为3000μg/mL和1600μg/mL,抗体浓度为稀释1.4倍,基于此建立了DMP免疫层析快速检测方法,其检测限为0.4μg/mL,5 min内肉眼可观察到检测结果,与其它结构功能类似物无明显交叉反应,特异性良好,白酒样品添加检测结果与GC-MS法相符。本法快速简单,稳定可靠,适用于实际样品中DMP的现场快速检测。

关键词：胶体金层析邻苯二甲酸甲酯快速检测

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan zhuang Shenghua Lu Qianqian Ge Hao li Yu deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Anlotinib-induced sick sinus syndrome:Two case reports

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World Journal of Clinical Cases 2025年第6期13卷 30-34页

作者： Cheng-Feng Fu li-Fen Yang Lei Tian Song deng Qi Zhang Biao Yao Department of Oncology Tongren People’s HospitalTongren 554300Guizhou ProvinceChina Department of Oncology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND This manuscript describes the first known cases of sick sinus syndrome(SSS)associated with the use of anlotinib in non-small cell lung cancer patients,highlighting the need for increased vigilance and cardiac *** SUMMARY Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment,respectively,presenting with syncope and *** confirmed SSS,and different treatment approaches were taken for each *** patient received a dual-chamber permanent pacemaker,while the other discontinued the medication and experienced symptom *** Anlotinib can induce SSS,suggesting that cardiac monitoring is crucial during anlotinib *** management strategies are necessary for affected individuals.

关键词： Lung cancer Anlotinib Sick sinus syndrome Cardiac pacemaker Adverse drug reaction Case report

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HPV检测联合SCC-Ag、CA19-9在宫颈癌诊断中的临床意义

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医学检验与临床 2019年第5期30卷 21-23页

作者：朱李登蔡丽平黄庆凤陈爱灼福建省宁德市蕉城区医院检验科福建宁德352000

目的:研究高危型人乳头瘤病毒(HPV)检测联合血清肿瘤标记物鳞状细胞癌抗原(SCC-Ag)、糖类抗原19-9(CA19-9)检测在宫颈癌诊断中的临床应用价值.方法:纳入在2016年9月~2018年9月我院收治的146例宫颈癌患者为研究对象,以同期入院体检的宫... 详细信息

目的:研究高危型人乳头瘤病毒(HPV)检测联合血清肿瘤标记物鳞状细胞癌抗原(SCC-Ag)、糖类抗原19-9(CA19-9)检测在宫颈癌诊断中的临床应用价值.方法:纳入在2016年9月~2018年9月我院收治的146例宫颈癌患者为研究对象,以同期入院体检的宫颈良性病变患者86例为对照组.对两组患者HPV、SCC-Ag、CA19-9进行检测,分析三项指标联检与单独检测诊断宫颈癌的灵敏度、特异度、阳性检出率之间的差异是否有统计学意义.结果:宫颈癌组HPV、SCC-Ag、CA19-9浓度明显高于对照组,且差异有统计学意义(P<0.05);联合检测诊断宫颈癌的灵敏度95.2%、特异性72.1%、阳性检出率93.1%,均高于上述单项检测指标(P<0.05).结论:HPV、SCC-Ag、CA19-9联合检测在宫颈癌病情进展中具有重要的临床价值,值得在临床应用中推广.

关键词：宫颈癌 HPV 肿瘤标记物 SCC-Ag CA19-9

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LDM-Satellite:A New Scheme for Packet Loss Classification over LEO Satellite Network

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China Communications 2022年第12期19卷 207-215页

作者： Ning li Qiaodi zhu Zhongliang deng School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

The packet loss classification has always been a hot and difficult issue in TCP congestion control *** with the terrestrial network,the probability of packet loss in LEO satellite network increases ***’s more,the problem of concept drifting is also more serious,which greatly affects the accuracy of the loss classification *** this paper,we propose a new loss classification scheme based on concept drift detection and hybrid integration learning for LEO satellite networks,named LDM-Satellite,which consists of three modules:concept drift detection,lost packet cache and hybrid integration *** far,this is the first paper to consider the influence of concept drift on the loss classification model in satellite *** also innovatively use multiple base classifiers and a naive Bayes classifier as the final hybrid *** a new weight algorithm for these classifiers is *** ns-2 simulation,LDM-Satellite has a better AUC(0.9885)than the single-model machine learning classification *** accuracy of loss classification even exceeds 98%,higher than traditional TCP ***,compared with the existing protocols used for satellite networks,LDM-Satellite not only improves the throughput rate but also has good fairness.

关键词： LEO Satellite Networ TCP congestion control concept drift detection ensemble learning loss classification

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Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan Wen Zhigang Tao Hai Pu Tianci deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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Film mulching reduces antibiotic resistance genes in the phyllosphere of lettuce

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Journal of Environmental Sciences 2022年第2期34卷 121-128页

作者： Beiqi deng Wen li Huijie Lu lizhong zhu College of Environmental and Resource Sciences Zhejiang UniversityHangzhou310058China Zhejiang Provincial Key Laboratory of Organic Pollution Process andControl Hangzhou310058China

Phyllosphere is an important reservoir of antibiotic resistance genes(ARGs),but the transfer mechanism of ARGs from soil and air to phyllosphere remains *** study demonstrated that soil-air-phyllosphere was the dominant ARG transfer pathway,and blocking it by film mulching can reduce typical phyllosphere ARGs in lettuce by 80.7%-98.7%(89.5%on average).To further eliminate phyllosphere ARGs in lettuce grown with film mulching,the internal soil-endosphere-phyllosphere transfer pathway deserves more *** analyzed the ARG hosts and the resistome in lettuce rhizosphere and phyllosphere with film mulching via hybrid Illumina-Nanopore *** sp.7SR1 was more abundant than other ARG hosts,accounting for 1.0%and 47.1%of the total bacteria in rhizosphere and phyllosphere,*** species has flagella that can promote mobility and can excrete extracellular polymeric substances and/or surfactant-like microbial products,which benefits its colonization in the *** the migration of Pseudomonas sp.7SR1 via the soil-endosphere-phyllosphere pathway would be effective to further reduce ARGs in *** resistant genes were predominant in phyllosphere(40.3%of the total),and 87.6%of the phyllosphere ARGs were located on chromosomes,indicating relatively low horizontal gene transfer(HGT)*** study provides insights into the transfer mechanism,hosts,and control strategies of phyllosphere ARGs in typical plants.

关键词： Antibiotic resistance genes Phyllosphere Rhizosphere Transfer pathway Host bacteria

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