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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia jian Zhou Zhoule zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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嘉绒藏绣纹样在女士化妆包设计中的应用研究

皮革科学与工程 2025年第1期35卷 107-113页

作者：朱文霜邓梦玮桂林理工大学艺术学院广西桂林541004

嘉绒藏族织绣工艺蕴含着丰富的文化内涵和艺术魅力,嘉绒藏绣非遗文化的创造性转化和发展能更好的保留传统文化记忆。通过文献调研法和案例分析法阐述嘉绒藏绣的纹样技法、风格特点及其当代应用,用设计学方法对嘉绒藏绣代表性纹样进行提... 详细信息

嘉绒藏族织绣工艺蕴含着丰富的文化内涵和艺术魅力,嘉绒藏绣非遗文化的创造性转化和发展能更好的保留传统文化记忆。通过文献调研法和案例分析法阐述嘉绒藏绣的纹样技法、风格特点及其当代应用,用设计学方法对嘉绒藏绣代表性纹样进行提取、分解、重构和再设计,并结合其典型的色彩和布局,融入当下文创市场流行的中青年女士化妆包中,验证嘉绒藏绣传统技艺活态化传承的可行性,拓展女士化妆包的设计创新路径。

关键词：刺绣纹样化妆包非遗文化设计嘉绒藏族

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Facile Synthesis of Chiral α-Hydroxy Ketones by a Ni-Catalyzed Multicomponent Hydrometallation–CO Insertion–Enantioconvergent Alkylation Cascade

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Chinese Journal of Chemistry 2023年第3期41卷 294-300页

作者： jian Chen Gao deng You Wang Shaolin zhu State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu210093 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan453007 China

NiH-catalyzed multicomponent reductive hydrofunctionalization of alkenes is an attractive but poorly explored approach to rapidly increasing molecular *** this process,the selective generation of the desired product can be ***,we report that a highly chemo-,regio-and enantioselective reductive hydrocarbonylation of alkenes has been achieved using a chloroformate ester as a source of CO.A wide range of structurally diverseα-hydroxy ketones,privileged structural elements in bioactive molecules and useful building blocks,were obtained from such reactions with high enantiomeric purity.

关键词： Alkenes Asymmetric catalysis Hydrofunctionalization Multicomponent reactions Nickel Nickel hydride Synthetic methods Hydrocarbonylation

A novel active-passive protection strategy endows carbonyl iron with excellent intelligent anti-corrosion and microwave absorption dual functional characteristics

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Nano Research 2025年第1期18卷 487-500页

作者： Wei Tian Quanyuan Feng Linbo Zhang Yinfan Liu Xian jian Longjiang deng Institute of Microelectronics School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China National Engineering Researching Centre of Electromagnetic Radiation Control Materials Key Laboratory of Multi-Spectral Absorbing Materials and Structures of Ministry of EducationState Key Laboratory of Electronic Thin Films and Integrated DevicesSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China The Yangtze Delta Region Institute(Huzhou)&School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaHuzhou 313001China

Carbonyl iron absorbers(CI)face significant challenges in practical applications,such as corrosion,interface bonding failure,detachment,and high maintenance ***,we have developed intelligent self-healing technology based on proactive/passive mechanisms via in situ synthesis of self-healing factors(polydopamine/benzotriazole(PDA/BTA))and physical barrier layers(SiO_(2)/1,1,1,3,3,3-hexamethyl disilazane,SiO_(2)/HMDS)to enhance corrosion resistance,while also being compatible with efficient microwave absorption *** unique multiscale structure gives full play to the utilization of the roles of each functional layer,including the intelligent self-healing features of PDA/BTA,physical shielding and spatial confinement characteristics of SiO_(2)/HMDS,and magnetic-dielectric synergistic mechanism resulted from the good impedance matching characteristics,the conduction loss,the interfacial polarization loss and natural *** asfabricated composites achieved an exceptional minimum reflection loss value of-55.4 dB at 10.7 GHz and the effective absorption band of 7.6 ***,it still exhibits obvious self-healing and corrosion resistance characteristics after 360 h corrosion treatment,ascribed to the self-healing mechanism of PDA/BTA and the blocking intervention effect of SiO_(2)/*** work is considered to pave the way for the synthesis of high-performance magnetic absorbers,especially in enhancing their intelligent self-healing ability in corrosive environments.

关键词： microwave absorption intelligent self-healing technology carbonyl iron multiscale structure magneticdielectric synergistic mechanism

Model predictive control of indoor thermal environment conditioned by a direct expansion air conditioning system

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Building Simulation 2023年第3期16卷 357-378页

作者： Yudong Xia Ming zhu Aipeng jiang jian Wang Xiaoxia Bai Shiming deng School of Automation(School of Artificial Intelligence) Hangzhou Dianzi UniversityHangzhouChina Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Mechanical and Industrial Engineering Qatar UniversityDohaQatar

Temperature and humidity are two important factors that influence both indoor thermal comfort and air *** varying compressor and supply fan speeds of a direct expansion(DX)air conditioning(A/C)unit,the air temperature and humidity in the conditioned space can be regulated ***,most existing controllers are designed to minimize the tracking errors between the system outputs with their corresponding settings as quickly as *** energy consumption,which is directly influenced by the compressor and supply fan speeds,is not considered in the relevant controller formulations,and thus the system may not operate with the highest possible energy *** effectively control temperature and humidity while minimizing the system energy consumption,a model predictive control(MPC)strategy was developed for a DX A/C system,and the development results are presented in this paper.A physically-based dynamic model for the DX A/C system with both sensible and latent heat transfers being considered was established and validated by *** facilitate the design of MPC,the physical model was further *** MPC scheme was then developed by formulating the objective function which sought to minimize the tracking errors of temperature and moisture content while saving energy *** on the results of command following and disturbance rejection tests,the proposed MPC scheme was capable of controlling temperature and humidity with adequate control accuracy and *** comparison to linear-quadratic-Gaussian(LQG)controller,better control accuracy and lower energy consumption could be realized when using the proposed MPC strategy to simultaneously control temperature and humidity.

关键词： direct expansion air conditioning humidity control model predictive control variable speed operational efficiency

Arabidopsis noncoding RNA modulates seedling greening during deetiolation

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Science China(Life Sciences) 2018年第2期61卷 199-203页

作者： Yuqiu Wang jian Li Xing-Wang deng Danmeng zhu State Key Laboratory of Protein and Plant Gene Research Peking-Tsinghua Center for Life Sciences School of Advanced Agricultural Sciences and School of Life Sciences Peking University

Seedling greening is essential for the survival of plants emerging from the soil. The abundance of chlorophyll precursors, including protochlorophyllide(Pchlide), is precisely controlled during the dark-to-light transition, as over-accumulation of Pchlide can lead to cellular photooxidative damage. Previous studies have identified and characterized multiple regulators controlling this important process. HID1(hidden treasure 1) is the first noncoding RNA(ncRNA) found in photomorphogenesis. Under continuous red light,HID1 has been shown to inhibit hypocotyl elongation by repressing the transcription of PIF3(phytochrome interacting factor 3).Here, we report that HID1 acts as a negative regulator of cotyledon greening. Knockdown of HID1 resulted in an increased greening rate of etiolated seedlings relative to wild type when exposed to white light. Genetically, HID1 acts downstream of PIF3 during the dark-to-light transition. The expression of HID1 is not regulated by PIF3 in the dark. Molecularly, the Pchlide content was reduced in dark-grown hid1 mutants than WT. Meanwhile, transcript levels of the protochlorophyllide oxidoreductases known to catalyze Pchlide to chlorophyllide conversion were significantly increased in hid1 seedlings. Thus, our study reveals an additional role of HID1 in the dark-to-light transition in Arabidopsis. Moreover, these results suggest HID1 could regulate distinct targets in different light-mediated developmental processes, and thus is essential to the control of these mechanisms.

关键词： Arabidopsis noncoding RNA cotyledon greening

Nonlinear perturbation developments in flow around a vibrating cylinder

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Journal of Hydrodynamics 2021年第6期33卷 1129-1138页

作者： jian deng Xuerui Mao State Key Laboratory of Fluid Power and Mechatronic Systems Department of MechanicsZhejiang UniversityHangzhou 310027China Faculty of Engineering University of NottinghamNottinghamUK

We investigate the flow around a circular cylinder vibrating with a prescribed magnitude and frequency at Reynolds number *** Navier-stokes equations and the adjoint equations are solved to search for the 3-D nonlinear optimal initial perturbation,which is amplified by the attached shear via the Orr mechanism and then activates wake *** energy growth and the spanwise distributions of the nonlinear optimal perturbation vary significantly with the initial phase to introduce the *** the initial perturbation energy increases,linear amplification,nonlinear saturation and nonlinear growth are sequently *** last one is owing to the generation of a spanwise homogeneous mode,which modifies the pressure distributions on the cylinder surface and induces an extra lift ***,at all the initial phases,this force is opposite to the acceleration of the cylinder,illustrating the potential to reduce the magnitude of vibration.

关键词： Vortex induced vibration nonlinear optimal perturbation Orr mechanism

Microbial Gas in the Mohe Permafrost, Northeast China and its Significance to Gas Hydrate Accumulation in Permafrost across China

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Acta Geologica Sinica(English Edition) 2018年第6期92卷 2251-2266页

作者： ZHAO Xingmin SUN Youhong deng jian RAO zhu Lü Cheng SONG jian Li Lixia Oil & Gas Survey China Geological SurveyBeijing 100029China Jilin University Changchun 130012China National Research Center of Geoanalysis Beijing 100037China China University of Petroleum-Bejing Beijing 102249China CNOOC Research Institute Beijing 100028China

The Mohe permafrost in northeast China possesses favorable subsurface ambient temperature, salinity, Eh values and pH levels of groundwater for the formation of microbial gas, and the Mohe Basin contains rich organic matter in the Middle Jurassic dark mudstones. This work conducted gas chromatography and isotope mass spectrometry analyses of nearly 90 core gas samples from the Mk-2 well in the Mohe Basin. The results show that the dryness coefficient(C1/C1–5) of core hydrocarbon gas from approximately 900 m intervals below the surface is larger than 98%, over 70% of the δ13 C values of methane are smaller than-55‰, and almost all δD values of methane are smaller than-250‰, indicative of a microbial origin of the gas from almost 900 m of the upper intervals in the Mohe permafrost. Moreover, the biomarker analyses of 72 mudstone samples from the Mohe area indicate that all of them contain 25-norhopane series compounds, thereby suggesting widely distributed microbial activities in the permafrost. This work has confirmed the prevailing existence of microbial gas in the Mohe area, which may be a potential gas source of gas hydrate formation in the Mohe permafrost. This result is of great significance to gas hydrate accumulation in the permafrost across China.

关键词： microbial gas gas hydrate accumulation permafrost oil and gas Mohe northeast China

A comparison between novel Gd_(2)Zr_(2)O_(7)and Gd_(2)Zr_(2)O_(7)/YSZ thermal barrier coatings fabricated by plasma spray-physical vapor deposition

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Rare Metals 2021年第8期40卷 2244-2253页

作者： Ren-Bo zhu jian-Peng Zou Jie Mao Zi-Qian deng Xiao-Feng Zhang Chun-Ming deng Min Liu School of Materials Science and Engineering University of New South WalesSydneyNSW2052Australia State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China National Engineering Laboratory for Modern Materials Surface Engineering Technology and Key Laboratory of Guangdong for Modern Surface Engineering Technology Guangdong Institute of New MaterialsGuangzhou510651China

Spherical Gd_(2)Zr_(2)O_(7)hollow powders with a mean size of 8.8μm were fabricated as feedstock for thermal barrier coatings(TBCs)by *** single-ceramic-layer(SCL)Gd_(2)Zr_(2)O_(7)TBCs and double-ceramic-layer(DCL)Gd_(2)Zr_(2)O_(7)/YSZ TBCs with quasicolumnar structure were successfully fabricated by plasma spray-physical vapor deposition(PS-PVD).Tensile and water-quenching tests were applied to evaluate TBCs *** results show that adhesion strength of SCL Gd_(2)Zr_(2)O_(7)TBCs and DCL Gd_(2)Zr_(2)O_(7)/YSZ TBCs is36.5 MPa and 15.4 MPa,*** delamination of SCL Gd_(2)Zr_(2)O_(7)TBCs and DCL Gd_(2)Zr_(2)O_(7)/YSZ TBCs in the tensile test takes place at the middle and bottom of Gd_(2)Zr_(2)O_(7)layer,respectively,due to relatively lower fracture toughness of Gd_(2)Zr_(2)O_(7)*** 40 cycles of water-quenching test,DCL Gd_(2)Zr_(2)O_(7)/YSZ TBC surface keeps relatively intact,while SCL Gd_(2)Zr_(2)O_(7)TBC surface shows 20%visible destroyed regions,which demonstrates that DCL Gd_(2)Zr_(2)O_(7)/YSZ TBCs have a better thermal shock resistance than SCL Gd_(2)Zr_(2)O_(7)*** cracks in the SCL system propagate near thermally grown oxide(TGO)due to thermal mismatch and TGO growing stress,while cracks in the DCL system propagate in the Gd_(2)Zr_(2)O_(7)layer due to its relatively lower fracture toughness.

关键词： Plasma spray-physical vapor deposition Thermal barrier coatings Gd_(2)Zr_(2)O_(7) Thermal shock resistance Adhesion strength