Facile Synthesis of Chiral α-Hydroxy Ketones by a Ni-Catalyzed Multicomponent Hydrometallation–CO Insertion–Enantioconvergent Alkylation Cascade

作     者：Jian Chen Gao Deng You Wang Shaolin Zhu Jian Chen;Gao Deng;You Wang;Shaolin Zhu

作者机构：State Key Laboratory of Coordination ChemistryJiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu210093 China School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan453007 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2023年第41卷第3期

页      面：294-300页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Support was provided by NSFC (92156004,22271143,22271146) NSF of Jiangsu Province (BK20190281,BK20201245) programs for high-level entrepreneurial and innovative talents introduction of Jiangsu Province (group program),Fundamental Research Funds for the Central Universities (020514380282) Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University.Gao Deng thanks the National College Students'Innovation and Entrepreneurship Training Program (0205145031) 

主　　题：Alkenes Asymmetric catalysis Hydrofunctionalization Multicomponent reactions Nickel Nickel hydride Synthetic methods Hydrocarbonylation 

摘      要：NiH-catalyzed multicomponent reductive hydrofunctionalization of alkenes is an attractive but poorly explored approach to rapidly increasing molecular *** this process,the selective generation of the desired product can be ***,we report that a highly chemo-,regio-and enantioselective reductive hydrocarbonylation of alkenes has been achieved using a chloroformate ester as a source of CO.A wide range of structurally diverseα-hydroxy ketones,privileged structural elements in bioactive molecules and useful building blocks,were obtained from such reactions with high enantiomeric purity.