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Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease:Current Progresses and Challenges

Journal of Clinical and Translational Hepatology 2022年第5期10卷 955-964页

作者： Yu-Xian Teng Si Xie Ping-Ping Guo zhu-jian deng Zi-Yi Zhang Wei Gao Wan-Guang Zhang jian-Hong Zhong Hepatobiliary Surgery Department Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research CenterGuangxi Medical University Cancer HospitalNanningGuangxiChina Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationGuangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorNanningGuangxiChina Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

The rising global prevalence of metabolic diseases has increased the prevalence of non-alcoholic fatty liver disease(NAFLD),leading to an increase in cases of NAFLD-related hepatocellular carcinoma(HCC).To provide an updated literature review detailing epidemiology,risk factors,pathogenic pathways,and treatment strategies linked to NAFLD-related HCC,we conducted a literature search on PubMed from its inception to December 31,*** 25%of the global population suffers from *** annual incidence of HCC among NAFLD patients is approximately 1.8 per 1,000 *** age,male sex,metabolic comorbidities,unhealthy lifestyle habits(such as smoking and alcohol consumption),physical inactivity,genetic susceptibility,liver fibrosis,and degree of cirrhosis in NAFLD patients are important risk factors for NAFLD-related ***,low-calorie diet,moderate-intensity exercise,treatment of metabolic comorbidities,and cessation of smoking and alcohol are the main measures to prevent NAFLD-related *** addition,all patients with advanced NAFLD-related fibrosis or cirrhosis should be screened for *** suppression disorders and changes in the liver microenvironment may be the main pathogenesis of NAFLD-related *** resection,liver transplantation,ablation,transarterial chemoembolization,radiotherapy,targeted drugs,and immune checkpoint inhibitors are used to treat NAFLD-related *** treatment may lead to better overall survival,while immune checkpoint inhibitors may lead to worse overall *** the specific risk factors for NAFLD-related HCC,primary prevention is ***,the same treatment may differ substantially in efficacy against NAFLD-related HCC than against HCC of other etiologies.

关键词： Epidemiology Hepatocellular carcinoma Non-alcoholic fatty liver disease Risk factor Treatment strategy

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Treatments of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus:Current Status and Controversy

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 147-158页

作者： zhu-jian deng Le Li Yu-Xian Teng Yu-Qi Zhang Yu-Xin Zhang Hao-Tian Liu jian-Li Huang Zhen-Xiu Liu Liang Ma jian-Hong Zhong Hepatobiliary Surgery Department Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research CenterGuangxi Medical University Cancer HospitalNanningGuangxiChina

The proportions of patients with hepatocellular carcinoma(HCC)involving portal vein tumor thrombus(PVTT)varies greatly in different countries or regions,ranging from 13%to 45%.The treatment regimens for PVTT recommended by HCC guidelines in different countries or regions also vary *** recent years,with the progress and development of surgical concepts,radiotherapy techniques,systematic therapies(for example,VEGF inhibitors,tyrosine kinase inhibitors and immune checkpoint inhibitors),patients with HCC involving PVTT have more treatment options and their prognoses have been significantly *** achieve the maximum benefit,both clinicians and patients need to think rationally about the indications of treatment modalities,the occurrence of severe adverse events,and the optimal fit for the *** this review,we provide an update on the treatment modalities available for patients with HCC involving *** with large sample size for patients with advanced or unresectable HCC are also reviewed.

关键词： Hepatocellular carcinoma Portal vein tumor thrombus Treatment modality

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin zhu Teng jiang Junshan Zhou Fuling Yan Qiwen deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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细胞自噬在植物应答盐胁迫中的作用研究

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四川大学学报（自然科学版） 2016年第6期53卷 1403-1408页

作者：朱峰简伟邓星光林宏辉四川大学生命科学学院成都610064 扬州大学园艺与植物保护学院扬州225009

本研究以模式植物拟南芥为材料,利用生理学和遗传学手段分析了盐胁迫下细胞自噬基因和活性氧(ROS)变化的相关性.结果表明野生型拟南芥Col-0在遭受盐胁迫处理3d表现了叶片漂白的症状并且会诱导ROS的产生和积累了大量的细胞死亡.荧光定量... 详细信息

本研究以模式植物拟南芥为材料,利用生理学和遗传学手段分析了盐胁迫下细胞自噬基因和活性氧(ROS)变化的相关性.结果表明野生型拟南芥Col-0在遭受盐胁迫处理3d表现了叶片漂白的症状并且会诱导ROS的产生和积累了大量的细胞死亡.荧光定量PCR实验表明盐胁迫会诱导细胞自噬相关基因的表达,细胞自噬参与了调控植物的防御机制来响应盐胁迫.进一步的实验表明拟南芥细胞自噬突变体atg2和atg5在遭受盐胁迫处理3d表现了更加严重的叶片漂白症状并且积累大量的细胞死亡和ROS.初步表明细胞自噬主要是通过调控ROS的产生来应答盐胁迫.

关键词：细胞自噬活性氧盐胁迫拟南芥

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BEBA对丁羟推进剂界面粘接作用的研究

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固体火箭技术 2016年第5期39卷 667-671页

作者：张习龙刘苗娥王祝愿邓剑如湖南大学化学化工学院长沙410082

合成了聚醚类和聚酯类互联单体,并用互联单体合成了硼酸酯键合剂(BEBA)。采用反相气相色谱法,测算了AP、RDX、丁羟聚氨酯(HTPB-PU)基体和BEBA间的界面酸碱作用焓。结果显示,5种BEBA与AP、RDX的界面作用焓,均远大于HTPB-PU基体与AP、RDX... 详细信息

合成了聚醚类和聚酯类互联单体,并用互联单体合成了硼酸酯键合剂(BEBA)。采用反相气相色谱法,测算了AP、RDX、丁羟聚氨酯(HTPB-PU)基体和BEBA间的界面酸碱作用焓。结果显示,5种BEBA与AP、RDX的界面作用焓,均远大于HTPB-PU基体与AP、RDX、BEBA的界面作用焓,表明5种BEBA均优先吸附在AP、RDX上,以聚酯链段合成的BEBA-4更有利于吸附,并采用EDS证实了BEBA-4吸附在AP、RDX表面。通过接触角法,测算了AP、RDX吸附BEBA-4后的AP、RDX与HTPB-PU基体间的界面张力和界面粘附功。结果表明,吸附BEBA-4的AP、RDX与HTPB-PU基体间的界面张力降低,界面粘附功增加,界面粘接强度增强。BEBA用于推进剂力学性能测试和SEM观察的结果与界面粘接作用结果基本吻合,即以聚己二酸丁二醇酯为互联链段合成的BEBA-4对推进剂力学性能改善的效果最为显著。

关键词：丁羟推进剂硼酸酯键合剂互联链段反相气相色谱接触角

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三相不平衡低压微网的多目标优化调度

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电力建设 2017年第2期38卷 106-113页

作者：朱健罗辉邓武军汪洪春吴志云国网四川省电力公司建设管理中心成都市610021

提出了一种含多种分布式电源的三相不平衡微网综合优化调度策略。首先,确定了三相不平衡微网安全、经济、高效运行的评价指标;建立了多目标优化调度模型,并通过对多目标调度模型的求解得到微网的运行策略。其次,对各目标函数从不同的运... 详细信息

提出了一种含多种分布式电源的三相不平衡微网综合优化调度策略。首先,确定了三相不平衡微网安全、经济、高效运行的评价指标;建立了多目标优化调度模型,并通过对多目标调度模型的求解得到微网的运行策略。其次,对各目标函数从不同的运行角度进行了分析,以充分利用多目标方法的有效性。算例仿真验证了所提出的优化调度策略在充分发挥各种分布式电源作用方面的优势。

关键词：不平衡微网分布式电源储能调度策略多目标优化

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying zhu Pu Chen Tong Zhou Zhe-Yi Han Jun Xiao jian-Feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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关于汶川8.0级地震前两项异常真伪的探讨

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四川地震 2010年第1期 13-17页

作者：朱航邓建平阳光四川省地震局

2008年5月12日汶川8.0级地震前出现了成都台重力和姑咱台钻孔应变异常现象,是否属于地震前兆还存在争论。本文针对这些问题,分析了可能存在的环境因素影响及其引起的测值变化形态特征,并以实验方法验证了对姑咱台钻孔应变异常原因的推... 详细信息

2008年5月12日汶川8.0级地震前出现了成都台重力和姑咱台钻孔应变异常现象,是否属于地震前兆还存在争论。本文针对这些问题,分析了可能存在的环境因素影响及其引起的测值变化形态特征,并以实验方法验证了对姑咱台钻孔应变异常原因的推断。结论表明,成都台重力震前异常是由台风活动引起,姑咱台钻孔应变异常是钻孔内水位干扰所致。

关键词：汶川8.0级地震前兆异常重力钻孔应变

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia jian Zhou Zhoule zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Facile Synthesis of Chiral α-Hydroxy Ketones by a Ni-Catalyzed Multicomponent Hydrometallation–CO Insertion–Enantioconvergent Alkylation Cascade

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Chinese Journal of Chemistry 2023年第3期41卷 294-300页

作者： jian Chen Gao deng You Wang Shaolin zhu State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu210093 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan453007 China

NiH-catalyzed multicomponent reductive hydrofunctionalization of alkenes is an attractive but poorly explored approach to rapidly increasing molecular *** this process,the selective generation of the desired product can be ***,we report that a highly chemo-,regio-and enantioselective reductive hydrocarbonylation of alkenes has been achieved using a chloroformate ester as a source of CO.A wide range of structurally diverseα-hydroxy ketones,privileged structural elements in bioactive molecules and useful building blocks,were obtained from such reactions with high enantiomeric purity.

关键词： Alkenes Asymmetric catalysis Hydrofunctionalization Multicomponent reactions Nickel Nickel hydride Synthetic methods Hydrocarbonylation

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