检索结果-南通市图书馆

低强度超声促进药物递送的作用机制及研究进展

在线全文

学校读者我要写书评

暂无评论

中国生物医学工程学报 2024年第4期43卷 477-488页

作者：朱文武杨辉胡凯严国飞王帆浙江省医疗器械审评中心杭州310000

近年来,低强度超声促进药物递送的相关研究发展迅速,其应用涵盖多个给药场景,包括经皮给药(超声导入术)、声动力治疗以及血脑屏障开放等。从这3个视角入手,阐述了低强度超声促进药物递送的作用机制,包括热效应、空化效应、机械效应及生... 详细信息

近年来,低强度超声促进药物递送的相关研究发展迅速,其应用涵盖多个给药场景,包括经皮给药(超声导入术)、声动力治疗以及血脑屏障开放等。从这3个视角入手,阐述了低强度超声促进药物递送的作用机制,包括热效应、空化效应、机械效应及生理调节效应等诸多生物效应,强调了局部空化作用和机械作用的重要性。此外,通过引用相关研究成果,展示了低强度超声在药物递送中的有效性,并指出了需进一步解决的相关问题,如药物释放的可控性与临床治疗的安全性,最后,概述了超声技术与纳米材料相结合,有望拓展药物递送的创新路径,为临床治疗提供更多有效安全的治疗方案。

关键词：低强度超声药物递送经皮给药声动力治疗血脑屏障开放

在线全文

学校读者我要写书评

暂无评论

内窥环境下多光谱血氧饱和度检测

光学学报 2024年第2期44卷 246-253页

作者：章昶威邹鸿博齐伟明朱文武王立强袁波浙江大学光电信息科学与工程学院浙江杭州310027 浙江省医疗器械审评中心浙江杭州310009 之江实验室类人感知研究中心浙江杭州311100

采用蒙特卡罗模拟技术对血管组织在可见光波段的多光谱成像进行建模仿真,通过分析不同血氧饱和度下血液后向散射功率的绝对值、相对值、绝对差值和对比度,并考虑可能的干扰因素,优选出适合内窥环境下使用的450 nm、525 nm、630 nm和660 ... 详细信息

采用蒙特卡罗模拟技术对血管组织在可见光波段的多光谱成像进行建模仿真,通过分析不同血氧饱和度下血液后向散射功率的绝对值、相对值、绝对差值和对比度,并考虑可能的干扰因素,优选出适合内窥环境下使用的450 nm、525 nm、630 nm和660 nm 4个成像波段。基于4个优选的成像波段展开了血氧饱和度检测的实验验证。在血管仿体组织上的实验结果表明,在95%的置信水平下,血氧饱和度的检测偏差为1.24%。研究结果验证了利用四波段进行内窥组织血氧饱和度检测的可行性。

关键词：医用光学多光谱成像内窥镜血氧饱和度蒙特卡罗仿真

无人机协同空天地一体化战场信息采集策略研究

在线全文

学校读者我要写书评

暂无评论

电光与控制 2024年第3期31卷 17-24页

作者：王易杰陈昕焦立博朱文武北京信息科技大学北京100000

围绕空天地一体化战场信息采集场景,建立优化目标为最大化系统效率和性能的信道分配和设备匹配模型。针对信道分配和设备匹配决策变量具有相关和耦合性的特点,提出一种基于遗传算法和深度强化学习的两阶段资源分配(GD2A)算法。通过仿真... 详细信息

围绕空天地一体化战场信息采集场景,建立优化目标为最大化系统效率和性能的信道分配和设备匹配模型。针对信道分配和设备匹配决策变量具有相关和耦合性的特点,提出一种基于遗传算法和深度强化学习的两阶段资源分配(GD2A)算法。通过仿真验证,分析超参数对GD2A算法的性能和收敛速度的影响。对比实验表明,GD2A算法能在6G空天地异构网络中保障军事通信的可靠性和安全性,最大化系统效用。

关键词：战场信息采集无人机空天地一体化深度强化学习遗传算法

维普期刊数据库博看期刊

Global finite-time attitude regulation using bounded feedback for a rigid spacecraft

在线全文

学校读者我要写书评

暂无评论

Control Theory and Technology 2017年第1期15卷 26-33页

作者： Yusong ZHOU wenwu zhu Haibo DU Anhui Vocational College of Press and Publishing Hefei Anhui 230601 China School of Electrical Engineering and Automation Hefei University of Technology Hefei Anhui 230009 China

This paper investigates the problem of global attitude regulation control for a rigid spacecraft under input saturation. Based on the technique of finite-time control and the switching control method, a novel global bounded finite-time attitude regulation controller is proposed. Under the proposed controller, it is shown that the spacecraft attitude can reach the desired attitude in a finite time. In addition, the bound of a proposed attitude controller can be adjusted to any small level to accommodate the actuation bound in practical implementation.

关键词： Global attitude regulation finite-time control bounded feedback

Finite-Time Position Tracking Control of a Quadrotor Aircraft

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Finite-Time Position Tracking Control of a Quadrotor Aircraf...

The self-regulation process and its mechanism of channels' bed changes in the Changjiang(Yangtze) Estuary in China

第36届中国控制会议

作者： Di Wu Haibo Du wenwu zhu School of Electrical Engineering and Automation Hefei University of Technology

ISBN: (纸本)9781538629185

This paper proposes a finite-time control law for quadrotor aircraft to achieve position tracking control in a finite ***, the position dynamical equation and the attitude dynamical equation are introduced respectively. Secondly, based on the technique of finite-time control, a finite-time position controller is designed to ensure the desired trajectory can be tracked by the real position in a finite time. Then, a finite-time attitude controller is designed which can guarantee that the desired attitude can be tracked in a finite time. Finally, to show effectiveness of the proposed method, a simulation example is given.

关键词： Quadrotor aircraft Tracking Control Finite-time control

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2015年第7期34卷 123-130页

作者： ZHANG Xiaohe LI Jiufa zhu wenwu CHENG Heqin CHEN Wei State Key Laboratory of Estuarine and Coastal Research East China Normal University Institute for Marine and Atmospheric Research Utrecht Utrecht University

Recent bathymetric changes in the Changjiang Estuary under the influence of artificial regulation engineerings and basin reservoirs have been analyzed based on the maritime charts since 1997 and recent fieldworks. The results indicate a slight erosion of the channels in the upper and middle estuary, continuing deposition and seaward move of the mouth bar crest and intensifying erosion at the nearshore seabed. It is noteworthy that the morphological evolution caused by intensive human activities dominates over the changes from nature process. First, the riverbes are eroded overall in the South Branch （SB）, the South Channel （SC） and the upper and middle reaches of the North Channel （NC）. The nearshore seabed outside the river mouth is being eroded slightly, which is attributed to the declining sediment supply from the Changjiang Basin due to the construction of the Three Gorges Dam upstream. The sediment above the seabed is very active and coarsened, meanwhile, sand waves are becoming more distinct. Second, a deposition occurs in the North Brach （NB）, the mouth of the NC, the mouth bars of the North Passage （NP） and the South Passage （SP） and especially the main channel of the NP, where it shows a massive siltation after the deep waterway project. The reasons for the recent changes are not only the dynamic structure in estuarine mouth bars, but also the supply of sediment resuspension in a local and offshore area. Meanwhile, the severe erosion and siltation in some reaches is related to the construction of estuarine engineerings. It is indicated that the Changjiang Estuary is gradually self-adjusted and adapting to the varying natural factors and intensive human activities. The study on the mechanism of self-regulation of the recent bathymetric changes in the Changjiang Estuary has important and practical significance.

关键词： Changjiang Estuary bathymetric changes self-regulation human activities tidal current sediment transport

在线全文

学校读者我要写书评

暂无评论

体外检测试剂盒阻断剂的制备方法及特性分析

发育医学电子杂志 2024年第1期12卷 1-6,19页

作者：何汝琴雷鹏邓龙芝朱文武朱雄伟熊梦瑶武汉工程大学环境生态与生物工程学院湖北武汉430205 武汉雁达生物技术有限公司湖北武汉430200

目的探讨体外检测试剂盒阻断剂的制备方法及特性。方法采用6周龄BALB/c小鼠进行抗原免疫,构建杂交瘤细胞并克隆。采用动物体内诱导单克隆抗体的方法大量制备单克隆抗体,分别采用G柱亲和层析、蓝胶+Q柱离子交换层析两种方法进行纯化,核... 详细信息

目的探讨体外检测试剂盒阻断剂的制备方法及特性。方法采用6周龄BALB/c小鼠进行抗原免疫,构建杂交瘤细胞并克隆。采用动物体内诱导单克隆抗体的方法大量制备单克隆抗体,分别采用G柱亲和层析、蓝胶+Q柱离子交换层析两种方法进行纯化,核酸蛋白检测仪记录波长280 nm下的光密度(optical density,OD),紫外分光光度计测量成品浓度。采用十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(sodium dodecylsulfate-polyacrylamide gel electrophoresis,SDS-PAGE)检测抗体纯度。采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)双抗体夹心法检测该阻断剂(CN302)对假阳性样本的阻断能力。结果G柱亲和层析法提取阻断剂的收率(3个批次分别为6.49、6.12、6.27 g/L)高于蓝胶+Q柱离子交换层析法(3个批次分别为1.78、1.68、1.61 g/L)。两种纯化方法的纯度均高达95%以上。G柱亲和层析法、蓝胶+Q柱离子交换层析法所得阻断剂的活性分别为106.54%、92.45%;与空白组相比,两种纯化方式所得阻断剂CN302对假阳性样本的检出率均降低,其OD值均小于0.2,与基准阻断剂大致相同。G柱亲和层析法所得阻断剂CN302未冻融的活性为99.86%,冻融5次后活性为99.83%。无阻断剂存在时,对假阳性样本检测的OD值约为2.5,最高可达到4.0;加入阻断剂后,OD值明显降低;阻断剂CN302对假阳性样本检测的OD值低于其他阻断剂。结论本研究所得阻断剂能显著消除样本内源性干扰,且活性几乎全部保留。G柱亲和层析法提取抗体的收率和阻断能力均高于蓝胶+Q柱离子交换层析法。

关键词：阻断剂体外检测试剂盒小鼠单克隆抗体 G柱亲和层析蓝胶+Q柱离子交换层析

基于时空流量预测的时延敏感无源光网络动态带宽调度技术

在线全文

学校读者我要写书评

暂无评论

山东电力技术 2024年第9期51卷 37-45,56页

作者：张浩王一蒙桑玮婧顾仁涛朱文武国网山东省电力公司经济技术研究院山东济南250021 北京邮电大学信息与通信工程学院北京100876

为了降低业务的时延和抖动,保证多业务场景下时延敏感业务的服务需求,提出一种基于时空流量预测的时延敏感业务无源光网络动态带宽调度算法。深入分析无源光网络中影响业务时延的主要因素,将时空流量预测与重排序算法相结合,保证时延敏... 详细信息

为了降低业务的时延和抖动,保证多业务场景下时延敏感业务的服务需求,提出一种基于时空流量预测的时延敏感业务无源光网络动态带宽调度算法。深入分析无源光网络中影响业务时延的主要因素,将时空流量预测与重排序算法相结合,保证时延敏感业务的低时延和抖动;同时,当网络流量较大时,利用最大最小公平算法为非时延敏感业务分配带宽,避免了光网络单元(opticalnetworkunit,ONU)在高负载下的饥饿问题,有效提高了网络的公平性。仿真结果表明,所提出的算法与对比算法相比,时延敏感业务的时延降低了约50%;在高负载情况下,系统的公平性接近于1,验证了所提算法在时延和公平性方面的有效性。

关键词：时延敏感业务无源光网络动态带宽分配

Spectral Index Distribution of Various Scale Components in Supernova Remnant Cassiopeia A

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第5期24卷 211-217页

作者： Xianhuan Lei Hui zhu Zongyao Yin Haiyan Zhang wenwu Tian Xianchuan Yu Key Laboratory of Radio Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China School of Artiﬁcial Intelligence Beijing Normal UniversityBeijing 100875China

Cassiopeia A(Cas A) is a well-known candidate for studying cosmic-ray acceleration, in which compact features of various scales have attracted much attention. Based on observations by the Very Large Array of Cas A at 6 cm and 21 cm, we measure the spectral index distribution of various scale components using the observation of the 1998 epoch. We decompose its total density image into nine scale components, and map the temperature spectral index distribution of each component, which ranges from-2.48 ± 0.01 to-2.91 ± 0.05. We find that the spectral indices increase from the small scale to large scale components. A damped post-shock magnetic field model with a strength larger than ~200 μG and a damping length scale less than ~10% of the remnant radius can account for the spectral index variation naturally.

关键词： ISM supernova remnants-(ISM:)cosmic rays-radio continuum ISM