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Translocation of telomerase reverse transcriptase coincided with ATP release in postnatal cochlear supporting cells

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Neural Regeneration Research 2024年第5期19卷 1119-1125页

作者： Yukai Zhang Keyong Tian Wei Wei Wenjuan Mi Fei Lu Zhenzhen Liu qingwen zhu Xinyu Zhang Panling Geng Jianhua Qiu Yongli Song Dingjun Zha Department of Otolaryngology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate(ATP)by supporting cells in the Kölliker’s ***,the mechanisms responsible for initiating spontaneous ATP release have not been *** previous study revealed that telomerase reverse transcriptase(TERT)is expressed in the basilar membrane during the first postnatal *** role in cochlear development remains *** this study,we investigated the expression and role of TERT in postnatal cochlea supporting *** results revealed that in postnatal cochlear Kölliker’s organ supporting cells,TERT shifts from the nucleus into the cytoplasm over *** found that the TERT translocation tendency in postnatal cochlear supporting cells in vitro coincided with that observed in *** analysis showed that TERT in the cytoplasm was mainly located in mitochondria in the absence of oxidative stress or apoptosis,suggesting that TERT in mitochondria plays roles other than antioxidant or anti-apoptotic *** observed increased ATP synthesis,release and activation of purine signaling systems in supporting cells during the first 10 postnatal *** phenomenon that TERT translocation coincided with changes in ATP synthesis,release and activation of the purine signaling system in postnatal cochlear supporting cells suggested that TERT may be involved in regulating ATP release and activation of the purine signaling *** study provides a new research direction for exploring the spontaneous electrical activity of the cochlea during the early postnatal period.

关键词： apoptosis ATP release Ca2+transients cochlea mitochondrial function reactive oxygen species spontaneous electrical activity supporting cells

以结节性红斑为首发的结核性中耳炎1例并文献复习

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中华耳科学杂志 2024年第2期22卷 351-352页

作者：姜媛耿猛杜希同张思琪王建涛崔卫娜朱庆文河北医科大学第二医院耳鼻咽喉二科石家庄050000

耳鼻咽喉结核以喉结核多见,咽结核次之,耳、鼻结核相对最少,随着广泛抗结核治疗,其临床表现越来越不典型。现报道1例以结节性红斑为首发的结核性中耳炎病例,并对相关文献进行复习,以提高对中耳结核感染的警惕性。1临床资料患者女性,27岁... 详细信息

耳鼻咽喉结核以喉结核多见,咽结核次之,耳、鼻结核相对最少,随着广泛抗结核治疗,其临床表现越来越不典型。现报道1例以结节性红斑为首发的结核性中耳炎病例,并对相关文献进行复习,以提高对中耳结核感染的警惕性。1临床资料患者女性,27岁,因右耳间断流脓伴听力下降、耳闷16个月于2021年10月25日于河北医科大学第二医院耳鼻咽喉二科就诊。患者曾多次于外院诊断为“慢性化脓性中耳炎”,长期行冲洗、抗炎治疗均无效。查体见右外耳道深部苍白肉芽样组织,鼓膜窥不清。

关键词：中耳炎结核结节性红斑淋巴结结核

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蒙医外治法的研究进展

光明中医 2024年第3期39卷 625-629页

作者：张潇洋李海龙冯旭朱庆文北京中医药大学北京100029 内蒙古自治区包头市蒙医中医医院名老中医工作室内蒙古包头014040 北京中医药大学中医学院北京100029

蒙医药学是祖国传统医学的重要组成部分,是在蒙古族人民长期的医疗实践中,吸收中医、藏医等医学理论,并在蒙古特色地域、饮食、文化下逐渐形成与发展起来的民族特色医学。蒙医药学中,外治法特色突出,可分药物外治法和非药物外治法2个角... 详细信息

蒙医药学是祖国传统医学的重要组成部分,是在蒙古族人民长期的医疗实践中,吸收中医、藏医等医学理论,并在蒙古特色地域、饮食、文化下逐渐形成与发展起来的民族特色医学。蒙医药学中,外治法特色突出,可分药物外治法和非药物外治法2个角度对蒙医外治法进行探讨,从药浴、外敷、吹药、含漱4个方面对蒙医药物外治法进行分析,从震脑术、灸法、针刺、刮痧、放血、整骨、腹罨、萨木那哈疗法8个方面对蒙医非药物外治法进行分析。通过综合分析,比较蒙医外治法与中医外治法的异同,对蒙医外治法的发展进行探讨。

关键词：蒙医外治法中医外治法综述

通窍鼻炎胶囊联合布地奈德对变应性鼻炎的疗效及对Th17/Treg平衡的影响

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安徽医药 2024年第2期28卷 399-402页

作者：李赞峰徐光吴蔚张秀娟朱卿文河南中医药大学第五临床医学院(郑州人民医院)耳鼻咽喉头颈外科河南郑州450000 郑州大学附属儿童医院、河南省儿童医院耳鼻喉科河南郑州450000

目的探究通窍鼻炎胶囊联合布地奈德对变应性鼻炎(AR)的治疗效果。方法抽取2020年2月至2022年2月郑州人民医院AR病人143例,采用随机数字表法分为联合组(n=49)、布地奈德组(n=48)和通窍鼻炎胶囊组(n=46)。布地奈德组接受布地奈德治疗,通... 详细信息

目的探究通窍鼻炎胶囊联合布地奈德对变应性鼻炎(AR)的治疗效果。方法抽取2020年2月至2022年2月郑州人民医院AR病人143例,采用随机数字表法分为联合组(n=49)、布地奈德组(n=48)和通窍鼻炎胶囊组(n=46)。布地奈德组接受布地奈德治疗,通窍鼻炎胶囊组接受通窍鼻炎胶囊治疗,联合组接受布地奈德加用通窍鼻炎胶囊治疗。对比三组总有效率、中医症状评分(鼻塞、鼻痒、流涕、喷嚏)、γ-干扰素(IFN-γ)、外周血辅助T细胞17(Th17)、白细胞介素-17(IL-17)、调节性T细胞(Treg)、免疫球蛋白E(IgE)、转化生长因子-β_(1)(TGF-β_(1))和血清阳离子蛋白(ECP)水平变化情况。统计三组不良反应发生率。结果治疗后联合组总有效率(93.88%比83.33%、73.91%)、IFN-γ[(86.47±4.85)mg/L比(80.63±4.28)mg/L、(75.46±4.73)mg/L]、Treg[(4.35±0.57)%比(4.08±0.53)%、(3.74±0.49)%]及TGF-β_(1)水平[(34.72±4.03)ng/L比(31.27±4.35)ng/L、(28.75±4.67)ng/L]均高于布地奈德组和通窍鼻炎胶囊组(P0.05)。结论通窍鼻炎胶囊联合布地奈德治疗AR,可调节Th17/Treg平衡,改善病人临床症状,减轻炎症反应,安全可靠。

关键词：鼻炎变应性通窍鼻炎胶囊布地奈德辅助T细胞17 调节性T细胞疗效

An innovative method to evaluate the severe level of general Qi deficiency

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Journal of Traditional Chinese Medicine 2018年第4期38卷 585-592页

作者： Lu Yu Niu Tingli Chen Tianyu Gao Lujiao Ma Liangxiao Li Haiyan zhu qingwen Yang Xuezhi Niu Xin Department of integrated Chinese and western medicine Foundation Traditioanl Chinese Medicine institudeBeijing University of Chinese Medicine Department of Medical Services Dongfang Hospital Affiliated to Beijing University of Chinese Medicine Department of Acupuncture and Massage Beijing University of Chinese Medicine

OBJECTIVE:The study aim was to use existing relevant indexes to establish an index series for the quantitative measurement of Qi deficiency pattern(QDP) in Traditional Chinese Medicine(TCM).METHODS:Seventeen indexes of arterial oxygen saturation(SaO_2),TCM pulse diagnosis,heart rate,and blood pressure were integrated into an index series,and 94 selected subjects were divided into a healthy control group,a mild QDP group,and a typical QDP *** three groups were then synchronously given a breath-holding(BH) test and index detections using TCM apparatus for auxiliary diagnosis and treatment and a *** detections were carried out repeatedly until there was no monotonic change in the value of the minimal SaO_(2d)uring a BH measurement(SaO_(2 min)) or in the duration of BH during a BH measurement(TBH).RESULTS:BH measurement and index detection data from 380 eligible cases were analyzed and a significant intergroup difference was found for 12 ***:An index series for quantitative QDP measurement could comprise the 12 effective indexes:RSaO_(2d)(rate of decline of SaO_(2d)uring a BH measurement),RSaO_(2r)(recovery rate of SaO_2 after a BH measurement),SaO_(2 min),BFV(blood flow velocity),TSaO_(2d)(the time at which SaO_2 started declining during a BH measurement),TBH,TSa_(O2 min)(the time of occurrence of the minimal SaO_(2d)uring a BH measurement),TSa O_(2 max)(the time of occurrence of the maximal SaO_2 after a BH measurement),PTP(pulse-touching pressure),SBP(systolic blood pressure),PWV(pulse wave velocity),and DBP(diastolic blood pressure).Of the indexes,RSaO_(2d)could play akey role in quantitative QDP measurement;RSaO_(2r) and Sa O_2 mincould be used to differentiate the QDP symptom of shortness of breath and as early-warning indexes for chronic obstructive pulmonary ***,TSaO_(2d),and TBHcould be used to quantitatively assess the QDP symptoms of spontaneous perspiration and shortness of breath.

关键词： Qi deficiency pattern Dynamic arterial oxygen saturation pulse diagnosis Breath-holding measurement TCM

Clinical treatment of depressive patients with Anshendingzhi decoction

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Journal of Traditional Chinese Medicine 2014年第6期34卷 652-656页

作者： Jianyu Yang Lijuan Jiang Yang Li qingwen zhu Dong Liu Wugeng Xue Bolong Cao Yingke Liu Xing Wang National Prominent Chinese Medicine Guangrong Sun Inheritance Studio Beijing University of Chinese Medicine The Prominent Chinese Medicine Doctors' Studio Beijing Hepingli Hospital Department of Science and Education Yunnan Provincial Hospital of Traditional Chinese Medicine Preclinical School of Beijing University of Chinese Medicine School of Basic Medical Beijing Fangzhuang Communuty Health Service Center Department of Endocrinology Eastern Area of Dongzhimen Hospital Beijing University of Chinese Medicine Department of Traditional Chinese Medicine Beijing Tongrentang Hospital of Traditional Chinese Medicine

OBJECTIVE: To determine the effects of Anshendingzhi decoction(ASDZD) on depression, to com-pare ASDZD with Danzhixiaoyao pill(DZXYP), and to provide evidence for the clinical treatment of depression with Traditional Chinese ***: Seventy-eight patients with depression were enrolled from 2011 to 2013 in this double-blinded study. Patients were randomly divided into two groups: ASDZD(treatment group, n=39)and DZXYP(control group, n=39). Hamilton Depressive Scale and TCM Syndrome Differentiation Scale were used to assess depression and efficacy before treatment and 2, 4, and 6 weeks after *** Treatment Emergent Symptoms Scale(TESS)was used to evaluate adverse reactions, observe,and record treatment ***: ASDZD was significantly more effective than DZXYP. There were significant differences between the two groups in terms of recovered patients, overall response rate, and TESS score(all P<0.05).CONCLUSION: ASDZD is an effective treatment for depression. ASDZD could improve clinical symptoms and warrants further clinical research and application.

关键词： Depression Anshendizhi decoction Danzhixiaoyao pill

Pharmacological effects of denervated muscle atrophy due to metabolic imbalance in different periods

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BIOCELL 2023年第11期47卷 2351-2359页

作者： JIAYING QIU YAN CHANG WENPENG LIANG MENGSI LIN HUI XU WANQING XU qingwen zhu HAIBO ZHANG ZHENYU ZHANG Department of Prenatal Screening and Diagnosis Center Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong226001China Nantong Institute of Genetics and Reproductive Medicine Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong226001China Department of Emergency Medicine Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong226001China Medical School of Nantong University Nantong UniversityNantong226001China School of Life Sciences Nantong UniversityNantong226001China

Denervation-induced skeletal muscle atrophy can potentially cause the decline in the quality of life of patients and an increased risk of *** pathophysiological mechanisms with dynamic alterations have been documented in skeletal muscle atrophy resulting from innervation ***,an in-depth comprehension of the key mechanisms and molecules governing skeletal muscle atrophy at varying stages,along with targeted treatment and protection,becomes essential for effective atrophy *** preliminary research categorizes the skeletal muscle atrophy process into four stages using microarray *** review extensively discusses the pathways and molecules potentially implicated in regulating the four stages of denervation and muscle ***,drugs targeting the reactivare oxygen species stage and the inflammation stage assume critical *** intervention during the initial atrophy stages can expedite protection against skeletal muscle ***,pharmaceutical intervention in the ubiquitin-proteasome pathway associated with atrophy and autophagy lysosomes can effectively slow down skeletal muscle *** molecules within this stage encompass MuRF1,MAFbx,LC3II,p62/SQSTM1,*** review also compiles a profile of drugs with protective effects against skeletal muscle atrophy at distinct postdenervation stages,thereby augmenting the evidence base for denervation-induced skeletal muscle atrophy treatment.

关键词： Pharmacological effects Denervated muscle atrophy Metabolic imbalance

染色体微阵列分析在流产物检测中的应用与意义

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中国优生与遗传杂志 2024年第3期32卷 528-534页

作者：林孟思仇嘉颖卞文君徐小柠蒋鸿儒曹娴王婧朱庆文南通市妇幼保健院产前诊断中心江苏南通226000

目的本研究旨在通过染色体微阵列分析(CMA)探究流产绒毛或胚胎组织中染色体异常的分布,及其与孕周和孕妇年龄的相关性,以评估CMA在自然流产遗传学诊断中的应用价值。方法研究收集了2021年2月至2023年11月南通市妇幼保健院处理的891例... 详细信息

目的本研究旨在通过染色体微阵列分析(CMA)探究流产绒毛或胚胎组织中染色体异常的分布,及其与孕周和孕妇年龄的相关性,以评估CMA在自然流产遗传学诊断中的应用价值。方法研究收集了2021年2月至2023年11月南通市妇幼保健院处理的891例流产女性样本,进行染色体微阵列分析和荧光定量PCR(QF-PCR)检测。样本根据CMA结果分为染色体数目异常、致病性拷贝数变异(CNV)、意义不明的变异(VOUS)和未见明显异常四类,比较不同年龄和孕周孕妇的CMA结果。结果 891例流产样本中,366例(41.08%)出现染色体数目异常,54例(6.06%)检出致病性CNV,67例(7.52%)为VOUS。孕早期(1~12周)样本中染色体数目异常比例为46.60%,孕中期(13~27周)降至38.35%,孕晚期(28周以上)的样本中未见染色体数目异常。非整倍体异常,尤其是常染色体三体或单体最多,以16号染色体三体较多见。致病性CNV中约75.93%为非平衡染色体异常。数据还显示孕妇年龄增长与遗传异常风险正相关,40岁以上孕妇遗传异常发生率显著增加。结论 CMA是胎儿流产遗传学诊断的重要工具,能检测染色体数量异常和基因组拷贝数变异,对评估再次怀孕风险提供重要指导。

关键词：流产绒毛染色体异常孕周相关性孕妇年龄 CMA检测

不同专业中医本科生生理学期末试卷的数据分析

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中国中医药现代远程教育 2024年第12期22卷 185-188页

作者：高蔚李海燕程薇朱庆文倪磊刘天华陈俞材郭健北京中医药大学中医学院生理教研室北京102488

目的提高生理学试卷质量及教学水平。方法运用北京中医药大学试卷分析系统,对北京中医药大学2019级五年制不同专业(中医学、中医学实验班、针灸推拿学)生理学期末考试试卷的难度、区分度、信度和效度进行评价,并统计分析试卷成绩。结果... 详细信息

目的提高生理学试卷质量及教学水平。方法运用北京中医药大学试卷分析系统,对北京中医药大学2019级五年制不同专业(中医学、中医学实验班、针灸推拿学)生理学期末考试试卷的难度、区分度、信度和效度进行评价,并统计分析试卷成绩。结果共分析了生理学期末试卷603份。试卷分析发现,该试卷难度适中、区分度较好,主观题难度大于客观题;学生成绩分布基本合理,成绩真实可靠。通过试卷成绩统计分析发现,中医学和中医学实验班在平均分、主观题、客观题的得分,以及及格率和优秀率上,都明显优于针灸推拿学(P<0.05)。结论文章为教师面对不同专业方向的学生开展有针对性的生理学教学活动提供了数据支持,也为提高生理学试卷出题质量和教学水平提供了参考依据。

关键词：生理学试卷分析系统成绩分析