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Single-incision laparoscopic transabdominal preperitoneal repair in the treatment of adult female patients with inguinal hernia

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 49-58页

作者： Xiao-Jun zhu Jing-Yi Jiao Hui-min Xue Peng Chen Chang-Fu Qin Peng Wang department of General Surgery The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina department of Hernia and Abdominal Wall Surgery Peking University People's HospitalBeijing 100044China

BACKGROUND Women have a 3%lifetime chance of developing an inguinal hernia,which is not as common in *** to its cosmetic benefits,single-incision laparoscopic transabdominal preperitoneal(SIL-TAPP)inguinal hernia repair is becoming in-creasingly popular in the management of inguinal hernia in ***,there are no studies comparing the safety and applicability of SIL-TAPP repair with conventional laparoscopic transabdominal preperitoneal(CL-TAPP)inguinal hernia repair for the treatment of inguinal hernia in *** To compare the outcomes of SIL-TAPP and CL-TAPP repair in adult female patients with inguinal hernia and to estimate the safety and applicability of SIL-TAPP repair in adult female inguinal hernia *** We retrospectively compared the clinical information and follow-up data of fe-male inguinal hernia patients who underwent SIL-TAPP inguinal hernia repair and those who underwent CL-TAPP inguinal hernia repair at the Affiliated Hos-pital of Nantong University from February 2018 to December 2020 and assessed the long-term and short-term outcomes of both *** This study included 123 patients,with 71 undergoing SIL-TAPP repair and 52 un-dergoing CL-TAPP *** two cohorts of patients and inguinal hernia charac-teristics were similar,with no statistically meaningful *** rate of intraoperative inferior epigastric vessel injury was lower in patients in the SIL-TAPP cohort(0,0%)than in patients in the CL-TAPP cohort(4,7.7%)and was significantly different(P<0.05).In addition,the median[interquartile range(IQR)]total hospitalization costs were significantly lower in patients in the SIL-TAPP cohort[$3287(3218-3325)]than in patients in the CL-TAPP cohort[$3511(3491-3599)].Postoperatively,the occurrence rate of trocar site hernia was lower in the SIL-TAPP cohort(0,0%)than in the CL-TAPP cohort(4,7.7%),and the median(IQR)cosmetic score was significantly higher in the SIL-TAPP cohort[10(10-10)]than in the CL-TAPP cohort[9(9

关键词： Single-incision Groin hernia Female Inguinal hernia Laparoscopic transabdominal preperitoneal inguinal hernia repair

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CdS/LaFeO_(3) heterojunctions with improved optical properties for visible-light catalytic applications

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Journal of Rare Earths 2024年第5期42卷 879-888,I0003页

作者： Jiaqi Wei Wen zhu Xuelian Xu Xiao Xu Junjiang zhu Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile University ChemistryWuhan430200China

Construction of heterojunctions is a normal and effective strategy to improve the photocatalytic performances of semiconductors,through which both the lifetime and the redox ability of electrons/holes can be improved,as co mpared to the respective *** this basis,we constructed Z-scheme CdS/LaFeO_(3) heterojunctions(CdS/LFO),by in-situ growing different amounts of CdS on the surface of LaFeO_(3),for photocatalytic degradation of tetracycline hydrochloride(TC)in aqueous solution at room *** crystal structure,surface morphology and optoelectronic properties of the COS/LFO heterojunctions were systemically characterized to correlate the reaction *** tests indicate that the CdS/LFO heterojunctions exhibit promising activity for TC degradation under visible light irradiation(λ≥420 nm),with 85%TC conversion obtained at reaction time of 45 min,which is 3.4 and 1.9 times higher than that of CdS and LaFeO_(3).The CdS/LFO heterojunctions are also stable in the reaction and can be reused for four cycles with no appreciable activity *** applicability of CdS/LFO to photocatalytic degradation of organic dyes,as well as the reaction mechanism,was also explored.

关键词： LaFeO_(3) CdS Photocatalytic degradation Tetracycline hydrochloride Reaction mechanism Rare earths

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Dual peroxisome proliferator-activated receptorα/δagonists:Hope for the treatment of alcohol-associated liver disease?

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World Journal of Gastroenterology 2024年第37期30卷 4163-4167页

作者： Xin-Yang Zhang Qin-Jun-Jie Chen Feng zhu min Li Dan Shang department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina department of Vascular Surgery Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061Hubei ProvinceChina

In this letter,we review the article“Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease”.We focus specifically on the detrimental effects of alcohol-associated liver disease(ALD)on human *** its insidious onset and increasing incidence,increasing awareness of ALD can contribute to reducing the prevalence of liver *** comprises a spectrum of several different disorders,including liver steatosis,steatohepatitis,fibrosis,cirrhosis,and hepatocellular *** pathogenesis of ALD is exceedingly *** studies have shown that peroxisome proliferator-activated receptors(PPARs)regulate lipid metabolism,glucose homeostasis and inflammatory responses within the ***,their dysfunction is a major contributor to the progression of *** is an oral,dual PPARαandδ*** effectiveness of elafibranor in the treatment of ALD remains *** this letter,we emphasize the harm of ALD and the burden it places on ***,we summarize the clinical management of all stages of ALD and present new insights into its pathogenesis and potential therapeutic ***,we discuss the mechanisms of action of PPARαandδagonists,the significance of their antifibrotic effects on ALD and future research directions.

关键词： Alcohol-associated liver disease Fibrosis Antifibrotic effect Elafibranor Peroxisome proliferator-activated receptor

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Microfluidic preparation of surfactant-free ultrafine DAAF with tunable particle size for insensitive initiator explosives

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Defence Technology（防务技术） 2024年第9期39卷 42-52页

作者： Bo Yang Rui Li Wei Cao Si-min He Jincan zhu Qi Wu Heng Ding Jin Chen Weimiao Wang Zhiqiang Qiao Xiaodong Li Guangcheng Yang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Southwest University of Science and Technology Mianyang 621010China School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China

High purity and ultrafine DAAF(u-DAAF)is an emerging insensitive charge in *** there are many ways to obtain u-DAAF,developing a preparation method with stable operation,accurate control,good quality consistency,equipment miniaturization,and minimum manpower is an inevitable requirement to adapt to the current social technology development *** reported is the microfluidic preparation of u-DAAF with tunable particle size by a passive swirling *** the guidance of recrystallization growth kinetics and mixing behavior of fluids in the swirling microreactor,the key parameters(liquid flow rate,explosive concentration and crystallization temperature)were screened and optimized through screening *** the condition that no surfactant is added and only experimental parameters are controlled,the particle size of recrystallized DAAF can be adjusted from 98 nm to 785 nm,and the corresponding specific surface area is 8.45 m^(2)·g^(-1)to 1.33 m^(2)·g^(-1).In addition,the preparation method has good batch stability,high yield(90.8%-92.6%)and high purity(99.0%-99.4%),indicating a high practical application *** explosion derived flyer initiation tests demonstrate that the u-DAAF shows an initiation sensitivity much lower than that of the raw DAAF,and comparable to that of the refined DAAF by conventional spraying crystallization *** study provides an efficient method to fabricate u-DAAF with narrow particle size distribution and high reproducibility as well as a theoretical reference for fabrication of other ultrafine explosives.

关键词： Microfluidic preparation Screening crystallization conditions Narrow particle size distribution Low initiation sensitivity Ultrafine DAAF

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A mixed-valence polyoxometalate-based 3D inorganic framework cathode material for high-efficiency rechargeable AZIBs

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Rare Metals 2024年第8期43卷 3677-3691页

作者： Qing Han Hao-Ran Xiao Tao Zhou Bing-Chuan Li Liu Yang Ling-Ling Xie Xue-Jing Qiu Xian-Yong Wu Li-min zhu Xiao-Yu Cao School of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou City Zhengzhou 450001China College of Materials Engineering Henan University of EngineeringZhengzhou450007China School of Environmental Engineering Henan University of TechnologyZhengzhou 450001China department of Chemistry University of Puerto Rico-Rio Piedras CampusSan JuanPR 00925USA

The global trend towards new energy storage systems has stimulated the development of electrochemical energy storage *** these technologies,rechargeable aqueous zinc-ion batteries(AZIBs)have attracted considerable interest as a potential alternative to lithium-ion batteries(LIBs)due to their affordable cost,environmental compatibility and high safety *** this study,a high-quality electrode for AZIBs has been successfully developed using a dehydrated mixed-valence polyoxometalate-based three-dimensional(3D)inorganic framework material known as[H_6Mn_(3)V^Ⅳ_(15)V-^Ⅴ_(4O)_(46)(H_2O)_(12)](3D-MnVO).This innovative 3D-MnVO material is built from the alternate connections of{V_(19)O_(46)}"sphere-shaped"clusters andμ_(2)-{Mn(H_(2)O)_(4)}bridges,where each{V_(19)O_(46)}cluster is surrounded by three pairs of vertically distributed{Mn(H_(2)O)_(4)}units,thus resulting in the 3D interpenetrating grid-like network from the infinite[-{V_(19)O_(46)}-μ_(2)-Mn(H_(2)O)_(4)-{V_(19)O_(46)}]_∞chains in three mutually perpendicular *** 3D framework structure of 3D-MnVO possesses abundant oxygen vacancies,spacious and multi-level interconnected channels for ion transport,which facilitates the efficient intercalation/deintercalation of hydrated Zn^(2+)into the pores of the primary structure via the intercalation capacitance *** a result,the 3D-MnVO electrode exhibits excellent diffusion rates and minimal interfacial *** a current density of 0.1 A·g^(-1),the 3D-MnVO cathode delivers a commendable discharge capacity of170.5 mAh·g^(-1)with 81.6%capacity retention after100 charge/discharge ***,even at a high current density of 1.0 A·g^(-1),the 3D-MnVO electrode delivers a remarkable reversible capacity of198.9 mAh·g^(-1).Our research results provide valuable insights into the development of advanced polyoxometalate-based 3D inorganic framework electrode materials for high-performance rechargeable AZIBs.

关键词： Cathode Polyoxometalate 3D inorganic framework Zinc-ion batteries Energy storage mechanism

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Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope

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Journal of Geriatric Cardiology 2024年第6期21卷 651-657页

作者： Bin TU Zi-Hao LAI Ai-Yue CHEN Zhi-Yuan WENG Si-min CAI zhu-Xin ZHANG Li-Kun ZHOU Li-Hui ZHENG Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesNational Key LaboratoryChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiac Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiovascular department The First Affiliated HospitalFujian Medical UniversityFujian Institute of HypertensionFujianChina department of Cardiovascular The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiangChina

BACKGROUND Cardioneuroablation(CNA)has shown encouraging results in patients with vasovagal syncope(VVS).However,data on different subtypes was *** This observational study retrospectively enrolled 141 patients[mean age:40±18 years,51 males(36.2%)]with the diagnosis of *** characteristics among different types of VVS and the outcomes after CNA were *** After a mean follow-up of 4.3±1.5 years,41 patients(29.1%)experienced syncope/pre-syncope events after ***/pre-syncope recurrence significantly differed in each subtype(P=0.04).The cardioinhibitory type of VVS had the lowest recurrence rate after the procedure(n=6,16.7%),followed by mixed(n=26,30.6%)and vasodepressive(n=9,45.0%).Additionally,a significant difference was observed in the analyses of the Kaplan-Meier survival curve(P=0.02).Syncope/pre-syncope burden was significantly reduced after CNA in the vasodepressive type(P<0.01).Vasodepressive types with recurrent syncope/pre-syncope after CNA have a lower baseline deceleration capacity(DC)level than those without(7.4±1.0 ms vs.9.0±1.6 ms,P=0.01).Patients with DC<8.4 ms had an 8.1(HR=8.1,95%CI:2.2-30.0,P=0.02)times risk of syncope/pre-syncope recurrence after CNA compared to patients with DC≥8.4 ms,and this association still existed after adjusting for age and sex(HR=8.1,95%CI:2.2-30.1,P=0.02).CONCLUSIONS Different subtypes exhibit different event-free *** vasodepressive type exhibited the lowest event-free rate,but those patients with DC≥8.4 ms might benefit from CNA.

关键词： syncope subtypes diagnosis

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High patatin like phospholipase domain containing 8 expression as a biomarker for poor prognosis of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 787-797页

作者： Peng-Yang Zhou De-Xiang zhu Yi-Jiao Chen Qing-Yang Feng Yi-Hao Mao Ao-Bo zhuang Jian-min Xu department of General Surgery Zhongshan Hospital Fudan UniversityShanghai 200032China

BACKGROUND Patatin like phospholipase domain containing 8(PNPLA8)has been shown to play a significant role in various cancer *** studies have focused on its roles as an antioxidant and in lipid ***,the role of PNPLA8 in colorectal cancer(CRC)progression is *** To explore the prognostic effects of PNPLA8 expression in *** A retrospective cohort containing 751 consecutive CRC patients was ***8 expression in tumor samples was evaluated by immunohistochemistry staining and semi-quantitated with immunoreactive *** patients were divided into high and low PNPLA8 expression groups based on the cut-off va-lues,which were calculated by X-tile *** prognostic value of PNPLA8 was identified using univariate and multivariate Cox regression *** over-all survival(OS)rates of CRC patients in the study cohort were compared with Kaplan-Meier analysis and Log-rank *** PNPLA8 expression was significantly associated with distant metastases in our cohort(P=0.048).CRC patients with high PNPLA8 expression indicated poor OS(median OS=35.3,P=0.005).CRC patients with a higher PNPLA8 expression at either stage I and II or stage III and IV had statistically significant shorter *** patients with left-sided colon and rectal cancer,the survival curves of two PN-PLA8-expression groups showed statistically significant *** analysis also confirmed that high PNPLA8 expression was an independent prog-nostic factor for overall survival(hazard ratio HR=1.328,95%CI:1.016-1.734,P=0.038).

关键词： Biomarker Colorectal cancer Expression level Overall survival Patatin like phospholipase domain containing 8 Prognosis

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Alkali Metal Ion Substituted Carboxymethyl Cellulose as Anode Polymeric Binders for Rapidly Chargeable Lithium-Ion Batteries

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Energy & Environmental Materials 2024年第1期7卷 77-82页

作者： Seoungwoo Byun zhu Liu Dong Ok Shin Kyuman Kim Jaecheol Choi Youngjoon Roh Dahee Jin Seungwon Jung Kyung-Geun Kim Young-Gi Lee Stefan Ringe Yong min Lee department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Intelligent Sensors Research Section Electronics and Telecommunications Research Institute(ETRI)Daejeon 34129Korea department of Advanced Device Technology University of Science and Technology(UST)Daejeon 34113Korea Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science University of WollongongWollongong NSW 2522Australia department of Chemistry Korea UniversitySeoul 02841Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea

The increasing demand for short charging time on electric vehicles has motivated realization of fast chargeable lithium-ion batteries(LIBs).However,shortening the charging time of LIBs is limited by Li^(+)intercalation process consisting of liquid-phase diffusion,de-solvation,SEI crossing,and solid-phase ***,we propose a new strategy to accelerate the de-solvation step through a control of interaction between polymeric binder and solvent-Li^(+)*** this purpose,three alkali metal ions(Li^(+),Na^(+),and K^(+))substituted carboxymethyl cellulose(Li-,Na-,and K-CMC)are prepared to examine the effects of metal ions on their *** lowest activation energy of de-solvation and the highest chemical diffusion coefficient were observed for ***,Li-CMC cell with a capacity of 3 mAh cm^(-2)could be charged to>95%in 10 min,while a value above>85%was observed after 150 ***,the presented approach holds great promise for the realization of fast charging.

关键词： de-solvation digital twins fast charging graphite anodes polymeric binders

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Comprehensive understanding on sources of high levels of fine particulate nitro-aromatic compounds at a coastal rural area in northern China

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Journal of Environmental Sciences 2024年第1期135卷 483-494页

作者： Yueru Jiang Xinfeng Wang min Li Yiheng Liang Zhiyi Liu Jing Chen Tianyi Guan Jiangshan Mu Yujiao zhu He Meng Yang Zhou Lan Yao Likun Xue Wenxing Wang Environment Research Institute Shandong UniversityQingdao 266237China department of Environmental Systems Science Swiss Federal Institute of Technology ZurichZurich 8092Switzerland department of Water Resources and Drinking Water Swiss Federal Institute of Aquatic Science and TechnologyDuebendorf 8600Switzerland Qingdao Eco-Environment Monitoring Center of Shandong Province Qingdao 266003China College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100China School of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200234China

Nitro-aromatic compounds(NACs)are among the major components of brown carbon(BrC)in the atmosphere,causing negative impacts on regional climate,air quality,and ecological *** to the extensive origins,it is still a challenge to figure out the contributions and originating regions for different sources of atmospheric ***,field observations on fine particulate NACs were conducted at a coastal rural area in Qingdao,China in the winter of 2018 and *** mean total concentrations of fine particulate nitro-aromatic compounds were 125.0±89.5 and 27.7±21.1 ng/m^(3)in the winter of 2018 and 2019,*** the measured eleven NACs,nitrophenols and nitrocatechols were the most abundant *** characteristics and correlation analysis showed that humidity and anthropogenic primary emissions had significant influences on the NAC *** this study,two tracing methods of the improved spatial concentration weighted trajectory(SCWT)model and the receptor model of positive matrix factorization(PMF)were combined to comprehensively understand the origins of NACs in fine particles at coastal *** major sources were identified,including coal combustion,biomass burning,vehicle exhaust,and secondary ***,coal combustion was responsible for about half of the observed nitro-aromatic compounds,followed by biomass burning(~30%).The results by SCWT demonstrated that the coal combustion dominated NACs mainly originated from the Shandong peninsula and the areas to the north and southwest,while those dominated by biomass burning primarily came from local Qingdao and the areas to the west.

关键词： Nitro-aromatic compounds Fine particles Source apportionment Originating region Combustion activities

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Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B

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Animal Models and Experimental Medicine 2024年第3期7卷 324-336页

作者： Bowen Niu Lingling Liu Qian Gao Meng-min zhu Lixiang Chen Xiu-Hua Peng Boying Qin Xiaohui Zhou Feng Li department of Laboratory Animal Science Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina department of Biology College of Life SciencesShanghai Normal UniversityShanghaiPeople's Republic of China

Background:Bitter taste receptors(Tas2rs)are generally considered to sense various bitter compounds to escape the intake of toxic *** taste receptors have been found to widely express in extraoral tissues and have important physiological functions outside the gustatory system in ***:To investigate the physiological functions of the bitter taste receptor cluster Tas2r106/Tas2r104/Tas2r105/Tas2r114 in lingual and extraoral tissues,multiple Tas2rs mutant mice and Gnat3 were produced using CRISPR/Cas9 gene-editing technique.A mixture containing Cas9 and sgRNA mRNAs for Tas2rs and Gnat3 gene was microinjected into the cytoplasm of the ***,T7EN1 assays and sequencing were used to screen genetic mutation at the target sites in founder *** real-time polymerase chain reaction(qRT-PCR)and immunostaining were used to study the expression level of taste signaling cascade and bitter taste receptor in taste *** to taste substance was also studied using twobottle preference ***:We successfully produced several Tas2rs and Gnat3 mutant mice using the CRISPR/Cas9 *** results showed that the expression of GNAT3 and PLCB2 was not altered in Tas2rs mutant *** qRT-PCR results revealed the changed expression profile of m Tas2rs gene in taste buds of these mutant *** two-bottle preference tests,these mutant mice eliminate responses to cycloheximide due to genetic mutation of *** addition,these mutant mice showed a loss of taste perception to quinine dihydrochloride,denatonium benzoate,and cucurbitacin B(CuB).Gnat3-mediated taste receptor and its signal pathway contribute to CuB ***:These findings implied that these mutant mice would be a valuable means to understand the biological functions of TAS2Rs in extraoral tissues and investigate bitter compound-induced responses mediated by these TAS2Rs in many extraoral tissues.

关键词： bitter taste receptor CRISPR/Cas9 genetic mutation two-bottle preference test type 2 taste receptors(Tas2rs)

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