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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li hai zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Understanding the Separations of Oil/Water Mixtures from Immiscible to Emulsions on Super-wettable Surfaces

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Journal of Bionic Engineering 2016年第1期13卷 1-29页

作者： hai zhu Zhiguang Guo Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials and Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei University Wuhan 430062 China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China

As the frequent oil spill accidents happens and large quantities of oily wastewater from all kinds of industries are being discharged, the environment has been seriously polluted and our living areas have been horribly threatened. To deal with these issues, attentions have been aroused on the treatments of the oily wastewater. Recently, numerous superwettable materials have been fabricated. In this review, we summarize the new development of the materials for the separation of oil/water mixtures, mainly including the immiscible and emulsified mixtures. For the separation of immiscible ones, special materials with fixed wettability are firstly detailed, where three types of materials can be classified based on their wettability, i.e. superhydrophobic and superoleophilic materials, superhydrophilic and underwater superoleophobic materials, and superhydrophilic and su- peroleophobic materials. Then, the smart materials with switchable wettabilities responsive to external stimulus, for instance, light, solvent, pH, temperature, and electrical potential, are presented. Meanwhile, the single, dual, and multiple stimu- lus-responsive materials are also described. As for the separation of emulsified oil/water mixtures, the materials for the sepa- ration of water-in-oil （W/O）, oil-in-water （O/W）, and both water-in-oil （W/O） and oil-in-water （O/W） emulsions are sequen- tially introduced. Finally, some challenges are discussed and the outlook in this filed is proposed.

关键词： superwettable immiscible mixtures emulsified mixtures separation materials

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Wetting Characterizations of Oilseed Rapes

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Journal of Bionic Engineering 2016年第2期13卷 213-219页

作者： hai zhu Zhiguang Guo Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials and Key Laboratory for the Green Preparation and Application of Functional Materials (Minisory of Education) Hubei University Wuhan 430062 China State Key Laboratory of Solid Lubrication Lanzhou hlstitute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China

Oilseed rape, widely cultivated all over the world, plays an important role for our daily life due to its high nutritional and economic values. In this paper, for the first time we discuss the surlhce wettability of oilseed rapes with special surface structures. It is found that the fresh rape flowers are superhydrophobic with a low Adhesion Force （AF）, showing the self-cleaning properties similar to lotus leaves. In contrast, the fresh rape leaves also exhibit hydrophobicity but a high AF, which resemble rose petals. Furthermore, we study the effect of storage time on the wetting properties of rape leaves. The high hydrophobicity of rape leaves gradually switches to hydrophilicity. Meanwhile, the AF intensely increases after placement at room temperature for 10 days. This research offers a profound inspiration to artificially fabricate biomimetic materials with high hydrophobicity and different adhesion characterizations.

关键词： oilseed rape wettability adhesion force lotus leaves rose petals biomimetic materials

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On Ding homological dimensions

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Applied Mathematics(A Journal of Chinese Universities) 2015年第4期30卷 491-502页

作者： zhu hai-yan College of Science Zhejiang University of Technology

In this paper, we investigate Ding projective dimensions and Ding injective di- mensions of modules and rings. Let R be a ring with rDPD（R） = n 〈 ∞, and let YYl = {Mild（M）〈 ∞}. We prove that （DP,W1） is a complete hereditary cotorsion pair such that a module M belongs to DD∩W1 if and only if M is projective, moreover, 1421 = （M[pd（M）〈 ∞} = {MIfd（M） ≤ n} = {MIpd（M） ≤ n}. Then we introduce and inves- tigate Ding derived functor Dext^i（-, -）, and use it to characterize global Ding dimension. We show that if R is a Ding-Chen ring, or if R is a ring with rDPD（R）〈≤ and rDID（R）〈 ≤, then rDPD（R）〈 n if and only if rDID（R）〈 n if and only if Dext^n＋i（M,N） = 0 for all modules M and N and all integer i ≥ 1.

关键词： Ding projective (injective) dimension cotorsion pair derived functor.

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Computations of unsteady transonic flow over airfoil at low Reynolds number

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航空动力学报 2013年第3期28卷 646-658页

作者： zhu hai-tao SHAN Peng School of Energy and Power Engineering Beijing University of Aeronautics and Astronautics Beijing 100191 China

Transonic flow over a thin airfoil at low Reynolds number was studied numerically by directly solving two-dimensional full Navier-Stokes equations through 5th order weighted essentially non-oscillatory(WENO) scheme without using any turbulence model.A series of distinguished unsteady phenomena for a thin 2-D transonic airfoil flow were *** to continuous adverse pressure gradient in the subsonic flow downstream of the sonic line,the unsteady separated boundary layer with main vortex and secondary vortex was developed at the rear of the *** the trailing edge,the vortex-shedding was characterized by periodical connection of the main vortex and secondary vortex on the other side of the *** unsteady separation and vortex-shedding occurred with the same *** the airfoil surface,the average pulse pressure related to the unsteady supersonic region was obviously smaller than that related to the vortex-shedding at the trailing *** the attack angle increasing from 0°to 2°,the frequency of vortex-shedding decreases about 4.2%.At last,the turbulence intensity and many second-order statistics in the wake region were investigated.

关键词： transonic flow unsteady flow direct numerical simulation(DNS) unsteady separation airfoil vortex-shedding

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An escape strategy in orbital pursuit-evasion games with incomplete information

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Science China(Technological Sciences) 2021年第3期64卷 559-570页

作者： LI ZhenYu zhu hai LUO YaZhong College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

The orbital pursuit-evasion game is typically formulated as a complete-information game,which assumes the payoff functions of the two players are common ***,realistic pursuit-evasion games typically have incomplete information,in which the lack of payoff information limits the player’s ability to play *** address this problem,this paper proposes a currently optimal escape strategy based on estimation for the *** this strategy,the currently optimal evasive controls are first derived based on the evader’s guess of the pursuer’s payoff *** an online parameter estimation method based on a modified strong tracking unscented Kalman filter is employed to modify the guess and update the strategy during the *** the estimation becomes accurate,the currently optimal strategy gets closer to the actually optimal *** results show the proposed strategy can achieve optimal evasive controls progressively and the evader’s payoff of the strategy is lower than that of the zero-sum escape ***,the proposed strategy is also effective in the case where the pursuer changes its payoff function halfway during the game.

关键词： orbital pursuit-evasion incomplete-information game online parameter estimation

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Tunable Emission and Energy Transfer of the Novel KY_(1-x)(MoO_(4))_(2-y)(WO_(4))y:xLn^(3+)(Ln^(3+)=Dy^(3+),Eu^(3+),and Tm^(3+))Single-phase White Luminescence Phosphor for White LEDs

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Journal of Wuhan University of Technology(Materials Science) 2023年第6期38卷 1278-1286页

作者： zhu hai HE Bin HUANG Weigang Department of Oncology The Third People's Hospital of ChengduAfiliated Hospital of Southwest Jiaotong University&The Second Affiliated Hospital of ChengduChongqing Medical UniversityChengdu 610031China Medical Research Center The Third People's Hospital of ChengduAfiliated Hospital of Southwest Jiaotong University&The Second Afiliated Hospital of ChengduChongqing Medical UniversityChengdu 610031China National Engineering Research Center for Biomaterials College of Biomedical MaterialsSichuan UniversityChengdu 610064China College of Materials Science and Engineering Sichuan UniversityChengd 610064China

The phosphors of KY_(1-x)(MoO_(4))_(2-y)(WO_(4))y:xLn^(3+)(Ln^(3+)=Tm^(3+),Dy^(3+),Eu^(3+))were synthesized by using a sol-gel ***,the crystal structure,luminescence properties,energy transfer,and white emission of the prepared materials were *** molar ratio of the anion group on the photoluminescence(PL)emission and excitation intensity were investigated,revealing that the optimum intensity could be obtained by using=3:*** optimal Dy^(3+) doping concentration of KY(MoO_(4))1.5(WO4)0.5was *** addition,the color-tunable emissions of Dy^(3+)/Eu^(3+)-codoped KY(MoO_(4))1.5(WO4)0.5phosphors were observed because of the effective energy transfer(ET)from Dy^(3+)to Eu^(3+)***,by doping appropriate concentrations of Tm^(3+),Dy^(3+),and Eu^(3+)and different concentrations of(WO_(4))^(2-),white light emitting phosphors KY_(0.92)(WO_(4))2:0.01Tm^(3+),0.06Dy^(3+),0.01Eu^(3+)with excellent color-rending properties were *** chromaticity coordinate was calculated as(x=0.3238,y=0.3173),closing to the artificial daylight(D65,x=0.313,y=0.329)illuminant,and which indicates the potential application of near ultraviolet White light-emitting diodes(WLEDs).

关键词： rare earth phosphors white LEDs energy transfer sol-gel method

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DIMENSIONS OF ATACTIC POLY(α-METHYLSTYRENE)ChaiNS WITH SIDE GROUPS

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Chinese Journal of Polymer Science 2006年第1期24卷 87-93页

作者： hai-zhu Ma Gao-xiang Ye Department of Physics Zhejiang University Hangzhou 310027 China Department of Physics Zhejiang Education Institute Hangzhou 310012 China

An improved configurational-confomational statistical method is developed and the mean-square radius of gyration for atactic poly（α-methylstyrene）（PαMS） chains is studied, in which the effect of large side groups is considered. The deduced formulas, based on the rotational isomer state theory, are used to investigate the configuration-dependent properties of the atactic polymer chain, and the statistical correlation of the unperturbed polymer chain dimension and structure parameters are calculated. For the fraction of meso dyads Wm= 0.4, the dependence of the radius of gyration Rg and the intrinsic viscosity [η] on the molecule mass M are Rg = 2.63×10^-2 M^0.50 nm and [η] = 7.36 × 10^-2 M^0.497, respectively, which are in agreement with the previous experimental data for the PαMS samples. A small hump is detected in the curve of the characteristic ratio of the unperturbed mean-square radius of gyration versus the chain length for short PαMS chains. The Rg increases linearly with the temperature T, and the effects of the chain length and the tacticity on the temperature coefficient are remarkable. These are quite different from the results for PαMS chains not considering side groups or for the monosubstituted polystyrene chain.

关键词： Side groups Rotational isomeric state Radius of gyration Poly(α-methylstyrene) chain.

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Unperturbed dimensions of atactic poly(dibenzyl itaconate)s

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 991-998页

作者： MA hai-zhu YE Gao-xiang Department of Physics Zhejiang University Hangzhou 310027 China School of Science and Technology Zhejiang Education Institute Hangzhou 310012 China

The unperturbed dimension and temperature character of poly(dibenzyl itaconate)s (PDBzI) are studied by a revised rotational isomeric state (RIS) method. The improved formulas of the mean-square radius of gyration, deduced by the pseudo-stereochemical equilibrium approach, may be used to investigate the configurational-conformational properties of atactic polymers with large side groups [poly(itaconates) for instance]. The calculated results showed that poly(itaconates) have larger dimension of the molecule than other vinyl polymers. Comparison of the dimension between considering and without considering side groups showed that the effect of large side groups on the unperturbed dimension for short-chain polymers is more obvious than that of long-chain polymers and, if the dimension of side groups increases, the effect also increases. The dimension differences of PDBzI between short-chain and long-chain polymers are investigated by the relation of characteristic ratios and temperature coefficients with temperature. Moreover, the dependence between the temperature coefficients and the tacticity of chains shows that the temperature characters of the isotactic, syndiotactic and atactic PDBzI chains have remarkable difference.

关键词： Poly(dibenzyl itaconate)s Mean-square radius of gyration Temperature coefficient Tacticity

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Laser-Manipulating Macroscopic Quantum States of a Bose-Einstein Condensate Held in a Kronig-Penny Potential

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Communications in Theoretical Physics 2009年第7期52卷 68-74页

作者： zhu Qian-Quan hai Wen-Hua DENG hai-Ming Department of Physics Hunan Normal University Changsha 410081 China

We investigate the boundary vaJue problem （BVP） of a quasi-one-dimensional Gross-Pitaevskii equation with the Kronig-Penney potential （KPP） of period d, which governs a repulsive Bose-Einstein condensate. Under the zero and periodic boundary conditions, we show how to determine n exact stationary eigenstates {Rn} corresponding to different chemical potentials {μn} from the known solutions of the system. The n-th eigenstate P~ is the Jacobian elliptic function with period 2din for n = 1,2,…, and with zero points containing the potential barrier positions. So Rn is differentiable at any spatial point and R2 describes n complete wave-packets in each period of the KPP. It is revealed that one can use a laser pulse modeled by a 5 potential at site xi to manipulate the transitions from the states of {Rn} with zero Point x≠xi to the states of {Rn＇} with zero Point x= Xi. The results suggest an experimental scheme for applying BEC to test the BVP and to observe the macroscopic quantum transitions.

关键词： Bose-Einstein Condenstate Kronig-Penney potential boundary value problem laser-manipulating macroscopic quantum state

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