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Role of the portal system in liver regeneration:From molecular mechanisms to clinical management

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“机械灌注+”应用于扩大标准供肝移植--肝尽其用

肝脏研究（英文） 2024年第1期8卷 1-10页

作者： Hanzhi Xu Xun Qiu zhoucheng wang Kai wang Yawen Tan Fengqiang Gao Marcos Vinicius Perini Xiao Xu Zhejiang University School of Medicine HangzhouZhejiangChina Zhejiang University School of Medicine HangzhouZhejiangChina Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province HangzhouZhejiangChina Department of Surgery University of MelbourneAustin HealthHeidelbergVictoriaAustralia

The liver has a strong regenerative capacity that ensures patient recovery after hepatectomy and liver *** portal system plays a crucial role in the dual blood supply to the liver,making it a significant factor in hepatic *** surgical strategies,such as portal vein ligation,associating liver partition and portal vein ligation for staged hepatectomy,and dual vein embolization,have high-lighted the portal system's importance in liver *** hepatectomy or liver trans-plantation,the hemodynamic properties of the portal system change dramatically,triggering regeneration via shear stress and the induction of ***,excessive portal hyperperfusion can harm the liver and negatively affect patient ***,as the importance of the gut-liver axis has gradually been revealed,the effect of metabolites and cytokines from gut microbes carried by portal blood on liver regeneration has been *** these perspectives,this review outlines the molecular mechanisms of the portal system's role in liver regeneration and summarizes therapeutic strategies based on the portal system intervention to promote liver regeneration.

关键词： Portal system Liver regeneration Hemodynamic properties Gut microbiota Therapeutic strategies

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Engineering 2024年第1期32卷 29-40页

作者： zhoucheng wang Jack Martin Jiongjie Yu Kai wang Kourosh Saeb-Parsy Xiao Xu Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Department of Surgery Cambridge University Hospitals&NHS Foundation TrustCambridge CB22QQ UK Department of Surgery University of Cambridge&NIHR Cambridge Biomedical Research CentreCambridge CB22QQUK Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China

Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor *** criteria donor(ECD)liver grafts are increasingly utilized in clinical practice to mitigate this ***,impaired ischemic tolerance of these grafts jeopardizes organ viability during cold *** perfusion(MP)was designed to improve organ preservation and reduce posttransplant ***,it is increasingly evident that MP alone may not preserve ECD grafts *** emphasis has thus been placed on modified MP strategies,including the use of different perfusates,modified perfusion modalities,and different therapeutic ***,we introduce a novel term,"MP Plus,"denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of ECD *** this review,we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different ECD grafts in clinical settings.

关键词： Liver transplantation Extended criteria donor Machine perfusion plus Organ shortage

Interface engineering of Zn meal anodes using electrochemically inert Al_(2)O_(3)protective nanocoatings

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Nano Research 2022年第8期15卷 7227-7233页

作者： Rui wang Qiongfei Wu Minjie Wu Jiaxian Zheng Jian Cui Qi Kang Zhengbing Qi JiDong Ma zhoucheng wang Hanfeng Liang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Key Laboratory of Functional Materials and Applications of Fujian Province School of Materials Science and EngineeringXiamen University of TechnologyXiamen 361024China Department of Polymer Science and Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong UniversityShanghai 200240China

Aqueous rechargeable Zn-ion batteries are regarded as a promising alternative to lithium-ion batteries owing to their high energy density,low cost,and high ***,their commercialization is severely restricted by the Zn dendrite formation and side ***,we propose that these issues can be minimized by modifying the interfacial properties through introducing electrochemically inert Al_(2)O_(3)nanocoatings on Zn meal anodes(Al_(2)O_(3)@Zn).The Al_(2)O_(3)nanocoatings can effectively suppress both the dendrite growth and side *** a result,the Al_(2)O_(3)@Zn symmetric cells show excellent electrochemical performance with a long lifespan of more than 4,000 h at 1 mA·cm^(−2)and 1 mAh·cm^(−2).Meanwhile,the assembled Al_(2)O_(3)@Zn//V_(2)O_(5)full cells can deliver a high capacity(236.2 mAh·g^(−1))and long lifespan with a capacity retention of 76.11%after 1,000 cycles at 4 A·g^(−1).

关键词： aqueous Zn-ion batteries Zn dendrites side reactions Al2O3 protective nanocoatings interface engineering

Recent progress in advanced catalysts for electrocatalytic hydrogenation of organics in aqueous conditions

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eScience 2023年第5期3卷 12-33页

作者： Ye Zeng Mengting Zhao Hongliang Zeng Qiu Jiang Fangwang Ming Kai Xi zhoucheng wang Hanfeng Liang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhouChina School of Chemistry Xi'an Key Laboratory of Sustainable Energy Materials ChemistryEngineering Research Center of Energy Storage Materials and DevicesMinistry of EducationState Key Laboratory for Electrical Insulation and Power EquipmentXi'an Jiaotong UniversityXi'an 710049China Materials Science and Engineering King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

Electrocatalytic hydrogenation(ECH)of organics using water as hydrogen donors has been regarded as a green organic reduction technique to replace traditional chemical reactions that use sacrificial *** development of ECH process provides potential applications in the production of value-added chemicals owing to its low energy consumption,low pollution,high safety,and superior ***,its application is limited by the low conversion rate and poor selectivity toward desired *** efficiency of ECH can be improved by rational design of *** review covers several representative electrocatalytic systems(aldehydes,ketones,phenolic organics,alkynes,and organonitrogen compounds)and summarizes different ECH mechanisms,followed by thorough discussion on the modification strategies of electrocatalysts that are currently adopted to enhance the catalytic ***,in view of the current challenges for ECH,we discuss possible future directions in the field,aiming to provide guidance to the catalyst design toward highly efficient ECH reactions over different organic feedstocks.

关键词： Electrocatalytic hydrogenation(ECH) Organic synthesis Electrochemistry Electrocatalyst

One-step synthesis of graphitic-C_3N_4/ZnS composites for enhanced supercapacitor performance

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Journal of Energy Chemistry 2018年第2期27卷 472-477页

作者： Binbin Wei Hanfeng Liang Rongrong wang Dongfang Zhang Zhengbing Qi zhoucheng wang College of Chemistry and Chemical Engineering Xiamen University Materials Science and Engineering King Abdullah University of Science and Technology (KAUST) School of Materials Science and Engineering Xiamen University of Technology

A series of graphitic-C3N4/ZnS（g-C3N4/ZnS） supercapacitor electrode materials have been prepared via a one-step calcination process of zinc acetate/thiourea with different mass ratios under nitrogen atmosphere. The optimized g-C3N4/ZnS composite shows a highest specific capacitance of 497.7 F/g at 1 A/g and good cycling stability with capacitance retention of 80.4% at 5 A/g after 1000 cycles. Moreover, gC3N4/ZnS composites display an improved supercapacitor performance in terms of specific capacitance compared to the pure g-C3N4 and ZnS. In addition, our designed symmetric supercapacitor device based on g-C3N4/ZnS composite electrodes can exhibit an energy density of 10.4 Wh/kg at a power density of 187.3 W/kg. As a result, g-C3N4/ZnS composites are expected to be a prospective material for supercapacitors and other energy storage applications.

关键词： g-C3 N4/ZnS Supercapacitor One-step calcination Energy storage

Study of GaAs/GaAlAs Multilayer Structural Materials by Electrolyte Electroreflectance

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Rare Metals 1990年第2期10卷 131-134页

作者： wang, zhoucheng Peng, Ruiwu Qian, Youhua Acad Sinica Fujian Inst of Research on the Structure of Matter China

Electrolyte electroreflectance (EER) has been widely employed to investigate the electronic energy band structure and related physical properties of semiconductors. The electrolyte electroreflectance (EER) method combined with electrochemical anodic dissolution was used to study GaAs/GaAlAs multilayer structural materials. According to variation of the EER spectra during anodic dissolution the characteristics of GaAs/GaAlAs multilayer structural materials such as properties of the interface, p-n junction positions and Al content profiles were obtained.

关键词： GaAs AI EER Study of GaAs/GaAlAs Multilayer Structural Materials by Electrolyte Electroreflectance

A novel nomogram for prognosis stratification in salvage liver transplantation:a national-wide study with propensity score matching analysis in China

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 854-867,I0006-I0009页

作者： Kai wang Fengqiang Gao Siyi Dong Jialu Ding Libin Dong Chuxiao Shao zhoucheng wang Xun Qiu Xuyong Wei Zhengxin wang Jiayin Yang Qiang Xia Shusen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina Institute of Organ Transplantation Zhejiang UniversityHangzhouChina Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina NHC Key Laboratory of Combined Multi-organ Transplantation HangzhouChina Zhejiang University School of Medicine HangzhouChina Department of Hepatobiliary and Pancreatic Surgery Affiliated Lishui HospitalZhejiang University School of MedicineLishuiChina National Center for Healthcare Quality Management in Liver Transplant HangzhouChina Graduate School Nanjing University of Chinese MedicineNanjingChina Department of General Surgery Huashan HospitalFudan UniversityShanghaiChina Liver Transplantation Center Department of Liver SurgeryWest China Hospital of Sichuan UniversityChengduChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Hepatobiliary and Pancreatic Surgery Shulan Hospital of HangzhouHangzhouChina

Background:Salvage liver transplantation(SLT)has been reported to be an efficient treatment option for patients with recurrent hepatocellular carcinoma(HCC)after liver resection(LR).However,for recipients who underwent liver transplantation(LT)due to recurrent HCC after LR in China,the selection criteria are not well ***:In this study,data from the China Liver Transplant Registry(CLTR)of 4,244 LT performed from January 2015 to December 2019 were examined,including 3,498 primary liver transplantation(PLT)and 746 SLT *** score matching(PSM)analysis was used to minimize between-group *** overall survival(OS)and disease-free survival(DFS)between PLT and SLT in recipients fulfilling the Milan or Hangzhou criteria were compared based on the multivariate analysis,nomograms were plotted to further classify the SLT group into low-and high-risk ***:In this study,the 1-,3-and 5-year OS and DFS of SLT recipients fulfilling Milan criteria(OS,P=0.01;DFS,P<0.001)or Hangzhou criteria(OS,P=0.03;DFS,P=0.003)were significantly reduced when compared to that of PLT group after PSM *** risk factors,including preoperative transarterial chemoembolization(TACE),alpha fetoprotein(AFP)level,tumor maximum size and tumor total diameter were selected to draw a prognostic *** low-risk SLT recipients(1-year,95.34%;3-year,84.26%;5-year,77.20%)showed a comparable OS with PLT recipients fulfilling Hangzhou criteria (P=0.107). Conclusions: An optimal nomogram model for prognosis stratification and clinical decision guidance of SLT was established. The low-risk SLT recipients based on the nomograms showed comparable survival with those fulfilling Hangzhou criteria in PLT group.

关键词： Salvage liver transplantation(SLT) nomogram primary liver transplantation(PLT) overall survival(OS) disease-free survival(DFS)

“机械灌注+”视阈下扩大标准供肝的修复与功能提升

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中华消化外科杂志 2022年第1期21卷 74-78页

作者：汪恺苏仁义王周城徐骁浙江大学医学院附属杭州市第一人民医院肝胆胰外科杭州310006

肝移植是终末期肝病最有效的治疗手段。我国是世界肝移植第二大国,为解决供肝短缺的瓶颈问题,扩大标准供肝的修复和功能提升是目前重要的研究方向。面向未来,基于医工信交叉融合创新平台,探求干细胞命运调控、器官修复与组织再生的基础... 详细信息

肝移植是终末期肝病最有效的治疗手段。我国是世界肝移植第二大国,为解决供肝短缺的瓶颈问题,扩大标准供肝的修复和功能提升是目前重要的研究方向。面向未来,基于医工信交叉融合创新平台,探求干细胞命运调控、器官修复与组织再生的基础理论突破,开展全国多中心、引领性的临床研究至关重要。由此,笔者综合国内外循证医学证据、最新研究成果及临床经验,基于“机械灌注+”的新理念,探索多组学技术、分子生物学技术、信息化技术、自动化技术、纳米靶向递送技术等与传统机械灌注技术相结合的新模式,以期实现实时、无创、智能化的供肝质量评估和检测,建立扩大标准供肝修复与功能提升的技术新体系,安全、有效地拓展供肝来源,降低移植后并发症风险,改善受者预后,从而推动我国肝移植事业更高质量发展。

关键词：普通外科肝移植扩大标准供肝机械灌注器官保存

Working Pressure Induced Microstructure and Stress Evolution of Sputtered ZrN Coatings

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稀有金属材料与工程 2012年第S1期41卷 429-432页

作者： Qi Zhengbing Yan Weili Hong Jinqing Zhu Fangping Sun Peng wang zhoucheng Wu Zhengtao Peng Dongliang Wu Chonghu Xiamen Univ Coll Chem & Chem Engn Xiamen 361005 Peoples R China China Natl R&D Ctr Tungsten Technol Xiamen 361005 Peoples R China

The influence of working pressure on microstructure and residual stress evolution of magnetron sputtered ZrN coatings were systemically *** and XRD results reveal that all as-deposited coatings at varying working pressure are stoichiometric ZrN with cubic NaCl structure.A decrease in working pressure results in preferred orientation evolution from(111)to(200).This evolution is driven by kinetics processes,such as adatom surface migration and competitive grain growth,rather than by *** explanation is also supported by morphology characterization as the surface and cross-section morphologies transition from tapered shape and columnar structure to round and non-columnar(equiaxed)structure.

关键词： ZrN coating working pressure preferred orientation residual stress microstructure