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Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism

Asian Journal of Andrology 2022年第5期24卷 540-548页

作者： Yu-Lin Deng Ren Liu zhou-da cai Zhao-Dong Han Yuan-Fa Feng Shang-Hua cai Qing-Biao Chen Jian-Guo Zhu Wei-De Zhong Guangdong Provincial Institute of Nephrology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Andrology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China Department of Urology Guangdong Key Laboratory of Clinical Molecular Medicine and DiagnosticsGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China Urology Key Laboratory of Guangdong Province The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510230China Department of Urology Guizhou Provincial People’s HospitalThe Affiliated Hospital of Guizhou Medical UniversityGuiyang 550002China Department of Urology Surgery Affiliated Foshan Hospital of Southern Medical UniversityFoshan 528000China

The limited treatment options for advanced prostate cancer(PCa)lead to the urgent need to discover new anticancer ***,an isomer of glucose,has been reported to have an anticancer effect on various ***,the anticancer effect of mannose in PCa remains *** this study,we demonstrated that mannose inhibits the proliferation and promotes the apoptosis of PCa cells in vitro,and mannose was observed to have an anticancer effect in mice without harming their *** of intracellular mannose simultaneously decreased the mitochondrial membrane potential,increased mitochondrial and cellular reactive oxygen species(ROS)levels,and reduced adenosine triphosphate(ATP)production in PCa *** treatment of PCa cells induced changes in mitochondrial morphology,caused dysregulated expression of the fission protein,such as fission,mitochondrial 1(FIS1),and enhanced the expression of proapoptotic factors,such as BCL2-associated X(Bax)and BCL2-antagonist/killer 1(Bak).Furthermore,lower expression of mannose phosphate isomerase(MPI),the key enzyme in mannose metabolism,indicated poorer prognosis in PCa patients,and downregulation of MPI expression in PCa cells enhanced the anticancer effect of *** study reveals the anticancer effect of mannose in PCa and its clinical significance in PCa patients.

关键词： mannose mannose phosphate isomerase metabolism mitochondria prostate cancer

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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui cai Bo Sun Huijun Wang Yi Zheng Siyu zhou Huixin Li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： daiyu Hu Yuanqing Cao Chenglin cai Guangming Wang Min zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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有机金属卤化物钙钛矿CH_(3)NH_(3)PbBr_(3)的各向异性Rashba效应

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原子与分子物理学报 2025年第6期42卷 153-158页

作者：蔡锦鸿余达明周贤中广东工业大学集成电路学院广州510006

本研究通过密度泛函理论结合全相对论赝势对钙钛矿CH_(3)NH_(3)PbBr_(3)中的各向异性Rashba效应进行了深入研究.发现,Pb-Br八面体的畸变引起了导带最小间隙的三重态在自旋轨道耦合(SOC)效应和晶格形变下的分裂,导致在不同方向上呈现出... 详细信息

本研究通过密度泛函理论结合全相对论赝势对钙钛矿CH_(3)NH_(3)PbBr_(3)中的各向异性Rashba效应进行了深入研究.发现,Pb-Br八面体的畸变引起了导带最小间隙的三重态在自旋轨道耦合(SOC)效应和晶格形变下的分裂,导致在不同方向上呈现出强烈的各向异性.Rashba带分裂的最大系数可达2.0 eV?,并通过分析能级和电荷密度分布解释了Rashba效应的形成机制.这些研究结果有助于深化对CH_(3)NH_(3)PbBr_(3)性质的理解,同时为其在自旋电子学领域的潜在应用提供了理论基础.

关键词：钙钛矿 CH_3NH_3PbBr_3 密度泛函理论自旋轨道耦合

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Targeted therapies for patients with advanced NSCLC harboring wild-type EGFR:what's new and what's enough

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Chinese Journal of Cancer 2015年第7期34卷 310-319页

作者： Fei zhou cai-Cun zhou Department of Medical Oncology Shanghai Pulmonary HospitalTongji University School of Medicine

Historically,non-small cell lung cancer(NSCLC) is divided into squamous and nonsquamous subtypes based on histologic *** a growing number of oncogenic drivers being identified in squamous and nonsquamous NSCLC,this malignancy has been recently divided into several distinct subtypes according to the specific molecular *** new paradigm has substantially highlighted the treatment of advanced NSCLC,shifting it from standard chemotherapy according to specific histologic subtypes to targeted therapy according to specific oncogenic *** application of epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKIs) in NSCLC patients harboring activating EGFR mutations has been a representative model of precise medicine in the treatment of *** the role of EGFR-TKIs in routine management of patients with advanced NSCLC has been well established,this review provides an overview of alternative targeted therapy in the treatment of NSCLC,including EGFR-TKIs for patients with wild-type EGFR NSCLC,as well as other targeted agents either clinical available or in early- to late-stage development.

关键词：非小细胞肺癌靶向治疗患者晚期表皮生长因子受体酪氨酸激酶抑制剂组织学特征 EGFR

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Zero extension for Poisson's equation

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Science China Mathematics 2020年第4期63卷 721-732页

作者： Yongyong cai Shulin zhou Beijing Computational Science Research Center Beijing 100193China LMAM and School of Mathematical Sciences Peking UniversityBeijing 100871China

In this paper,we present a necessary and sufficient condition to guarantee that the extended function of the solution for Poisson's equation in a smaller domain by zero extension is still the solution of the corresponding extension problem in a larger *** prove the results under the frameworks of classical solutions,strong solutions and weak ***,we give some observations for the nonlinear pLaplace equation.

关键词： Poisson's equation zero extension a necessary and sufficient condition

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Ullmann-Ma Reaction:Development,Scope and Applications in Organic Synthesis

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Chinese Journal of Chemistry 2020年第8期38卷 879-893页

作者： Qian cai Wei zhou College of Pharmacy Jinan UniversityNo.601 Huangpu Avenue WestGuangzhouGuangdong 510632China

Copper-catalyzed cross-couplings of aryl halides and nucleophiles,traditionally called Ullmann-type coupling reactions,were initially reported by Ullmann et *** 1901-1929.A seminal report in 1998 by Ma et *** Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences revealed an accelerating effect caused by amino acids,which brought Ullmann-type coupling reactions into a ligand-accelerating *** 1999 to the first 10 years of 2000s,the first-generation ligands were developed by many researchers and promoted Ullmann-type coupling reactions of aryl iodides and bromides under relatively mild *** acid ligands,developed by Ma and coworkers,are one class of the most important first-generation *** the second 10 years of 2000s,Ma et *** the discovery of second-generation ligands for copper-catalyzed cross-coupling *** great breakthroughs have been realized by using second-generation oxalic diamide and related amide ligands,with aryl chlorides as general coupling partner and with low catalyst *** copper-catalyzed cross coupling reactions of aryl halides and nucleophiles with amino acids or oxalic diamides and related amides as ligands are recognized as Ullmann-Ma reactions and have found extensive applications in organic synthesis.

关键词： synthesis coupling Ullmann

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Development and simulation of a gridded thermionic cathode electron gun for a high-energy photon source

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Nuclear Science and Techniques 2023年第3期34卷 73-81页

作者： Sheng-Chang Wang da-Yong He cai Meng Jing-Yi Li Zu-Sheng zhou Jin-Dong Liu Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

A gridded thermionic cathode electron gun was developed for the linear accelerator of the High Energy Photon Source(HEPS).An electron gun should provide a large maximum bunch charge with a wide adjustable *** satisfy these requirements,the shape of the electrode was optimized using a multi-objective genetic algorithm.A large bunch charge with an adjustable range was achieved using the grid-limited gun,the flow of which was analyzed using 3-D *** electron gun has been manufactured and tested,and the measured data of the grid-limited current and simulation results are compared and discussed in this study.

关键词： Electron gun Multi-objective genetic algorithm Grid CST

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Systematic diesel molecular performance evaluation based on quantitative structure-property relationship model

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Petroleum Science 2022年第2期19卷 809-818页

作者： Guang-Qing cai Lin-zhou Zhang State Key Laboratory of Heavy Oil Processing Petroleum Molecular Engineering Center(PMEC)China University of PetroleumBeijing 102249China

The production and separation of optimal molecules in diesel fuels require a systematic property evaluation for the containing *** paper evaluates the diesel molecules based on four key quality indicators:low-temperature fluidity,cleanliness,ignition,and power *** established the corresponding quantitative structure-property relationship models for corresponding properties,which are freezing point,yield sooting index,cetane number,and combustion *** models were applied for the screening of the high-performance molecules that is suitable for *** molecular performance distribution of the conventional diesel and biodiesel were also ***,we analyzed the effect of different transformation paths on molecular properties,giving guidance on the conversion process design.

关键词： Diesel Optimal molecules QSPR Molecular screening

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头孢克洛致视物模糊1例

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医药导报 2025年第1期44卷 138-139页

作者：蔡志琴周福永王枳人浙江省台州医院儿科临海317000

患儿,男,7岁,因支气管炎给予头孢克洛颗粒0.2 g,tid,口服3 h后出现视物模糊,及时停用,对症治疗后未发生严重不良后果,预后良好。该例不良反应临床罕见,建议在使用头孢克洛颗粒等抗菌药物时关注患者是否有视力改变、色弱等相关不适,并及... 详细信息

患儿,男,7岁,因支气管炎给予头孢克洛颗粒0.2 g,tid,口服3 h后出现视物模糊,及时停用,对症治疗后未发生严重不良后果,预后良好。该例不良反应临床罕见,建议在使用头孢克洛颗粒等抗菌药物时关注患者是否有视力改变、色弱等相关不适,并及时向临床反馈不适症状。

关键词：头孢克洛视物模糊药品不良反应

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