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Urinary.exosomal microRNA-145-5p and microRNA-27a-3p act.as noninvasive diagnost.c biomarkers for diabet.c kidney.disease

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World Journal of Diabet.s 2024年第1期15卷 92-104页

作者： Lu-Lu Han Sheng-Hai Wang Ming-y.n y.o Hong zhou Depart.ent.of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Depart.ent.of Endocrinology Baoding No.1 Central HospitalBaoding 071000Hebei ProvinceChina Depart.ent.of Crit.cal Care Medicine The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BACKGROUND Diabet.c kidney.disease(DKD),charact.rized by.increased urinary.microalbumin levels and decreased renal funct.on,is t.e primary.cause of end-st.ge renal *** pat.ological mechanisms are complicat.d and mult.fact.rial;t.erefore,sensit.ve and specific biomarkers are *** exosome originat. from diverse renal cells in nephron segment. and part.ally.mirror t.e pat.ological changes in t.e *** microRNAs(miRNAs)in urinary.exosome are remark-ably.st.ble and highly.t.ssue-specific for t.e *** t.0}e 2 diabet.c mellit.s(t.DM)pat.ent. were recruit.d from t.e Second Hospit.l of Hebei Medical Universit.0}and were divided int. t.o groups:DM,diabet.c pa-t.ent. wit.out.albuminuria[urinary.albumin t. creat.nine rat.o(UACR)t.c pat.ent. wit. albuminuria(UACR≥30 mg/g).Healt.y.subject. were t.e normal cont.ol(NC)*** exosomal miR-145-5p,miR-27a-3p,and miR-29c-3p,were det.ct.d using real-t.me quant.t.t.ve poly.erase chain *** correlat.on bet.een exosomal miRNAs and t.e clinical in-dexes was *** diagnost.c values of exosomal miR-145-5p and miR-27a-3p in DKD were det.rmined using receiver operat.ng charact.rist.c(ROC)*** funct.ons of miR-145-5p were invest.gat.d by.performing RESULt. Urinary.exosomal expression of miR-145-5p and miR-27a-3p was more upregulat.d in t.e DKD group t.an in t.e DM group(miR-145-5p:4.54±1.45 vs 1.95±0.93,Pt.e NC group(miR-145-5p:4.54±1.45 vs 1.55±0.83,Pt.e exosomal miR-145-5p and miR-27a-3p posit.vely.correlat.d wit. albuminuria and serum creat.nine and negat.vely.correlat.d wit. t.e est.mat.d glomerular filt.at.on ***-27a-3p was also closely.relat.d t. blood glucose,gly.cosy.at.d hemoglobin A1c,and low-densit.0}lipoprot.in *** analy.is revealed t.at.miR-145-5p had a bet.er area under t.e curve of 0.88[95%confidence int.rval(CI):0.784-0.985

关键词： Urinary.exosome MicroRNA-145-5p MicroRNA-27a-3p Diabet.c kidney.disease Diagnost.c biomarkers

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St.dy.on t.e ant.-inflammat.ry.mechanism of moxibust.on in rheumat.id art.rit.s in rat. based on phospholipaseA2 signaling inhibit.on by.Annexin 1

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Journal of t.adit.onal Chinese Medicine 2024年第4期44卷 753-761页

作者： GUO y.nding LUO Kun ZHANG Linlin LU Went.ng SHANG y.nan ZHONG y.mei HU Danhui y.NG Xin zhou Haiy.n Depart.ent.of Acupunct.re-Moxibust.on and t.ina the Third Affiliated HospitalChengdu University of Traditional Chinese MedicineChengdu 610075China Ext.rnal t.eat.ent.Cent.r First People's Hospital of ChengduChengdu 610095China Depart.ent.of Chengdu Int.grat.d t.adit.onal Chinese Medicine and West.rn Medicine Hospit.l Chengdu 610075China Depart.ent.of Healt. Rehabilit.t.on School Chengdu University of Traditional Chinese MedicineChengdu 610075China

OBJECt.VE:t. det.rmine whet.er moxibust.on had an ant.-inflammat.ry.effect.on rheumat.id art.rit.s(RA)by.regulat.ng Annexin 1 expression and int.rfering wit. t.e phospholipaseA2 signaling ***:t.irt.0}male Sprague-Dawley.rat. were randomly.cat.gorized int. five groups(six rat. per group):blank cont.ol(CON)group,RA model(RA)group,moxibust.on(MOX)group,Annexin 1 lent.viral int.rvent.on(RNAi-Anxa1)group,and Annexin 1 lent.viral int.rvent.on+moxibust.on(RNAi-Anxa1+MOX)*** rat. in t.e RNAi-Anxa1 and t.e RNAi-Anxa1+MOX groups were inject.d wit. t.e lent.viral vect.r-mediat.d RNAi-Anxa1 int. t.e rat.foot.*** experiment.l RA rat.model was est.blished by.inject.ng Freund's complet. adjuvant.FCA)int. t.e RA,MOX,RNAi-Anxa1,and RNAi-Anxa1+MOX *** in t.e MOX and RNAiAnxa1+MOX groups received moxibust.on *** modeling,using moxibust.on“Shenshu(BL23)”and“Zusanli(St.6)”,each point.is 5 t.mes,bilat.ral alt.rnat.ng,once a day.6 t.mes for a course of t.eat.ent.bet.een t.e courses of rest.for a one day.A t.t.l of t.ree t.eat.ent.courses were *** bilat.ral pad t.icknesses were measured using Vernier calipers on experiment.l day. 1,7,14,21,and *** expression of cPLA2αsignaling in t.e sy.ovium of diseased joint. was observed using West.rn *** pat.ology.of t.e rat.ankle sy.ovium was observed using hemat.xy.ineosin(HE)***(IL)-1β,IL-10,prost.glandin E2(PGE2),and leukot.iene B4(Lt.4)were det.ct.d using enzy.e-linked immunosorbent.***:Moxibust.on increased t.e levels of Annexin 1 and decreased t.e inflammat.ry.response in rat. wit. *** increasing t.e expression of Annexin 1,t.e phosphory.at.d expression of cPLA2αwas inhibit.d,t.e serum levels of IL-1β,PGE2,and Lt.4 decreased,and t.e level of IL-10 *** moxibust.on t.eat.d RA rat. aft.r t.e Annexin 1 lent.viral int.rvent.on,t.e serum levels of IL-1β,PGE2,Lt.4,and IL-10 were almost.***:Moxibust.on enhanced t.e negat.ve regulat.on of

关键词： annexins group IV phospholipases A2 signal t.ansduct.on moxibust.on art.rit.s,rheumat.id

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Doping-driven dual het.rogeneous int.rfacial st.uct.res boost.ng t.e durabilit.0}of indust.y.compat.ble wat.r split.ing at.high current.densit.

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Science China Chemist.y 2024年第10期67卷 3468-3481页

作者： Chunming y.ng Lihai zhou Zhijie Kong Xiang Li Wangchuan Zhu Guangqing Wang y.nzhong Zhen Feng Fu y.cang Liang Research Inst.t.t. of Comprehensive Energy.Indust.y.t.chnology College of Chemistry&Chemical EngineeringYan’an UniversityYan’an 716000China Henan Key.Laborat.ry.of Cry.t.lline Molecular Funct.onal Mat.rials Green Catalysis CenterCollege of ChemistryZhengzhou UniversityZhengzhou 450001China Inst.t.t.für Anorganische Chemie Eberhard Karls UniversitätTübingen 72076Germany

Developing highly.st.ble elect.ocat.ly.t. under indust.y.compat.ble current.densit.es(>500 mA cm^(-2))in an anion-exchange membrane wat.r elect.oly.er(AEMWE)is an enormous challenge for wat.r ***,based on t.e result. of densit.0}funct.on t.eory.calculat.ons,a dual het.rogeneous int.rfacial st.uct.red NiSe/Fe-Ni(OH)_(2)cat.ly.t.was subt.y.designed and successfully.prepared by.elect.odeposit.ng Fe-doped Ni(OH)_(2)on NiSe-loaded nickel foam(NF).Fe doping-driven het.rogeneous st.uct.res in NiSe/Fe-Ni(OH)_(2)markedly.boost.cat.ly.ic act.vit.0}and durabilit.0}at.indust.ially.compat.ble current.densit.es in single hy.rogen and oxy.en evolut.on react.ons under alkaline *** part.cular,NiSe/Fe-Ni(OH)_(2)shows a negligible performance loss at.600 mA cm^(-2)at.least.1,000 h for overall wat.r split.ing,a dist.nguished long-t.rm durabilit.0}act.ng as AEMWE elect.odes at.600 mA cm^(-2)and 1 A cm^(-2)at.85℃for at.least.95 *** t. Fe doping-induced st.ong sy.erget.c effect.bet.een Ni and Fe,dual het.rost.uct.re-promot.d charge t.ansfer and redist.ibut.on,abundant.cat.ly.ic act.ve sit.s,and improvement.of st.bilit.0}and durabilit.0}a mechanism of Fe doping-driven het.rogeneous int.rfacial st.uct.repromot.d cat.ly.ic performance was *** st.dy.provides a successful example of t.eory.direct.d cat.ly.t.preparat.on and pioneers a creat.ve st.at.gy.for indust.y.compat.ble wat.r split.ing at.high current.densit.0}

关键词： doping-induced het.rojunct.on st.uct.re NiSe/Fe-Ni(OH)_(2) large current.densit. anion-exchange membrane indust.y.ompat.ble wat.r elect.oly.is

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Inhibit.on of Het.rogeneous Nucleat.on in Wat.r by.Hy.rogel Coat.ng

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Research 2024年第2期2023卷 139-147页

作者： Siy.ng Li Panpan Zhu y.ot.ng Xue Lei Wangg t.ck-Why. Wong Xuxu y.ng Haoei zhou t.efeng Li We y.ng Depart.ent.of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Key.Laborat.ry.of Soft.Machines and Smart.Devices of Zhejiang Province Zhejiang UniversityHangzhou 310027China Cent.r for X-Mechanics Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China School of Biomedical Engineering and Healt. Sciences and Advanced Membrane t.chnology.Research Cent.e Universiti Teknologi MalaysiaSkudai 81310Malaysia

Het.rogeneous nucleat.on play. a crit.cal role in t.e phase t.ansit.on of wat.r,which can cause damage in various ***,we report.t.at.het.rogeneous nucleat.on can be inhibit.d by.ut.lizing hy.rogel coat.ngs t. isolat. solid surfaces and ***,which cont.in over 90%wat.r when fully.swelled,exhibit.a high degree of similarit.0}t. *** t. t.is similarit.0}t.ere is a great.energy.barrier for het.rogeneous nucleat.on along t.e wat.r-hy.rogel ***,hy.rogel coat.ngs,which possess poly.er net.orks,exhibit.higher fract.re energy.and more robust.adhesion t. solid surfaces compared t. *** high fract.re and adhesion energy.act. as a det.rrent.for fract.re nucleat.on wit.in t.e hy.rogel or along t.e hy.rogel-solid *** a hy.rogel lay.r approximat.ly.100μm t.ick,t.e boiling t.mperat.re of wat.r under at.ospheric pressure can be raised from 100 t. 108℃.Not.bly.hy.rogel coat.ngs also result.in remarkable reduct.ons in cavit.t.on pressure on mult.ple solid *** have demonst.at.d t.e efficacy.of hy.rogel coat.ngs in prevent.ng damages result.ng from accelerat.on-induced *** coat.ngs have t.e pot.nt.al t. alt.r t.e energy.landscape of het.rogeneous nucleat.on on t.e wat.r-solid int.rface,making t.em an excit.ng avenue for innovat.on in heat.t.ansfer and fluidic sy.t.ms.

关键词： fract.re cavit.t.on similarit.

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Fast.response,high-sensit.vit.0}mult.-modal t.ct.le sensors based on PPy.t._(3)C_(2)t.(x) films for mult.funct.onal applicat.ons

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Nano Research 2024年第5期17卷 4410-4419页

作者： Guangshuai Xi Dongzhi Zhang Mingcong t.ng Hao Zhang y.ehang Sun y.biao Zhang Haolin Cai Hui Xia Dandi zhou College of Cont.ol Science and Engineering China University of Petroleum(East China)Qingdao 266580China

In recent.y.ars,mult.-modal flexible t.ct.le sensors have become an import.nt.direct.on in t.e development.of elect.onic skin because of t.eir excellent.sensit.vit.0}flexibilit.0}and wearable *** t.is work,a humidit.0}pressure mult.-modal flexible sensor based on poly.y.role(PPy./t._(3)C_(2)t.(x) sensit.ve film packaged wit. porous poly.imet.y.siloxane(PDMS)is invest.gat.d by.combining t.e sensit.ve st.uct.re generat.on mechanism of in sit. poly.erizat.on t. achieve t.e simult.neous det.ct.on of humidit.0}and pressure,which has a sensit.vit.0}of 89,113.4Ω/%RH in a large humidit.0}range of 0%-97%RH,and response/recovery.t.me of 2.5/1.9 *** t.ct.le pressure sensing has a high sensit.vit.0}a fast.response of 67/52 ms,and a wide det.ct.on *** device also has excellent.performance in t.rms of st.bilit.0}and repeat.bilit.0}making it.promising for respirat.ry.pat.ern and mot.on *** work provides a new solut.on t. address t.e const.uct.on of mult.-modal t.ct.le sensors wit. pot.nt.al applicat.ons in t.e fields of medical healt.,epidemic prevent.on.

关键词： mult.-modal sensors humidit.0}pressure t.ct.le sensors resist.ve sensors t.3C2t. human respirat.ry.and mot.on det.ct.on

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Phot.-promot.d rapid reconst.uct.on induced alt.rat.ons in act.ve sit. of Ag@amorphous NiFe hy.roxides for enhanced oxy.en evolut.on react.on

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Carbon Energy 2024年第9期6卷 210-220页

作者： Zhi Cai Mingy.an Xu y.nhong Li Xiny.n zhou Kexin y.n Lidong Li Binbin Jia Lin Guo Hewei Zhao School of Chemist.y Beijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijingChina School of Phy.ics Beihang UniversityBeijingChina Key.Laborat.ry.of Inorganic Nonmet.llic Cry.t.lline and Energy.Conversion Mat.rials College of Materials and Chemical EngineeringChina Three Gorges UniversityYichangHubeiChina

t.e dy.amic surface self-reconst.uct.on behavior in local st.uct.re correlat.s wit. oxy.en evolut.on react.on(OER)performance,which has become an effect.ve st.at.gy.for const.uct.ng t.e cat.ly.ic act.ve ***,it.remains a challenge t. underst.nd t.e mechanisms of reconst.uct.on and t. accomplish it.fast.and ***,we report.d a phot.-promot.d rapid reconst.uct.on(PRR)process on Ag nanopart.cle-loaded amorphous Ni-Fe hy.roxide nanosheet. on carbon clot. for enhanced *** phot.generat.d holes generat.d by.Ag in conjunct.on wit. t.e anodic pot.nt.al cont.ibut.d t. a t.orough reconst.uct.on of t.e amorphous *** valence st.t. of unsat.rat.d coordinat.d Fe at.ms,which serve as act.ve sit.s,is significant.y.increased,while t.e corresponding cry.t.lline subst.at. shows lit.le *** different.st.uct.ral evolut.ons of amorphous and cry.t.lline subst.at.s during reconst.uct.on lead t. diverse pat.way. of *** PRR ut.lizing loaded noble met.l nanopart.cles can accelerat. t.e generat.on of act.ve species in t.e subst.at. and increase t.e elect.ical conduct.vit.0}which provides a new inspirat.on t. develop efficient.cat.ly.t. via reconst.uct.on st.at.gies.

关键词： Ag amorphous Ni-Fe hy.roxide OER phot.-promot.d rapid reconst.uct.on

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Confinement.of Fe at.ms bet.een MoS_(2) int.rlay.rs drives phase t.ansit.on for improved react.vit.0}in Fent.n-like react.ons

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Nano Research 2024年第3期17卷 1132-1139页

作者： y.bing Sun y. zhou Hongchao Li Chuan Wang Xuan Zhang Qian Ma y.ngchun Cheng Jieshu Qian Bingcai Pan Jiangsu Key.Laborat.ry.of Chemical Pollut.on Cont.ol and Resources Reuse School of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China Key.Laborat.ry.of Flexible Elect.onics and Inst.t.t. of Advanced Mat.rials Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China Depart.ent.of General Dent.st.y Affiliated Stomatological Hospital of Nanjing Medical UniversityJiangsu Province Key Laboratory of Oral DiseasesNanjing 210029China Research Cent.r for Environment.l Nanot.chnology.ReCENt. State Key Laboratory of Pollution Control and Resources ReuseSchool of EnvironmentNanjing UniversityNanjing 210023China

Phase manipulat.on of MoS_(2) from t.ermody.amically.st.ble 2H phase t. t.e unst.ble but.more react.ve 1t.phase represent. a crucial st.at.gy.for improving t.e react.vit.0}in many.*** widely.adopt.d wet.chemist.y.approach uses int.rcalat.ng ent.t.es especially.alkali met.l ions t. achieve t.e phase t.ansit.on;however,t.ese ent.t.es are normally.inert.for t.e t.rget.***,we describe t.e first.use of iron at.ms for t.e int.rcalat.on of 2H-MoS_(2) lay.rs,driving t.e part.al t.ansit.on from 2H t. 1t.***,in t.e peroxy.onosulfat.(PMS)-based Fent.n-like react.ons,t.e int.rlay.red confinement.of Fe at.ms not.only.act.vat.s t.e inert.basal plane,but.also adds more react.ve Fe sit.s for t.e format.on of met.l-PMS complex as primary.react.ve species for pollut.nt.*** t.e degradat.on of a model pollut.nt.carbamazepine(CBZ),t.e Fe-int.rcalat.d MoS_(2) exhibit. a first.order rat. const.nt.13.3 t.mes higher t.an 2H-MoS_(2).t.is st.at.gy.is a new direct.on for manipulat.ng t.e phase composit.on and boost.ng t.e cat.ly.ic react.vit.0}of MoS_(2)-based cat.ly.t. in various scenarios,including environment.l remediat.on and energy.applicat.ons.

关键词： confinement MoS_(2) Fe at.ms Fent.n-like react.ons hy.rogen evolut.on react.on

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Periodont.t.s exacerbat.s pulmonary.hy.ert.nsion by.promot.ng IFNγ^(+)t.cell infilt.at.on in mice

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Int.rnat.onal Journal of Oral Science 2024年第2期16卷 359-369页

作者： Xiaoqian Meng Linjuan Du Shuo Xu Lujun zhou Boy.n Chen y.lin Li Chumao Chen Huilin y. Jun Zhang Guocai t.an Xuebing Bai t.ng Dong Wenzhen Lin Mengjun Sun Kecong zhou y.n Liu Wuchang Zhang Shengzhong Duan Depart.ent.of Endodont.cs Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Laborat.ry.of Oral Microbiot. and Sy.t.mic Diseases Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Hongqiao Int.rnat.onal Inst.t.t. of Medicine Shanghai Tongren Hospital/Faculty of Basic MedicineKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghaiChina Depart.ent.of Ort.odont.cs Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Depart.ent.of Periodont.logy Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina St.mat.logy.Hospit.l School of StomatologyZhejiang University School of MedicineHangzhouChina

Uncovering t.e risk fact.rs of pulmonary.hy.ert.nsion and it. mechanisms is crucial for t.e prevent.on and t.eat.ent.of t.e *** t.e current.st.dy.we showed t.at.experiment.l periodont.t.s,which was est.blished by.ligat.on of molars followed by.orally.smearing subgingival plaques from pat.ent. wit. periodont.t.s,exacerbat.d hy.oxia-induced pulmonary.hy.ert.nsion in ***,periodont.t.s dy.regulat.d t.e pulmonary.microbiot. by.promot.ng ect.pic colonizat.on and enrichment.of oral bact.ria in t.e lungs,cont.ibut.ng t. pulmonary.infilt.at.on of int.rferon gamma posit.ve(IFNγ^(+))t.cells and aggravat.ng t.e progression of pulmonary.*** addit.on,we ident.fied Prevot.lla zoogleoformans as t.e crit.cal periodont.t.s-associat.d bact.rium driving t.e exacerbat.on of pulmonary.hy.ert.nsion by.periodont.t.s,and t.e exacerbat.on was pot.nt.y.ameliorat.d by.bot. cervical ly.ph node excision and IFNγneut.alizing *** st.dy.suggest. a proof of concept.t.at.t.e combined prevent.on and t.eat.ent.of periodont.t.s and pulmonary.hy.ert.nsion are necessary.

关键词： hy.ert.nsion prevent.on int.rferon

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CCL9/CCR1 axis-driven chemot.ct.c nanovesicles for at.enuat.ng met.st.sis of SMAD4-deficient.colorect.l cancer by.t.apping t.F-β

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Act. Pharmaceut.ca Sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu t.any. t.an Lu Wang y.nmei t.an t.an t.an y.any.an Guo Hu zhou Zhiping Zhang t.ngji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Depart.ent.of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Depart.ent.of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmaceut.cal Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China Nat.onal Engineering Research Cent.r for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Cent.e for Novel Drug Delivery.Sy.t.m Huazhong University of Science and TechnologyWuhan 430030China

SMAD4 deficiency.in colorect.l cancer(CRC)is highly.correlat.d wit. liver met.st.sis and high mort.lit.0}y.t.t.ere are few effect.ve precision t.erapies ***,we show t.at.CCR1^(+)-granulocy.ic my.loid-derived suppressor cells(G-MDSCs)are highly.infilt.at.d in SMAD4-deficient.CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive t.F-β,secret.d by.t.mor-infilt.at.d CCR1^(+)-G-MDSCs,suppresses t.e immune response of cy.ot.xic t.ly.phocy.es(Ct.s),t.us facilit.t.ng ***,we develop engineered nanovesicles display.ng CCR1 and t.FBR2 molecules(C/t.NVs)t. chemot.ct.cally.t.rget.t.e t.mor driven by.CCL9/CCR1 axis and t.ap t.F-βt.rough t.F-β-t.FBR2 specific *** C/t.NVs count.ract.CCR1^(+)-G-MDSC infilt.at.on t.rough compet.t.ve responding CCL9/CCR1 axis.C/t.NVs-induced int.at.moral t.F-βexhaust.on alleviat.s t.e t.F-β-suppressed immune response of ***,C/t.NVs at.enuat. liver met.st.sis of SMAD4-deficient.*** furt.er explorat.on,high expression of programmed cell deat. ligand-1(PD-L1)is observed in clinical specimens of SMAD4-deficient.*** C/t.NVs wit. ant.-PD-L1 ant.body.aPD-L1)induces t.rt.ary.ly.phoid st.uct.re format.on wit. sust.ined act.vat.on of Ct.s,CXCL13^(+)-CD4^(+)t.CXCR5^(+)-CD20^(+)B cells,and enhanced secret.on of cy.ot.xic cy.okine int.rleukin-21 and IFN-γaround t.mors,t.us eradicat.ng met.st.t.c *** st.at.gy.elicit. pleiot.opic ant.met.st.t.c immunit.0}paving t.e way.for nanovesicle-mediat.d precision immunot.erapy.in SMAD4-deficient.CRC.

关键词： SMAD4-deficient.CRC Met.st.sis G-MDSCs t.F-β CCR1 t.FBR2

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St.uct.ral insight. int. At.BCG25,an angiosperm-specific abscisic acid export.r

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Plant.Communicat.ons 2024年第1期5卷 284-295页

作者： Jian Xin y.ling zhou y.chun Qiu He Geng y.zhu Wang y. Song Jiansheng Liang Kaige y.n Depart.ent.of Chemical Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Inst.t.t. of Plant.and Food Science Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Max Planck Inst.t.t. of Molecular Plant.Phy.iology Potsdam-GolmGermany Inst.t.t. for Biological Elect.on Microscopy Southern University of Science and TechnologyShenzhenGuangdongChina

Cellular hormone homeost.sis is essent.al for precise spat.al and t.mporal signaling responses and *** acid(ABA)play. pivot.l roles in orchest.at.ng various development.l and st.ess re-sponses and confersfit.ess benefit. over ecological and evolut.onary.t.mescales in t.rrest.ial *** ABA level is regulat.d by.complex processes,including biosy.t.esis,cat.bolism,and ***25 is t.efirst.ABA export.r ident.fied t.rough genet.c screening and affect. diverse ABA *** t.e st.uct.ral basis of ABA export.by.ABCG25 is crit.cal for furt.er manipulat.ons of ABA homeost.sis and *** used cry.-elect.on microscopy.t. elucidat. t.e st.uct.ral dy.amics of At.BCG25 and successfully.charact.rized different.st.t.s,including apo At.BCG25,ABA-bound At.BCG25,and At.-bound At.BCG25(E232Q).Not.bly.At.BCG25 forms a homodimer t.at.fea-t.res a deep,slit.like cavit.0}in t.e t.ansmembrane domain,and we precisely.charact.rized t.e crit.cal residues in t.e cavit.0}where ABA *** binding t.iggers closure of t.e nucleot.de-binding domains and conformat.onal t.ansit.ons in t.e t.ansmembrane *** show t.at.At.BCG25 belongs t. a conserved ABCG subfamily.t.at.originat.d during t.e evolut.on of *** subfamily.neofunct.onalized t. regulat. seed germinat.on via t.e endosperm,in concert.wit. t.e evolut.on of t.is angio-sperm-specific,embry.-nourishing ***,t.esefindings provide valuable insight. int. t.e int.icat. subst.at. recognit.on and t.ansport.mechanisms of t.e ABA export.r At.BCG25,paving t.e way.for genet.c manipulat.on of ABA homeost.sis and plant.it.ess.

关键词： At.BCG25 abscisic acid ABC t.ansport.rs cry.-EM st.uct.re

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