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Genome-Wide Identification and Expression Analysis of the Phytocyanin Gene Family in Nicotiana tabacum

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Phyton-International Journal of Experimental Botany 2023年第5期92卷 1469-1492页

作者： Peiling Wang Xiaohong Xu Yong Li Hecui Zhang Xuejie Zhang siru zhou Yimei Liu Yunyan Feng Tonghong Zuo Liquan Zhu School of Agronomy and Biotechnology Engineering Research Center of South Upland AgricultureMinistry of EducationSouthwest UniversityChongqing400715China Tobacco Science Research Institute of Chongqing Tobacco Company Chongqing400715China Chongqing Qianjiang Tobacco Branch Company Chongqing Institute of Tobacco Science Chongqing400715China

Phytocyanin(PC)is a class of plant-specific blue copper proteins involved in electron transport,plant growth,development,and stress ***,PC proteins have not been systematically evaluated in tobacco *** determined the whole-genome sequences of the PC family in the tobacco cultivar‘K326.’The transcriptome data were used to analyze the expression of the NtPC family at different development stages and tissue-specific ***-time fluorescence quantitative analysis was used to analyze the expression of the NtPC gene family under low temperature and methyl jasmonate *** tobacco NtPC family contained 110 members and was divided into four subfamilies:early nodulin-like protein(NtENODL),uclacyanin-like protein,stellacyanin1-like protein,and plantacyanin-like *** to phylogenetic and structural analyses,the NtPC family could be divided into eight structural ***-three NtPCs were randomly distributed on 22 of 24 tobacco *** analysis revealed 33 pairs of genes belonging to the NtPC *** ontology analysis showed that the PC genes are components of the plasma membrane and may participate in plasma membrane-related *** NtPC family contained numerous elements related to hormonal and abiotic stress responses and was specifically expressed in the tobacco prosperous,maturation,and budding ***-specific expression analysis showed that some genes were tissue *** expression of NtENODL58 and other genes was significantly induced by low-temperature and methyl jasmonate ***,the NtPC gene family plays an important role in plant stress response.

关键词： Tobacco phytocyanin gene family bioinformatics gene expression

基于CiteSpace和VOSviewer软件的处方前置审核研究热点及发展趋势分析

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广西医学 2024年第3期46卷 416-421页

作者：卢晓张宏亮黄晓青周思茹王丹丹黄全元广西医科大学第一附属医院药学部广西南宁市530021

目的基于CiteSpace和VOSviewer软件分析处方前置审核领域的研究热点和发展趋势。方法检索中国知网、中国生物医学文献服务系统、万方数据知识服务平台、维普资讯中文期刊服务平台中2012年1月至2023年8月处方前置审核的相关文献,采用Micr... 详细信息

目的基于CiteSpace和VOSviewer软件分析处方前置审核领域的研究热点和发展趋势。方法检索中国知网、中国生物医学文献服务系统、万方数据知识服务平台、维普资讯中文期刊服务平台中2012年1月至2023年8月处方前置审核的相关文献,采用Microsoft Office Excel软件绘制相关文献发文量年份分布图,应用CiteSpace和VOSviewer软件构建机构、作者、期刊和关键词的共现及突现分析可视化图谱。结果共检索到688篇处方前置审核的相关文献。2012—2023年,处方前置审核领域的发文量呈上升趋势,发文量最多的机构和期刊分别是首都医科大学宣武医院和《海峡药学》,而发文量最多的作者是崔晓辉和邬蓉。高频关键词包括合理用药、处方点评等,突现强度最高的关键词为实时审核,推测该领域的研究热点与前沿是审核规则。结论研究处方前置审核的规则是处方前置审核领域的研究热点,探究构建精细化的专科用药审核规则是该领域的发展趋势。

关键词：处方前置审核 VOSviewer软件 CiteSpace软件合理用药审核规则

Degradation strategies of pesticide residue:From chemicals tosynthetic biology

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Synthetic and Systems Biotechnology 2023年第2期8卷 302-313页

作者： Bi Ruomeng Ou Meihao zhou siru Geng Shichen Zheng Yixian Chen Junhong Mo Ruijie Li Yuan Xiao Gezhi Chen Xingyu Zhai Shiyi Zhang Aihui Fang Baishan XMU-China Team Innovative Practice Platform for Genetic Engineering Machine DesignXiamen UniversityXiamenFujian361005PR China College of Chemistry and Chemical Engineering Xiamen UniversityXiamenFujian361005PR China School of Public Health Xiamen UniversityXiamenFujian361005PR China College of Energy Xiamen UniversityXiamenFujian361005PR China School of Life Sciences Xiamen UniversityXiamenFujian361005PR China School of Pharmaceutical Science Xiamen UniversityXiamenFujian361005PR China Shenzhen Research Institute of Xiamen University Shenzhen518000PR China

The past 50 years have witnessed a massive expansion in the demand and application of ***,pesticides are difficult to be completely degraded without intervention hence the pesticide residue could pose a persistent threat to non-target organisms in many *** aim at the problem of the abuse of pesticide products and excessive pesticide residues in the environment,chemical and biological degradation methods are widely developed but are scaled and insufficient to solve such a *** recent years,bio-degradative tools instructed by synthetic biological principles have been further studied and have paved a way for pesticide *** the customized design strategy and standardized assembly mode,the engineering bacteria for multi-dimensional degradation has become an effective tool for pesticide residue *** review introduces the mechanisms and hazards of different pesticides,summarizes the methods applied in the degradation of pesticide residues,and discusses the advantages,applications,and prospects of synthetic biology in degrading pesticide residues.

关键词： Synthetic biology Degradation Remediation Biological engineering Pesticide residue

Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice

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Bone Research 2022年第1期10卷 65-80页

作者： Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang siru zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie Center of Bone Metabolism and Repair Department of Wound Repair and Rehabilitation MedicineState Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqingChina Senior Department of Orthopedics the Fourth Medical Center of PLA General HospitalBeijingChina Department of Orthopedic Surgery The Second Affiliated HospitalChongqing Medical UniversityChongqingChina Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Faculty of Health Sciences University of MacaoMacao SARChina

The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD.

关键词： Hif1α degeneration aberrant

Exosomes: roles and therapeutic potential in osteoarthritis

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Bone Research 2020年第2期8卷 139-156页

作者： Zhenhong Ni siru zhou Song Li Liang Kuang Hangang Chen Xiaoqing Luo Junjie Ouyang Mei He Xiaolan Du Lin Chen Department of Wound Repair and Rehabilitation Medicine Center of Bone Metabolism and RepairLaboratory for Prevention and Rehabilitation of Training InjuriesState Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqingChina State Key Laboratory of Trauma Burns and Combined InjuryMedical Cformation of H-type vessel in subchondral enter of Trauma and War InjuryDaping HospitalArmy Medical University of PLAChongqingChina Eleven Squadron Three Brigade School of Basic Medical ScienceArmy Medical UniversityChongqingChina

Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis(OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone *** review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future.

关键词： Exosomes therapeutic inhibiting

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论科学基金与大学的学科成长

科技管理研究 2006年第3期26卷 90-91,95页

作者：周巳入宣勇浙江工业大学经贸学院浙江杭州310014

以浙江省自然科学基金为例,从影响大学学科成长的不同因素出发,论述科学基金对大学学科成长的推动作用。

关键词：科学基金学科成长

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外军延时伤员救治现状与思考

创伤外科杂志 2022年第12期24卷 891-894页

作者：周思儒张宏雁沈岳陆军军医大学大坪医学战创伤医学中心重庆400042

延时伤员救治是近年外军根据循证研究和战伤救治实践,结合未来对抗需求提出的战伤救治最新理念。本文拟从野战外科的角度,围绕延时伤员救治的总体原则,就其产生背景及实践意义,核心内涵及基本理念,相关技术运用的基本要求等进行初步探讨... 详细信息

延时伤员救治是近年外军根据循证研究和战伤救治实践,结合未来对抗需求提出的战伤救治最新理念。本文拟从野战外科的角度,围绕延时伤员救治的总体原则,就其产生背景及实践意义,核心内涵及基本理念,相关技术运用的基本要求等进行初步探讨,助力我国提高战创伤救治能力。

关键词：战伤救治卫勤保障战术战伤救治延时现场救治延时伤员救治

Human thermal comfort under lateral radiant asymmetries

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Energy and Built Environment 2023年第4期4卷 432-444页

作者： siru Gao Liu Yang Mingyang Shi Shengkai Zhao Xiang zhou Yongchao Zhai State Key Laboratory of Green Building in Western China Xi’an University of Architecture and TechnologyXi’anShaanxi 710055China College of Architecture Xi’an University of Architecture and TechnologyXi’anShaanxi 710055China School of Mechanical Engineering Tongji UniversityShanghai 200092China

Occupants’thermal comfort in buildings may be affected by the cool wall and warm wall,which is attributed to the effect of asymmetric ***,the previous majority of the researches on asymmetric radiation were mainly about the comfort limits under thermally neutral condition within 1∼1.5 h but had not considered the effect of exposure duration and the condition beyond *** investigate the human thermal comfort under an asymmetric environment caused by the cool wall and warm wall,forty-four subjects were exposed to neutral air temperature with lateral radiant asymmetries in winter and summer for 3 *** results indicated that the cool wall caused thermal discomfort easier than the warm wall because the thermal sensation decreased and deviated from neutral with ***’sensitivity of local parts to asymmetric radiation was affected in the conditions beyond neutral,thus their acceptability to asymmetric radiation *** currently used limits of radiant temperature asymmetry tended to underestimate the local discomfort due to the *** the conditions tested,The limits of 5%dissatisfaction in radiant temperature asymmetry were 4.4°C(180 min)and 1.8°C(60 min and 120 min)for the warm wall,and 1.8°C at 60 min for the cool wall.

关键词： Asymmetric radiation Thermal condition Exposure duration Thermal comfort Comfort limits

Exogenous PTH1-34 can rescue the delayed fracture healing caused by gain-of-function mutation of FGFR3 in mice

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Exogenous PTH1-34 can rescue the delayed fracture healing ca...