Exosomes: roles and therapeutic potential in osteoarthritis

作     者：Zhenhong Ni Siru Zhou Song Li Liang Kuang Hangang Chen Xiaoqing Luo Junjie Ouyang Mei He Xiaolan Du Lin Chen Zhenhong Ni;Siru Zhou;Song Li;Liang Kuang;Hangang Chen;Xiaoqing Luo;Junjie Ouyang;Mei He;Xiaolan Du;Lin Chen

作者机构：Department of Wound Repair and Rehabilitation MedicineCenter of Bone Metabolism and RepairLaboratory for Prevention and Rehabilitation of Training InjuriesState Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqingChina State Key Laboratory of TraumaBurns and Combined InjuryMedical Cformation of H-type vessel in subchondral enter of Trauma and War InjuryDaping HospitalArmy Medical University of PLAChongqingChina Eleven Squadron Three BrigadeSchool of Basic Medical ScienceArmy Medical UniversityChongqingChina 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2020年第8卷第2期

页      面：139-156页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China (2018YFA0800802) the National Natural Science Foundation of China (No. 81530071 No. 31571382 No. 81871817) the Key Project of Innovation Program in Military Medicine (16CXZ016) the Sports Scientific Research Project of Chongqing (B201801) the Basic and Advanced Research Project in Chongqing (cstc2017jcyjAX0148) the Project of the State Key Laboratory of Trauma, Burns and Combined Injury (No. SKLZZ(Ⅲ)201601) 

主　　题：Exosomes therapeutic inhibiting 

摘      要：Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis(OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone *** review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future.