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Reversed－Phase　High－Performance　Liquid　　Chromatographic　Determination　of　Drugs　of　Abuse

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Chinese Chemical Letters 1996年第11期7卷 1027-1028页

作者： Ma, C Duan, HJ Xu, YQ zhou, th CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

A high-performance liquid chromatographic method using uv detection for thedetermination of 10 drugs of abuse is described. the method is sample and sensitive. the linear rangesare 20￣100ng/ml with relative standard ... 详细信息

关键词： Determination Drugs Abuse Chromatographic

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胰高血糖素样肽1的研究及应用进展

中国组织工程研究与临床康复 2007年第29期11卷 5806-5809页

作者：马义周天鸿暨南大学生命科学技术学院广东省广州市510632

目的:全面介绍胰高血糖素样肽1的结构及其生理功能以及有关重组或修饰后的胰高血糖素样肽1或其类似物的研发进展和应用前景。资料来源:应用计算机检索Elsevier-SDOL(ScienceDirect OnLine)1980-01/2007-04和Blackwell 1980-01/2007-04... 详细信息

目的:全面介绍胰高血糖素样肽1的结构及其生理功能以及有关重组或修饰后的胰高血糖素样肽1或其类似物的研发进展和应用前景。资料来源:应用计算机检索Elsevier-SDOL(ScienceDirect OnLine)1980-01/2007-04和Blackwell 1980-01/2007-04期间的相关文章,检索词“Glucagon like peptide-1,incretin,type 2 diabetes mellitus”,并限定文章语言种类为English。并手工检索2000-01/2007-04期间的相关专著。资料选择:对资料进行初审,选取包括胰高血糖素样肽1及其类似物的有关动物及人体的临床及临床前研究文献,开始查找全文。纳入标准:有关胰高血糖素样肽1及其类似物对哺乳动物及人体的细胞及个体实验和相关研究;重组胰高血糖素样肽1及其类似物与胰高血糖素样肽1受体结合及半衰期实验和相关研究。排除标准:有关胰高血糖素样肽1及其类似物在低等动物类群中的研究。资料提炼:共收集到48篇关于胰高血糖素样肽1及其类似物对哺乳动物及人体的细胞及个体实验和相关研究,39个研究符合纳入标准。排除的9篇研究中,6篇因系重复的同一研究,3篇为非哺乳动物及人体的相关研究。资料综合:胰高血糖素样肽1为糖尿病的治疗提供了新的方法,它能从多条途径改善糖代谢,降低血糖,同时还能降低体质量,但它不会引起显著的临床低血糖反应,这保证了用胰高血糖素样肽1治疗糖尿病的安全性,这一点显著优于磺脲类药物。同时,它还可能通过对血管的影响延缓糖尿病进程。结论:重组或修饰后的胰高血糖素样肽1或其类似物在体内具有刺激胰岛素分泌和胰岛素的生物合成,抑制胰高血糖素的分泌等多种生理功能,且更能抵抗二肽基肽酶IV的切割作用,从而有效延长其在生物体内的半衰期,因此重组或修饰后的胰高血糖素样肽1或其类似物成为研发治疗2型糖尿病新药的热点之一。

关键词：胰高血糖素样肽1 肠促胰岛素 2型糖尿病

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Preface:In honor of the 100th Anniversary of Harbin Institute of Technology

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Science China(Technological Sciences) 2020年第8期63卷 1323-1324页

作者： zhou Yu Harbin Institute of Technology

Harbin Institute of Technology(HIT)was established in 1920 in Harbin,Heilongjiang,*** 1954,HIT became one of China’s first six leading *** HIT is a member of China’s top nine University Union(C9).It is a National Ke... 详细信息

关键词： China. honor universities

Invariant holomorphic extension in several complex variables Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China Mathematics 2006年第11期49卷 1593-1598页

作者： zhou Xiangyu Institute of Mathematics AMSS Beijing Chinese Academy of Sciences

Two fundamental problems on the invariant holomorphic extensions have been posed, which are naturally arose from our solution of the extended future tube conjecture and closely and deeply related to the general theory of Stein manifolds due to Cartan-Serre. In this paper, the relationship is presented between the two problems, the motivation of considering the problems, and the methods to approach the problems. We have also posed some questions and conjectures related to this two problems.

关键词： Stein manifold, group action, plurisubharmonic function, minimum principle, categorical quotient.

Review of Sodic Soil Reclamation with a Snapshot of Current Research Activity

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Chinese Geographical Science 2022年第6期32卷 1099-1109页

作者： TÓth Tibor Institute for Soil Sciences Centre for Agricultural ResearchBudapest 1022Hungary

For centuries, reclamation of sodic soils has been an essential part of cropping practices in several parts of the world. Parallel to increasing population, the need for new cropland constantly re-evaluates land suitability concepts. therefore, the importance of sodic soils as potential croplands is increasing worldwide. Although theoretically farmers can choose from a wide variety of reclamation options, according to profitability, business plans, and human and financial resources, in practice, few reclamation methods are applied at large scale. this article touches on the early history, 20th Century intensive research, and current trends of sodic soil reclamation. New approaches such as leaching, chemical amendments, addition of organic material, and biological and microbial improvements are discussed, and also brand-new approaches are reviewed. the early history is reviewed using historical books, the achievements of the last hundred years using basic technical literature, mostly books, and the current approaches of our time with fresh publications, mostly papers and two very recent conferences published in English.

关键词： gypsuming liming chemical reclamation new technology sodic soil

Precipitation Changes in Wet and Dry Seasons over the 20th Century Simulated by Two Versions of the FGOALS Model

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Advances in Atmospheric Sciences 2015年第6期32卷 839-854页

作者： MA Shuangmei zhou Tianjun State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Climate Change Research Center Chinese Academy of Sciences

Seasonal precipitation changes over the globe during the 20th century simulated by two versions of the Flexible Global Ocean-Atmosphere-Land System （FGOALS） model are assessed. the two model versions differ in terms of their AGCM component, but the remaining parts of the system are almost identical. Both models reasonably reproduce the mean-state features of the timings of the wet and dry seasons and related precipitation amounts, with pattern correlation coefficients of 0.65-0.84 with observations. Globally averaged seasonal precipitation changes are analyzed. the results show that wet sea- sons get wetter and the annual range （precipitation difference between wet and dry seasons） increases during the 20th century in the two models, with positive trends covering most parts of the globe, which is consistent with observations. However, both models show a moistening dry season, which is opposite to observations. Analysis of the globally averaged moisture budget in the historical climate simulations of the two models shows little change in the horizontal moisture advection in both the wet and dry seasons. the globally averaged seasonal precipitation changes are mainly dominated by the changes in evaporation and vertical moisture advection. Evaporation and vertical moisture advection combine to make wet seasons wetter and enhance the annual range. In the dry season, the opposite change of evaporation and vertical moisture advection leads to an insignificant change in precipitation. Vertical moisture advection is the most important term that determines the changes in precipitation, wherein the thermodynamic component is dominant and the dynamic component tends to offset the effect of the thermodynamic component.

关键词： 20th century historical climate simulation FGOALS-g2 FGOALS-s2 wet season dry season precipitation change water vapor budget diagnosis

Information schema constructs for defining warehouse databases of genotypes and phenotypes of system manifestation features

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Frontiers of Information Technology & Electronic Engineering 2016年第9期17卷 862-884页

作者： Shahab POURTALEBI Imre HORVáth Faculty of Industrial Design Engineering Delft University of Technology

Our long-term objective is to develop a software toolbox for pre-embodiment design of complex and heterogeneous systems, such as cyber-physical systems. the novelty of this toolbox is that it uses system manifestation features(SMFs) for transdisciplinary modeling of these systems. the main challenges of implementation of the toolbox are functional design- and language-independent computational realization of the warehouses, and systematic development and management of the various evolving implements of SMFs(genotypes, phenotypes, and instances). therefore, an information schema construct(ISC) based approach is proposed to create the schemata of the associated warehouse databases and the above-mentioned SMF implements. ISCs logically arrange the data contents of SMFs in a set of relational tables of varying semantics. In this article we present the ISCs necessary for creation of genotypes and phenotypes. they increase the efficiency of the database development process and make the data relationships transparent. Our follow-up research focuses on the elaboration of the SMF instances based system modeling methodology.

关键词： Cyber-physical systems Software toolbox Pre-embodiment design System manifestation features(SMFs) Warehouses Database schemata SMF genotypes SMF phenotypes SMF instances Information schema constructs

An Innovative State-of-charge Estimation Method of Lithium-ion Battery Based on 5th-order Cubature Kalman Filter

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Automotive Innovation 2021年第4期4卷 448-458页

作者： Huang Yi Shichun Yang Sida zhou Xinan zhou Xiaoyu Yan Xinhua Liu School of Vehicle and Mobility Tsinghua UniversityBeijingChina School of Transportation Science and Engineering Beihang UniversityBeijingChina

the lithium-ion batteries have drawn much attention as the major energy storage ***,the battery state estimation still suffers from inaccuracy under dynamic operational conditions,with the unstable environmental noise influencing the robustness of *** paper presents a 5th-order cubature Kalman filter with improvements on adaptivity for real-time state-of-charge *** second-order equivalent circuit model is developed for describing the characteristics of battery,and parameter identification is carried out according to particle swarm *** developed method is validated in stable and dynamic conditions,and simulation results show a satisfactory consistency with the experimental *** maximum estimation error under static conditions is less than 3%and the maximum error under dynamic conditions is 5%.Numerical analysis indicates that the method has better convergence and robustness than the traditional method under the disturbances of initial error,which demonstrates the potential for EV applications in harsh *** proposed method shows application potential for both online estimations and cloud-computing system,indicating its diverse application prospect in electric vehicles.

关键词： 5th-order cubature Kalman filter Parameter identification Equivalent circuit model State of charge Lithium-ion battery