检索结果-南通市图书馆

JW-1-283 inhibits melanoma tumor growth via stabilization of the p53 pathway

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 18-21页

作者： Yang Xie Ruida Hou Kelli lHartman Jianxiong Jiang zhongzhi Wu Wei li Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN38163USA

Melanoma is a lethal skin malignancy and the fifth most diagnosed cancer in the United States.1 Currently,for unresectable melanoma,the recommended treatment options include checkpoint inhibitor immunotherapy targeting programmed cell death 1(PD-1),and inhibitors targeting the mitogen-activated protein kinase(MAPK)***,the response rate may vary among the patients,and therefore demanding the development of novel treatment *** suppressor TP53has been suggested as one of the critical regulators mediating the aggressiveness and progression of melanoma.

关键词： melanoma suppressor death

Building a domain-specific compiler for emerging processors with a reusable approach

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第1期67卷 20-38页

作者： Mingzhen lI Yi lIU Bangduo CHEN Hailong YANG zhongzhi l.an Depei QIAN State Key laboratory of Software Development Environment School of Computer Science and Engineering Beihang University

High-performance computing and deep learning domains have been motivating the design of domain-specific *** these processors can provide promising computation capability,they are notorious for exotic programming *** improve programming productivity and fully exploit the performance potential of these processors,domain-specific compilers(DSCs) have been ***,building DSCs for emerging processors requires tremendous engineering efforts because the commonly used compilation stack is difficult to be *** to the advent of multilevel intermediate representation(MlIR),DSC developers can leverage reusable infrastructure to extend their customized functionalities without rebuilding the entire compilation *** this paper,we further demonstrate the effectiveness of MlIR by extending its reusable infrastructure to embrace a heterogeneous many-core processor(Sunway processor).In particular,we design a new Sunway dialect and corresponding backend for the Sunway processor,fully exploiting its architectural advantage and hiding its programming *** show the ease of building a DSC,we leverage the Sunway dialect and existing MlIR dialects to build a stencil compiler for the Sunway *** experimental results show that our stencil compiler,built with a reusable approach,can even perform better than state-of-the-art stencil compilers.

关键词： domain-specific compiler emerging processor reusable dialect performance optimization MlIR

Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure,lipid profile and blood glucose level

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2008年第2期2卷 178-181页

作者： zhongzhi TANG Junyao lI Jianhong YANG Department of Critical Care Medicine Wuhan General HospitalGuangzhou Command of PLAWuhan 430070China

To study the relationship of the polymorphism of endothelial nitric oxide synthase(eNOS)gene and blood pressure,lipid profiles and blood glucose *** using PCR-RFlP,the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood *** into account eNOS Glu298Asp poly-morphisms,the relationship of blood pressure with trigly-cerides(TG),total cholesterol(TC),high density lipoprotein(HDl),low density lipoprotein(lDl.and blood glucose level was *** distribution of eNOS Glu298Asp polymorphism had no significant differ-ence between different blood pressure groups and gender groups,but there was a significant difference between dif-ferent age groups,diastolic blood pressure groups or BMI groups(Ply increased the risk of hypertension in individuals with serum TC above 5.4 mmol/l(P=0.03,OR=52.65).eNOS Glu298Asp polymorphism and serum lipid could synergis-tically modulate the blood *** Asp/Asp geno-type could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/*** Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.

关键词： endothelial cells nitric oxide synthase type III hypertension serum lipid blood glucose

Designing principles of an ecological water storage basin on coastal saline: a case study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2005年第1期17卷 62-66页

作者： lIUPing-ping YINCheng-qing QUJiu-hui ZHANGGuang-yun FENGWen-qing lIUJun-xin zhongzhi SKlEAC ResearchCenterforEco-EnvironmentalSciencesChineseAcademyofSciencesBeijing100085China TEDAWaterworksCo. Tianjin300457China

The degradation of water source environment becomes serious problems accompanying with rapid urbanization in China. Ecological engineering provides ecologically sound and cost effective solution to solving this problem. As a case study, a 15 hm 2 ecological water storage basin for a water plant was designed and constructed on the TEDA area in Tianjin City. located on saline, the construction of this project has to face serious difficulties, such as high salinity, scarce seed banks of macrophytes, and strong winds. Freshwater replacement, soil amendation and macrophytes planting at the basinshore, wooden water breaker and plastic membrane installation and other measures were conducted for the assistance of plant community establishment. The result showed that the chloride concentration in the basin water decreased from 11600 mg/l to less than 100 mg/l, and the chloride content in the basin sediment decreased from 2 1% to 0 35% after freshwater soaking. The introduced macrophytes of 8 species all survived and 11 other macrophytes species were occurred in the basin. A new ecosystem was created with increased biological diversity in the original saline, and the water quality was improved. This ecological water storage basin also provided a pleasing landscape for local people.

关键词： drinking water source water quality coastal saline urban ecological engineering

A　SYNCHRONOUS　PARAllEl　MUlTISPlITTING　NONlINEAR　GAUSS-SEIDEl　ITERATION

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 1997年第2期12卷 55-70页

作者： BAI zhongzhi AND WANG DEREN

An asynchronous parallel multisplitting nonlinear Gauss Seidel iterative method is established for the particularly structured system of nonlinear equations Aφ(x)+Bψ(x)=b with A,B∈l(R n),φ,ψ∶R n→R n...

关键词：

Phytoremediation of petroleum polluted soil

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2008年第2期5卷 167-171页

作者： Wang Jing Zhang zhongzhi Su Youming He Wei He Feng Song Hongguang School of Chemical Science ＆ Engineering China University of Petroleum Beijing 102249 China

An experimental study of the rhizosphere effect on phytoremediation of petroleum polluted soil was carried out with three species of grasses, namely Pannicum, Eleusine indica （l.） Gaerth, and Tall Fescue. After a period of 150 days, this pot experiment showed that the rhizosphere of these three species accelerated the degradation of petroleum hydrocarbons to different extents. The results showed that the number of microorganisms in the rhizosphere increased by three orders of magnitude. The induction of the plant rhizosphere and the coercion influence of petroleum changed the species and activity of microorganisms. The degradation of petroleum hydrocarbons in the rhizosphere was 3-4 times that in unplanted soil. The dehydrogenase activity in the rhizosphere was 1.61-2.20 times that in unplanted soil, but the catalase activity was 0.90-0.93 times that in unplanted soil, and soil moisture content increased by 5% compared with the unplanted soil.

关键词： Phytoremediation rhizosphere microbial number dehydrogenase activity catalaseactivity petroleum hydrocarbon degeneration

DNA Binding Properties and Cytotoxic Activities of Two Trinuclear Ruthenium（Ⅱ） Polypyridyl Complexes

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2014年第3期30卷 461-467页

作者： XU li CHEN Yu WEI Hui WU Wenshan lI zhongzhi lIN Yiwei CHAO Hui JI l.angnian School of Chemistry and Chemical Engineering Guangdong Pharmaceutical University Zhongshan 528458 P R. China State Key laboratory of Biocontrol Department of Biochemistry College of Life Sciences Sun Yat-sen University Guangzhou 510006 P. R. China School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275 P. R. China

The interactions between two trinuclear Ru（II） complexes and calf thymus DNA（CT DNA） were studied via absorption spectroscopy, reverse salt titrations, binding stoichiometry, DNA melting experiments, as well as viscosity measurement. The results indicate that complexes 1 and 2 bind to DNA via the interaction of the planar π-delocalized system of the complexes with intrinsic binding constants of 4.18 × 10^5 and 3.85 × 10^6 l/tool, respectively, and non-electrostatic binding free energy makes a predominant contribution to the binding free energy. The in vitro cytotoxic activity of complexes 1 and 2 was evaluated by the MTT[3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl- 2H-tetrazolium bromide] method. Complex I shows higher anticancer potency than complex 2 against four tumor cell lines. Further mechanism study indicates that complexes 1 and 2 can cause cell cycle arrest in the G2/M phase.

关键词： Ruthenium(Ⅱ) complex DNA binding Cell cycle

Ecotoxicological effects of mixed pollutants resulted from e-wastes recycling and bioaccumulation of polybrominated diphenyl ethers in Chinese loach(Misgurnus anguillicaudatus)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2009年第12期21卷 1695-1701页

作者： QIN Xiaofei XIA Xijuan lI Yan ZHAO Yaxian YANG zhongzhi FU Shan TI-AN Mi ZHAO Xingru QIN Zhanfen XU Xiaobai YANG Yongjian State Key laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences Chinese Academy of Sciences Beijing 100085 China Taizhou No.1 Middle School Taizhou 318000 China

To understand potential ecotoxicological effects of electrical.and electronic equipment waste （e-waste） recycling and polybrominated diphenyl ethers （PBDEs） bioaccumulation in loaches, a semi-field experiment using Chinese loach （Misgurnus anguiUicaudatus） as experimental fish was performed. larval loaches were kept in net-cage for three months in an e-wastes recycling site and a reference site in Southeastern China. There was significant difference of the survival rate between the loaches from the e-wastes recycling site （27%, 19/70） and from reference site （70%, 49/70）. Histopathological responses were also found in all the livers examined in loaches from the e-wastes recycling site. These results showed that mixed pollutants resulted from e-wastes recycling led to ecotoxicological effects on loaches. The bioaccumulation of polybrominated diphenyl ethers （PBDEs）, the main pollutants in e-waste, in loaches was also studied, the mean concentration of total PBDEs in sediment was 6726.17 ng/g wet weight and in water samples was 4.08 ng/l （dissolved phase）. BDE 209 was the dominant congener in sediment and with relatively high concentration in water. Relatively low concentration of BDE 209 （less than 0.01% of total PBDEs） and high concentration of BDE47 （up to 39.34% of total PBDEs） were detected in loaches.

关键词： e-wastes loach ecotoxicological effects polybrominated diphenyl ethers semi-field experiment

Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2010年第5期22卷 744-751页

作者： Xiaofei Qin Xijuan Xia zhongzhi Yang Shishuai Yan Yaxian Zhao Rongguo Wei Yan li Mi Tian Xingru Zhao Zhanfen Qin Xiaobai Xu State Key laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences Chinese Academy of Sciences Beijing 100085 China Chinese Research Academy of Environmental Sciences Beijing 100012 China

Decabromodiphenyl ether （decaBDE）,as a flame retardant,is widely produced and *** study the thyroid disruption by technical decaBDE at low concentrations,Xenopus laevis tadpoles were exposed to technical decaBDE mixture DE-83R （1-1000 ng/l） in water from stage 46/47 （free swimming larvae,system of Nieuwkoop and Faber） to stage ***-83R at concentration of 1000 ng/l significantly delayed the time to metamorphosis （presented by forelimb emergence,FlE）.Histological examination showed that DE83R at all tested concentrations caused histological alterations-multilayer follicular epithelial cell.and markedly increased follicle size accompanied by partial colloid depletion and increase in the peripheral colloid vacuolation,in thyroid *** tested concentrations of DE-83R also induced a down-regulation of thyroid receptor mRNA *** results demonstrated that technical decaBDE disrupted the thyroid system in *** *** of polybrominated diphenyl ethers （PBDEs）（sum of 39 congeners） in *** indicated that mean concentrations of total PBDEs in *** exposed to 1,10,100,1000 ng/l were 11.0,128.1,412.1,1400.2 ng/g wet weight,*** that PBDEs burden of *** tadpoles was close to PBDEs levels in amphibians as reported in previous studies,our study has raised new concerns for thyroid disruption in amphibians of technical decaBDE at environmentally relevant concentrations.

关键词： decabromodiphenyl ether Xenopus laevis thyroid disruption metamorphosis thyroid hormone receptor