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逍遥散对慢性束缚应激肝郁脾虚证焦虑模型大鼠血清IL-1β、IL-6、TNF-α的影响

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中医学报 2016年第6期31卷 822-826页

作者：金钟晔李娜赵宏波李晓娟刘玥芸陈家旭北京中医药大学北京100029 北京大学首钢医院北京100144 北京市石景山区中医医院北京100043

目的:观察逍遥散对慢性束缚应激肝郁脾虚证焦虑模型大鼠血清炎性因子白介素(interleukin,IL-1β)、IL-6、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)的影响,以此研究逍遥散的干预作用。方法:28只雄性SD大鼠随机分为正常组、模型组... 详细信息

目的:观察逍遥散对慢性束缚应激肝郁脾虚证焦虑模型大鼠血清炎性因子白介素(interleukin,IL-1β)、IL-6、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)的影响,以此研究逍遥散的干预作用。方法:28只雄性SD大鼠随机分为正常组、模型组、逍遥散组、氟西汀组;正常组不做任何处理,模型组、逍遥散组和氟西汀组通过连续14天慢性束缚应激建立肝郁脾虚证焦虑模型,逍遥散组和氟西汀组于每天上午束缚前分别灌服逍遥散混悬液(0.006 1 g·g-1)以及氟西汀(0.002mg·g-1),正常组和模型组灌服去离子水。第15天,观察各组大鼠的宏观表征、体质量变化、新环境进食抑制实验,高架十字迷宫实验。第16天,用ELISA方法测定大鼠血清的IL-1β、IL-6、TNF-α的变化。结果:实验第15天模型组的行为学均明显变化。体质量:正常组、模型组、逍遥散组和氟西汀组分别为(353.14±5.80)g、(334.17±5.18)g、(353.95±8.00)g、(355.65±4.92)g,模型组明显低于其余3组(P0.05)。与模型组相比,除氟西汀组开放臂停留时间以外,其余3组大鼠的开放臂进入次数与开放臂停留时间均高于模型组(P0.05)。与模型组比较,其余3组大鼠的3个血清指标低于模型组(P<0.05,P<0.01)。结论:逍遥散可降低慢性束缚应激肝郁脾虚证焦虑模型大鼠IL-1β、IL-6、TNF-α,对焦虑有一定作用。

关键词：逍遥散慢性束缚应激焦虑白介素肿瘤坏死转移因子大鼠

Comparison of Chondrogenic Ability between Mesenchymal Stem Cells and Buffy Coat <i>in Vitro</i>

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Journal of Biosciences and Medicines 2018年第3期6卷 86-94页

作者： Longhao jin zhongye Zhang Yanqun Liu Kumar Gurung Yongjun jin Yuanming He Yu jin Zhehu jin Department of Orthopedic Surgery Yanbian University Hospital Yanji City China Department of Orthopedic Surgery Songyuan Central Hospital Songyuan City China Department of Anatomy School of Medicine Yanbian University Yanji City China Department of Dermatology Yanbian University Hospital Yanji City China

Objective: In vitro comparison of chondrogenic differentiation ability of bone marrow extracted mesenchymal stem cells (MSCs) and buffy coat. Methods: MSCs of New Zealand white rabbits were cultured in vitro and adherent cells were passaged. The cells were inoculated on polyglycolic acid (PGA) scaffold (3 mm in diameter and 2 mm in height) liquid for 21 days. Under the same conditions, without subculture, buffy coat was directly inoculated into the cell scaffold. The degree of chondrogenic differentiation was compared by Safranin-Ostaining, histological scoring and biochemical functional detection. Results: The chondrogenic differentiation ability of the buffy coat group was better than that of the MSC group. Safranin-Ostain was stronger in buffy coat group than in MSC group. The Bern Score was also higher in the buffy coat group than in the MSC group and the total amount of sulfated glycosaminoglycans (GAGs) in buffy coat group was higher than that in MSC group. Conclusion: The chondrogenic differentiation ability of buffy coat is higher than that of MSC. Through this result, it was found buffy coat can also differentiate into sub-cartilage without stimulating growth factor. Thus, buffy coat can make a great source in artificial cartilage engineering.

关键词： Chondrogenic Buffy Coat Mesenchymal Stem Cells

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陈家旭教授从肝论治围绝经期综合征思路

世界中医药 2014年第6期9卷 800-802页

作者：李娜赵歆景玉霞金钟晔李晓娟白晓晖白明华赵洪波刘玥芸王利敏陈家旭北京中医药大学基础医学院北京100029 新疆医科大学中医学院乌鲁木齐830054 北京市石景山区中医医院北京100043

围绝经期综合征是女性临床上的常见病,症状复杂且迁延难愈。陈家旭老师从肝论治此病,立法遣方用药独特,并重视对患者的情志调节,使人体之"升降出入"气机恢复常态。陈老师擅用逍遥散及其他单元药组治疗此病,为临床提供了新的思路和方法。

关键词：围绝经期综合征从肝论治逍遥散

The Application Prospect Autologous Bone Marrow Extract Buffy Coat in Cartilage Tissue Engineering: A Mini-Review

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Journal of Biosciences and Medicines 2019年第12期7卷 9-17页

作者： Zhiyu Li zhongye Zhang Guo Song Shouyong Fu Longhao jin Yanqun Liu Department of Orthopedic Surgery Yanbian University Hospital Yanji China Department of Orthopedic Surgery Songyuan Central Hospital Songyuan China

Cartilage injury is an important cause of osteoarthritis;however, there is no effective method of cartilage regeneration at present. Therefore, it would be of great value to explore and develop new methods of cartilage regeneration. In recent years, it has become a hot topic on repairing damaged cartilage by using tissue engineered cartilage domestic and abroad. It’s the key factor to success for getting cell source which is effective, applicable and easy to obtain in the technology of cartilage tissue engineering filed. This article summarizes the research progress of bone marrow extract buffy coat in cartilage tissue engineering.

关键词： Buffy Coat Cartilage Tissue Engineering

改良固定法在新生儿会阴肛门成形术肛管固定中的效果观察

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浙江医学教育 2021年第6期20卷 46-48页

作者：贾丽金芹莫钟烨嘉兴市妇幼保健院浙江嘉兴314000

目的:观察改良固定法在新生儿会阴肛门成形术肛管固定中的应用效果。方法:选择2017年12月至2020年12月在我科接受会阴肛门成形术需留置肛管的60例患儿作为研究对象,2017年12月至2019年8月使用传统“Y”形肛管固定法的患儿30例作为对照组... 详细信息

目的:观察改良固定法在新生儿会阴肛门成形术肛管固定中的应用效果。方法:选择2017年12月至2020年12月在我科接受会阴肛门成形术需留置肛管的60例患儿作为研究对象,2017年12月至2019年8月使用传统“Y”形肛管固定法的患儿30例作为对照组;2019年9月至2020年12月使用肛管改良固定法的患儿30例作为观察组。比较2组患儿肛管移位程度、胶带卷边率、固定肛管所需的时间。结果:观察组肛管移位程度轻于对照组、胶带卷边率低于对照组、固定肛管所需的时间小于对照组,差异具有统计学意义(P<0.05)。结论:使用改良固定法进行新生儿会阴肛门成形术的肛管固定,其效果好于传统“Y”形胶带固定法,值得临床推广。

关键词：改良固定法新生儿肛管效果

Life Cycle Assessment of Iron Ore Sintering Process

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Journal of Iron and Steel Research International 2015年第6期22卷 473-477页

作者： Zong-ping LI Xiao-hui FAN Gui-ming YANG jin-chao WEI Ying SUN Min WANG School of Minerals Processing and Bioengineering Central South University zhongye Changtian International Engineering Co. Ltd.

Iron ore sintering is an energy＇intensive process associated with emission of pollutants in iron and steel in- dustry. In order to comprehensively evaluate the environmental impacts of sintering, a detailed life cycle assessment of a sintering plant was conducted. Life cycle inventory showed that, in the production of 1 t sinter ore, 241.53 kg CO2 , 22.68 kg CO, 0. 294 kg SO2 , 0.63 kg NO, , 1.18 /lg dioxin and 0.48 kg dust were discharged. Global war- ming potentials, acidification potentials, photochemical ozone creation potentials and human toxicity potentials were selected as four impact categories, and the evaluation index for the sintering plant was calculated as 3.45 × 10 ^-12. Fi nally, based on the environmental impact analysis, several measures of reducing environmental [oadings of the sinte- ring plant were provided, which included the utilization of denitrification equipment, recirculation of the hot waste gas and process improvement to reduce fuel consumption.

关键词： iron ore sintering plant life cycle assessment pollutant emission environmental loading

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虎芪活血煎治疗特发性肺纤维化临床研究

中医学报 2014年第9期29卷 1269-1270页

作者：张桂才林敏乐进仇中叶周贤梅盐城市中医院江苏盐城224001 江苏省中医院江苏南京210029

目的:观察虎芪活血煎治疗特发性肺纤维化的临床疗效。方法:60例特发性肺纤维化患者随机平均分为治疗组与对照组。对照组采用口服糖皮质激素醋酸泼尼松治疗;治疗组采用口服中药虎芪活血煎治疗。比较两组临床疗效、不良反应、治疗费用等... 详细信息

目的:观察虎芪活血煎治疗特发性肺纤维化的临床疗效。方法:60例特发性肺纤维化患者随机平均分为治疗组与对照组。对照组采用口服糖皮质激素醋酸泼尼松治疗;治疗组采用口服中药虎芪活血煎治疗。比较两组临床疗效、不良反应、治疗费用等指标。结果:所有患者均顺利完成治疗及随访,治疗组显效8例,有效15例,无效7例,有效率76.7%(23/30);对照组显效5例,有效11例,无效14例,有效率53.3%(16/30)。两组有效率比较,差异有统计学意义(P<0.05);治疗组的不良发应发生率为6.7%,低于对照组,差异具有统计学意义(P<0.01);治疗组的平均治疗费用低于对照组,差异有统计学意义(P<0.05)。结论:虎芪活血煎治疗特发性肺纤维化疗效显著。

关键词：虎芪活血煎肺纤维化糖皮质激素

M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator

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Bioactive Materials 2023年第10期28卷 273-283页

作者： Yili Wang Qiushui Lin Hao Zhang Sicheng Wang jin Cui Yan Hu jinlong Liu Mengmeng Li Kun Zhang Fengjin Zhou Yingying jing Zhen Geng Jiacan Su Institute of Translational Medicin5 Shanghai UniversityShangha9200444China School of Medicin5 Shanghai UniversityShangha9200444China School of Life Sciences Shanghai UniversityShangha9200444China Organoid Research Center Shanghai UniversityShangha9200444China National Center for Translational Medicine(Shanghai)SHU Branc8 Shanghai UniversityShangha9200444China Department of Spine Surgery First Affiliated Hospital of Naval Medical UniversityShangha9200433China Department of Orthopedics Shanghai Zhongye HospitalShangha9200941China Department of Orthopedics Traum1 Changhai HospitalSecond Military Medical UniversityShangha9200433China Department of Orthopedics Honghui HospitalXi’an Jiao Tong UniversityXi’an710000China Suzhou Innovation Center of Shanghai University Suzhou215000JiangsuChina Shaoxing Institute of Technology at Shanghai University Shaoxin7312000Zhejian7China Department of Orthopedics Xinhua HospitalShanghai Jiao Tong University School of Medicin5Shangha9200092China

Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture *** play a key role in the process of fracture healing by undergoing polarization into either M1 or M2 subtypes,which respectively exhibit pro-inflammatory or anti-inflammatory ***,modulation of macrophage polarization to the M2 subtype is beneficial for fracture *** perform an important role in improving the osteoimmune microenvironment due to their extremely low immunogenicity and high *** this study,we extracted the M2-exosomes and used them to intervene the bone repair in diabetic *** results showed that M2-exosomes significantly modulate the osteoimmune microenvironment by decreasing the proportion of M1 macrophages,thereby accelerating diabetic fracture *** further confirmed that M2-exosomes induced the conversion of M1 macrophages into M2 macrophages by stimulating the PI3K/AKT *** study offers a fresh perspective and a potential therapeutic approach for M2-exosomes to improve diabetic fracture healing.

关键词： M2-exosomes Diabetic fracture healing Osteoimmune microenvironment Macrophage polarization PI3K/AKT signaling pathway

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鸡腿葱新品种新葱5号的选育

中国蔬菜 2013年第06X期 104-106页

作者：张国进王文洁段风华任福森河南省新乡市农业科学院河南新乡453000 河南敦煌种业新科种子有限公司河南新乡453000

新葱5号是采用多亲本、多重杂交技术,综合众多亲本的优良性状,经多年系统选育出的大葱新品种。株高95～100cm,葱白长35～40cm,底茎粗6～7cm,中茎粗2.5～3.0cm,叶片深绿色,生长期功能叶6～8片,平均每667m2产量5000kg,适合河南、河北、山... 详细信息

新葱5号是采用多亲本、多重杂交技术,综合众多亲本的优良性状,经多年系统选育出的大葱新品种。株高95～100cm,葱白长35～40cm,底茎粗6～7cm,中茎粗2.5～3.0cm,叶片深绿色,生长期功能叶6～8片,平均每667m2产量5000kg,适合河南、河北、山西、山东等地种植。

关键词：鸡腿葱新葱5号多重杂交系统选育